Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Latex pillow OEM production in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan neck support pillow OEM factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam OEM insole and pillow supplier

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow for sleep brands Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ODM ergonomic pillow solution factory Taiwan

Recent research discovers that our ability to distinguish similar memories improves over time due to the dynamic nature of engrams, brain cells involved in memory storage. This finding provides key insights into the treatment of memory disorders. Credit: SciTechDaily.com Neuroscientists demonstrate how the brain improves its ability to distinguish between similar experiences, findings that could lead to treatments for Alzheimer’s disease and other memory disorders. Think of a time when you had two different but similar experiences in a short period. Maybe you attended two holiday parties in the same week or gave two presentations at work. Shortly afterward, you may find yourself confusing the two, but as time goes on that confusion recedes and you are better able to differentiate between these different experiences. New research published today (January 19) in Nature Neuroscience reveals that this process occurs on a cellular level, findings that are critical to the understanding and treatment of memory disorders, such as Alzheimer’s disease. Dynamic Engrams Store Memories The research focuses on engrams, which are neuronal cells in the brain that store memory information. “Engrams are the neurons that are reactivated to support memory recall,” says Dheeraj S. Roy, PhD, one of the paper’s senior authors and an assistant professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. “When engrams are disrupted, you get amnesia.” In the minutes and hours that immediately follow an experience, he explains, the brain needs to consolidate the engram to store it. “We wanted to know: What is happening during this consolidation process? What happens between the time that an engram is formed and when you need to recall that memory later?” Dheeraj Roy, PhD, assistant professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB, is a senior author on a new paper that explains aspects of how memory works at the cellular level. Credit: Sandra Kicman/Jacobs School of Medicine and Biomedical Sciences The researchers developed a computational model for learning and memory formation that starts with sensory information, which is the stimulus. Once that information gets to the hippocampus, the part of the brain where memories form, different neurons are activated, some of which are excitatory and others that are inhibitory. When neurons are activated in the hippocampus, not all are going to be firing at once. As memories form, neurons that happen to be activated closely in time become a part of the engram and strengthen their connectivity to support future recall. “Activation of engram cells during memory recall is not an all or none process but rather typically needs to reach a threshold (i.e., a percentage of the original engram) for efficient recall,” Roy explains. “Our model is the first to demonstrate that the engram population is not stable: The number of engram cells that are activated during recall decreases with time, meaning they are dynamic in nature, and so the next critical question was whether this had a behavioral consequence.” Dynamic Engrams Are Needed for Memory Discrimination “Over the consolidation period after learning, the brain is actively working to separate the two experiences and that’s possibly one reason why the numbers of activated engram cells decrease over time for a single memory,” he says. “If true, this would explain why memory discrimination gets better as time goes on. It’s like your memory of the experience was one big highway initially but over time, over the course of the consolidation period on the order of minutes to hours, your brain divides them into two lanes so you can discriminate between the two.” Roy and the experimentalists on the team now had a testable hypothesis, which they carried out using a well-established behavioral experiment with mice. Mice were briefly exposed to two different boxes that had unique odors and lighting conditions; one was a neutral environment but in the second box, they received a mild foot shock. A few hours after that experience, the mice, who typically are constantly moving, exhibited fear memory recall by freezing when exposed to either box. “That demonstrated that they couldn’t discriminate between the two,” Roy says. “But by hour twelve, all of a sudden, they exhibited fear only when they were exposed to the box where they were uncomfortable during their very first experience. They were able to discriminate between the two. The animal is telling us that they know this box is the scary one but five hours earlier they couldn’t do that.” Using a light-sensitive technique, the team was able to detect active neurons in the mouse hippocampus as the animal was exploring the boxes. The researchers used this technique to tag active neurons and later measure how many were reactivated by the brain for recall. They also conducted experiments that allowed a single engram cell to be tracked across experiences and time. “So I can tell you literally how one engram cell or a subset of them responded to each environment across time and correlate this to their memory discrimination,” explains Roy.” The team’s initial computational studies had predicted that the number of engram cells involved in a single memory would decrease over time, and the animal experiments bore that out. “When the brain learns something for the first time, it doesn’t know how many neurons are needed and so on purpose a larger subset of neurons is recruited,” he explains. “As the brain stabilizes neurons, consolidating the memory, it cuts away the unnecessary neurons, so fewer are required and in doing so helps separate engrams for different memories.” What Is Happening With Memory Disorders? The findings have direct relevance to understanding what is going wrong in memory disorders, such as Alzheimer’s disease. Roy explains that to develop treatments for such disorders, it is critical to know what is happening during the initial memory formation, consolidation and activation of engrams for recall. “This research tells us that a very likely candidate for why memory dysfunction occurs is that there is something wrong with the early window after memory formation where engrams must be changing,” says Roy. He is currently studying mouse models of early Alzheimer’s disease to find out if engrams are forming but not being correctly stabilized. Now that more is known about how engrams work to form and stabilize memories, researchers can examine which genes are changing in the animal model when the engram population decreases. “We can look at mouse models and ask, are there specific genes that are altered? And if so, then we finally have something to test, we can modulate the gene for these ‘refinement’ or ‘consolidation’ processes of engrams to see if that has a role in improving memory performance,” he says. Reference: “Dynamic and selective engrams emerge with memory consolidation” by Douglas Feitosa Tomé, Ying Zhang, Tomomi Aida, Olivia Mosto, Yifeng Lu, Mandy Chen, Sadra Sadeh, Dheeraj S. Roy and Claudia Clopath, 19 January 2024, Nature Neuroscience. DOI: 10.1038/s41593-023-01551-w Now at the Jacobs School, Roy conducted the research while a McGovern Fellow at the Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University. Roy is one of three neuroscientists recruited to the Jacobs School this year to launch a new focus on systems neuroscience in the school’s Department of Physiology and Biophysics. Co-authors on the paper are from Imperial College in London; the Institute of Science and Technology in Austria; the McGovern Institute for Brain Research at MIT; and the Center for Life Sciences & IDG/McGovern Institute for Brain Research at Tsinghua University in China. The work was funded by the President’s PhD Scholarship from Imperial College London; Wellcome Trust; the Biotechnology and Biological Sciences Research Council; the Simons Foundation; the Engineering and Physical Sciences Research Council; the School of Life Sciences and the IDG/McGovern Institute for Brain Research. Roy was supported by the Warren Alpert Distinguished Scholar Award and the National Institutes of Health.

One of just seven specimens of the mysterious Leyte Chorus Frog collected by W. H. Stickel on Nov. 20, 1944, from Leyte, Philippines. Part of the collection of the Field Museum of Natural History. Credit: Sarah Drasner The Leyte Chorus Frog is a rare, non-reproducing hybrid caused by deforestation-driven overlap between two frog species, finally identified using modern genomics and decades-old museum specimens. Evolutionary biologists working in the Philippines have long been puzzled by a hard-to-find amphibian mystery: the Leyte Chorus Frog. This small, ground-dwelling frog is native to Leyte Island in the Visayan province of the eastern Philippines. The country, an island archipelago once blanketed with dense forests, now retains only small fragments of that habitat—an unfortunate consequence of intensive logging. The Leyte Chorus Frog was first collected in 1944 and noted for its unusual toe discs when it was described in an academic paper in 1954. Since then, despite a concerted search by researchers, it went unseen for decades. Now, a report from the University of Kansas appearing in the Genetics Society journal Heredity confirms that Kaloula conjuncta stickeli (the scientific name of the strange chorus frog) is a hybrid of two species with overlapping ranges whose intermingling likely was driven by deforestation. “It’s this really weird, enigmatic frog in the Philippines,” said Chan Kin Onn, a postdoctoral researcher at KU’s Biodiversity Institute and Natural History Museum, who served as lead author on the paper. Chan credits his mentor Rafe Brown, curator-in-charge of the herpetology division at the iInstitute, for years of fieldwork that undergird the findings. A Puzzle of Rarity and Classification “The reason the frog’s enigmatic is that it was collected a long time ago,” Chan said. “It looks really distinct — you can just eyeball a specimen and immediately tell it’s not this, it’s not that; it’s something else. When it was originally described, it was classified as a subspecies.” Chan said evolutionary biologists tend to think of a “subspecies” as a population that looks slightly different, but not obviously unique enough to qualify as a separate species. The problem was that only a few Leyte Chorus Frogs were ever discovered despite regular sampling by scientists in the region — its rarity was a puzzle that raised questions about its status as a subspecies. “The person who first discovered it collected only two specimens,” Chan said. “Over the course of several decades, despite many researchers returning to the same locations, only five more specimens have been found. The lack of material makes it really difficult to study — only seven specimens exist in collections worldwide. For the longest time, we didn’t have the tools to figure it out, so people considered it either a subspecies or questioned its validity. Some hypothesized that it might be a full species, one that might already be extinct. No one really knew for sure, so it remained in this gray area.” Distribution of the frogs studied and examples of their finger disc widths. Distribution of the Kaloula conjuncta complex A and B K. picta. Diamond = location of samples sequenced for this study; star = type locality of K. c. stickeli; red box = location of the putative hybrid zone where K. c. meridionalis, K. c. stickeli, and K. picta co-occur. C Differences in widths of the finger discs in the focal taxa. Credit: Chan et al Fieldwork in the Philippines by co-author Brown, who also serves as KU professor of ecology & evolutionary biology, turned up several of the Leyte Chorus Frogs specimens — but this time from the southern island of Mindanao. Today, they’re housed in collections of the National Museum of the Philippines, the Texas Memorial Museum, and the University of Texas at Austin. “Ever since catching these curious, oddball specimens in 1996, the summer before I started grad school at UT Austin, the unanswered question of what they really were — or what they could possibly represent — has bugged me on and off, occasionally resurfacing from memory,” Brown said. “It has been like a note-to-self: Don’t forget to get back to those weird frogs from Mindanao because we still don’t know the answer.” Genomic Tools Offer a Breakthrough Following up on Brown’s questions, Chan looked into the mystery of the Leyte Chorus Frog using the same specimens from 1944 and 1996, as well as the latest tools of the evolutionary biology trade. He used genetic material from specimens in biodiversity collections and analyzed relevant portions of the genome using labs at KU and offsite, looking to accurately place the frog in its family tree. “Today we have a bunch of those ‘Star Trek’-style science gizmos,” Brown said. “We’ve got genomic resources, bioinformatic tools, really powerful computers, and most importantly Dr. Chan, whose insight provided the final pieces to come together, for a much anticipated resolution of the mystery.” “We thought, ‘Let’s see if genomics can answer this question,’” Chan said. “So, we did, and the result was surprising — this frog is actually a hybrid. Not just any hybrid — an ‘F1 hybrid,’ meaning it’s the first-generation offspring of two distinct parent species. Because of that, it has 50% of its genetic material from one parent and 50% from the other.” The analysis found that the odd Leyte Chorus Frogs are a hybrid between K. c. meridionalis and K. picta. “Normally, these two frog species wouldn’t meet because one lives in trees and bushes, but the other on the ground, and they breed in completely different places,” Chan said. “But deforestation changed their environment, creating new open spaces where their habitats overlapped. This led to tree-dwelling females being drawn to the calls of ground-dwelling males, resulting in unexpected hybridization. Scientists suspected this years ago when they observed the frogs interacting in the wild, but they lacked the tools to prove it.” A Frog Between Two Worlds Chan said the hybrid Leyte Chorus Frogs were particularly interesting because their two parent species look and act so differently. “One is large, with big expanded toe pads for climbing,” he said. “The other is smaller, with almost no expanded toe pads because it’s a ground dweller. This enigmatic frog is a perfect intermediate between them — it has intermediate-sized toe pads. Just by eyeballing the size of the toe pads, you can tell what’s what.” In the end, the KU researchers determined the hybrid isn’t a distinct species and doesn’t warrant its own scientific name. Further, its rarity comes down to the fact that it cannot reproduce and is an evolutionary dead end. “When they breed, we think it likely that genetic incompatibilities form,” Chan said. “Apparently, the hybrids are incompatible with each other, and with the two species that produced them, so they cannot progress beyond that first generation F1 hybrid. At least, this is what we suspect, and it opens the door for future research to verify this.” Brown emphasized the critical role played by specimen-based museum research for deciphering biological problems that rely on clues only to be gleaned from biological specimens properly preserved and cared for in natural history museums. “Chan’s work is really impressive, and with this new publication, he closed the book on the Leyte Chorus Frog ‘stickeli’ mystery,” Brown said. “That’s thanks to his hard work, analytical abilities, writing skills, and cutting-edge genomic data. That said, this project would not have been possible if we had been unable to access the exact same museum specimens that stupefied field biologists 30 to 80 years ago. Lucky for us, they made note of their observations, collected the specimens and preserved them for use by future researchers.” Reference: “Deforestation-induced Hybridization in Philippine Frogs Creates a Distinct Phenotype With an Inviable Genotype” by Kin Onn Chan, Paul M. Hime and Rafe M. Brown, 16 February 2025, Heredity. DOI: 10.1038/s41437-025-00748-y

Researchers have found that maternal obesity causes long-term changes in the brain via the microRNA miR-505-5p, leading offspring to prefer high-fat diets and increasing their risk of obesity. This effect can be mitigated by maternal exercise during pregnancy, according to a new study in PLOS Biology. A study reveals that maternal obesity in mice increases microRNA levels in the hypothalamus in offspring, leading to overeating. Maternal obesity impacts the eating behaviors of offspring via long-term overexpression of the microRNA miR-505-5p. This is according to a study published today (June 4th) in the open-access journal PLOS Biology by Laura Dearden and Susan Ozanne from the MRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, UK, and colleagues. Link Between Maternal Obesity and Offspring Health Risks Previous studies in both humans and animal models have shown that the offspring of obese mothers have a higher risk of obesity and type 2 diabetes. While this relationship is likely the result of a complex relationship between genetics and environment, emerging evidence has implicated that maternal obesity can disrupt the hypothalamus—the region of the brain responsible for nutrition sensing and energy homeostasis. In animal models, offspring exposed to overnutrition during key periods of development eat more, but little is known about the molecular mechanisms that lead to these changes in eating behavior. Study Findings on MicroRNA and Eating Behaviors In this study, researchers found that mice born from obese mothers had higher levels of the microRNA miR-505-5p in their hypothalamus—from as early as the fetal stage into adulthood. The researchers found that the mice ate more and showed a preference for high-fat foods. Interestingly, the effect of maternal obesity on miR-505-5p and eating behaviors was mitigated if the mothers exercised during pregnancy. Molecular Mechanisms and Preventative Measures Cell culture experiments showed that miR-505-5p expression could be induced by exposing hypothalamic neurons to long-chain fatty acids and insulin, which are both high in pregnancies complicated by obesity. The researchers identified miR-505-5p as a novel regulator of pathways involved in fatty acid uptake and metabolism, therefore high levels of the miRNA make the offspring brain unable to sense when eating high-fat foods. Several of the genes that miR-505-5p regulates have been associated with high body mass index in human genetic studies. The study is one of the first to demonstrate the molecular mechanism linking nutritional exposure in utero to eating behavior. Conclusion and Implications The authors add, “Our results show that obesity during pregnancy causes changes to the baby’s brain that makes them eat more high-fat food in adulthood and more likely to develop obesity. “Importantly we showed that moderate exercise, without weight loss, during pregnancies complicated by obesity prevented the changes to the baby’s brain. This helps us understand why the children of mothers living with obesity are more likely to become obese themselves, with early life exposures, genetics, and current environment all being contributing factors.” Reference: “Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food” by Laura Dearden, Isadora C. Furigo, Lucas C. Pantaleão, L W. P. Wong, Denise S. Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A. Kentistou, Maria V. Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K. Ong, John R. B. Perry, Jose Donato Jr and Susan E. Ozanne, 4 June 2024, PLOS Biology. DOI: 10.1371/journal.pbio.3002641

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