Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Custom foam pillow OEM in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam OEM insole and pillow supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene cushion OEM factory in China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China flexible graphene product manufacturing

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Customized sports insole ODM Vietnam

In the U.S., bumble bees are typically seen as yellow and black, while in other regions, they display a range of colors. Researchers are exploring how evolutionary genetics shapes these regional variations in bee coloration. Utilizing the computational capabilities of the Roar supercomputer, a new study details how a Hox gene and its gene targets craft the unique color patterns of bumble bees, enhancing our understanding of genetic contributions to their mimicry and defensive signaling. While most people in the U.S. may think of bumble bees as the standard yellow and black variety, there are an estimated 260 bee species that sport about 400 different color patterns. One reason many people associate bumble bees with distinct colors is because evolution can influence multiple bee species to share similar color patterns in specific geographic regions, which scientists call mimicry. When multiple species mimic each other’s patterns they alert would-be predators in a certain area that when they see these colors, a painful sting may follow. In other places of the world, bees use a palette of blacks, oranges, reds, yellows, and whites to create that shared warning signal. Genetic Drivers of Bee Coloration Now, researchers are finding out more about the role that evolutionary genetics plays in shaping the distinctive color patterns that give different bee species their regional flare. In a study, the researchers report how a Hox gene, a major developmental gene that regulates the identity of structures on the segments of the bee, turns on a complex set of downstream genes that ultimately drive segmental changes in the bee’s pigmentation. “In a previous paper, what we couldn’t explain is how a change in the Hox gene called Abdominal-B leads to a change in the pigments that color these bees,” said Heather Hines, associate professor of biology and entomology. “In this particular paper, we were trying to fill in that gap and understand what genes are being targeted by this first gene, and what is the cascade of events that ultimately leads to these mimetic color differences.” Uncovering the Role of Pheomelanin in Insects The researchers, who report their findings in a recent issue of Genome Biology and Evolution, found that genomic targeting of a major developmental gene allows several melanin genes, rather than just one specific enzyme, to be altered to reinforce these color traits. They also said that the study adds to the knowledge about the genes involved in the production of a pigment called pheomelanin. The pigment was known to be involved in red coloration in vertebrates, but only recently was found to occur in insects. According to Hines, a lot of work remains on understanding the evolutionary genetics of these bees. “Understanding these genes, we now have the potential to look at so many different bee species and how they’ve diversified,” said Hines. “So, it’s not a case that once we are finished here that we’re done. Given the diversity in these bees, there’s just so much more that can be done with the discovery. This is just really the first step.” Researchers tend to use certain organisms — or model organisms — when they investigate evolutionary genetics because they are convenient and easy to study. This is one of the few studies that looked at coloration genes outside of these well-studied organisms, or non-models. Studying non-model systems allows researchers to understand the evolution of some of nature’s most exceptional diversifications of form, such as this color radiation. “This really adds to non-model, evolutionary genetic research, which is a growing field and the field is also expanding to be more comparative,” Hines said. “As we move forward, researchers will be looking at how genes and gene pathways have evolved across a broader diversity of species.” Computationally Expensive Research: ROAR to the Rescue “The use of high-performance computation power has made this type of research more manageable and reproducible,” said Sarthok Rahman, former doctoral student and ICDS student affiliate, Penn State and postdoctoral researcher in biological sciences, University of Alabama, and first author of the study. The researchers relied on the Institute for Computational and Data Sciences’ Roar supercomputer to provide that computational power for the gene expression studies on the bees. “We did the sequencing in the Genomics Core Facility, and then we mostly used the operational server for the differential gene expression analysis. Because it’s a non-model organism, we also have to use other genomic sources from Drosophila and mice, for example, to search the genes and assign the identity,” said Rahman. “These analyses can be pretty computationally expensive and would take a lot of time if it were done on an everyday laptop or desktop, which is why we used the ICDS supercomputing facility for this paper and the paper before it.” Reference: “Developmental Transcriptomics Reveals a Gene Network Driving Mimetic Color Variation in a Bumble Bee” by Sarthok Rasique Rahman, Tatiana Terranova, Li Tian and Heather M Hines, 21 April 2021, Genome Biology and Evolution. DOI: 10.1093/gbe/evab080 The team also included Tatiana Terranova, an honors undergraduate research student at Penn State; and Li Tian, former postdoctoral researcher in the Hines Lab at Penn State. The National Science Foundation supported the work.

For many heartbreaking diseases of the brain — dementia, Parkinson’s, Alzheimer’s, and others — doctors can only treat the symptoms. Medical science does not have a cure.Why? Because it’s confounding to cure what we don’t understand, and the human brain, with its millions of neurons connected by a hundred trillion synapses, is almost hopelessly complex.A Princeton-led team of neuroscientists has now made a massive step toward understanding the human brain, by building a neuron-by-neuron and synapse-by-synapse roadmap — scientifically speaking, a “connectome” — through the brain of an adult fruit fly (Drosophila melanogaster).Credit: Amy Sterling / FlyWire / Princeton University FlyWire Consortium built a complete connectome of every neuron in a Drosophila brain. A Princeton-led team of scientists has created the first detailed connectome of an adult fruit fly brain, a complex network with almost 140,000 neurons. This significant step in neuroscience was featured in Nature and involved contributions from various global institutions, highlighting both the complexity of the fly’s brain and the potential insights it offers into human neurological diseases. This image shows the complete fruit fly connectome: all 139,255 brain cells in the brain of an adult fruit fly. Activity within these neurons drives an entire organism, from sensory perception to decision-making to flying. These neurons are connected by more than 50 million connections (synapses). A Princeton-led team of gamers, neuroscientists and professional tracers painstakingly mapped out the locations and connections of every brain cell, using 21 million images. Credit: Tyler Sloan / FlyWire / Princeton University Groundbreaking Brain Mapping: A Connectome for the Adult Fruit Fly Researchers led by Princeton University have constructed the first detailed neuron-by-neuron and synapse-by-synapse roadmap through the brain of an adult fruit fly (Drosophila melanogaster), achieving a major milestone in brain research. This study is the flagship article in the October 2 special issue of Nature, which is devoted to the new fruit fly “connectome.” Previous efforts mapped the brain of a C. elegans worm, with its 302 neurons, and the brain of a larval fruit fly, which comprises about 3,000 neurons. However, the adult fruit fly is several orders of magnitude more complex, with nearly 140,000 neurons and approximately 50 million synapses connecting them. Fruit flies share 60% of human DNA, and three in four human genetic diseases have a parallel in fruit flies. Understanding the brains of fruit flies is a stepping stone to understanding brains of larger more complex species, like humans. Collaborative Effort in Neuroscience Research “This is a major achievement,” said Mala Murthy, director of the Princeton Neuroscience Institute and, with Sebastian Seung, co-leader of the research team. “There is no other full brain connectome for an adult animal of this complexity.” Murthy is also Princeton’s Karol and Marnie Marcin ‘96 Professor of Neuroscience. Princeton’s Seung and Murthy are co-senior authors on the flagship paper of the Nature issue, which includes a suite of nine related papers with overlapping sets of authors, led by researchers from Princeton University, the University of Vermont, the University of Cambridge, the University of California-Berkeley, UC-Santa Barbara, Freie Universität-Berlin, and the Max Planck Florida Institute for Neuroscience. The work was funded in part by the NIH’s BRAIN Initiative, the Princeton Neuroscience Institute’s Bezos Center for Neural Circuit Dynamics and McDonnell Center for Systems Neuroscience, and other public and private neuroscience institutes and funds, listed at the end of this document. This map shows the precise location and arrangement of the 50 largest neurons of the fly brain connectome. These 50, along with another 139,205 brain cells in the brain of an adult fruit fly, were painstakingly mapped by a Princeton University-led team of neuroscientists, gamers and professional tracers. Activity within these neurons (brain cells) drives everything the organism does, from sensory perception to decision-making to controlling flight. The brain cells are connected by more than 50 million connections (synapses). Credit: Tyler Sloan and Amy Sterling / FlyWire / Princeton University Building the Brain Atlas: The FlyWire Consortium The map was developed by the FlyWire Consortium, which is based at Princeton University and made up of teams in more than 76 laboratories with 287 researchers around the world as well as volunteer gamers. Sven Dorkenwald, the lead author on the flagship Nature paper, spearheaded the FlyWire Consortium. “What we built is, in many ways, an atlas,” said Dorkenwald, a 2023 Ph.D. graduate of Princeton now at the University of Washington and the Allen Institute for Brain Science. “Just like you wouldn’t want to drive to a new place without Google Maps, you don’t want to explore the brain without a map. What we have done is build an atlas of the brain, and added annotations for all the businesses, the buildings, the street names. With this, researchers are now equipped to thoughtfully navigate the brain as we try to understand it.” And just like a map that traces out every tiny alley as well as every superhighway, the fly connectome shows connections within the fruit fly brain at every scale. 3D rendering of the ~100 motor neurons of the fruit fly brain. These neurons control the fly’s mouth parts. The colors correspond to the nerve they project through. Credit: FlyWire.ai, Philipp Schlegel (University of Cambridge/MRC LMB) Advances in AI and Neuroscience The map was built from 21 million images taken of a female fruit fly brain by a team of scientists led by Davi Bock, then at the Howard Hughes Medical Institute’s Janelia Research Campus and now at the University of Vermont. Using an AI model built by researchers and software engineers working with Princeton’s Sebastian Seung, the lumps and blobs in those images were turned into a labeled, three-dimensional map. Instead of keeping their data confidential, the researchers opened their in-progress neural map to the scientific community from the beginning. 3D rendering of the 75k neurons in the fly’s visual system. Credit: FlyWire.ai, Philipp Schlegel (University of Cambridge/MRC LMB) “Mapping the whole brain has been made possible by advances in AI computing. It would have not been possible to reconstruct the entire wiring diagram manually. This is a display of how AI can move neuroscience forward,’ said Prof. Sebastian Seung, one of the co-leaders of the research and Princeton’s Evnin Professor in Neuroscience and a professor of computer science. “Now that we have this brain map, we can close the loop on which neurons relate to which behaviors,” said Dorkenwald. The development could lead to tailored treatments to brain diseases. “In many respects, it (the brain) is more powerful than any human-made computer, yet for the most part we still do not understand its underlying logic,” said John Ngai, director of the U.S. National Institutes of Health’s BRAIN Initiative, which provided partial funding for the FlyWire project. “Without a detailed understanding of how neurons connect with one another, we won’t have a basic understanding of what goes right in a healthy brain or what goes wrong in disease.” For more on this breakthrough: A Stunning Journey Through 139,255 Neurons Inside the Fruit Fly’s Brain Reference: “Neuronal wiring diagram of an adult brain” by Sven Dorkenwald, Arie Matsliah, Amy R. Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin, Will Silversmith, Casey Schneider-Mizell, Chris S. Jordan, Derrick Brittain, Akhilesh Halageri, Kai Kuehner, Oluwaseun Ogedengbe, Ryan Morey, Jay Gager, Krzysztof Kruk, Eric Perlman, Runzhe Yang, David Deutsch, Doug Bland, Marissa Sorek, Ran Lu, Thomas Macrina, Kisuk Lee, J. Alexander Bae, Shang Mu, Barak Nehoran, Eric Mitchell, Sergiy Popovych, Jingpeng Wu, Zhen Jia, Manuel A. Castro, Nico Kemnitz, Dodam Ih, Alexander Shakeel Bates, Nils Eckstein, Jan Funke, Forrest Collman, Davi D. Bock, Gregory S. X. E. Jefferis, H. Sebastian Seung, Mala Murthy and The FlyWire Consortium, 2 October 2024, Nature. DOI: 10.1038/s41586-024-07558-y This research was supported by the National Institutes of Health (NIH) BRAIN Initiative (RF1 MH117815, RF1 MH129268, 1RF1MH120679-01 and U24 NS126935) and National Institute Of Neurological Disorders And Stroke (NINDS) (RF1NS121911); the Princeton Neuroscience Institute’s Bezos Center for Neural Circuit Dynamics and McDonnell Center for Systems Neuroscience; Google; the Allen Institute for Brain Science; the National Science Foundation (NSF Neuronex2 2014862, Neuronex2 MRC MC_EX_MR/T046279/1, MRC MC-U105188491, PHY-1734030); Wellcome Trust Collaborative Award (203261/Z/16/Z and 220343/Z/20/Z); a Marie Skłodowska-Curie postdoctoral fellowship (H2020-WF-01-2018-867459); the Portuguese Research Council (Grant PTDC/MED-NEU/4001/2021); and the Intelligence Advanced Research Projects Activity (IARPA) via the Department of Interior (DOI) (D16PC0005).

New researchers reveals that lonely individuals have distinct and varied brain processing patterns when compared to those who aren’t lonely, which may contribute to their feelings of isolation. Despite their number of friends, individuals with high loneliness levels exhibited these unique brain responses, suggesting that it’s not about the quantity of social connections, but the quality and shared understanding. A researcher from USC Dornsife in psychology comparing brain images has found significant differences in the brain processing patterns of lonely individuals when compared to those who aren’t lonely. The Russian writer and philosopher Leo Tolstoy may have been onto something when he wrote the opening line of Anna Karenina: “Happy families are all alike; every unhappy family is unhappy in its own way.” A recent study published in Psychological Science and led by a scholar now at the USC Dornsife College of Letters, Arts, and Sciences, suggests that while individuals who aren’t experiencing loneliness exhibit similar patterns in brain information processing, those who are lonely seem to interpret the world in a manner that is distinctly unique to each individual. Copious research shows that loneliness is detrimental to well-being and is often accompanied by self-reported feelings of not being understood by others. A recent report from the United States Surgeon General’s office referred to loneliness as a public health crisis in reaction to the growing number of adults suffering from this condition. Even before the onset of the COVID-19 pandemic, approximately half of U.S. adults reported experiencing measurable levels of loneliness. Loneliness Is Idiosyncratic While she was a postdoctoral fellow at UCLA, Elisa Baek, assistant professor of psychology at USC Dornsife, sought to better understand what contributes to such feelings of disconnection and being misunderstood. Baek and her team used a neuroimaging technique called functional magnetic resonance imaging (fMRI) to examine the brains of 66 first-year college students while they watched a series of video clips. The videos ranged in topic from sentimental music videos to party scenes and sporting events, providing a diverse array of scenarios for analysis. Before being scanned, the participants, who ranged in age from 18 to 21, were asked to complete the UCLA Loneliness Scale, a survey that measures a person’s subjective feelings of loneliness and feelings of social isolation. Based on the survey results, the researchers separated the participants into two groups: lonely and “nonlonely” (those not experiencing loneliness). They then scanned each participant’s brain using fMRI as the participant watched the videos. Comparing the brain imaging data between the two groups, the researchers discovered that lonelier individuals exhibited more dissimilar and idiosyncratic brain processing patterns than their non-lonely counterparts. This finding is significant because it reveals that neural similarity, which refers to how similar the brain activity patterns of different individuals are, is linked to a shared understanding of the world. This shared understanding is important for establishing social connections. People who suffer from loneliness are not only less similar to society’s norm of processing the world, but each lonely person differs in unique ways, as well. That uniqueness may further impact the feelings of isolation and lacking social connections. Baek said, “It was surprising to find that lonely people were even less similar to each other.” The fact that they don’t find commonality with lonely or nonlonely people makes achieving social connection even more difficult for them. “The ‘Anna Karenina principle’ is a fitting description of lonely people, as they experience loneliness in an idiosyncratic way, not in a universally relatable way,” she added. Loneliness Isn’t About Having or Not Having Friends So, does idiosyncratic processing in lonely individuals cause loneliness, or is it a result of loneliness? The researchers observed that individuals with high levels of loneliness — regardless of how many friends or social connections they had — were more likely to have idiosyncratic brain responses. This raised the possibility that being surrounded by people who see the world differently from oneself may be a risk factor for loneliness, even if one socializes regularly with them. The study also suggests that because social connections or disconnections fluctuate over time, it may influence the extent to which an individual processes the world idiosyncratically. Looking forward, Baek said she is interested in examining people who have friends and are socially active but still feel lonely. In addition, the researchers are looking at what particular situations lonely individuals process differently. For example, do lonely people show idiosyncrasies when processing unexpected events or ambiguous social contexts in which things can be interpreted differently? Reference: “Lonely Individuals Process the World in Idiosyncratic Ways” by Elisa C. Baek, Ryan Hyon, Karina López, Meng Du, Mason A. Porter and Carolyn Parkinson, 7 April 2023, Psychological Science. DOI: 10.1177/09567976221145316 The study was funded by the National Science Foundation and the National Institute of Mental Health.

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