Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Latex pillow OEM production facility in Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene insole manufacturer in Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand insole ODM design and production

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan insole ODM design and production

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Pillow ODM design company in Vietnam

Still frame image showing the hindfoot of a live Wandering Salamander (Aneides vagrans) from a ventral perspective just before the salamander takes a step forward. This image shows the large digital blood sinuses and the points at which they connect near the distal-most joint. Credit: William P. Goldenberg Wandering salamanders control blood flow in their toes to improve grip and detachment, a finding that may inspire new adhesive and robotic technologies. Wandering salamanders are known for gliding high through the canopies of coastal redwood forests, but how these small amphibians manage to stick their landings and take off with ease remains somewhat of a mystery. A new study in the Journal of Morphology suggests the answer may lie in a surprising mechanism: blood-powered toes. Researchers led by Washington State University discovered that wandering salamanders (Aneides vagrans) can rapidly fill, trap, and drain blood in their toe tips, optimizing attachment, detachment, and overall locomotion in their arboreal environment. The research not only uncovers a previously unknown physiological mechanism in salamanders but also has implications for bioinspired designed. Insights into salamander toe mechanics could ultimately inform the development of adhesives, prosthetics, and even robotic appendages. A Wandering Salamander (Aneides vagrans) clings to a camera lens with a single forelimb after leaping onto the lens during scientific investigation of their jumping, parachuting, and gliding behaviors. Credit: Christian Brown “Gecko-inspired adhesives already allow surfaces to be reused without losing stickiness,” said Christian Brown, lead author of the study and an integrative physiology and neuroscience postdoctoral researcher at WSU. “Understanding salamander toes could lead to similar breakthroughs in attachment technologies.” Discovery sparked by a documentary shoot Salamanders of the Aneides genus have long puzzled scientists with their square-shaped toe tips and bright red blood “lakes” that can be seen just beneath their translucent skin. Historically, these features were thought to aid oxygenation, but no evidence supported that claim. Brown’s interest in the topic traces back to an unexpected observation during the filming of the documentary, “The Americas,” which airs on Feb. 23 on NBC and Peacock. While assisting on set as the resident salamander expert, Brown had the opportunity to observe through the production team’s high-powered camera lenses how the amphibians move around. He noticed something strange. Blood was rushing into the small creatures’ translucent toe tips moments before they took a step. Brown and camera assistant William Goldenberg repeatedly observed the phenomenon. “We looked at each other like, ‘Did you see that?’” Brown said. A Wandering Salamander (Aneides vagrans) stands/clings to a horizontal/vertical surface while a camera and high-powered lens capture the blood activity within the toes. Credit: Christian Brown Though the producers moved on, Brown’s curiosity didn’t. After the shoot, he reached out to Goldenberg and asked if he was interested in using his film equipment to investigate what they had observed in a scientific and repeatable way. Through high-resolution video trials and corroborating analysis in WSU’s Franceschi Microscopy & Imaging Center, Brown, Goldenberg and colleagues at WSU and Gonzaga University uncovered that wandering salamanders can finely control and regulate blood flow to each side of their toe tips. This allows them to adjust pressure asymmetrically, improving grip on irregular surfaces like tree bark. Surprisingly, the blood rushing in before “toe off” appears to help salamanders detach rather than attach. By slightly inflating the toe tip, the salamanders reduce the surface area in contact with the surface they are on, minimizing the energy required to let go. This dexterity is crucial for navigating the uneven and slippery surfaces of the redwood canopy—and for sticking safe landings when parachuting between branches. “If you’re climbing a redwood and have 18 toes gripping bark, being able to detach efficiently without damaging your toe tips makes a huge difference,” Brown said. The implications of the research could extend beyond Aneides vagrans. Similar vascularized structures are found in other salamander species, including aquatic ones, suggesting a universal mechanism for toe stiffness regulation that may serve different purposes depending on the salamander’s environment. Moving forward, Brown and colleagues plan to expand the research to look at how the mechanism works in other salamander species and habitats. “This could redefine our understanding of how salamanders move across diverse habitats,” Brown said. Reference: “Vascular and Osteological Morphology of Expanded Digit Tips Suggests Specialization in the Wandering Salamander (Aneides vagrans)” by Christian E. Brown, William P. Goldenberg, Olivia M. Hinds, Mary Kate O’Donnell and Nancy L. Staub, 8 January 2025, Journal of Morphology. DOI: 10.1002/jmor.70026

The study makes major advances in the use of synthetic cells, or protocells, to more precisely mimic the intricate composition, structure, and function of living cells. The study uses bacteria to bring scientists closer to building these artificial lifelike cells. Researchers have used bacteria to help develop advanced synthetic cells that imitate the real-life functionality of cells. The study, conducted by the University of Bristol and published in the journal Nature, advances the development of synthetic cells, or protocells, to more precisely replicate the complex composition, structure, and function of living cells. Establishing true-to-life functionality in protocells is a global great challenge involving several fields, from the origin of life research to bottom-up synthetic biology and bioengineering. Due to previous failures in modeling protocells using microcapsules, the research team turned to bacteria to construct sophisticated synthetic cells utilizing a living material assembly process. Bacteria as Building Blocks for Protocell Assembly Professor Stephen Mann from the School of Chemistry at the University of Bristol and the Max Planck Bristol Centre for Minimal Biology, and colleagues Drs. Can Xu, Nicolas Martin (now at the University of Bordeaux), and Mei Li from the Bristol Centre for Protolife Research have demonstrated a method for building highly complex protocells using viscous micro-droplets filled with living bacteria as a microscopic building site. The group initially exposed the empty droplets to two different types of bacteria. One population was captured spontaneously inside the droplets, while the other was confined at the droplet surface. Then, both types of bacteria were destroyed so that the released cellular components remained trapped inside or on the surface of the droplets to produce membrane-coated bacteriogenic protocells containing thousands of biological molecules, parts, and machinery. Achieving Cellular Functions in Synthetic Cells The researchers discovered that the protocells were able to produce energy-rich molecules (ATP) via glycolysis and synthesize RNA and proteins by in vitro gene expression, indicating that the inherited bacterial components remained active in the synthetic cells. Further testing the capacity of this technique, the team employed a series of chemical steps to remodel the bacteriogenic protocells structurally and morphologically. The released bacterial DNA was condensed into a single nucleus-like structure, and the droplet interior infiltrated with a cytoskeletal-like network of protein filaments and membrane-bounded water vacuoles. As a step towards the construction of a synthetic/living cell entity, the researchers implanted living bacteria into the protocells to generate self-sustainable ATP production and long-term energization for glycolysis, gene expression, and cytoskeletal assembly. Curiously, the protoliving constructs adopted an amoeba-like external morphology due to on-site bacterial metabolism and growth to produce a cellular bionic system with integrated life-like properties. Corresponding author Professor Stephen Mann said: “Achieving high organizational and functional complexity in synthetic cells is difficult, especially under close-to-equilibrium conditions. Hopefully, our current bacteriogenic approach will help to increase the complexity of current protocell models, facilitate the integration of myriad biological components and enable the development of energized cytomimetic systems.” Future Applications in Synthetic Biology and Biotechnology First author Dr. Can Xu, a Research Associate at the University of Bristol, added: “Our living-material assembly approach provides an opportunity for the bottom-up construction of symbiotic living/synthetic cell constructs. For example, using engineered bacteria it should be possible to fabricate complex modules for development in diagnostic and therapeutic areas of synthetic biology as well as in biomanufacturing and biotechnology in general.” Reference: “Living material assembly of bacteriogenic protocells” by Can Xu, Nicolas Martin, Mei Li, and Stephen Mann, 14 September 2022, Nature. DOI: 10.1038/s41586-022-05223-w

A team at the University of Bath has refined a promising molecule that blocks the harmful aggregation of alpha-synuclein in Parkinson’s disease. This molecule is more effective than its earlier version and could lead to a drug that combats the disease at its source. A peptide known to prevent the protein error that gives rise to Parkinson’s disease has been optimized by scientists, making it a strong candidate for future development into a cure. A molecule that shows promise in preventing Parkinson’s disease has been refined by scientists at the University of Bath. It has the potential to be developed into a drug to treat the incurable neurodegenerative disease. Professor Jody Mason, who led the research from the Department of Biology and Biochemistry, said: “A lot of work still needs to happen, but this molecule has the potential to be a precursor to a drug. Today there are only medicines to treat the symptoms of Parkinson’s – we hope to develop a drug that can return people to good health even before symptoms develop.” Parkinson’s disease is characterized by a specific protein in human cells ‘misfolding’, where it becomes aggregated and malfunctions. The protein – alpha-synuclein (αS) – is abundant in all human brains. After misfolding, it accumulates in large masses, known as Lewy bodies. These masses consist of αS aggregates that are toxic to dopamine-producing brain cells, causing them to die. It is this drop in dopamine signaling that triggers the symptoms of Parkinson’s, as the signals transmitting from the brain to the body become noisy, leading to the distinctive tremors seen in sufferers. Dr. Richard Meade. Credit: University of Bath Peptide-Based Approach to Prevent Protein Misfolding Previous efforts to target and ‘detoxify’ αS-induced neurodegeneration have seen scientists analyze a vast library of peptides (short chains of amino acids – the building blocks of proteins) to find the best candidate for preventing αS misfolding. Of the 209,952 peptides screened in earlier work by scientists at Bath, peptide 4554W showed the most promise, inhibiting αS from aggregating into toxic disease forms in lab experiments, both in solutions and on live cells. In their latest work, this same group of scientists tweaked peptide 4554W to optimize its function. The new version of the molecule – 4654W(N6A) – contains two modifications to the parental amino-acid sequence and has proven to be significantly more effective than its predecessor at reducing αS misfolding, aggregation, and toxicity. However, even if the modified molecule continues to prove successful in lab experiments, a cure for the disease is still many years away. Professor Jody Mason. Credit: University of Bath Dr. Richard Meade, the lead author of the study, said: “Previous attempts to inhibit alpha-synuclein aggregation with small molecule drugs have been unfruitful as they are too small to inhibit such large protein interactions. This is why peptides are a good option – they are big enough to prevent the protein from aggregating but small enough to be used as a drug. The effectiveness of the 4654W(N6A) peptide on alpha-synuclein aggregation and cell survival in cultures is very exciting, as it highlights that we now know where to target on the alpha-synuclein protein to suppress its toxicity. Not only will this research lead to the development of new treatments to prevent the disease, but it is also uncovering fundamental mechanisms of the disease itself, furthering our understanding of why the protein misfolds in the first place.” Professor Mason added: “Next, we’ll be working on how we can take this peptide to the clinic. We need to find ways to modify it further so it is more drug-like and can cross biological membranes and get into the cells of the brain. This may mean moving away from naturally occurring amino acids towards molecules that are made in the lab.” Broader Implications for Other Neurodegenerative Diseases This research also has implications for Alzheimer’s disease, Type 2 diabetes, and other serious human diseases where symptoms are triggered by protein misfolding. Dr. Rosa Sancho, head of research at Alzheimer’s Research UK, said: “Finding ways to stop alpha-synuclein from becoming toxic and damaging brain cells could highlight a new pathway for future drugs to stop devastating diseases like Parkinson’s and dementia with Lewy bodies. “We’re pleased to have supported this important work to develop a molecule that can stop alpha-synuclein from misfolding. The molecule has been tested in cells in the laboratory and will need further development and testing before it can be made into a treatment. This process will take a number of years, but it is a promising discovery that could pave the way for a new drug in future. “Currently there are no disease-modifying treatments available for Parkinson’s disease or dementia with Lewy bodies, which is why continued investment in research is so important for all those living with these diseases.” Reference: “A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding” by Richard M.Meade, Kathryn J.C. Watt, Robert J. Williams and Jody M. Mason, 22 October 2021, Journal of Molecular Biology. DOI: 10.1016/j.jmb.2021.167323 This research was funded by BRACE, Alzheimer’s Research UK, Engineering and Physical Sciences Research Council.

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