Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Pillow ODM design company in Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Arch support insole OEM from China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Custom graphene foam processing Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China custom insole OEM supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Latex pillow OEM production in Vietnam

Corals display glowing colors (fluorescence). Credit: Tel Aviv University Researchers have proved for the first time that corals’ fluorescent colors are intended to attract prey. For the first time, a recent study from Tel Aviv University, in association with the Steinhardt Museum of Natural History and the Interuniversity Institute for Marine Sciences in Eilat, has established that the magical phenomenon in deep reefs where corals exhibit glowing colors (fluorescence) is intended to serve as a mechanism for luring prey. The research demonstrates that the marine creatures that corals feed on are drawn to fluorescent colors. Professor Yossi Loya from the School of Zoology and the Steinhardt Museum of Natural History at Tel Aviv University supervised the research, which was led by Dr. Or Ben-Zvi, Yoav Lindemann, and Dr. Gal Eyal. Fluorescence as a Prey-Attracting Strategy According to the researchers, the ability of aquatic organisms to glow has long attracted both scientists and those who love nature. The biological role of the phenomena, which occurs often in corals that produce reefs, has been fiercely disputed. A variety of possibilities have been explored over the years, including: Does this phenomenon defend against radiation? improve photosynthesis? an antioxidant activity? According to the most recent research, coral fluorescence actually serves as a lure for prey. In the study, the researchers put their hypothesis to the test; to this end, they first sought to determine whether plankton (small organisms that drift in the sea along with the current) are attracted to fluorescence, both in the laboratory and at sea. Then, in the lab, the researchers quantified the predatory capabilities of mesophotic corals (corals that live between the shallow coral reef area and the deep, completely dark zone of ​​the ocean), which exhibit different fluorescent appearances. Plankton Attraction In order to test the planktons’ potential attraction to fluorescence, the researchers used, inter alia, the crustacean Artemia salina, which is used in many experiments as well as for food for corals. The researchers noted that when the crustaceans were given a choice between a green or orange fluorescent target versus a clear “control” target, they showed a significant preference for the fluorescent target. Moreover, when the crustaceans were given a choice between two clear targets, their choices were observed to be randomly distributed in the experimental setup. In all of the laboratory experiments, the crustaceans vastly exhibited a preferred attraction toward a fluorescent signal. Similar results were presented when using a native crustacean from the Red Sea. However, unlike the crustaceans, fish that are not considered coral prey did not exhibit these trends, and rather avoided the fluorescent targets in general and the orange targets in particular. A scientist obtaining data for the study. Credit: Tel Aviv University In the second phase of the study, the experiment was carried out in the corals’ natural habitat, about 40 meters deep in the sea, where the fluorescent traps (both green and orange) attracted twice as many plankton as the clear trap. Dr. Or Ben-Zvi says, “We conducted an experiment in the depths of the sea in order to examine the possible attraction of diverse and natural collections of plankton to fluorescence, under the natural currents and light conditions that exist in deep water. Since fluorescence is ‘activated’ principally by blue light (the light of the depths of the sea), at these depths the fluorescence is naturally illuminated, and the data that emerged from the experiment were unequivocal, similar to the laboratory experiment.” Predation Rates Linked to Fluorescent Coloration in Corals In the last part of the study, the researchers examined the predation rates of mesophotic corals that were collected at 45-meter (148-foot) depth in the Gulf of Eilat and found that corals that displayed green fluorescence enjoyed predation rates that were 25 percent higher than corals exhibiting yellow fluorescence. Professor Loya: “Many corals display a fluorescent color pattern that highlights their mouths or tentacle tips, a fact that supports the idea that fluorescence, like bioluminescence (the production of light by a chemical reaction), acts as a mechanism to attract prey. The study proves that the glowing and colorful appearance of corals can act as a lure to attract swimming plankton to ground-dwelling predators, such as corals, and especially in habitats where corals require other energy sources in addition or as a substitute for photosynthesis (sugar production by symbiotic algae inside the coral tissue using light energy).” Dr. Ben-Zvi concludes: “Despite the gaps in the existing knowledge regarding the visual perception of fluorescence signals by plankton, the current study presents experimental evidence for the prey-luring role of fluorescence in corals. We suggest that this hypothesis, which we term the ‘light trap hypothesis’, may also apply to other fluorescent organisms in the sea, and that this phenomenon may play a greater role in marine ecosystems than previously thought.” Reference: “Coral fluorescence: a prey-lure in deep habitats” by Or Ben-Zvi, Yoav Lindemann, Gal Eyal, and Yossi Loya, 2 June 2022, Communications Biology. DOI: 10.1038/s42003-022-03460-3

A study conducted by researchers from Florida Atlantic University and various international institutions has revealed that Vibrio bacteria, which can cause deadly human diseases, can quickly stick to and potentially adapt to plastic marine debris and Sargassum, a rapidly expanding type of seaweed found in the Sargasso Sea and beyond. This study, the first to assemble a Vibrio spp. genome from plastic debris, emphasizes the potential health risks associated with increased human interaction with Sargassum and plastic marine debris, and the researchers urge caution regarding the harvest and processing of Sargassum biomass until the risks are thoroughly investigated. Genomics study in the Caribbean and Sargasso Seas signifies the first assembly of vibrio bacteria sourced from plastic waste. Recent research has unveiled how the interaction among Sargassum species, plastic marine waste, and Vibrio bacteria creates the perfect “pathogen” that poses threats to marine biodiversity and public health. Vibrio bacteria, commonly found in global waters, are the leading cause of marine-related human fatalities. For instance, Vibrio vulnificus, often known as the flesh-eating bacteria, can cause severe foodborne illnesses from consuming seafood and can lead to infections and death from open wounds. From 2011 onwards, there’s been a notable increase in the presence of Sargassum, a type of free-living brown macroalgae, in the Sargasso Sea and other open ocean areas like the Great Atlantic Sargassum Belt, with regular and unusual seaweed accumulation events occurring on beaches. Additionally, plastic marine waste, initially discovered in the surface waters of the Sargasso Sea, has emerged as a global concern due to its longevity, persisting for decades longer than natural substrates in the marine ecosystem. Currently, little is known about the ecological relationship of vibrios with Sargassum. Moreover, genomic and metagenomic evidence has been lacking as to whether vibrios colonizing plastic marine debris and Sargassum could potentially infect humans. As summer kicks into high gear and efforts are underway to find innovative solutions to repurpose Sargassum, could these substrates pose a triple threat to public health? (Blood agar test on the left; β hemolysis phenotype on the right): More than 40 percent of plastic derived Vibrio isolates displayed hemolytic activity, consistent with pathogenic potential. Credit: Tracy Mincer, Florida Atlantic University Vibrio Pathogens: Aggressive Adapters Researchers from Florida Atlantic University and collaborators fully sequenced the genomes of 16 Vibrio cultivars isolated from eel larvae, plastic marine debris, Sargassum, and seawater samples collected from the Caribbean and Sargasso seas of the North Atlantic Ocean. What they discovered is Vibrio pathogens have the unique ability to “stick” to microplastics and that these microbes might just be adapting to plastic. “Plastic is a new element that’s been introduced into marine environments and has only been around for about 50 years,” said Tracy Mincer, Ph.D., corresponding lead author and an assistant professor of biology at FAU’s Harbor Branch Oceanographic Institute and Harriet L. Wilkes Honors College. “Our lab work showed that these Vibrio are extremely aggressive and can seek out and stick to plastic within minutes. We also found that there are attachment factors that microbes use to stick to plastics, and it is the same kind of mechanism that pathogens use.” The study, published in the journal Water Research, illustrates that open ocean vibrios represent an up-to-now undescribed group of microbes, some representing potential new species, possessing a blend of pathogenic and low nutrient acquisition genes, reflecting their pelagic habitat and the substrates and hosts they colonize. Utilizing metagenome-assembled genome (MAG), this study represents the first Vibrio spp. genome assembled from plastic debris. Some cultivation-based data show beached Sargassum appear to harbor high amounts of Vibrio bacteria. Credit: Brian Lapointe, FAU Harbor Branch Pathogenic Genes and Biofilm Formation The study highlighted vertebrate pathogen genes closely related to cholera and non-cholera bacterial strains. Phenotype testing of cultivars confirmed rapid biofilm formation, hemolytic and lipophospholytic activities, consistent with pathogenic potential. Researchers also discovered that zonula occludens toxin or “zot” genes, first described in Vibrio cholerae, which is a secreted toxin that increases intestinal permeability, were some of the most highly retained and selected genes in the vibrios they found. These vibrios appear to be getting in through the gut, getting stuck in the intestines, and infecting that way. “Another interesting thing we discovered is a set of genes called ‘zot’ genes, which causes leaky gut syndrome,” said Mincer. “For instance, if a fish eats a piece of plastic and gets infected by this Vibrio, which then results in a leaky gut and diarrhea, it’s going to release waste nutrients such nitrogen and phosphate that could stimulate Sargassum growth and other surrounding organisms.” Findings show some Vibrio spp. in this environment have an ‘omnivorous’ lifestyle targeting both plant and animal hosts in combination with an ability to persist in oligotrophic conditions. With increased human-Sargassum-plastic marine debris interactions, associated microbial flora of these substrates could harbor potent opportunistic pathogens. Importantly, some cultivation-based data show beached Sargassum appear to harbor high amounts of Vibrio bacteria. “I don’t think at this point, anyone has really considered these microbes and their capability to cause infections,” said Mincer. “We really want to make the public aware of these associated risks. In particular, caution should be exercised regarding the harvest and processing of Sargassum biomass until the risks are explored more thoroughly.” Reference: “Sargasso Sea Vibrio bacteria: underexplored potential pathovars in a perturbed habitat” by Tracy J. Mincer, Ryan P. Bos, Erik R. Zettler, Shiye Zhao, Alejandro A. Asbun, William D. Orsi, Vincent S. Guzzetta and Linda A. Amaral-Zettler, 3 May 2023, Water Research. DOI: 10.1016/j.watres.2023.120033 Study co-authors represent the NIOZ Royal Netherlands Institute for Sea Research, the Japan Agency for Marine-Earth Science and Technology, the Ludwig Maximilian University of Munich, Germany, Emory University, the University of Amsterdam and the Marine Biological Laboratory. This research was supported by the National Science Foundation (NSF) (grant OCE-1155671 awarded to Mincer), FAU World Class Faculty and Scholar Program (awarded to Mincer), NSF (grant OCE-1155571 awarded to Linda A. Amaral-Zettler, Ph.D., corresponding author, NIOZ), NSF (grant OCE-1155379 awarded to Erik R. Zettler, Ph.D., co-author, NIOZ), NSF TUES grant (DUE-1043468 awarded to Linda Zettler and Erik Zettler).

MIT scientists found that the protein perlecan, found in both flies and humans, is vital for maintaining the structural integrity of neuronal axons. Without it, axons can break, leading to the death of synapses. Scientists find a protein common to flies and people is essential for supporting the structure of axons that neurons project to make circuit connections. In a study conducted by MIT’s Picower Institute for Learning and Memory, researchers found that a protein named perlecan plays a crucial role in maintaining the structural integrity of neurons. Perlecan is part of the extracellular matrix that surrounds cells and helps them develop in a supportive, yet non-rigid environment. The study revealed that, without perlecan, the axons (long projections of neurons used for connection) can break apart during development, leading to the death of synapses (neuronal connections). Perhaps the most obvious feature of a neuron is the long branch called an axon that ventures far from the cell body to connect with other neurons or muscles. If that long, thin projection ever seems like it could be vulnerable, a new MIT study shows that its structural integrity may indeed require the support of a surrounding protein called perlecan. Without that protein in Drosophila fruit flies, researchers at The Picower Institute for Learning and Memory found axonal segments can break apart during development and the connections, or synapses, that they form end up dying away. Perlecan helps make the extracellular matrix, the proteins, and other molecules that surround cells, stable and flexible so that cells can develop and function in an environment that is supportive without being rigid. “What we found was that the extracellular matrix around nerves was being altered and essentially causing the nerves to break completely. Broken nerves eventually led to the synapses retracting,” says study senior author Troy Littleton, the Menicon Professor in MIT’s departments of Biology and Brain and Cognitive Sciences. MIT researchers have found that a protein called Perlecan is key for sustaining the structural integrity of neuronal axons. In this figure from the paper, microtubules within a broken neural axon become misdirected and tangled during late-stage development of a fly larvae lacking Perlecan. Credit: Courtesy of the Littleton Lab/Picower Institute. Humans need at least some perlecan to survive after birth. Mutations that reduce, but don’t eliminate, perlecan can cause Schwartz-Jampel syndrome, in which patients experience neuromuscular problems and skeletal abnormalities. The new study may help explain how neurons are affected in the condition, Littleton says, and also deepen scientists’ understanding of how the extracellular matrix supports axon and neural circuit development. Ellen Guss PhD ’23, who recently defended her doctoral thesis on the work, led the research published on June 8 in the journal eLife. At first she and Littleton didn’t expect the study to yield a new discovery about the durability of developing axons. Instead, they were investigating a hypothesis that perlecan might help organize some of the protein components in synapses that fly nerves develop to connect with muscles. But when they knocked out the gene called “trol” that encodes perlecan in flies, they saw that the neurons appeared to “retract” many synapses at a late stage of larval development. Proteins on the muscle side of the synaptic connection remained, but the neuron side of the connection withered away. That suggested that perlecan had a bigger role than they first thought. The Neural Lamella and Its Protective Function Indeed, the authors found that the perlecan wasn’t particularly enriched around synapses. Where it was pronounced was in a structure called the neural lamella, which surrounds axon bundles and acts a bit like the rubbery cladding around a TV cable to keep the structure intact. That suggested that a lack of perlecan might not be a problem at the synapse, but instead causes trouble along axons due to its absence in the extracellular matrix surrounding nerve bundles. Littleton’s lab had developed a technique for daily imaging of fly neural development called serial intravital imaging. They applied it to watch what happened to the fly axons and synapses over a four-day span. They observed that while fly axons and synapses developed normally at first, not only synapses but also whole segments of axons faded away. They also saw that the farther an axon segment was from the fly’s brain, the more likely it was to break apart, suggesting that the axon segments became more vulnerable the further out they extended. Looking segment by segment, they found that where axons were breaking down, synapse loss would soon follow, suggesting that axon breakage was the cause of the synapse retraction. “The breakages were happening in a segment-wide manner,” Littleton says. “In some segments the nerves would break and in some they wouldn’t. Whenever there was a breakage event, you would see all the neuromuscular junctions (synapses) across all the muscles in that segment retract.” When they compared the structure of the lamella in mutant versus healthy flies, they found that the lamella was thinner and defective in the mutants. Moreover, where the lamella was weakened, axons were prone to break and the microtubule structures that run the length of the axon would become misdirected, protruding outward and becoming tangled up in dramatic bundles at sites of severed axons. In one other key finding, the team showed that perlecan’s critical role depended on its secretion from many cells, not just neurons. Blocking the protein in just one cell type or another did not cause the problems that total knockdown did, and enhancing secretion from just neurons was not enough to overcome its deficiency from other sources. Rigidity vs. Flexibility Altogether, the evidence pointed to a scenario where lack of perlecan secretion caused the neural lamella to be thin and defective, with the extracellular matrix becoming too rigid. The further from the brain nerve bundles extended, the more likely movement stresses would cause the axons to break where the lamella had broken down. The microtubule structure within the axons then became disorganized. That ultimately led to synapses downstream of those breakages dying away because the disruption of the microtubules means the cells could no longer support the synapses. “When you don’t have that flexibility, although the extracellular matrix is still there, it becomes very rigid and tight and that basically leads to this breakage as the animal moves and pulls on those nerves over time,” Littleton says. “It argues that the extracellular matrix is functional early on and can support development, but doesn’t have the right properties to sustain some key functions over time as the animal begins to move and navigate around. The loss of flexibility becomes really critical.” Reference: “Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development” by Ellen J. Guss, Yulia Akbergenova, Karen L. Cunningham and J. Troy Littleton, 7 June 2023, eLife. DOI: 10.7554/eLife.88273.1 In addition to Littleton and Guss, the paper’s other authors are Yulia Akbergenova and Karen Cunningham. Support for the study came from the National Institutes of Health. The Littleton Lab is also supported by The Picower Institute for Learning and Memory and The JPB Foundation.

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