Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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ODM pillow for sleep brands China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Flexible manufacturing OEM & ODM Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ODM pillow factory in China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan insole ODM full-service provider factory

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.One-stop OEM/ODM solution provider Indonesia

The researchers found that heat turns off the brain. Zebrafish experiments demonstrate how vulnerable freshwater and marine species may be impacted by climate change. When the climate changes, which organisms survive and which die? A small larval fish is offering unexpected insight into how the brain reacts to rising temperatures. “It was pretty incredible, actually. The whole brain lit up,” said Anna Andreassen, a Ph.D. candidate at the Norwegian University of Science and Technology (NTNU). Living organisms, whether it be fish or humans, tend to function worse as the temperature increases. Many people have probably gone through this on a summer day that was a bit too hot. But what precisely occurs inside the body when it becomes uncomfortably warm? In order to figure out the answer, biologists from NTNU’s Department of Biology have combined genetic technology with neurophysiological techniques. “We wanted to look at the mechanisms that limit organisms’ thermal tolerance. Which animals will survive when the Earth’s temperature increases due to climate change, and why? We chose to look at the brain,” says Andreassen. Zebrafish play the lead role when Ph.D. candidate Anna H. Andreassen conducts experiments to find out how brain cells react to temperature changes. Credit: Ingebjørg Hestvik Climate Change Causing Heat Waves Anna H. Andreassen, a Ph.D. candidate at NTNU. Credit: Norwegian University of Science and Technology Animals that dwell in water are experiencing temperatures that are increasing to fatal levels, and heat waves that traverse continents are getting more frequent. To forecast how species will adapt to climate change, it is essential to understand what limits survival at very high temperatures. “Thermal tolerance is a topic that has been researched for decades, and the idea that temperature affects brain activity is an old one. What’s new is that we can now use genetic technology and neurophysiology to study the phenomenon,” says Andreassen. Researchers at NTNU in Trondheim studied the brain activity of newly hatched zebrafish larvae while progressively raising the temperature around the larval fish. “These fish have been genetically modified so that the neurons in the brain give off a fluorescent light when they’re active. We can see this light under a microscope while the larvae swim around. These larval fish also have the advantage that they’re transparent. We get to look directly into the brains of the living larvae,” says Andreassen. Lose the Ability to Respond In this way, the researchers can follow brain activity while gradually increasing the temperature of the water that the fish are swimming in. “We can see how the larvae behave as it gets warmer. When it starts to get extremely warm, they lose their balance and start swimming around in circles, belly up.” The researchers poked the fish larvae to check their response. They nudged the larvae’s tails, which normally triggers a swimming response. “At a certain temperature, the fish stopped reacting to the pokes. They were still alive, but in an ecological sense, they could be considered dead. In that condition out in nature, they wouldn’t be able to swim away from predators or find their way to colder water,” says Andreassen, who adds that this condition is only temporary in the small experimental fish. “They’re in just as good shape as soon as we get them into cooler water again,” says Andreassen. Researchers use fish to get answers to many questions in biological research. Departmental engineer Eline Rypdal (right) assists with animal care. Credit: Ingebjørg Hestvik Heat Turns Off the Brain So far, the experiments had gone as the researchers were expecting. By shining light in front of the fish’s eyes, they could also check whether the brain was perceiving visual impressions. As the temperature rose, the brain completely stopped responding to stimuli and was completely inactive. But then, when they turned the temperature up a little more, something happened. “The whole brain lit up. The closest I can come to describing what we saw was a kind of seizure,” says Andreassen. Normally, you only see brain activity in the form of small spots of light in defined parts of the brain. Now the amazed researchers could observe under the microscope how the fluorescent light spread out within a few seconds and covered the entire brain of the small fish larva. “We know that zebrafish brains have quite a lot in common with the human brain – 70 percent of the genetic material is the same – and researchers have speculated whether there could be a connection between what we saw in these fish larvae and what you see in the brains of children who have a fever,” says Andreassen. Next, the researchers want to put a special type of brain cell – glial cells –under the microscope. “What we’re excited to investigate here is the activity of glial cells during heating. These cells play a central role in the oxygen supply to the brain – they both check the oxygen level and regulate the blood flow and thereby the oxygen supply. Because we can see that oxygen levels affect thermal tolerance, one hypothesis is that the brain stops working because the glial cells are no longer able to regulate the oxygen level.” Differences Advance Evolution In order to take a closer look at what happened, the researchers in Trondheim began to manipulate the amount of oxygen in the water the fish were swimming in, while increasing the temperature. “To our surprise, we found that the oxygen level played a part in controlling the thermal tolerance. When we added extra oxygen, the larval fish did better at high temperatures, had higher brain activity, and also recovered faster from being exposed to upper thermal limits compared to the fish with low oxygen. Studies of other species have yielded contrasting results when testing the effect of oxygen concentration on thermal tolerance. “Being ‘insensitive’ to fluctuations in oxygen levels could thus be an evolutionary advantage as the temperature on Earth rises. “The findings show that thermal tolerance is something that varies between species. This could be a characteristic that determines whether a species is able to adapt to climate change or will succumb to rising temperatures. A lot of organisms live in oxygen-poor environments where temperatures can quickly become higher than normal. They’ll be especially vulnerable,” says Andreassen. She gives as an example organisms that live in shallow freshwater areas, in rivers, or in the intertidal zone. “These are habitats where large fluctuations in the oxygen level can occur, often at the same time as temperature fluctuations. In these habitats, fish whose thermal tolerance is limited by the oxygen level are likely to struggle more than fish who are not affected by it. Animals that manage to maintain nerve function under low oxygen levels might be the ones that will tolerate high temperatures best,” says Andreassen. Reference: “Brain dysfunction during warming is linked to oxygen limitation in larval zebrafish” by Anna H. Andreassen, Petter Hall, Pouya Khatibzadeh, Fredrik Jutfelt and Florence Kermen, 19 September 2022, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2207052119

In new research, scientists reveal another factor implicated in the aging process—a class of lipids called SGDGs that decline in the brain with age and may have anti-inflammatory effects. The molecules, called SGDGs, may lead to new ways to treat age-related neurological diseases. Aging involves complicated plot twists and a large cast of characters, including inflammation, stress, metabolism changes, and many others. Now, a team of scientists reveal another factor implicated in the aging process—a class of lipids called SGDGs (3-sulfogalactosyl diacylglycerols) that may have anti-inflammatory effects and decline in the brain with age. The research helps unravel the molecular basis of brain aging, reveals new mechanisms underlying age-related neurological diseases, and offers future opportunities for therapeutic intervention. The study, by scientists from the Salk Institute and the University of California, San Diego (UCSD), was published on October 20, 2022, in the journal Nature Chemical Biology. “These SGDGs clearly play an important role in aging, and this finding opens up the possibility that there are other critical aging pathways we’ve been missing,” says co-corresponding author Alan Saghatelian. “This is a pretty clear case of something that should be dug into more in the future.” Saghatelian is a professor in Salk’s Clayton Foundation Laboratories for Peptide Biology and holder of the Dr. Frederik Paulsen Chair. The brain is comprised of lipids or fats, but the role of these molecules in health and disease remains unknown. The newly identified class of lipids, called SGDGs, decrease with aging, which suggests they may play a role in brain aging. Credit: Salk Institute SGDGs are a class of lipids, which are also called fats. Lipids contribute to the structure, development, and function of healthy brains, while badly regulated lipids are linked to aging and diseased brains. However, lipids, unlike genes and proteins, are not well understood and have often been overlooked in aging research. Saghatelian specializes in discovering new lipids and determining their structures. In collaboration with Professor Dionicio Siegel at UC San Diego, Saghatelian’s lab made three discoveries involving SGDGs: In the brain, lipid levels are very different in older mice than in younger mice; all SGDG family members and related lipids change significantly with age; and SGDGs may be regulated by processes that are known to regulate aging. To reach these findings, the team took an unusual, exploratory approach that combined the large-scale study of lipids (lipidomics) with structural chemistry and advanced data analytics. They first obtained lipid profiles of mouse brains at five ages, ranging from one to 18 months, using liquid chromatography-mass spectrometry. Technological advances in this instrumentation vastly expanded the number of data points available to the scientists, and advanced data analysis allowed them to determine age-related patterns in the enormous lipid profiles. The team then constructed SGDG molecules and tested them for biological activity. From left: Joan Vaughan, Srihari Konduri, Cynthia Donaldson, Peter Gray, Dionicio Siegel, Dan Tan, Alan Saghatelian, and Antonio Pinto. Credit: Salk Institute “SGDGs were first identified in the 1970s, but there were few follow-up studies. These lipids were essentially forgotten and missing from the lipid databases. Nobody knew SGDGs would be changing or regulated in aging, let alone that they have bioactivity and, possibly, be therapeutically targetable,” says first author Dan Tan, a postdoctoral fellow in Saghatelian’s lab at Salk. The analysis showed that SGDGs possess anti-inflammatory properties, which could have implications for neurodegenerative disorders and other neurological conditions that involve increased inflammation in the brain. The team also discovered that SGDGs exist in human and primate brains, suggesting that SGDGs may play an important role in animals other than mice. Further research will be required to show if SGDGs contribute to human neuroinflammation. In the future, the team will examine how SGDGs are regulated with aging and what proteins are responsible for making them and breaking them down, which may open the door to discovering novel genetic activity associated with aging. “With the understanding of the structure of SGDGs and our ability to create them in the laboratory, the study of these important lipids is now wide open and ripe for discovery,” says Siegel, co-corresponding author of the study. Reference: “A class of anti-inflammatory lipids decrease with aging in the central nervous system” by Dan Tan, Srihari Konduri, Meric Erikci Ertunc, Pan Zhang, Justin Wang, Tina Chang, Antonio F. M. Pinto, Andrea Rocha, Cynthia J. Donaldson, Joan M. Vaughan, Raissa G. Ludwig, Elizabeth Willey, Manasi Iyer, Peter C. Gray, Pamela Maher, Nicola J. Allen, J. Bradley Zuchero, Andrew Dillin, Marcelo A. Mori, Steven G. Kohama, Dionicio Siegel and Alan Saghatelian, 20 October 2022, Nature Chemical Biology. DOI: 10.1038/s41589-022-01165-6 Additional authors included Meric Erikci Ertunc, Justin Wang, Tina Chang, Antonio F. M. Pinto, Andrea Rocha, Cynthia J. Donaldson, Joan M. Vaughan, Peter C. Gray, Pamela Maher, and Nicola J. Allen of Salk; Srihari Konduri of UC San Diego; Pan Zhang of UC Los Angeles; Raissa G. Ludwig and Marcelo A. Mori of the University of Campinas, Brazil; Elizabeth Willey and Andrew Dillin of UC Berkeley; Manasi Iyer and Bradley Zuchero of Stanford University; and Steven G. Kohama of Oregon Health and Science University. This work was funded by Ferring Pharmaceuticals and Frederik Paulsen, the National Institutes of Health (P30 CA014195, R01DK106210, R01NS119823, R01AG069206 and RF1AG061296), the Oregon National Primate Research Center (P51 OD 010092), the Wu Tsai Human Performance Alliance and the Joe and Clara Tsai Foundation, the Anderson Foundation, the Bruce Ford and Anne Smith Bundy Foundation, the Pioneer Fellowship, the Howard Hughes Medical Institute, the CZI Neurodegeneration Network, and The Sãn Paulo Research Foundation (2017/01184-9).

New mapping of the cuttlefish brain could explain how, and why, the marine animal employs its distinct camouflage ability. Credit: Dr. Wen-Sung Chung / Queensland Brain Institute A new brain map explains cuttlefish camouflage and offers insights into cephalopod and human brain evolution. Researchers from The University of Queensland (UQ) and the Queensland Brain Institute (QBI) have uncovered new insights into the cuttlefish brain, offering an explanation for the marine animal’s unique ability to camouflage. The neuroscientists have created the first-ever detailed map of the cuttlefish brain structure and neuronal network, opening up a new avenue of discovery. “Much of our understanding of the cuttlefish brain has been based on a single species, the nocturnal European common cuttlefish,” Lead author Dr. Wen-Sung Chung from QBI’s Marshall Lab said. “We wanted to fill in the gaps of this knowledge by focusing on selected cuttlefish which are active during the day and further compare with other species from the Mediterranean and Indo-Pacific regions.” The research team from The University of Queensland’s Queensland Brain Institute utilized gross anatomy and Magnetic Resonance Imaging (MRI) to monitor alterations in the visual and learning areas of the brain and compared their findings with those from other cuttlefish species to develop a comprehensive brain connectivity map. Insights into Camouflage and Sensory Networks “What we discovered was the neuronal network which involved chemosensory function and body patterning control, which enables the cuttlefish to use in foraging and its camouflage,” Dr. Chung said. “We also discovered that the brain adaptations reflect the requirement of their daily life regarding ecology and habitats.” The map of the brain structure could also help researchers understand the evolutionary pathway of the cuttlefish brain and, in turn, possibly gain insights into the evolution of our own brain. “This research adds to our growing understanding of the cuttlefish brain along with our recent discoveries in the brains of octopus and squid,” Dr. Chung said. “It suggests that the brain structures can be used to investigate the evolutionary history of cephalopods. And by understanding the brain structures and networks of other animals, we can start to perceive more of the forces that shaped our brain.” Reference: “The brain structure and the neural network features of the diurnal cuttlefish Sepia plangon” by Wen-Sung Chung, Alejandra López-Galán, Nyoman D. Kurniawan and N. Justin Marshall, 21 December 2022, iScience. DOI: 10.1016/j.isci.2022.105846 The study was funded by the Australian Research Council, the Office of Naval Research Global, and the National Council for Science and Technology of Mexico (Consejo Nacional de Ciencia y Tecnología – CONACYT).

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