Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Private label insole and pillow OEM China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Thailand graphene sports insole ODM

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China eco-friendly graphene material processing

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.One-stop OEM/ODM solution provider China

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China pillow OEM manufacturer

Researchers have devised a method to selectively activate gene therapies in target cells, including human cells. Their technology can identify specific messenger RNA sequences within cells, which then triggers the production of a particular protein from a transgene or artificial gene. A new RNA-based control switch could be used to trigger production of therapeutic proteins to treat cancer or other diseases. Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences in cells, and that detection then triggers the production of a specific protein from a transgene, or artificial gene. Because transgenes can have negative and even dangerous effects when expressed in the wrong cells, the researchers wanted to find a way to reduce off-target effects from gene therapies. One way of distinguishing different types of cells is by reading the RNA sequences inside them, which differ from tissue to tissue. By finding a way to produce transgene only after “reading” specific RNA sequences inside cells, the researchers developed a technology that could fine-tune gene therapies in applications ranging from regenerative medicine to cancer treatment. For example, researchers could potentially create new therapies to destroy tumors by designing their system to identify cancer cells and produce a toxic protein just inside those cells, killing them in the process. Researchers at MIT and Harvard University have designed a way to selectively turn on gene expression in target cells, including human cells. Their technology can detect specific mRNA sequences (represented in the center of the illustration), which triggers production of a specific protein (bottom right). Credit: Jose-Luis Olivares, MIT, with figures from iStockphoto “This brings new control circuitry to the emerging field of RNA therapeutics, opening up the next generation of RNA therapeutics that could be designed to only turn on in a cell-specific or tissue-specific way,” says James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering and the senior author of the study. This highly targeted approach, which is based on a genetic element used by viruses to control gene translation in host cells, could help to avoid some of the side effects of therapies that affect the entire body, the researchers say. Evan Zhao, a research fellow at the Wyss Institute for Biologically Inspired Engineering at Harvard University, and Angelo Mao, an MIT postdoc and technology fellow at the Wyss Institute, are the lead authors of the study, which was published on October 28, 2021, in Nature Biotechnology. RNA detection Messenger RNA (mRNA) molecules are sequences of RNA that encode the instructions for building a particular protein. Several years ago, Collins and his colleagues developed a way to use RNA detection as a trigger to stimulate cells to produce a specific protein in bacterial cells. This system works by introducing an RNA molecule called a “toehold,” which binds to the ribosome-binding site of an mRNA molecule that codes for a specific protein. (The ribosome is where proteins are assembled based on mRNA instructions.) This binding prevents the mRNA from being translated into protein, because it can’t attach to a ribosome. The RNA toehold also contains a sequence that can bind to a different mRNA sequence that serves as a trigger. If this target mRNA sequence is detected, the toehold releases its grip, and the mRNA that had been blocked is translated into protein. This mRNA can encode any gene, such as a fluorescent reporter molecule. That fluorescent signal gives researchers a way to visualize whether the target mRNA sequence was detected. In the new study, the researchers set out to try to create a similar system that could be used in eukaryotic (non-bacterial) cells, including human cells. Because gene translation is more complex in eukaryotic cells, the genetic components that they used in bacteria couldn’t be imported into human cells. Instead, the researchers took advantage of a system that viruses use to hijack eukaryotic cells to translate their own viral genes. This system consists of RNA molecules called internal ribosome entry sites (IRES), which can recruit ribosomes and initiate translation of RNA into proteins. “These are complicated folds of RNA that viruses have developed to hijack ribosomes because viruses need to find some way to express protein,” Zhao says. The researchers started with naturally occurring IRES from different types of viruses and engineered them to include a sequence that binds to a trigger mRNA. When the engineered IRES is inserted into a human cell in front of an output transgene, it blocks translation of that gene unless the trigger mRNA is detected inside the cell. The trigger causes the IRES to recover and allows the gene to be translated into protein. Targeted therapeutics The researchers used this technique to develop toeholds that could detect a variety of different triggers inside human and yeast cells. First, they showed that they could detect mRNA encoding viral genes from Zika virus and the SARS-CoV-2 virus. One possible application for this could be designing T cells that detect and respond to viral mRNA during infection, the researchers say. They also designed toehold molecules that can detect mRNA for proteins that are naturally produced in human cells, which could help to reveal cell states such as stress. As an example, they showed they could detect expression of heat shock proteins, which cells make when they are exposed to high temperatures. Lastly, the researchers showed that they could identify cancer cells by engineering toeholds that detect mRNA for tyrosinase, an enzyme that produces excessive melanin in melanoma cells. This kind of targeting could enable researchers to develop therapies that trigger production of a protein that initiates cell death when cancerous proteins are detected in a cell. “The idea is that you would be able to target any unique RNA signature and deliver a therapeutic,” Mao says. “This could be a way of limiting expression of the biomolecule to your target cells or tissue.” The new technique represents “a conceptual quantum leap in controlling and programming mammalian cell behavior,” says Martin Fussenegger, a professor of biotechnology and bioengineering at ETH Zurich, who was not involved in the research. “This novel technology sets new standards by which human cells could be treated to sense and react to viruses such as Zika and SARS-CoV-2.” All of the studies done in this paper were performed in cells grown in a lab dish. The researchers are now working on delivery strategies that would allow the RNA components of the system to reach target cells in animal models. Reference: “RNA-responsive elements for eukaryotic translational control” by Evan M. Zhao, Angelo S. Mao, Helena de Puig, Kehan Zhang, Nathaniel D. Tippens, Xiao Tan, F. Ann Ran, Isaac Han, Peter Q. Nguyen, Emma J. Chory, Tiffany Y. Hua, Pradeep Ramesh, David B. Thompson, Crystal Yuri Oh, Eric S. Zigon, Max A. English and James J. Collins, 28 October 2021, Nature Biotechnology. DOI: 10.1038/s41587-021-01068-2 The research was funded by BASF, the National Institutes of Health, an American Gastroenterological Association Takeda Pharmaceuticals Research Scholar Award in Inflammatory Bowel Disease, and the Schmidt Science Fellows program.

Potential inhibitors of SARS-CoV-2 could not only target viral proteins like the spike protein (red), but also act directly on the viral RNA (yellow, inside the virus). Certain regions of the SARS-CoV-2 genome might be a suitable target for future drugs. This is what researchers at Goethe University, together with their collaborators in the international COVID-19-NMR consortium, have now discovered. With the help of dedicated substance libraries, they have identified several small molecules that bind to certain areas of the SARS-CoV-2 genome that are almost never altered by mutations. When SARS-CoV-2 infects a cell, it introduces its RNA into it and re-programs it in such a way that the cell first produces viral proteins and then whole viral particles. In the search for active substances against COVID-19, researchers have so far mostly concentrated on the viral proteins and on blocking them, since this promises to prevent, or at least slow down, replication. But attacking the viral genome, a long RNA molecule, might also stop or slow down viral replication. The scientists in the COVID-19-NMR consortium, which is coordinated by Professor Harald Schwalbe from the Institute of Organic Chemistry and Chemical Biology at Goethe University, have now completed an important first step in the development of such a new class of SARS-CoV-2 drugs. They have identified 15 short segments of the SARS-CoV-2 genome that are very similar in various coronaviruses and are known to perform essential regulatory functions. In the course of 2020 too, these segments were very rarely affected by mutations. The researchers let a substance library of 768 small, chemically simple molecules interact with the 15 RNA segments and analyzed the result by means of NMR spectroscopy. In NMR spectroscopy, molecules are first labeled with special types of atoms (stable isotopes) and then exposed to a strong magnetic field. The atomic nuclei are excited by means of a short radio frequency pulse and emit a frequency spectrum, with the help of which it is possible to determine the RNA and protein structure and how and where small molecules bind. This enabled the research team led by Professor Schwalbe to identify 69 small molecules that bound to 13 of the 15 RNA segments. Professor Harald Schwalbe: “Three of the molecules even bind specifically to just one RNA segment. Through this, we were able to show that the SARS-CoV-2 RNA is highly suitable as a potential target structure for drugs. In view of the large number of SARS-CoV-2 mutations, such conservative RNA segments, like the ones we’ve identified, are particularly interesting for developing potential inhibitors. And since the viral RNA accounts for up to two thirds of all RNA in an infected cell, we should be able to disrupt viral replication on a considerable scale by using suitable molecules.” Against this background, Schwalbe continues, the researchers have now already started follow-up trials with readily available substances that are chemically similar to the binding partners from the substance library. Reference: “Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome” by Dr. Sridhar Sreeramulu, Dr. Christian Richter, Hannes Berg, Maria A. Wirtz Martin, Betül Ceylan, Tobias Matzel, Jennifer Adam, Nadide Altincekic, Dr. Kamal Azzaoui, Jasleen Kaur Bains, Dr. Marcel J. J. Blommers, Dr. Jan Ferner, Dr. Boris Fürtig, Prof. Dr. Michael Göbel, J. Tassilo Grün, Dr. Martin Hengesbach, Katharina F. Hohmann, Daniel Hymon, Bozana Knezic, Jason N. Martins, Klara R. Mertinkus, Dr. Anna Niesteruk, Stephen A. Peter, Dennis J. Pyper, Dr. Nusrat S. Qureshi, Dr. Ute Scheffer, Dr. Andreas Schlundt, Dr. Robbin Schnieders, Elke Stirnal, Alexey Sudakov, Alix Tröster, Jennifer Vögele, Dr. Anna Wacker, Dr. Julia E. Weigand, Dr. Julia Wirmer-Bartoschek, Prof. Dr. Jens Wöhnert and Prof. Dr. Harald Schwalbe, 23 June 2021, Angewandte Chemie International Edition. DOI: 10.1002/anie.202103693

Fire Ant Raft Fire ants survive floods by forming rafts made up of thousands of wriggling insects. New research reveals how these creepy-crawly lifeboats change shape over time. Noah rode out his flood in an ark. Winnie-the-Pooh had an upside-down umbrella. Fire ants (Solenopsis invicta), meanwhile, form floating rafts made up of thousands or even hundreds of thousands of individual insects. A new study by engineers at CU Boulder lays out the simple physics-based rules that govern how these ant rafts morph over time: shrinking, expanding or growing long protrusions like an elephant’s trunk. The team’s findings could one day help researchers design robots that work together in swarms or next-generation materials in which molecules migrate to fix damaged spots. The results were published recently in the journal PLOS Computational Biology. Fire ants form a protrusion from an ant raft. Credit: Vernerey Researcher Group at CU Boulder “The origins of such behaviors lie in fairly simple rules,” said Franck Vernerey, primary investigator on the new study and professor in the Paul M. Rady Department of Mechanical Engineering. “Single ants are not as smart as one may think, but, collectively, they become very intelligent and resilient communities.” Fire ants form these giant floating blobs of wriggling insects after storms in the southeastern United States to survive raging waters. In their latest study, Vernerey and lead author Robert Wagner drew on mathematical simulations, or models, to try to figure out the mechanics underlying these lifeboats. They discovered, for example, that the faster the ants in a raft move, the more those rafts will expand outward, often forming long protrusions. “This behavior could, essentially, occur spontaneously,” said Wagner, a graduate student in mechanical engineering. “There doesn’t necessarily need to be any central decision-making by the ants.” Treadmill Time Wagner and Vernerey discovered the secrets of ant rafts almost by accident. In a separate study published in 2021, the duo dropped thousands of fire ants into a bucket of water with a plastic rod in the middle—like a lone reed in the middle of stormy waters. Then they waited. “We left them in there for up to 8 hours to observe the long-term evolution of these rafts,” Wagner said. “What we ended up seeing is that the rafts started forming these growths.” In this timelapse footage, researchers capture a fire ant raft morphing from a spread-out state with long protrusions to a more compact form. Credit: Warner and Vernerey, PLOS Computational Biology, 2022 Rather than stay the same shape over time, the structures would compress, drawing in to form dense circles of ants. At other points, the insects would fan out like pancake batter on a skillet, even building bridge-like extensions. The group reported that the ants seemed to modulate these shape changes through a process of “treadmilling.” As Wagner explained, every ant raft is made up of two layers. On the bottom, you can find “structural” ants who cling tight to each other and make up the base. Above them are a second layer of ants who walk around freely on top of their fellow colony-members. Over a period of hours, ants from the bottom may crawl up to the top, while free-roaming ants will drop down to become part of the structural layer. “The whole thing is like a donut-shaped treadmill,” Wagner said. Engineers at CU Boulder developed computer simulations to try to recreate the dynamics of fire ant rafts. Blue dots represent ants at the bottom of the raft, and red dots are ants walking around freely on top of the raft. Credit: Warner and Vernerey, PLOS Computational Biology, 2022 Bridge to Safety In the new study, he and Vernerey wanted to explore what makes that treadmill go round. To do that, the team created a series of models that, essentially, turned an ant raft into a complicated game of checkers. The researchers programmed roughly 2,000 round particles, or “agents,” to stand in for the ants. These agents couldn’t make decisions for themselves, but they did follow a simple set of rules: The fake ants, for example, didn’t like bumping into their neighbors, and they tried to avoid falling into the water. When they let the game play out, Wagner and Vernerey found their simulated ant rafts behaved a lot like the real things. Fire ants form an ant raft. Credit: Vernerey Researcher Group at CU Boulder In particular, the team was able to tune how active the agents in their simulations were: Were the individual ants slow and lazy, or did they walk around a lot? The more the ants walked, the more likely they were to form long extensions that stuck out from the raft—a bit like people funneling toward an exit in a crowded stadium. “The ants at the tips of these protrusions almost get pushed off of the edge into the water, which leads to a runaway effect,” he said. Wagner suspects fire ants use these extensions to feel around their environments, searching for logs or other bits of dry land. The researchers still have a lot to learn about ant rafts: What makes ants in the real world, for example, opt to switch from sedate to lazy? But, for now, Vernerey says engineers could learn a thing or two from fire ants. “Our work on fire ants will, hopefully, help us understand how simple rules can be programmed, such as through algorithms dictating how robots interact with others, to achieve a well-targeted and intelligent swarm response,” he said. Reference: “Computational exploration of treadmilling and protrusion growth observed in fire ant rafts” by Robert J. Wagner and Franck J. Vernerey, 17 February 2022, PLoS Computational Biology. DOI: 10.1371/journal.pcbi.1009869

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