Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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ODM pillow production factory in Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan graphene material ODM factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.High-performance insole OEM Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand pillow ODM development service

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Latex pillow OEM production in China

A new study reveals that humanity is at risk of falling into 14 evolutionary dead ends, termed “evolutionary traps,” ranging from climate change to artificial intelligence. The research, focusing on the Anthropocene era, highlights the need for global cooperation and active societal transformation to avoid these traps. Misaligned AI is not the one you should worry most about (yet). For the first time, scientists have used the concept of evolutionary traps on human societies at large. They find that humankind risks getting stuck in 14 evolutionary dead ends, ranging from global climate tipping points to misaligned artificial intelligence, chemical pollution, and accelerating infectious diseases. The Anthropocene Era: Success and Challenges The evolution of humankind has been an extraordinary success story. But the Anthropocene — the proposed geological epoch shaped by us humans — is showing more and more cracks. Multiple global crises, such as the COVID-19 pandemic, climate change, food insecurity, financial crises, and conflicts have started to occur simultaneously in something that scientists refer to as a polycrisis. (a) System dynamics associated with three major groups of Anthropocene traps, global traps, technology traps andstructural traps (including temporal and connectivity traps). Two reinforcing feedback loops are indicated with R and interactions between dynamics across groups of traps are indicated with colored superscript letters (color of causal node) and stippled lined arrows.(b) A heatmap of the interactions between outcomes of the 14 proposed Anthropocene traps.Credit: Philosophical Transactions of the Royal Society B Human Creativity and Unintended Consequences “Humans are incredibly creative as a species. We are able to innovate and adapt to many circumstances and can cooperate on surprisingly large scales. But these capabilities turn out to have unintentional consequences. Simply speaking, you could say that the human species has been too successful and, in some ways, too smart for its own future good,” says Peter Søgaard Jørgensen, researcher at the Stockholm Resilience Centre at Stockholm University and at the Royal Swedish Academy of Sciences’ Global Economic Dynamics and the Biosphere program and Anthropocene laboratory. Peter Søgaard Jørgensen is lead author of the study. He isa researcher at the Stockholm Resilience Centre at Stockholm University and at the Royal Swedish Academy of Sciences’ Global Economic Dynamics and the Biosphere programme and Anthropocene laboratory.Credit: Stockholm Resilience Centre A Landmark Study on Evolutionary Traps He is the lead author of a new landmark study published today as part of a larger assessment in the journal Philosophical Transactions of the Royal Society B. The assessment gathers insights from a wide range of different scientific disciplines across the natural and social sciences and humanities, to understand how the Anthropocene evolved and how global sustainability can continue to evolve in the future. Identifying and Understanding Evolutionary Traps The new study shows how humanity could get stuck in “evolutionary traps” — dead ends that occur from initially successful innovations. In a first scoping effort, they identify 14 of these, including the simplification of agriculture, economic growth that does not deliver benefits for humans or the environment, the instability of global cooperation, climate tipping points, and artificial intelligence (for a full list of traps see table further down). Evolutionary Traps in the Animal World and Human Societies “Evolutionary traps are a well-known concept in the animal world. Just like many insects are attracted by light, an evolutionary reflex that can get them killed in the modern world, humankind is at risk of responding to new phenomena in harmful ways,” explains Peter Søgaard Jørgensen. The simplification of agricultural systems is an example of such a trap. Relying on a few highly productive crops such as wheat, rice, maize, and soya, has meant that calories produced have skyrocketed over the past century. But it also meant that the food system has become very vulnerable to environmental change, such as weather extremes, or new diseases. The Severity and Interconnectivity of Traps Of the 14 evolutionary traps, 12 are in an advanced state, meaning that humankind is on the verge of getting stuck to a degree where it becomes very difficult to get out. What’s more, societies are continuing to move in the wrong direction in 10 of these 14. Alarmingly, these evolutionary traps tend to reinforce each other. If societies get stuck in one dead end, they are more likely to get stuck in others as well. The two dead ends that currently are less advanced are the autonomy of technology – AI and robotics – and a loss of social capital through digitalization. Lan Wang Erlandsson, is a co-author and researcher at the the Stockholm Resilience Centre at Stockholm University and the Royal Swedish Academy of Sciences’ Anthropocene laboratory. Credit: Stockholm Resilience Centre The new assessment also looks into why societies struggle so hard to move out of these traps. Global Challenges and the Need for Collaboration “The evolutionary forces that created the Anthropocene do not work well at the global level. In today’s global systems, social and environmental problems grow in places that seem distant to the societies that could prevent them. Also, addressing them often requires global collaboration on a scale that many evolutionary forces often do not align well with,” says co-author Lan Wang-Erlandsson, researcher at the Stockholm Resilience Centre at Stockholm University and the Royal Swedish Academy of Sciences’ Anthropocene laboratory. A Call to Action for Humanity This does not mean that humanity is doomed to fail, argue the researchers. But we must start to transform our societies actively. So far, the Anthropocene has to a large extent been an unconscious byproduct of other evolutionary processes. “It’s time for humans to become aware of the new reality and to collectively move where we want to as a species. We have the capability to do that and are already seeing signs of such movements. Our creativity, and our power to innovate and collaborate equip us with the perfect tools to actively design our future. We can break out of dead ends and business-as-usual, but for that, we must nurture the capacity for collective human agency and design settings where it can flourish,” explains Peter Søgaard Jørgensen. He continues: “A very simple thing that everybody can do is to engage more in nature and society while also learning about both the positive and negative global consequences of our own local actions. There’s nothing better than exposing yourself to what needs protecting.” Reference: “Evolution of the polycrisis: Anthropocene traps that challenge global sustainability” by Peter Søgaard Jørgensen, Raf E. V. Jansen, Daniel I. Avila Ortega, Lan Wang-Erlandsson, Jonathan F. Donges, Henrik Österblom, Per Olsson, Magnus Nyström, Steven J. Lade, Thomas Hahn, Carl Folke, Garry D. Peterson and Anne-Sophie Crépin, 1 January 2024, Philosophical Transactions of the Royal Society B. DOI: 10.1098/rstb.2022.0261

Ketamine is a medication that is primarily used as an anesthetic in surgical procedures and veterinary medicine. However, it also has potential therapeutic uses as an antidepressant and in treating chronic pain. Researchers discovered ketamine switches neuronal activity by suppressing inhibitory neurons, which activates previously silent excitatory neurons, suggesting links to its rapid therapeutic effects. According to a new study by researchers at Penn Medicine, ketamine, which is well-known as an anesthetic and is becoming increasingly popular as an antidepressant, dramatically reorganizes activity in the brain, almost as if a switch were turned on. The study, published in Nature Neuroscience, found that after administering ketamine, there were drastic changes in the patterns of neuronal activity in the cerebral cortex of animal models. Neurons that were usually active were silenced, while others that were usually inactive suddenly became active. This ketamine-induced activity switch in key brain regions tied to depression may impact our understanding of ketamine’s treatment effects and future research in the field of neuropsychiatry. “Our surprising results reveal two distinct populations of cortical neurons, one engaged in normal awake brain function, the other linked to the ketamine-induced brain state,” said the co-lead and co-senior author Joseph Cichon, MD, Ph.D., an assistant professor of Anesthesiology and Critical Care and Neuroscience in the Perelman School of Medicine at the University of Pennsylvania. “It’s possible that this new network induced by ketamine enables dreams, hypnosis, or some type of unconscious state. And if that is determined to be true, this could also signal that it is the place where ketamine’s therapeutic effects take place.” Ketamine’s Unique Effect on Neuronal Activity Anesthesiologists routinely deliver anesthetic drugs before surgeries to reversibly alter activity in the brain so that it enters its unconscious state. Since its synthesis in the 1960s, ketamine has been a mainstay in anesthesia practice because of its reliable physiological effects and safety profile. One of ketamine’s signature characteristics is that it maintains some activity states across the surface of the brain (the cortex). This contrasts with most anesthetics, which work by totally suppressing brain activity. It is these preserved neuronal activities that are thought to be important for ketamine’s antidepressant effects in key brain areas related to depression. But, to date, how ketamine exerts these clinical effects remains mysterious. In their new study, the researchers analyzed mouse behaviors before and after they were administered ketamine, comparing them to control mice who received placebo saline. One key observation was that those given ketamine, within minutes of injection, exhibited behavioral changes consistent with what is seen in humans on the drug, including reduced mobility, and impaired responses to sensory stimuli, which are collectively termed “dissociation.” “We were hoping to pinpoint exactly what parts of the brain circuit ketamine affects when it’s administered so that we might open the door to better study of it and, down the road, more beneficial therapeutic use of it,” said co-lead and co-senior author Alex Proekt, MD, Ph.D., an associate professor of Anesthesiology and Critical Care at Penn. Two-photon microscopy was used to image cortical brain tissue before and after ketamine treatment. By following individual neurons and their activity, they found that ketamine turned on silent cells and turned off previously active neurons. Mechanisms Behind Ketamine’s Effects The neuronal activity observed was traced to ketamine’s ability to block the activity of synaptic receptors — the junction between neurons — called NMDA receptors and ion channels called HCN channels. The researchers found that they could recreate ketamine’s effects without the medications by simply inhibiting these specific receptors and channels in the cortex. The scientists showed that ketamine weakens several sets of inhibitory cortical neurons that normally suppress other neurons. This allowed the normally quiet neurons, the ones usually being suppressed when ketamine wasn’t present, to become active. The study showed that this dropout in inhibition was necessary for the activity switch in excitatory neurons — the neurons forming communication highways, and the main target of commonly prescribed antidepressant medications. More work will need to be undertaken to determine whether the ketamine-driven effects in excitatory and inhibitory neurons are the ones behind ketamine’s rapid antidepressant effects. “While our study directly pertains to basic neuroscience, it does point at the greater potential of ketamine as a quick-acting antidepressant, among other applications,” said co-author Max Kelz, MD, Ph.D., a distinguished professor of Anesthesiology and vice chair of research in Anesthesiology and Critical Care. “Further research is needed to fully explore this, but the neuronal switch we found also underlies dissociated, hallucinatory states caused by some psychiatric illnesses.” Reference: “Ketamine triggers a switch in excitatory neuronal activity across neocortex” by Joseph Cichon, Andrzej Z. Wasilczuk, Loren L. Looger, Diego Contreras, Max B. Kelz and Alex Proekt, 24 November 2022, Nature Neuroscience. DOI: 10.1038/s41593-022-01203-5 The study was funded by the Foundation for Anesthesia Education and Research and the National Institutes of Health.

The researchers have learned about species-specific differences in neuron architecture. There Are Differences in the Neuronal Architecture of Primates and Non-Primates A multinational research team has now been able to increase their understanding of species-specific variations in the architecture of cortical neurons thanks to high-resolution microscopy. Researchers from the Developmental Neurobiology research group at Ruhr-Universität Bochum, led by Professor Petra Wahle, have demonstrated that primates and non-primates differ in an important aspect of their architecture: the origin of the axon, which is the process responsible for the transmission of electrical signals known as action potentials. The results were recently published in the journal eLife. The researchers worked exclusively with archived tissues and specimens, including specimens that have been and continue to be used for decades for the education of students. Credit: RUB, Kramer Axons Can Emerge From Dendrites Until now, it was considered textbook knowledge that the axon always, with few exceptions, arises from the cell body of a neuron. However, it may also originate from dendrites, which serve to collect and integrate the incoming synaptic signals. This phenomenon has been termed “axon-carrying dendrites”. Various Mammalian Species and High-Resolution Microscopy Reveal the Variable Axonal Origin “A unique aspect of the project is that the team worked with archived tissue and slide preparations, which included material that has been used for years to teach students,” explains Petra Wahle. A variety of animals, including rodents (mouse, rat), ungulates (pig), carnivores (cat, ferret), and macaques and humans of the zoological order primates, were also researched. The scientists came to the conclusion that there is a species difference between non-primates and primates via the use of five distinct staining techniques and evaluation of more than 34,000 neurons. There are noticeably fewer axon-carrying dendrites on excitatory pyramidal neurons in the outer layers II and III of the cerebral cortex of primates than on excitatory pyramidal neurons in non-primates. Additionally, for inhibitory interneurons, substantial variations in the percentage of axon-carrying dendrite cells were discovered between the cat and human species. No quantitative differences were observed when comparing macaque cortical areas with primary sensory and higher brain functions. High-resolution microscopy was of particular importance, as Petra Wahle describes: “This allowed the detection of axonal origins accurately tracked at the micrometer level, which is sometimes not so easy with conventional light microscopy.” Evolutionary Advantage Still Enigmatic Little is known about the function of axon-carrying dendrites. Usually, a neuron integrates excitatory inputs arriving at the dendrites with inhibitory inputs, a process termed somatodendritic integration. The neuron then decides if inputs are strong enough and important enough to be transmitted via action potentials to other neurons and brain areas. Axon-carrying dendrites are considered privileged because depolarizing inputs to these dendrites are able to evoke action potentials directly without the involvement of somatic integration and somatic inhibition. Why this species difference has evolved, and the potential advantage it may have for the neocortical information processing in primates, is as yet unknown. Reference: “Neocortical pyramidal neurons with axons emerging from dendrites are frequent in non-primates, but rare in monkey and human” by Petra Wahle, Eric Sobierajski, Ina Gasterstädt, Nadja Lehmann, Susanna Weber, Joachim HR Lübke, Maren Engelhardt, Claudia Distler and Gundela Meyer, 20 April 2022, eLife. DOI: 10.7554/eLife.76101 The study was funded by the German Research Foundation.

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