Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Custom graphene foam processing factory Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan orthopedic insole OEM manufacturing site

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Arch support insole OEM from Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China neck support pillow OEM

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Flexible manufacturing OEM & ODM Thailand

Immunofluorescence staining of human pluripotent stem cell-derived axioloids. Credit: Alev Lab (ASHBi/Kyoto University) ASHBi Researchers Have Helped Uncover the Secrets of the Human Body’s Plan Michelangelo’s David captures the beauty of the human form, but scientists have been baffled for over 100 years by how this perfect body structure develops. This mystery has been hard to unravel due to technical limitations and ethical issues surrounding research on human embryos. However, now, work published in Nature by an international team of scientists led by Dr. Cantas Alev, at the Institute for the Advanced Study of Human Biology (ASHBi) in Kyoto University, has uncovered using their own mallet and chisel –a petri dish and induced pluripotent stem cells (iPSCs)– how the early stages of the human body plan are established. Segmentation and the Role of Somites Similar to other organisms within the animal kingdom, the human body consists of repetitive anatomical units or segments – a prominent example being the vertebrae of the human spine. The most primitive version of such segments in the human embryo, known as somites, arise from an embryonic tissue called presomitic mesoderm (PSM) and contribute to the formation of various structures including cartilage, bone, skin, and skeletal muscle. Graphical abstract of the paper. Credit: Alev Lab (ASHBi/Kyoto University) / Misaki Ouchida While previous work by Alev and colleagues reconstituted the so-called segmentation clock, a molecular oscillator and dynamic ‘wave’ of gene expression required for the proper formation of human somites (somitogenesis), it could not recapitulate the complex three-dimensional (3-D) morphological and structural changes occurring during human body-axis development. In their new study, Alev and co-workers, using a cocktail consisting of human iPSCs-derived cells and Matrigel –a viscous gel compound enriched with extracellular matrix components– have now generated a 3-D model that can recapitulate the development of our early body plan in a dish, which they coined ‘axioloids’. “(Our) axioloids capture, not only the oscillatory nature of the segmentation clock but also the molecular as well as the 3-D morphological and structural characteristics observed during the process of segmentation and somitogenesis,” says Alev. Vitamin A’s Role in Somitogenesis By taking a bottom-up approach in their experimental design, Alev and his team identified a previously unappreciated functional role for retinoids, more commonly known as vitamin A and its derivatives, during somite formation. “Our bottom-up approach was critical to unraveling the role of retinoids during somitogenesis. It is likely that many researchers missed this essential role because vitamin A is a common supplement that usually gets included into culture media” comments Alev. When Alev’s axioloids were compared to actual human embryos, they revealed “remarkable similarities to Carnegie Stage 9-12 human embryos, which is known to be a critical stage during human development where organs such as the brain and heart start forming” explains Alev. Applications for Congenital Spine Disease Research Lastly, using iPSCs containing mutations commonly associated with congenital spine disease, Alev and co-authors demonstrated that axioloids can be instrumental in delineating how these mutations contribute to the pathogenesis of such diseases. Alev comments, “our (bottom-up) approach of generating axioloids have not only allowed us to uncouple fundamental biological processes, such as cell morphology and cell states, but it allowed us to determine how mutations contribute to spine disease” and he continues, “we also anticipate similar strategies will become increasingly necessary in order to understand better the etiology and pathology of other diseases.” Reference: “Reconstituting human somitogenesis in vitro” by Yoshihiro Yamanaka, Sofiane Hamidi, Kumiko Yoshioka-Kobayashi, Sirajam Munira, Kazunori Sunadome, Yi Zhang, Yuzuru Kurokawa, Rolf Ericsson, Ai Mieda, Jamie L. Thompson, Janet Kerwin, Steven Lisgo, Takuya Yamamoto, Naomi Moris, Alfonso Martinez-Arias, Taro Tsujimura and Cantas Alev, 21 December 2022, Nature. DOI: 10.1038/s41586-022-05649-2

Two gray wolves (lower left) confront a pack of dire wolves over a bison carcass in Southwestern North America 15,000 years ago. Credit: Art by Mauricio Anton DNA reveals dire wolves weren’t gray wolf relatives, but a distinct and ancient species. The iconic, prehistoric dire wolf, which prowled through Los Angeles and elsewhere in the Americas over 11 millennia ago, was a distinct species from the slightly smaller gray wolf, an international team of scientists reported in the journal Nature. The study, which puts to bed a mystery that biologists have pondered for more than 100 years, was led by researchers from UCLA, along with colleagues from Durham University in the U.K., Australia’s University of Adelaide and Germany’s Ludwig Maximilian University. “The terrifying dire wolf, a legendary symbol of Los Angeles and the La Brea Tar Pits, has earned its place among the many large, unique species that went extinct at the end of the Pleistocene epoch,” said UCLA’s Robert Wayne, a distinguished professor of ecology and evolutionary biology and the study’s co-senior author. The Pleistocene, commonly called the Ice Age, ended roughly 11,700 years ago. Unlocking the Past with Ancient DNA More than 4,000 dire wolves have been excavated from the La Brea Tar Pits, but scientists have known little about their evolution or the reasons for their ultimate disappearance. Gray wolves, also found in the fossil-rich pits, have survived until this day. “Dire wolves have always been an iconic representation of the last ice age in the Americas, but what we know about their evolutionary history has been limited to what we can see from the size and shape of their bones,” said co-lead author Angela Perri of Durham University. Those bones are now revealing much more. Using cutting-edge molecular approaches to analyze five dire wolf genomes from fossil bones dating back 13,000 to 50,000 years ago, the researchers were able to reconstruct the evolutionary history of the long-extinct carnivore for the first time. Significantly, they found no evidence for the flow of genes between dire wolves and either North American gray wolves or coyotes. The absence of any genetic transference indicates that dire wolves evolved in isolation from the Ice Age ancestors of these other species. “We have found the dire wolf is not closely related to the gray wolf. Further, we’ve shown that the dire wolf never interbred with the gray wolf,” said co-lead author Alice Mouton, who conducted the research as a UCLA postdoctoral scholar in ecology and evolutionary biology in Wayne’s laboratory. The American Origins of a Lone Lineage The ancestors of the gray wolf and the much smaller coyote evolved in Eurasia and are thought to have moved into North America less than 1.37 million years ago, relatively recently in evolutionary time. The dire wolf, on the other hand, based on its genetic difference from those species, is now believed to have originated in the Americas. “When we first started this study, we thought that dire wolves were just beefed-up gray wolves, so we were surprised to learn how extremely genetically different they were, so much so that they likely could not have interbred,” said the study’s last author, Laurent Frantz, a professor at Ludwig Maximillian University and the U.K.’s Queen Mary University. “This must mean that dire wolves were isolated in North America for a very long time to become so genetically distinct.” “Dire wolves are sometimes portrayed as mythical creatures — giant wolves prowling bleak frozen landscapes — but reality turns out to be even more interesting,” said Kieren Mitchell of the University of Adelaide, a co-lead author. The Dire Wolf Was a ‘Lone Wolf’ When It Came to Breeding Interbreeding is quite common among wolf lineages when their geographical ranges overlap. Modern gray wolves and coyotes, for example, frequently interbreed in North America. Yet the researchers, using a data set that included a Pleistocene dire wolf, 22 modern North American gray wolves and coyotes, and three ancient dogs, found that the dire wolf hadn’t interbred with any of the others — likely because it was genetically unable to reproduce with those species. “Our finding of no evidence for gene flow between dire wolves and gray wolves or coyotes, despite the substantial range overlap during the Late Pleistocene, suggests that the common ancestor of gray wolves and coyotes probably evolved in geographical isolation from members of the dire wolf lineage,” Wayne said. “This result is consistent with the hypothesis that dire wolves originated in the Americas.” Another hypothesis about the dire wolf — one untested in the current study — concerns its extinction. It is commonly thought that because of its body size — larger than gray wolves and coyotes — the dire wolf was more specialized for hunting large prey and was unable to survive the extinction of its regular food sources. A lack of interbreeding may have hastened its demise, suggested Mouton, now a postdoctoral researcher at Belgium’s University of Liege. “Perhaps the dire wolf’s inability to interbreed did not provide necessary new traits that might have allowed them to survive,” she said. While the dire wolves sequenced in this study possessed no ancestry from gray wolves, coyotes, or their recent North American ancestors, a comparison of the DNA of dire wolves with that of gray wolves, coyotes and a wide variety of other wolf-like species revealed a common but distant evolutionary relationship.   “The ancestors of dire wolves likely diverged from those of gray wolves more than 5 million years ago — it was a great surprise to discover that this divergence occurred so early,” Mouton said. “This finding highlights how special and unique the dire wolf was.” Based on their genomic analyses, the researchers also concluded that there are three primary lineages that descend from the shared ancestry: dire wolves, African jackals and a group comprising all other existing wolf-like species, including the gray wolf. Rewriting Canid Family Ties Gray wolves, which today live mostly in wilderness and remote regions of North America, are more closely related to African wild dogs and Ethiopian wolves than to dire wolves, Wayne noted. The study is the first ever to report genome-wide data on dire wolves. The genomic analyses — conducted in a joint effort at UCLA, Durham University, the University of Oxford, the University of Adelaide, Ludwig Maximilian University and Queen Mary University — focused on both the nuclear genome and the mitochondrial genome, which is abundant in ancient remains. “The decreased cost of sequencing analyses, in addition to state-of-the-art molecular biology methods for highly degraded materials, allows us to recover DNA from fossils,” Mouton said. “Ancient DNA genomic analyses represent an incredible tool to better understand the evolutionary history of ancient and extinct species.” Reference: “Dire wolves were the last of an ancient New World canid lineage” by Angela R. Perri, Kieren J. Mitchell, Alice Mouton, Sandra Álvarez-Carretero, Ardern Hulme-Beaman, James Haile, Alexandra Jamieson, Julie Meachen, Audrey T. Lin, Blaine W. Schubert, Carly Ameen, Ekaterina E. Antipina, Pere Bover, Selina Brace, Alberto Carmagnini, Christian Carøe, Jose A. Samaniego Castruita, James C. Chatters, Keith Dobney, Mario dos Reis, Allowen Evin, Philippe Gaubert, Shyam Gopalakrishnan, Graham Gower, Holly Heiniger, Kristofer M. Helgen, Josh Kapp, Pavel A. Kosintsev, Anna Linderholm, Andrew T. Ozga, Samantha Presslee, Alexander T. Salis, Nedda F. Saremi, Colin Shew, Katherine Skerry, Dmitry E. Taranenko, Mary Thompson, Mikhail V. Sablin, Yaroslav V. Kuzmin, Matthew J. Collins, Mikkel-Holger S. Sinding, M. Thomas P. Gilbert, Anne C. Stone, Beth Shapiro, Blaire Van Valkenburgh, Robert K. Wayne, Greger Larson, Alan Cooper and Laurent A. F. Frantz, 13 January 2021, Nature. DOI: 10.1038/s41586-020-03082-x The study’s 49 co-authors also include Blaire Van Valkenburgh, a UCLA distinguished professor of ecology and evolutionary biology who holds the Donald R. Dickey Chair in Vertebrate Biology; Julie Meachen, who earned her doctorate in ecology and evolutionary biology at UCLA and is now an associate professor of anatomy at Des Moines University in Iowa; and Colin Shew, a UCLA laboratory technician in ecology and evolutionary biology; as well as dozens of other researchers from the U.K., Australia, Germany, Russia, Spain, France, Denmark and other countries. Funding sources for the research included the National Science Foundation, the Office of Naval Research, the Marie Curie COFUND, the European Research Council, the Natural Environmental Research Council, the Wellcome Trust and the Australian Research Council. The Nature paper lists many other acknowledgments.

By assembling into large structures, the antibiotic plectasin latches onto its target on the bacterial cell surface. This is comparable to how both sides of Velcro form a bond. Credit: Gloria Fuentes, edited Researchers discovered a novel antibacterial mechanism of plectasin, an antibiotic derived from a fungus. The study reveals that plectasin forms Velcro-like structures that trap crucial bacterial components, preventing their escape and enhancing drug effectiveness. This mechanism could guide the development of new antibiotics to fight antimicrobial resistance. Plectasin, a small antibiotic, uses an innovative mechanism to kill bacteria. It assembles to form a large structure that latches onto its target on the bacterial cell surface comparable to how both sides of Velcro form a bond. A research team mapped how the Velcro-structure is formed. Their discovery unveils a new approach that could have broad implications for the development of antibiotics to combat antimicrobial resistance. Published today (May 23) in the scientific journal Nature Microbiology, the research was led by structural biologist Markus Weingarth and biochemist Eefjan Breukink at Utrecht University. Innovative Research Techniques The research team delved into the workings of plectasin, an antibiotic derived from the fungus Pseudoplectania nigrella. The scientists employed advanced biophysical techniques, including solid-state NMR and, in collaboration with Wouter Roos from Groningen, atomic force microscopy. Traditionally, antibiotics function by targeting specific molecules within bacterial cells. However, the mechanism behind plectasin’s action was not fully understood until now. Previous studies suggested a conventional model where plectasin binds to a molecule called Lipid II, crucial for bacterial cell wall synthesis, akin to a key fitting into a lock. Maik Derks, Eefjan Breukink, Shehrazade Miranda Jekhmane, and Markus Weingarth (from left to right). Credit: Utrecht University Velcro-Like Structures in Antibacterial Action The new study reveals a more intricate process. Plectasin doesn’t just act like a key in a lock; instead, it forms dense structures on bacterial membranes containing Lipid II. These supramolecular complexes trap their target Lipid II, preventing it from escaping. Even if one Lipid II breaks free from plectasin, it remains contained within the Velcro-structure, unable to escape. Weingarth compares this structure to Velcro, where plectasin forms the microscopic hooks that attach to bacterial ‘loops’. In normal Velcro, if one of the loops breaks free from its hook, it is still trapped by the entire structure. The same goes for bacteria trapped in the plectasin superstructure: they can break free from the plectasin’s binding, but stay trapped in the superstructure. This prevents the bacteria to escape and cause further infections. Role of Calcium Ions in Plectasin’s Effectiveness Moreover, the researchers found that the presence of calcium ions further enhances plectasin’s antibacterial activity. These ions coordinate with specific regions of plectasin, causing structural changes that significantly improve the antibacterial effectiveness. That ions play a critical part in the action of plectasin was discovered by PhD students Shehrazade Miranda Jekhmane and Maik Derks, co-first authors of the study. They realized that plectasin samples had a peculiar color, which hinted at the presence of ions. Implications for Future Antibiotic Development Markus Weingarth, the lead author of the study, expects this finding could open new avenues for developing superior antibiotics. “Plectasin is presumably not the ideal antibiotic candidate due to safety concerns. However, in our study, we show that the ‘Velcro-mechanism’ appears widely used among antibiotics, which was thus far ignored. Future drug design efforts hence not only need to focus on how to bind targets, but also how drugs can self-assemble efficiently. Thereby, our study closes a major knowledge gap which could have broad implications for the design of better drugs to combat the growing threat of antimicrobial resistance.” Reference: “Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism” by Shehrazade Jekhmane, Maik G. N. Derks, Sourav Maity, Cornelis J. Slingerland, Kamaleddin H. M. E. Tehrani, João Medeiros-Silva, Vicky Charitou, Danique Ammerlaan, Céline Fetz, Naomi A. Consoli, Rachel V. K. Cochrane, Eilidh J. Matheson, Mick van der Weijde, Barend O. W. Elenbaas, Francesca Lavore, Ruud Cox, Joseph H. Lorent, Marc Baldus, Markus Künzler, Moreno Lelli, Stephen A. Cochrane, Nathaniel I. Martin, Wouter H. Roos, Eefjan Breukink and Markus Weingarth, 23 May 2024, Nature Microbiology. DOI: 10.1038/s41564-024-01696-9

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