Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan pillow OEM manufacturing factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia ergonomic pillow OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand orthopedic insole OEM manufacturer

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan flexible graphene product manufacturing

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole manufacturing factory in Taiwan

Researchers at City of Hope have identified a crucial interaction between two proteins that facilitate cancer cell growth, offering a new target for developing effective cancer treatments. Credit: SciTechDaily.com Scientists identify treatment target that disrupts proteins’ interaction, offering hope for new therapeutic approach. Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have discovered a new cellular mechanism that plays an important role in cancer cells’ ability to cause disease. The study will be published today (February 5) in Nature Structural & Molecular Biology. Key Protein Interaction Identified A team led by Chun-Wei (David) Chen, Ph.D., an associate professor of systems biology at City of Hope, pinpointed two cell-surface proteins, integrin αV and β5, that partner to spur cancer cell growth. The researchers next identified a region of integrin αV called the β-propeller domain that controls the interaction between the two proteins. Protein surface (left) and ribbon (right) models of integrin αV’s β-propeller domain illustrate the capacity of Cpd_AV2 (yellow) in disrupting the interaction between integrin β5’s βA loop (cyan; green indicates the key interacting residue lysine 287) and integrin αV. The integrin αV’s β-propeller domain is colored by normalized CRISPR-tiling score (NCS). Credit: Chun-Wei (David) Chen, Ph.D. / City of Hope Advancement in Cancer Treatment Blending laboratory experiments with computer simulations, Chen’s team created a powerful digital application of CRISPR gene-tiling technology to uncover potential cancer medicines that precisely target the β-propeller domain. After identifying the chemical compound Cpd_AV2 as a strong candidate, the team applied this compound to human cancer cells in the laboratory. Integrin αV and β5 rapidly separated, dissolving communication between the two proteins and causing cellular death, effectively halting growth in cancer cell lines. Clinically, the researchers found integrin αV overexpression in multiple cancer types, highlighting integrin αV’s lead role in cancer progression. High levels of integrin αV were also associated with a poor prognosis in 3,700 patients with cancers of the breast, pancreas, liver, lung, and brain. Expanding Therapeutic Horizons By expanding opportunities for developing targeted therapies that sever the connection between integrin αV and β5, the City of Hope-led findings suggest a potent new approach for cancer treatment and future medicine discovery studies. “Our study showcases an innovative application of CRISPR gene-tiling technology, revealing previously undiscovered sites on proteins with the capacity to cause cancer,” said Chen, who is also division director of epigenetic and transcriptional engineering at Beckman Research Institute of City of Hope. “This breakthrough opens new avenues for the advancement of next-generation oncologic therapies, marking a significant milestone in City of Hope’s battle against cancer.” Scientists estimate that up to 1,100 different proteins live on the plasma membrane, or semi-permeable surface of the cancer cell; many of these proteins’ biological functions could influence disease progression and therapeutic response. The region offers a valuable pool of targets for medical intervention because there are plenty of surface receptors and signaling proteins that can be engineered to aid in the delivery of cancer treatments. Integrin αV and β5 belong to the integrin family, a group of cell-surface receptors that play a central role in regulating cellular interactions, particularly across cell membranes. Reference: “A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens” by Nicole M. Mattson, Anthony K. N. Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven. T. Rosen, Jianjun Chen, Mark A. LaBarge, John E. Shively, Nagarajan Vaidehi, Russell C. Rockne, Mingye Feng and Chun-Wei Chen, 5 February 2024, Nature Structural & Molecular Biology. DOI: 10.1038/s41594-024-01211-y The research was partly supported by grants from the American Society of Hematology, Alex’s Lemonade Stand Foundation (18-11849), Stand Up To Cancer & Cancer Research UK (RT617) and the National Institutes of Health’s National Cancer Institute (CA197489, CA233691, CA236626, CA243124, CA278050, CA274649, CA233922, CA255250, CA258778), National Institute of General Medical Sciences (GM117923, CA033572). The National Cancer Institute/Developmental Therapeutics Program provided the compound library.

A new study reveals that southeast Alaska’s humpback whales are sophisticated tool users, creating bubble nets to enhance krill hunting. Using advanced tracking technologies, researchers have documented these unique behaviors, emphasizing the need for targeted conservation efforts to protect these crucial marine areas. Southeast Alaska’s humpback whales use bubble nets for efficient krill hunting, a behavior documented by researchers aiming to bolster conservation efforts. A new study published in Royal Society Open Science suggests humpback whales may be among the rare group of animals that both manufacture and use their own tools. While it was previously known that humpback whales create “bubble-nets” to hunt, the new study reveals that they also manipulate this unique tool in a variety of ways to maximize their food intake in Alaskan feeding grounds. This research, conducted by the Marine Mammal Research Program (MMRP) at UH Hawaiʻi Institute of Marine Biology (HIMB) and Alaska Whale Foundation (AWF), demystifies a behavior key to the whales’ survival and provides valuable insights that could improve targeted conservation efforts. Dr. Will Gough skillfully deploys a suction-cup tag on a foraging humpback whale in Southeast Alaska. Credit: MMRP/AWF Unique Hunting Techniques of Humpback Whales “Many animals use tools to help them find food,” explains Professor Lars Bejder, co-lead author of the study and Director of MMRP, “but very few actually create or modify these tools themselves. We discovered that solitary humpback whales in southeast (SE) Alaska craft complex bubble nets to catch krill, which are tiny shrimp-like creatures. These whales skillfully blow bubbles in patterns that form nets with internal rings, actively controlling details like the number of rings, the size and depth of the net, and the spacing between bubbles. This method lets them capture up to seven times more prey in a single feeding dive without using extra energy. This impressive behavior places humpback whales among the rare group of animals that both make and use their own tools for hunting.” Success in hunting is key for the whalesʻ survival. The population of humpback whales in SE Alaska overwinters in Hawaiʻi, and their energy budget for the entire year depends on their ability to capture enough food during summer and fall in SE Alaska. Unraveling the nuances of their carefully honed hunting technique sheds light on how migratory humpback whales consume enough calories to traverse the Pacific Ocean. Infographic showing features of the bubble-net. Humpback whales can manipulate these features: number of rings in the net, distance between bubbles in the inner and outer rings) to effectively concentrate prey and keep them from escaping. Credit: Marine Mammal Research Program, UHM/ SOEST Research Methods and Challenges Marine mammals known as cetaceans include whales, dolphins, and porpoises, and they are notoriously difficult to study. Advances in research tools are making it easier to track and understand their behavior, and in this instance, researchers employed specialty tags and drones to study the whalesʻ movements from above and below the water. “We deployed non-invasive suction-cup tags on whales and flew drones over solitary bubble-netting humpback whales in SE Alaska, collecting data on their underwater movements,” shares co-author and MMRP researcher William Gough. The tools have incredible capability, but honing them takes practice. Gough reflects, “Whales are a difficult group to study, requiring skill and precision to successfully tag and/or drone them.” The logistics of working in a remote location in SE Alaska brought its own challenges to the research. “We are so grateful to our research partners at the Alaska Whale Foundation (AWF) for their immense knowledge of the local area and the whales in that part of the world,” emphasizes Bejder. “This research would not have been possible without the strong collaborative effort with AWF.” MMRP/AWF researchers await optimal conditions to deploy a suction-cup tag on humpback whales in Southeast Alaska. Credit: MMRP/AWF Implications for Conservation Cetaceans throughout the globe face a slough of threats that range from habitat degradation, climate change, and fisheries, to chemical and noise pollution. One-quarter of the 92 known cetacean species are at risk of extinction, and there is a clear and urgent need to implement effective conservation strategies on their behalf. How the animals hunt is key to their survival, and understanding this essential behavior makes resource managers better poised to adeptly monitor and conserve the feeding grounds that are critical to their survival. “This little-studied foraging behavior is wholly unique to humpback whales,” notes Gough. “It’s so incredible to see these animals in their natural habitat, performing behaviors that only a few people ever get to see. And it’s rewarding to be able to come back to the lab, dive into the data, and learn about what they’re doing underwater once they disappear from view.” With powerful new tools in researchersʻ hands, many more exciting cetacean behavioral discoveries lie on the horizon. “This is a rich dataset that will allow us to learn even more about the physics and energetics of solitary bubble-netting,” shares Bejder. “There is also data coming in from humpback whales performing other feeding behaviors, such as cooperative bubble-netting, surface feeding, and deep lunge feeding, allowing for further exploration of this population’s energetic landscape and fitness.” “What I find exciting is that humpbacks have come up with complex tools allowing them to exploit prey aggregations that otherwise would be unavailable to them,” says Dr. Andy Szabo, AWF Executive Director and study co-lead. “It is this behavioral flexibility and ingenuity that I hope will serve these whales well as our oceans continue to change.” Reference: “Solitary humpback whales manufacture bubble-nets as tools to increase prey intake” by A. Szabo, L. Bejder, H. Warick, M. van Aswegen, A. S. Friedlaender, J. Goldbogen, J. M. Kendall-Bar, E. M. Leunissen, M. Angot and W. T. Gough, 1 August 2024, Royal Society Open Science. DOI: 10.1098/rsos.240328 This study was made possible with support from Lindblad Expeditions – National Geographic Fund, the University of Hawaiʻi at Mānoa, and a Department of Defense (DOD) Defense University Research Instrumentation Program (DURIP) grant. This study was conducted under a NOAA permit issued to Alaska Whale Foundation (no. 19703). All research was conducted under institution IACUC approvals.

Scientists identified three insights from Darwin’s work on human evolution that modern science has reinforced. When Charles Darwin published Descent of Man 150 years ago, he launched scientific investigations on human origins and evolution. Last week, three leading scientists in different, but related disciplines published “Modern theories of human evolution foreshadowed by Darwin’s Descent of Man,” in Science, in which they identify three insights from Darwin’s opus on human evolution that modern science has reinforced. “Working together was a challenge because of disciplinary boundaries and different perspectives, but we succeeded,” said Sergey Gavrilets, lead author and professor in the Departments of Ecology and Evolutionary Biology and Mathematics at the University of Tennessee, Knoxville. Their goal with this review summary was to apply the framework of modern speciation theory to human origins and summarize recent research to highlight the fact that Darwin’s Descent of Man foreshadowed many recent scientific developments in the field. They focused on the following three insights: We share many characteristics with our closest relatives, the anthropoid apes, which include genetic, developmental, physiological, morphological, cognitive, and psychological characteristics. Humans have a talent for high-level cooperation reinforced by morality and social norms. We have greatly expanded the social learning capacity that we see already in other primates. “The paper’s insights have important implication for understanding behavior of modern humans and for developing policies to solve some of the most pressing problems our society faces,” Gavrilets said. Gavrilets is director of the Center for the Dynamics of Social Complexity (DySoC) at UT, which promotes transdisciplinary research into the origins, evolution, and futures of human social complexity. This paper is one of the outcomes of activities from the Center. Other related outcomes include free online learning modules on cultural evolution and a series of online webinars about cultural evolution and human origins, which thousands of students and researchers worldwide have watched. Reference: “Modern theories of human evolution foreshadowed by Darwin’s Descent of Man” by Peter J. Richerson, Sergey Gavrilets and Frans B. M. de Waal, 21 May 2021, Science. DOI: 10.1126/science.aba3776 Co-authors are Peter Richerson, a cultural evolutionist with the Department of Environmental Science and Policy at the University of California, Davis, and Frans de Waal, a primatologist with Living Links, Yerks National Primate Research Center at Emory University in Atlanta, Georgia. The paper was sponsored by the UT National Institute for Mathematical and Biological Synthesis with an NSF award. Researchers also received support from the US Army Research Office, the Office of Naval Research, the John Templeton Foundation, and the NIH.

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