Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam custom insole OEM supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Thailand pillow ODM development service

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia insole ODM design and production

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Orthopedic pillow OEM solutions Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Custom foam pillow OEM in Thailand

A study finds that auditory hallucinations in schizophrenia may be due to defects in brain processes that manage self-generated sounds, pointing to new therapeutic targets. Researchers have identified two potential brain process failures contributing to auditory hallucinations in schizophrenia: malfunctioning corollary discharge and overly active efference copy. Their study, involving EEGs of patients, shows these flaws may prevent the brain from properly identifying self-generated sounds, offering a new direction for treatment. Auditory hallucinations are likely the result of abnormalities in two brain processes: a “broken” corollary discharge that fails to suppress self-generated sounds, and a “noisy” efference copy that makes the brain hear these sounds more intensely than it should. That is the conclusion of a new study published today (October 3rd) in the open-access journal PLOS Biology by Xing Tian, of New York University Shanghai, China, and colleagues. Insights From EEG Experiments Patients with certain mental disorders, including schizophrenia, often hear voices in the absence of sound. Patients may fail to distinguish between their own thoughts and external voices, resulting in a reduced ability to recognize thoughts as self-generated. In the new study, researchers carried out electroencephalogram (EEG) experiments measuring the brain waves of twenty patients diagnosed with schizophrenia with auditory hallucinations and twenty patients diagnosed with schizophrenia who had never experienced such hallucinations. The cognitive neural mechanism of auditory hallucinations. Dissociative impairment of functional distinct signals in motor-to-sensory transformation process – a ‘broken’ monitoring signal plus a ‘noisy’ activation signal in the – causes erroneous monitoring of the imprecise generation of internal auditory representation and yields auditory hallucinations. (adapted from the manuscript.) Credit: Fuyin Yang and Xing Tian (CC-BY 4.0) Mechanisms Behind Hearing Voices In general, when people are preparing to speak, their brains send a signal known as “corollary discharge” that suppresses the sound of their own voice. However, the new study showed that when patients with auditory hallucinations were preparing to speak a syllable, their brains not only failed to suppress these internal sounds, but had an enhanced “efference copy” response to internal sounds other than the planned syllable. Future Directions for Treatment The authors conclude that impairments in these two processes likely contribute to auditory hallucinations and that targeting them in the future could lead to new treatments for such hallucinations. The authors add, “People who suffer from auditory hallucinations can ‘hear’ sounds without external stimuli. A new study suggests that impaired functional connections between motor and auditory systems in the brain mediate the loss of ability to distinguish fancy from reality.” Reference: “Impaired motor-to-sensory transformation mediates auditory hallucinations” by Fuyin Yang, Hao Zhu, Xinyi Cao, Hui Li, Xinyu Fang, Lingfang Yu, Siqi Li, Zenan Wu, Chunbo Li, Chen Zhang and Xing Tian, 3 October 2024, PLOS Biology. DOI: 10.1371/journal.pbio.3002836 Funding: This study was supported by the National Natural Science Foundation of China 32071099 and 32271101, Natural Science Foundation of Shanghai 20ZR1472100, Program of Introducing Talents of Discipline to Universities, Base B16018 to X.T., East China Normal University (ECNU) Academic Innovation Promotion Program for Excellent Doctoral Students YBNLTS2019-026 and China Postdoctoral Foundation under Grant Number 2024M752047 to F.Y. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

A comprehensive study led by Paul Valentich-Scott from the Santa Barbara Museum of Natural History has uncovered new aspects of galeommatoidean bivalves in South Africa. The research reveals a new species and highlights the unique symbiotic relationships these bivalves maintain with sea urchins. The findings enhance our understanding of marine biodiversity and emphasize the need for the conservation of these lesser-known marine organisms. The image above depicts the newly discovered species, Brachiomya ducentiunus, crawling on a sea urchin spine. Credit: Craig Foster Researchers discovered a new species of marine bivalve in South Africa, providing new insights into the biodiversity of the region and emphasizing conservation. Galeommatoidean bivalves are a highly diverse, yet poorly known, group of marine mollusks. Now, a study led by Paul Valentich-Scott from the Santa Barbara Museum of Natural History, along with collaborators from the University of Cape Town, Sea Change Trust, Stellenbosch University, and the University of Colorado Boulder, has uncovered new insights into the habitats, symbiotic relationships, and taxonomy of these fascinating animals. Discovery of New Species In the study, recently published in the scientific journal ZooKeys, the researchers collected four species of galeommatoidean bivalves collected from the Western Cape region of South Africa. Among these is one new species, Brachiomya ducentiunus. This small clam, which is only 2 mm (less than 1/8th inch) in length, spends its life crawling between the spines of sea urchins. The new species has so far only been found in one locality in False Bay, South Africa, where it was found attached to the burrowing sea urchin Spatagobrissus mirabilis in coarse gravel at a depth of about 3 m. It has not been observed free-living, without the host urchin. Brachiomya ducentiunus was discovered while preparing and working on the 1001 Seaforest Species project, a research and storytelling program aimed at increasing awareness of regional kelp bed ecosystems colloquially referred to as ‘the Great African Seaforest’. Dozens of Brachiomya ducentiunus crawling on the surface of a sea urchin. Credit: Charles Griffiths Impact on Biodiversity Knowledge “This study marks a significant advancement in our understanding of the biodiversity and ecological interactions of galeommatoidean bivalves,” says Valentich-Scott. “By uncovering the hidden lives of these small but ecologically important organisms, we hope to contribute to the broader knowledge of marine biodiversity and the conservation of these unique habitats.” Importance of Regional Marine Research Co-author Charles L. Griffiths, emeritus professor at the University of Cape Town, says, “A large proportion of smaller marine invertebrates remain undescribed in western South Africa and almost any project that samples specialized habitats turns up many new records and species.” In a similar vein, co-author Jannes Landschoff, a marine biologist at the Sea Change Trust, says “Creating foundational biodiversity knowledge is a most important step to the humbling realization of how fascinating and uniquely diverse a place is. I see this every day through our work in the rich coastal waters of Cape Town, where an extensive underwater kelp forest, the ‘Great African Seaforest,’ grows.” Reference: “Bivalves of superfamily Galeommatoidea (Mollusca, Bivalvia) from western South Africa, with observations on commensal relationships and habitats” by Paul Valentich-Scott, Charles Griffiths, Jannes Landschoff, Ruiqi Li and Jingchun Li, 22 July 2024, ZooKeys. DOI: 10.3897/zookeys.1207.124517

Researchers have conducted a comprehensive study on how serotonin affects behavior using the nematode worm C. elegans. They found that the worm’s six serotonin receptors each play distinct roles, with three driving behavioral slowing and the rest modulating their function. The study provides insight into the complexities of the serotonergic system and implications for psychiatric drug development. Scientists at The Picower Institute for Learning and Memory at MIT have provided comprehensive insight into how serotonin affects behavior in a study using the nematode worm C. elegans, a simple animal model. The research team identified the functional roles of the worm’s six serotonin receptors by creating 64 different mutant strains, each missing different combinations of receptors. They discovered that three receptors primarily drove the slowing behavior associated with serotonin release, while the other three receptors interacted with the primary receptors and modulated their function. Furthermore, different receptors were found to respond to different patterns of serotonin release. By fluorescently tagging each receptor gene in each neuron across the brain, the team observed how serotonin’s effects worked at a circuit level. The study provides a view of the complexities and opportunities for the development of psychiatric drugs that target the serotonergic system. Because serotonin is one of the primary chemicals the brain uses to influence mood and behavior, it is also the most common target of psychiatric drugs. To improve those drugs and to invent better ones, scientists need to know much more about how the molecule affects brain cells and circuits both in health and amid disease. In a new study, researchers at The Picower Institute for Learning and Memory at MIT working in a simple animal model present a comprehensive accounting of how serotonin affects behavior from the scale of individual molecules all the way to the animal’s whole brain. “There have been major challenges in rationally developing psychiatric drugs that target the serotonergic system,” said Steve Flavell, associate professor in The Picower Institute and MIT’s Department of Brain and Cognitive Sciences, and senior author of the study in Cell. “The system is wildly complex. There are many different types of serotonergic neurons with widespread projections throughout the brain and serotonin acts through many different receptors, which are often activated in concert to change the way that neural circuits work.” A 3D rendering of a C. elegans worm, mapping all of its neurons. Credit: Steve Flavell/MIT Picower Institute These same complexities that scientists face in people are all afoot in the nematode worm C. elegans, but to a more manageably limited degree. C. elegans has only 302 neurons (rather than billions) and only six serotonin receptors (rather than the 14 found in people). Moreover, all C. elegans neurons and their connections have been mapped out and its cells are accessible for genetic manipulation. Finally, Flavell’s team has developed imaging technologies that enable them to track and map neural activity across the worm’s brain simultaneously. For all these reasons, the lab was able to produce a novel study revealing how the far-reaching molecular activity of serotonin changes brain-wide activity and behavior. “These results provide a global view of how serotonin acts on a diverse set of receptors distributed across a connectome to modulate brain-wide activity and behavior,” the research team wrote in Cell. The study’s co-lead authors are Picower Institute postdoc Ugur Dag, MIT Brain and Cognitive Sciences graduate student Di Kang, and former research technician Ijeoma Nwabudike, who is now a MD-PhD student at Yale. Slowing for Savoring Flavell showed in Cell in 2013 that C. elegans uses serotonin to slow down when it reaches a patch of food and traced its source to a neuron called NSM. In the new study, the team used their many new capabilities developed since then at MIT to examine serotonin’s effects comprehensively. First, they focused on identifying the functional roles of the worm’s six serotonin receptors. To do that they created 64 different mutant strains covering the different combinations of knocking out the various receptors. For instance, one strain would have just one receptor knocked out while another strain would have all but that one missing and another would be missing three. In each of these worms the team stimulated serotonin release from the NSM neuron to prompt slowing behaviors. Analysis of all the resulting data revealed at least two key findings: One was that three receptors primarily drove the slowing behavior. The second was that the other three receptors “interacted” with the receptors that drive slowing and modulated how they function. These complex interactions between serotonin receptors in the control of behavior is likely to be directly relevant to psychiatric drugs that target these receptors, Flavell said. A wiring diagram of the C. elegans worm shows neurons and muscle cells (dots) that express receptors for serotonin. Each color denotes a specific receptor. Some neurons express more than one. The diagram appears as a figure in the research paper. Credit: Di Kang/MIT Picower Institute The researchers also gained other important insights into serotonin’s actions. One was that different receptors respond to different patterns of serotonin release in live animals. For example, the SER-4 receptor only responded to sudden increases in serotonin release by the NSM neuron. However, the MOD-1 receptor responded to continuous “tonic” changes in serotonin release by NSM. This suggests that different serotonin receptors are engaged at different times in the live animal. Brain-Wide Mapping Having teased out the roles of the serotonin receptors in the control of C. elegans behavior, the research team then used their imaging technologies to see how serotonin’s effects worked at a circuit level. For instance, they fluorescently tagged each receptor gene in each neuron across the brain so that they could see all the specific cells that expressed each receptor, providing a brain-wide map of where the serotonin receptors are located in C. elegans. About half of the worm’s neurons express serotonin receptors with some neurons expressing as many as five different types. Finally, the team used their ability to track all neuron activity (based on their calcium fluctuations) and all behaviors to watch how the serotonergic neuron NSM affected other cells’ activity as worms freely explored their surroundings. About half of the neurons across the worm’s brain changed activity when serotonin was released. Since they knew which exact neurons they were recording from, the research team asked whether knowing which serotonin receptors each cell expressed could predict how they responded to serotonin. Indeed, knowing which receptors were expressed in each neuron and its input neurons gave strong predictive power of how each neuron was impacted by serotonin. “We performed brain-wide calcium imaging in freely-moving animals with knowledge of cellular identity during serotonin release, providing, for the first time, a view of how serotonin release is associated with changes in activity across the defined cell types of an animal’s brain,” the researchers concluded. All these findings shed light on the kinds of complexities and opportunities facing drug developers, Flavell noted. The study’s findings show how the effects of targeting one serotonin receptor could depend on how other receptors or the cell types that express them are functioning. In particular, the study highlights how the serotonin receptors act in concert to change the activity states of neural circuits. Reference: “Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale” by Ugur Dag, Ijeoma Nwabudike, Di Kang, Matthew A. Gomes, Jungsoo Kim, Adam A. Atanas, Eric Bueno, Cassi Estrem, Sarah Pugliese, Ziyu Wang, Emma Towlson and Steven W. Flavell, 15 May 2023, Cell. DOI: 10.1016/j.cell.2023.04.023 In addition to Flavell, Dag, Nwabudike and Kang, the paper’s other authors are Matthew Gomes, Jungsoo Kim, Adam Atanas, Eric Bueno, Cassi Estrem, Sarah Pugliese, Ziyu Wang and Emma Towlson. Study funders included the National Institutes of Health, the National Science Foundation, the McKnight Foundation, the Alfred P. Sloan Foundation, the Picower Institute and the JPB Foundation.

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