Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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PU insole OEM production in Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan athletic insole OEM production plant

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ODM pillow production factory in Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan graphene sports insole ODM factory

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene sheet OEM supplier factory Taiwan

CRISPR illustration. Credit: National Institutes of Health Multiplexed gene activation system allows for four to six times the activation capacity of current CRISPR technology, with simultaneous activation of up to seven genes at once. In new research published in Nature Plants, Yiping Qi, associate professor of Plant Science at the University of Maryland (UMD), introduces a new and improved CRISPR 3.0 system in plants, focusing on gene activation instead of traditional gene editing. This third-generation CRISPR system focuses on multiplexed gene activation, meaning that it can boost the function of multiple genes simultaneously. According to the researchers, this system boasts four to six times the activation capacity of current state-of-the-art CRISPR technology, demonstrating high accuracy and efficiency in up to seven genes at once. While CRISPR is more often known for its gene editing capabilities that can knock out genes that are undesirable, activating genes to gain functionality is essential to creating better plants and crops for the future. “While my lab has produced systems for simultaneous gene editing [multiplexed editing] before, editing is mostly about generating loss of function to improve the crop,” explains Qi. “But if you think about it, that strategy is finite, because there aren’t endless genes that you can turn off and actually still gain something valuable. Logically, it is a very limited way to engineer and breed better traits, whereas the plant may have already evolved to have different pathways, defense mechanisms, and traits that just need a boost. Through activation, you can really uplift pathways or enhance existing capacity, even achieve a novel function. Instead of shutting things down, you can take advantage of the functionality already there in the genome and enhance what you know is useful.” In his new paper, Qi and his team validated the CRISPR 3.0 system in rice, tomatoes, and Arabidopsis (the most popular model plant species, commonly known as rockcress). The team showed that you can simultaneously activate many kinds of genes, including faster flowering to speed up the breeding process. But this is just one of the many advantages of multiplexed activation, says Qi. “Having a much more streamlined process for multiplexed activation can provide significant breakthroughs. For example, we look forward to using this technology to screen the genome more effectively and efficiently for genes that can help in the fight against climate change and global hunger. We can design, tailor, and track gene activation with this new system on a larger scale to screen for genes of importance, and that will be very enabling for discovery and translational science in plants.” Since CRISPR is usually thought of as “molecular scissors” that can cut DNA, this activation system uses deactivated CRISPR-Cas9 that can only bind. Without the ability to cut, the system can focus on recruiting activation proteins for specific genes of interest by binding to certain segments of DNA instead. Qi also tested his SpRY variant of CRISPR-Cas9 that greatly broadens the scope of what can be targeted for activation, as well as a deactivated form of his recent CRISPR-Cas12b system to show versatility across CRISPR systems. This shows the great potential of expanding for multiplexed activation, which can change the way genome engineering works. “People always talk about how individuals have potential if you can nurture and promote their natural talents,” says Qi. “This technology is exciting to me because we are promoting the same thing in plants – how can you promote their potential to help plants do more with their natural capabilities? That is what multiplexed gene activation can do, and it gives us so many new opportunities for crop breeding and enhancement.” Reference: “CRISPR–Act3.0 for highly efficient multiplexed gene activation in plants” by Changtian Pan, Xincheng Wu, Kasey Markel, Aimee A. Malzahn, Neil Kundagrami, Simon Sretenovic, Yingxiao Zhang, Yanhao Cheng, Patrick M. Shih and Yiping Qi, 24 June 2021, Nature Plants. DOI: 10.1038/s41477-021-00953-7 This work is funded by the National Science Foundation, Award #1758745 and #2029889.

Candida albicans usually co-exists peacefully in the body, but under the right conditions it transforms into hyphae, the dark red filaments pictured above, which can form harmful biofilms. Research shows that a gut hormone called peptide YY also plays a vital role in maintaining the health of the gut microbiome by preventing helpful fungi from turning into more dangerous, disease-causing forms. Peptide YY (PYY), a hormone produced by gut endocrine cells that was already known to control appetite, also plays an important role in maintaining the balance of fungi in the digestive system of mammals, according to new research from the University of Chicago. In a study published in the journal Science, researchers found that specialized immune cells in the small intestine called Paneth cells express a form of PYY that prevents the fungus Candida albicans from turning into its more virulent form. PYY was already known to be produced by endocrine cells in the gut as a hormone that signals satiety, or when an animal has had enough to eat. The new research shows that it also functions as an antimicrobial peptide that selectively allows commensal yeast forms of C. albicans to flourish while keeping its more dangerous forms in check. “So little is known about what regulates these fungi in our in our microbiome. We know that they’re there, but we have no idea what keeps them in a state that provides health benefit to us,” said Eugene B. Chang, MD, Martin Boyer Professor of Medicine at UChicago and senior author of the study. “We now think that this peptide we discovered is actually important for maintaining fungal commensalism in the gut.” Regulating the ‘Mycobiome’ Chang and his team didn’t set to explore the fungal side of the gut microbiome, or “mycobiome” as he calls it. Joseph Pierre, PhD, a former postdoctoral scholar in Chang’s lab who is now an Assistant Professor of Nutritional Sciences at the University of Wisconsin-Madison, was studying the enteroendocrine cells in mice that produce PYY when he noticed that it was also present in Paneth cells. These are important immune system defenders in the gut of mammals, secreting several antimicrobial compounds to prevent dangerous bacteria from flourishing. At first this didn’t make sense, because until then, PYY was only recognized as an appetite hormone. When they tested it against a variety of bacteria, it wasn’t very good at killing them either. But when they ran a computer search for other classes of peptides with a similar structure, they discovered one similar to PYY called magainin 2, which is found on the skin of the African clawed frog. This peptide protects the frogs from infection by both bacteria and fungi, so Chang’s team thought to test PYY’s antifungal properties too. As it turns out, it is not only an effective antifungal agent, but a very specific one as well. “So little is known about what regulates these fungi in our in our microbiome. We know that they are there, but we have no idea what keeps them in a state that provides health benefit to us.” Eugene B. Chang, MD C. albicans is a yeast that typically grows in small amounts in the mouth, on the skin, and in the intestines. The basic yeast form is commensal, or coexists peacefully in the body, but given the right conditions it transforms into what are called hyphae that branch out to form biofilms. When too much grows, it causes thrush, an infection in the mouth and throat, vaginal yeast infections, or more serious generalized infections in the body. When Chang’s team tested PYY against both forms of the fungus, it effectively prevented growth and killed the more dangerous hyphae while sparing the commensal Candida yeast. “This is a unique example of an ‘innate’ antimicrobial peptide secreted by Paneth cells that specifically kills the virulent form of this fungi and has no effect on the on the commensal form,” Chang said. Making the Most Out of Your Molecules While PYY could be useful as a tool to combat fungal infections, its newly discovered function may play a role in digestive diseases as well. Patients with Crohn’s disease of the ileum, the last portion of the small intestine, often have dysfunctional Paneth cells. Chang said it’s possible that this dysfunction, and lack of PYY, could create an environment for fungi to overgrow and trigger the onset of disease. The full, unmodified version of PYY has 36 amino acids, and when Paneth cells secrete it into the gut it’s an effective antifungal peptide. But when endocrine cells produce PYY, an enzyme clips off two amino acids to turn it into a hormone that can travel through the bloodstream and tell the brain you’re not hungry. Just like discovering its function from a frog, Chang hopes more research on this peptide will turn up more surprises. “This is an example of the wisdom and beauty of nature that has repurposed a molecule, so it has two different functions,” he said. “That’s really cool, because this is an efficient way of making the most out of things you already have.” Reference: “Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism” by Joseph F. Pierre, Brian M. Peters, Diana La Torre, Ashley M. Sidebottom, Yun Tao, Xiaorong Zhu, Candace M. Cham, Ling Wang, Amal Kambal, Katharine G. Harris, Julian F. Silva, Olga Zaborina, John C. Alverdy, Herbert Herzog, Jessica Witchley, Suzanne M. Noble, Vanessa A. Leone and Eugene B. Chang, 3 August 2023, Science. DOI: 10.1126/science.abq3178 The study was supported by the National Institutes of Health, the Kenneth Rainin Foundation, and the University of Chicago Gastrointestinal Research Foundation. Additional authors include Brian M. Peters from the University of Tennessee; Diana La Torre, Ashley M. Sidebottom, Yun Tao, Xiaorong Zhu, Candace M. Cham, Ling Wang, Amal Kambal, Julian F. Silva, Olga Zaborina, and John C. Alverdy from the University of Chicago; Katharine G. Harris from Franklin College; Herbert Herzog from the Garvan Institute of Medical Research; Suzanne M. Noble and Jessica Witchley from the University of California-San Francisco; and Vanessa A. Leone from the University of Wisconsin – Madison.

A Kirtland’s Warbler in Michigan. Credit: Nathan W. Cooper The trillions of bacteria living in our guts play a crucial role in our ability to digest food and fight off disease. All other animals also have communities of bacteria living inside them, that scientists call microbiomes, and learning about them can help scientists put together a more complete picture of how those animals interact with the world. In a new study in the journal Molecular Ecology, researchers used tiny radio trackers to follow the movements of birds that migrated between The Bahamas and Michigan, and they found that the same individual birds’ gut bacteria were different in the two locations. And to figure that out, the scientists had to get up close and personal with a lot of bird poop. “We’ve seen in other animals that microbiomes can be influenced by the places their hosts live. Lots of birds migrate, and they experience different environments at different points of their migratory cycle. We didn’t know how these different environments affected the birds’ microbiomes,” says Heather Skeen, a PhD student at the Field Museum and the University of Chicago and the lead author of the Molecular Ecology study with the Field Museum’s John Bates and Shannon Hackett, Nathan Cooper at the Smithsonian Conservation Biology Institute, and Peter Marra at Georgetown University. A Kirtland’s Warbler in its breeding habitat in Michigan. Credit: Nathan W. Cooper “This study shows how much we can learn about even foundational aspects of bird biology, such as migration, from the combination of new and old technologies–fieldwork and following birds in their breeding, migrating, and wintering habitats, to newer technologies of radiotelemetry and next-generation DNA sequencing,” says Hackett, an associate curator at the Field Museum. While thousands of bird species migrate, Skeen and her colleagues honed in on just one for this study: Kirtland’s Warbler, one of the rarest birds in the world. Kirtland’s Warblers are tiny yellow-breasted songbirds that spend their winters in The Bahamas and migrate to northern Michigan in the spring, where they breed only in young jack pine forest. They nearly went extinct in the 20th century, falling to just 167 males left in the wild in 1987, but their populations have stabilized thanks to intense conservation efforts on the breeding grounds. A Kirtland’s Warbler with a tiny radio tracking device on its back. Credit: Heather Skeen Still, they’re a rarity in the bird world, and that rarity, paired with their extreme pickiness in breeding grounds, made them ideal subjects for this study. “We picked Kirtland’s Warbler because there are very, very few species of birds where you would have been able to track individual birds from their non-breeding grounds and then capture them on their breeding grounds,” says Skeen. Trying to follow individuals of extremely common, widely distributed birds like robins would have been like trying to find a needle in a haystack; with Kirtland’s Warblers, there’s a much smaller haystack to choose from, spread over a much smaller geographic area. The researchers started by doing fieldwork in The Bahamas, where they lured Kirtland’s Warblers with recorded bird calls and fitted them with tiny radio tracking devices. The birds themselves are tiny, about half an ounce, so the geolocators weighed less than half a gram. (For context, a penny weighs about 2.5 grams.) After attaching the trackers, Skeen and her colleagues then put the birds inside of wax paper bags for a few minutes. The birds promptly turned the bags into their own private bathrooms. The warblers were then released, leaving Skeen to go into the bags and collect fecal samples. A few months later, when the birds migrated from The Bahamas to Michigan, Skeen and her colleagues used a large network of automated radio towers, known as the Motus Wildlife Tracking System, to locate the exact same individual birds that they’d sampled in The Bahamas. “There were 12 radio towers spread throughout the birds’ breeding range in Michigan, and when one of our birds’ trackers pinged near a tower, we would drive around the range using a handheld radio antenna, looking for the bird,” says Skeen. “Once we picked up the signal, we got out of the car and walked around, trying to attract the birds using recordings of their songs.” When the birds flew into the nets that the researchers set up, the scientists repeated the paper bag procedure before letting the birds go again. Researchers doing fieldwork, putting radio trackers on Kirtland’s Warblers in The Bahamas. Credit: Adrienne Dale Armed with nearly two hundred samples of bird poop and samples from the same individual birds in both The Bahamas and Michigan, the researchers conducted genetic analyses of the bacteria present in the poop. They found that the bacteria present in the Michigan poop was different from the bacteria in The Bahamas poop. But, more importantly, the same individual birds had different bacteria in their digestive tracts depending on where they were when the poop was collected. “One of the most important parts about this study is that we were able to recapture birds at different portions of the annual cycle in different locations, and we have this one-to-one comparison of the same population and the same individuals and how their microbiomes changed,” says Skeen. “If we’d tested different individual birds, we wouldn’t have been able to say for sure if the changes we saw were due to location or if they were just differences between populations. Since we were looking at the exact same birds, these results are much more supported.” The study’s findings that bird microbiomes vary from one location to another, even within the same individuals, can help scientists puzzle out how bird microbiomes work. “We know that birds’ microbiomes are different from most mammals’, but we don’t know exactly how or why,” says Skeen. In most mammals, the kinds of gut bacteria present are closely tied to the animal’s species and evolutionary history, but with birds, those connections appear to be looser. Instead, previous studies have indicated that birds’ gut microbiomes have more to do with where they live than what species they are. “In our study, we found that there are some groups of bacteria that are probably transient– the birds acquire the bacteria from their food, they poop it out, and it’s gone,” says Skeen. “These bacteria don’t colonize the bird, they go in and out.” Skeen also notes that the climate crisis might make gut microbiomes especially important as animals attempt to survive in changing environments. “An animal’s gut microbiome is an additional level of molecular diversity, and as global climate change alters ecosystems, the gut microbiome might be one of the avenues in which animals can adapt to the changing environment,” says Skeen. “The gut microbiome has its own unique ecosystem, and it’s ripe for discoveries.” Reference: “Repeated sampling of individuals reveals impact of tropical and temperate habitats on microbiota of a migratory bird” by Heather R. Skeen, Nathan W. Cooper, Shannon J. Hackett, John M. Bates and Peter P. Marra, 28 September 2021, Molecular Ecology. DOI: 10.1111/mec.16170

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