Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan insole ODM manufacturing factory for global brands

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Memory foam pillow OEM factory Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Cushion insole OEM solution Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Custom foam pillow OEM in Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Insole ODM factory in China

A new research study reveals how a common type of epigenetic modification can be transmitted via sperm not only from parents to offspring, but to the next generation (“grandoffspring”) as well. Changing the epigenetic marks on chromosomes results in altered gene expression in offspring and in grandoffspring, demonstrating ‘transgenerational epigenetic inheritance.’ Without changing the genetic code in the DNA, epigenetic modifications can alter how genes are expressed, affecting an organism’s health and development. It was once a radical idea that such changes in gene expression can be inherited. Now there is a growing body of evidence behind it, but the mechanisms involved are still poorly understood. Scientists at the University of California, Santa Cruz show in a new study how a common type of epigenetic modification can be transmitted via sperm not only from parents to offspring, but to the next generation (“grandoffspring”) as well. This is called “transgenerational epigenetic inheritance.”  It may explain how a person’s health and development could be influenced by the experiences of his or her parents and grandparents. Published the week of September 26 in the Proceedings of the National Academy of Sciences (PNAS), the study focused on a particular modification of a histone protein that changes the way DNA is packaged in the chromosomes. This widely studied epigenetic mark (called H3K27me3) is known to turn off or “repress” the affected genes. It is found in all multicellular animals—from humans to the nematode worm C. elegans used in this research. How Histone Marks Affect Gene Expression “These results establish a cause-and-effect relationship between sperm-transmitted histone marks and gene expression and development in offspring and grandoffspring,” said corresponding author Susan Strome. She is professor emerita of molecular, cell and developmental biology at UC Santa Cruz. Histones are the primary proteins involved in the packaging of DNA in the chromosomes. The epigenetic mark known as H3K27me3 refers to methylation of a certain amino acid in the histone H3. This results in the DNA being more densely packaged, making the genes in that region less accessible for activation. In a study of epigenetic inheritance, researchers created embryos of the worm C. elegans that inherited egg chromosomes properly packaged with the epigenetic mark H3K27me3 and sperm chromosomes lacking the mark. The one-cell embryo on the left inherited the pink chromosomes from the egg and the green chromosomes from the sperm, the colors showing the presence or absence of H3K27me3. The two-cell embryo on the right shows the egg and sperm chromosomes united in each nucleus. Credit: Photo by Laura Gaydos In the recent work, this histone mark was selectively stripped from the chromosomes of C. elegans sperm, which were then used to fertilize eggs with fully marked chromosomes. In the resulting offspring, the scientists observed abnormal gene expression patterns, with genes on the paternal chromosomes (inherited from the sperm) turned on or “upregulated” in the absence of the repressive epigenetic mark. This resulted in tissues turning on genes they would not normally express. For instance, germline tissue (which produces eggs and sperm) turned on genes normally expressed in neurons. “In all the tissues we analyzed, genes were aberrantly expressed, but different genes were turned up in different tissues, demonstrating that the tissue context determined which genes were upregulated,” Strome said. Analysis of the chromosomes in the offspring’s germline tissue showed that the upregulated genes still lacked the repressive histone mark, while the mark had been restored on the genes that were not upregulated. Passing Epigenetic Marks to Future Generations “In the germline of the offspring, some genes were aberrantly turned on and stayed in the state lacking the repressive mark, while the rest of the genome regained the mark, and that pattern was passed on to the grandoffspring,” Strome explained. “We speculate that if this pattern of DNA packaging is maintained in the germline, it could potentially be passed on for numerous generations.” In the grandoffspring, the investigators observed a range of developmental effects, including some worms that were completely sterile. This mix of outcomes is due to how chromosomes get distributed during the cell divisions that produce sperm and eggs, resulting in many different combinations of chromosomes that can be passed on to the next generation. Researchers in Strome’s lab have been studying epigenetic inheritance in C. elegans for years, and she said this paper represents the culmination of their work in this area. She noted that other scientists researching mammalian cells in culture have reported results very similar to her lab’s findings in worms, although those studies did not show transmission across multiple generations. “This looks like a conserved feature of gene expression and development in animals, not just a weird worm-specific phenomenon,” she said. “We can do amazing genetic experiments in C. elegans that can’t be done in humans, and the results of our experiments in worms can have broad implications in other organisms.” Reference: “Sperm-inherited H3K27me3 epialleles are transmitted transgenerationally in cis” Kiyomi Raye Kaneshiro, Thea A. Egelhofer, Andreas Rechtsteiner, Chad Cockrum and Susan Strome, 26 September 2022, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2209471119 The co-first authors of the paper are Kiyomi Kaneshiro, who worked on the study as a graduate student in Strome’s lab and is currently a postdoctoral researcher at the Buck Institute for Research on Aging, and UCSC research associate Thea Egelhofer. The coauthors also include bioinformaticist Andreas Rechtsteiner and graduate student Chad Cockrum (now at IDEXX Laboratories). This work was supported by the National Institutes of Health.

A variety of cells (white) proliferate at the ragged edge of a five-day-old wound, including epidermal stem cells (basal layer of epithelium in green), which secrete IL24. Credit: Laboratory of Elaine Fuchs A newly identified IL24-driven mechanism helps skin and possibly other organs repair injuries by responding to hypoxia rather than pathogens. This evolutionary pathway enables efficient tissue regeneration. The world can be a hazardous place, with various dangers lurking around us such as bacteria, viruses, accidents, and injuries. Our skin acts as the ultimate shield, providing a steadfast defense against these threats. It serves as the boundary between the internal and external environment and is the largest organ in the body, functioning nearly seamlessly to protect us. Still, the skin is not immune to harm. It endures daily assaults and still tries to keep us safe by detecting and responding to these dangers. One method is the detection of pathogens, which activates the immune system. However, recent research conducted by Elaine Fuchs at Rockefeller University and published in the journal Cell, has uncovered a new protection mechanism that responds to injury signals in damaged tissue, such as low oxygen levels caused by blood vessel disruption and scab formation. This mechanism is activated without the need for an infection. The study is the first to identify a damage response pathway that is distinct from but parallel to the classical pathway triggered by pathogens. At the helm of the response is interleukin-24 (IL24), whose gene is induced in skin epithelial stem cells at the wound edge. Once unleashed, this secreted protein begins to marshal a variety of different cells to begin the complex process of healing. “IL24 is predominately made by the wound-edge epidermal stem cells, but many cells of the skin—the epithelial cells, the fibroblasts, and the endothelial cells—express the IL24 receptor and respond to the signal. IL24 becomes an orchestrator that coordinates tissue repair,” says Fuchs, head of the Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development. Hints From Pathogen-Induced Signaling Scientists have long understood how the host responses protect our body from pathogen-induced threats: somatic cells recognize invading bacteria or viruses as foreign entities and induce a number of defense mechanisms with the help of signaling proteins such as type 1 interferons. But how does the body respond to an injury that may or may not involve foreign invaders? If we cut a finger while slicing a cucumber, for example, we know it instantly—there’s blood and pain. And yet how the detection of injury leads to healing is poorly understood on a molecular basis. While type 1 interferons rely on the signaling factors STAT1 and STAT2 to regulate the defense against pathogens, previous research by the Fuchs lab had shown that a similar transcription factor known as STAT3 makes its appearance during wound repair. Siqi Liu, a co-first author in both studies, wanted to trace STAT3’s pathway back to its origin. IL24 stood out as a major upstream cytokine that induces STAT3 activation in the wounds. Microbe-Independent Action In collaboration with Daniel Mucida’s lab at Rockefeller, the researchers worked with mice under germ-free conditions and found that the wound-induced IL24 signaling cascade is independent of germs. But what injury signals induced the cascade? Wounds often extend into the skin dermis, where capillaries and blood vessels are located. “We learned that the epidermal stem cells sense the hypoxic environment of the wound,” says Yun Ha Hur, a research fellow in the lab and a co-first author on the paper. When the blood vessels are severed and a scab forms, epidermal stem cells at the edge of the wound are starved of oxygen. This state of hypoxia is an alarm bell for cell health and induced a positive feedback loop involving transcription factors HIF1a and STAT3 to amplify IL24 production at the wound edge. The result was a coordinated effort by a variety of cell types expressing the IL24 receptor to repair the wound by replacing damaged epithelial cells, healing broken capillaries, and generating fibroblasts for new skin cells. Collaborating with Craig Thompson’s group at Memorial Sloan Kettering Cancer Center, the researchers showed that they could regulate Il24 gene expression by changing oxygen levels. Once the researchers pinpointed the origin of the tissue-repair pathway in epidermal stem cells, they studied the wound repair process in mice that had been genetically modified to lack IL24 functionality. Without this key protein, the healing process was sluggish and delayed, taking days longer than in normal mice to completely restore the skin. They speculate that IL24 might be involved in the injury response in other body organs featuring epithelial layers, which act as a protective sheath. In recent studies, elevated IL24 activity has been spotted in epithelial lung tissue of patients with severe COVID-19 and in colonic tissue in patients with ulcerative colitis, a chronic inflammatory bowel disease. “IL24 could be working as a cue to signal the need for injury repair in many organs,” Hur says. Linked by Function and Evolution “Our findings provide insights into an important tissue damage sensing and repair signaling pathway that is independent of infections,” explains Fuchs. An analysis with evolutionary biologist Qian Cong at UT Southwestern Medical Center revealed that IL24 and its receptors share close sequence and structure homology with the interferon family. Though they may not always be working in coordination at every moment, IL24 and interferons are evolutionarily related and bind to receptors sitting near each other on the surface of cells. The researchers suspect that these signaling molecules derive from a common molecular pathway dating far back in our past. “We think that hundreds of millions of years ago, this ancestor might have diverged into two pathways—one being pathogen defense and the other being tissue injury,” Liu says. Perhaps the split occurred to cope with an explosion of pathogens and injuries that caused a sea of troubles for life on Earth. Reference: “A tissue injury sensing and repair pathway distinct from host pathogen defense” by Siqi Liu, Yun Ha Hur, Xin Cai, Qian Cong, Yihao Yang, Chiwei Xu, Angelina M. Bilate, Kevin Andrew Uy Gonzales, S. Martina Parigi, Christopher J. Cowley, Brian Hurwitz, Ji-Dung Luo, Tiffany Tseng, Shiri Gur-Cohen, Megan Sribour, Tatiana Omelchenko, John Levorse, Hilda Amalia Pasolli, Craig B. Thompson, Daniel Mucida and Elaine Fuchs, 24 April 2023, Cell. DOI: 10.1016/j.cell.2023.03.031

A fossil leopard’s lower jawbone next to a skull fragment of a juvenile Paranthropus robustus. Note the two punctures in the skull, which match the spacing of the tips of the leopard’s fangs—implying that this unfortunate hominin child was killed and eaten by a leopard. Credit: Jason L. Heaton Remarkable new fossils from Swartkrans Cave reveal that a prehistoric relative of humans was also extremely small and vulnerable to predators. Paranthropus robustus was a prehistoric hominin species that lived in what is now South Africa approximately two million years ago. It coexisted with Homo ergaster, a direct ancestor of modern humans. Fossils of Paranthropus robustus are particularly abundant at Swartkrans Cave, located roughly midway between Johannesburg and Pretoria. Since scientific excavations began there in 1948, researchers have uncovered numerous skulls and hundreds of teeth, offering valuable insights into the species’ diet and social behavior. For instance, the extremely heavy jaws and thickly enameled teeth of Paranthropus robustus suggest that, during times of scarcity, it was capable of subsisting on low-quality foods that were difficult to chew. Moreover, some of the skulls and teeth of Paranthropus robustus are exceptionally large, while others are robust but not as large as those in the first group. This suggests that the species was characterized by larger males and smaller females, indicating a mating system known as polygyny, in which a single dominant male mates with multiple females. Unfortunately, Swartkrans has yielded far fewer bones from the rest of the Paranthropus robustus skeleton over the years, limiting our understanding of its stature, posture, and locomotion, essential characteristics related to finding food and mates. A major new discovery from Swartkrans, the first articulating hip bone, thigh bone, and shin bone of Paranthropus robustus, is now changing that. The new Paranthropus robustus thigh and shin bones, articulated at the knee joint. Credit: Jason L. Heaton A Significant Fossil Find: Confirming Upright Walking A team of international researchers affiliated to the Evolutionary Studies Institute at the University of the Witwatersrand (Wits University), in South Africa including Travis Pickering, Matthew Caruana, Marine Cazenave, Ron Clarke, Jason Heaton, A.J. Heile, Kathleen Kuman, and Dominic Stratford, indicates in new research that this group of fossils belong to a single, young adult Paranthropus robustus. The fossil not only demonstrates that the species was, like modern humans, a habitual upright walker, but also confirms it was also extremely small. The research was published in the Journal of Human Evolution. “It is estimated that this individual, probably a female, was only about a meter tall and 27 kg when it died, making it even smaller than adults from other diminutive early human species, including those represented by the famous ‘Lucy’ (Australopithecus afarensis, about 3.2 million years old) and ‘Hobbit’ (Homo floresiensis, about 90,000 years old) skeletons, from Ethiopia and Indonesia, respectively,” says Professor Pickering from the Univesity of Wisconsin-Madison, who led the research. Predators and Survival Challenge The small size of the new Paranthropus robustus individual would have made it vulnerable to predators — such as sabertooth cats and giant hyenas — known to have occupied the area around Swartkrans Cave. This notion is confirmed by the team’s investigation of damage on the surface of the fossils, which includes tooth marks and other chewing damage identical to that made by leopards on the bones of their prey. The newly described, leopard-chewed Paranthropus robustus hip bone fossil, superimposed on an outline of a complete hominin hip bone to show the extent of the chewing damage on it. Credit: Jason L. Heaton “Although it seems that this particular Paranthropus robustus individual was the unfortunate victim of predation, that conclusion does not mean that the entire species was inept. We know that Paranthropus robustus survived in South Africa for over a million years and is found invariably, and at various sites, in spatial association with stone and bone tools,” says Pickering. Those implements were used for a variety of purposes, including butchering animals for their meat and digging for edible roots and underground insects. It is a matter of current research whether Paranthropus robustus, contemporaneous Homo ergaster, or both, was the maker and user of those important tools—but the Swartkrans team believes that Paranthropus robustus very likely possessed the cognitive and physical capabilities to do both. The team’s continued investigation of the fossils includes CT-scan analyses of internal bone structures, which will provide additional information on the growth and developmental patterns of Paranthropus robustus, as well as adding details to our growing appreciation of its locomotor behaviors. Reference: “First articulating os coxae, femur, and tibia of a small adult Paranthropus robustus from Member 1 (Hanging Remnant) of the Swartkrans Formation, South Africa” by Travis Rayne Pickering, Marine Cazenave, R.J. Clarke, A.J. Heile, Matthew V. Caruana, Kathleen Kuman, Dominic Stratford, C.K. Brain and Jason L. Heaton, 4 March 2025, Journal of Human Evolution. DOI: 10.1016/j.jhevol.2024.103647

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