Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan graphene material ODM factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia graphene sports insole ODM

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene-infused pillow ODM Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand pillow OEM manufacturer

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand ODM expert for comfort products

Researchers developed a gene sequencing technique using a new machine learning algorithm to accurately identify the origin and concentration of tagged DNA. This method effectively separates bacterial DNA from human and other non-bacterial DNA. Previous studies of a genetic on/off switch may have been confounded by contamination, but Mount Sinai scientists have created a new tool for accurately determining whether it plays a role in human disease. A tiny team of cutting-edge medical experts has been examining a biochemical, DNA tagging mechanism that turns genes on and off for decades. Some have recently discovered evidence of it in plants, flies, human brain tumors, and even bacteria, which has long been researched in bacteria. A new study by scientists at the Icahn School of Medicine at Mount Sinai, however, suggests that there may be a problem: a large portion of the evidence for its presence in higher organisms may be caused by bacterial contamination, which was challenging to detect using current experimental techniques. New Sequencing Technique to Differentiate DNA Sources To solve this problem, the researchers developed a special gene sequencing technique that makes use of a brand-new machine learning algorithm to precisely determine the origin and concentration of tagged DNA. This made it easier for them to separate bacterial DNA from human and other non-bacterial cell DNA. The findings reported in Science confirmed the hypothesis that this mechanism may exist naturally in cells other than bacteria, although the levels were significantly lower than those reported in some earlier research and were easily influenced by bacterial contamination or modern experimental techniques. Similar results were obtained in experiments using human brain cancer cells. “Pushing the boundaries of medical research can be challenging. Sometimes the ideas are so novel that we have to rethink the experimental methods we use to test them out,” said Gang Fang, PhD, Associate Professor of Genetics and Genomic Sciences at Icahn Mount Sinai. “In this study, we developed a new method for effectively measuring this DNA mark in a wide variety of species and cell types. We hope this will help scientists uncover the many roles these processes may play in evolution and human disease.” Researchers at the Icahn School of Medicine at Mount Sinai developed an advanced method for determining whether cells may use an obscure DNA tagging system for turning genes on or off. Credit: Courtesy of Do lab, Mount Sinai, N.Y., N.Y. Exploring DNA Adenine Methylation in Various Organisms The study focused on DNA adenine methylation, a biochemical reaction which attaches a chemical, called a methyl group, to an adenine, one of the four building-block molecules used to construct lengthy DNA strands and encode genes. This can “epigenetically” activate or silence genes without actually altering DNA sequences. For instance, it is known that adenine methylation plays a critical role in how some bacteria defend themselves against viruses. For decades, scientists thought that adenine methylation strictly happened in bacteria whereas human and other non-bacterial cells relied on the methylation of a different building block—cytosine—to regulate genes. Then, starting around 2015, this view changed. Scientists spotted high levels of adenine methylation in plant, fly, mouse, and human cells, suggesting a wider role for the reaction throughout evolution. However, the scientists who performed these initial experiments faced difficult trade-offs. Some used techniques that can precisely measure adenine methylation levels from any cell type but do not have the capacity to identify which cell each piece of DNA came from, while others relied on methods that can spot methylation in different cell types but may overestimate reaction levels. In this study, Dr. Fang’s team developed a method called 6mASCOPE which overcomes these trade-offs. In it, DNA is extracted from a sample of tissue or cells and chopped up into short strands by proteins called enzymes. The strands are placed into microscopic wells and treated with enzymes that make new copies of each strand. An advanced sequencing machine then measures in real time the rate at which each nucleotide building block is added to a new strand. Methylated adenines slightly delay this process. The results are then fed into a machine learning algorithm which the researchers trained to estimate methylation levels from the sequencing data. Refining the Understanding of DNA Methylation “The DNA sequences allowed us to identify which cells—human or bacterial—methylation occurred in while the machine learning model quantified the levels of methylation in each species separately,” said Dr. Fang, Initial experiments on simple, single-cell organisms, such as green algae, suggested that the 6mASCOPE method was effective in that it could detect differences between two organisms that both had high levels of adenine methylation. The method also appeared to be effective at quantifying adenine methylation in complex organisms. For example, previous studies had suggested that high levels of methylation may play a role in the early growth of the fruit fly Drosophila melanogaster and of the flowering weed Arabidopsis thaliana. In this study, the researchers found that these high levels of methylation were mostly the result of contaminating bacterial DNA. In reality, the fly and the plant DNA from these experiments only had trace amounts of methylation. Likewise, experiments on human cells suggested that methylation occurs at very low levels in both healthy and disease conditions. Immune cell DNA obtained from patient blood samples had only trace amounts of methylation. Similar results were also seen with DNA isolated from glioblastoma brain tumor samples. This result was different than a previous study, which reported much higher levels of adenine methylation in tumor cells. However, as the authors note, more research may be needed to determine how much of this discrepancy may be due to differences in tumor subtypes as well as other potential sources of methylation. Finally, the researchers found that plasmid DNA, a tool that scientists use regularly to manipulate genes, may be contaminated with high levels of methylation that originated from bacteria, suggesting this DNA could be a source of contamination in future experiments. “Our results show that the manner in which adenine methylation is measured can have profound effects on the result of an experiment. We do not mean to exclude the possibility that some human tissues or disease subtypes may have highly abundant DNA adenine methylation, but we do hope 6mASCOPE will help scientists fully investigate this issue by excluding the bias from bacterial contamination,” said Dr. Gang. “To help with this we have made the 6mASCOPE analysis software and a detailed operating manual widely available to other researchers.” Reference: “Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution” by Yimeng Kong, Lei Cao, Gintaras Deikus, Yu Fan, Edward A. Mead, Weiyi Lai, Yizhou Zhang, Raymund Yong, Robert Sebra, Hailin Wang, Xue-Song Zhang and Gang Fang, 3 February 2022, Science. DOI: 10.1126/science.abe7489 This work was supported by the National Institutes of Health (GM139655, HG011095, AG071291); the Icahn Institute for Genomics and Multiscale Biology; the Irma T. Hirschl/Monique Weill-Caulier Trust; the Nash Family Foundation; and the Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai. Methods validation using Mass Spectrometry was supported by the collaborators at the Chinese Academy of Sciences (XDPB2004) and the National Natural Science Foundation of China (22021003).

Red-lipped Blenny, a tropical marine species in which the researchers discovered the ichthyocolids. Credit: Philippe Guillaume Scientists have used genome reconstruction to identify a previously “invisible” fish parasite, found globally in numerous marine fish species. This parasite, part of the apicomplexans—a critical group of clinical parasites—had been overlooked in earlier research. Its presence is widespread both geographically and across different fish species worldwide, which has significant implications for commercial fishing and marine food chains. An international team of scientists from the Rosenstiel School of Marine, Atmospheric, and Earth Science at the University of Miami and the Institute of Evolutionary Biology (IBE), a collaborative center of the Spanish National Research Council (CSIC) and Pompeu Fabra University (UPF), has identified a new parasite in the red-lipped blenny, a tropical reef fish. This research has also uncovered the global distribution of this parasite in fish populations worldwide. Published recently in the journal Current Biology, the research used an innovative method to reconstruct part of the parasite’s genome from sequencing data obtained from its host, and be able to detect its presence in other fish using genetic “barcodes” (DNA barcoding). An “invisible” parasite has been unveiled Despite its presence in fish worldwide, the parasite had not been properly characterized until now. The genomic data of the study reveals that this parasite belongs to a group of organisms previously uncharacterized and have been named ichthyocolids, from the Latin “fish dweller.” “Although it had been previously identified by microscopy, we had not been able to separate the genomic signal from the host fish and the parasite until now. For the first time, we have been able to identify them through their DNA, and place them within the well-known group of apicomplexan parasites,” said Javier del Campo, lead of the study and principal investigator at IBE in the Microbial Ecology and Evolution group and at the Rosenstiel School in Miami. The parasite is present in fish around the world Beyond allowing the description of an entirely new group of apicomplexans, the genome reconstruction has allowed researchers to identify a series of genes that can be used to detect the presence of this organism in other genomic or microbiome samples as if it was a “barcode.” “Once we found ichthyocolids in the red-lipped blenny, a tropical fish, we wondered if it would also be part of the microbiota of other fish,” says Anthony Bonacolta, a PhD candidate in marine biology and ecology at the Rosenstiel School and first author of the study. The team compared the DNA of these apicomplexans with public databases of the microbiomes of hundreds of species of freshwater and marine fish. The results showed that these parasites appear associated with the majority of marine fish species analyzed and are present in all oceans. It would therefore be one of the most widespread parasites among marine fish, with potential implications for commercial fishing and oceanic food webs. “Future studies could help us better understand the impact of parasites as prevalent as ichthyocolids in marine ecosystems,” del Campo says. A new member of apicomplexan parasites The Ichthyocolids belong to Apicomplexa, a large group of parasites including the ones that cause malaria and toxoplasmosis. However, these parasites do not pose a direct risk to human health, but are important to study for the health of the oceanic ecosystems and for more context on the evolution of those human parasites. The discovery of the ichthyocolids adds more context to this evolution. For the first time, they are placed as a sister group to well-known coral inhabitants, the corallicolids, also recently described as apicomplexans. “Studying ichthyocolids not only reveals more about the evolution of major parasites, but also the other basic traits of apicomplexans which may be important in a clinical sense. They may use similar infection mechanisms (as they are also a blood parasite) or have other similar biology which can enlighten our understanding of other apicomplexans,” said Bonacolta. Reference: “A new and widespread group of fish apicomplexan parasites” by Anthony M. Bonacolta, Joana Krause-Massaguer, Nico J. Smit, Paul C. Sikkel and Javier del Campo, 30 May 2024, Current Biology. DOI: 10.1016/j.cub.2024.04.084

Coastal podded hydroid Aglaophenia pluma and open-ocean gooseneck barnacles Lepas living on floating plastic collected in the North Pacific Subtropical Gyre. Credit: The Ocean Cleanup, in coordination with Smithsonian Institution A study reveals coastal invertebrates are thriving on plastic debris in the North Pacific, forming neopelagic communities previously unseen in open oceans, posing risks of invasive species spreading to ecosystems like Hawaii’s fragile reefs. A team of researchers from the Smithsonian Environmental Research Center (SERC) and the University of Hawai‘i (UH) at Mānoa, has recently published a study in Nature Ecology and Evolution, revealing that a surprising number of coastal marine invertebrate species have colonized the high seas and are now thriving and reproducing in the open ocean, significantly shaping the composition of the floating community. The study conducted by the researchers discovered that over 70 percent of the plastic debris they examined in the eastern North Pacific Subtropical Gyre was colonized by diverse coastal species belonging to various taxonomic groups and possessing different life history traits. Additionally, the plastic debris was found to carry more coastal species than open ocean species. “This discovery suggests that past biogeographical boundaries among marine ecosystems — established for millions of years — are rapidly changing due to floating plastic pollution accumulating in the subtropical gyres,” said lead author Linsey Haram, research associate at SERC. These researchers only recently discovered the existence of these “neopelagic communities,” or floating communities in deep ocean waters. To understand the ecological and physical processes that govern communities on floating marine debris, SERC, and UH Mānoa formed a multi-disciplinary Floating Ocean Ecosystem (FloatEco) team. UH Mānoa led the assessment of physical oceanography and SERC evaluated the biological and ecological dimensions of the study. Examples of floating plastics collected in the North Pacific Subtropical Gyre during The Ocean Cleanup’s 2018 expedition. Credit: The Ocean Cleanup For this study, the FloatEco team analyzed 105 plastic samples collected by The Ocean Cleanup during their 2018 and 2019 expeditions in the North Pacific Subtropical Gyre, which occupies most of the northern Pacific Ocean. The fieldwork relied on the participation of both individual volunteers and non-governmental organizations. “We were extremely surprised to find 37 different invertebrate species that normally live in coastal waters, over triple the number of species we found that live in open waters, not only surviving on the plastic but also reproducing,” said Haram. “We were also impressed by how easily coastal species colonized new floating items, including our own instruments — an observation we’re looking into further.” Paradigm Shift in Marine Biogeography “Our results suggest coastal organisms now are able to reproduce, grow, and persist in the open ocean — creating a novel community that did not previously exist, being sustained by the vast and expanding sea of plastic debris,” said co-author Gregory Ruiz, senior scientist at SERC. “This is a paradigm shift in what we consider to be barriers to the distribution and dispersal of coastal invertebrates.” While scientists already knew organisms, including some coastal species, colonized marine plastic debris, scientists were unaware until now that established coastal communities could persist in the open ocean. These findings identify a new human-caused impact on the ocean, documenting the scale and potential consequences that were not previously understood. “The Hawaiian Islands are neighbored in the northeast by the North Pacific garbage patch,” said Nikolai Maximenko, co-author and senior researcher at the UH Mānoa School of Ocean and Earth Science and Technology. “Debris that breaks off from this patch constitutes the majority of debris arriving on Hawaiian beaches and reefs. In the past, the fragile marine ecosystems of the islands were protected by the very long distances from coastal communities of Asia and North America. The presence of coastal species persisting in the North Pacific Subtropical Gyre near Hawai‘i is a game changer that indicates that the islands are at an increased risk of colonization by invasive species.” “Our study underscores the large knowledge gap and still limited understanding of rapidly changing open ocean ecosystems,” said Ruiz. “This highlights the need for dramatic enhancement of the high-seas observing systems, including biological, physical, and marine debris measurements.” Reference: “Extent and reproduction of coastal species on plastic debris in the North Pacific Subtropical Gyre” by Linsey E. Haram, James T. Carlton, Luca Centurioni, Henry Choong, Brendan Cornwell, Mary Crowley, Matthias Egger, Jan Hafner, Verena Hormann, Laurent Lebreton, Nikolai Maximenko, Megan McCuller, Cathryn Murray, Jenny Par, Andrey Shcherbina, Cynthia Wright and Gregory M. Ruiz, 17 April 2023, Nature Ecology & Evolution. DOI: 10.1038/s41559-023-01997-y The study was funded by NASA and Life in Moving Ocean.

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