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“有用抗憂鬱藥治療偏頭痛 Migraines 的嘛?”Treating Migraines With Antidepressants
2020/05/17 07:06
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儘管它被歸類抗憂鬱藥,

但神奇的抑制劑也可以治療憂鬱症以外相關症狀

什麼是抗憂鬱藥?What are antidepressants?

憂鬱藥是抑制化學物質,改變大腦細胞之間神經傳遞的快樂元素。

Most of them change a type of chemical called a neurotransmitter. These carry messages between the cells in your brain.


儘管它被歸類抗憂鬱,但神奇的抑制劑也可以治療憂鬱症以外的其他相關症狀,包括:

Despite their name, antidepressants may use many conditions other than depression, including:

* 焦慮感  anxiety and panic disorders

* 暴食或厭食失調  eating disorders

* 失眠數羊族  insomnia

* 唉呀慢性疼痛 chronic pain

* 要扇子減潮熱  hot flashes

抗憂鬱藥物也用來預防偏頭痛 Antidepressants may also effectively prevent migraines.

那麼你問我,有哪些不同的抗憂鬱藥物化學類型?So You ask me,"What are the different types?"

抗憂鬱藥主要有四種類型:There are four main types of antidepressants:



    1. 選擇血清素回收抑制劑(SSRIs, Selective serotonin 血清胺 reuptake inhibitors ,又簡稱SSRI, 它會增加大腦血清素serotonin 的含量。 不少醫師習慣使用這些藥物。,因為它們的副作用很少,患者易接受。
    2. 正腎上腺素與血清素回收抑制劑(SNRI, Serotonin-norepinephrine 血清胺、正腎上腺素二種合作的reuptake inhibitors,簡略為 SNRIs,看字名就知道它增加大腦中血清胺和正腎上腺素的含量。
    3. 三環抗鬱劑(TCA),Cyclic Antidepressants, 三環類,我覺得TCA是「亂劍打蟲」這也是會增加血清素和正腎上腺素的含量。

  1. Monoamine oxidase inhibitors ,簡縮成MAOIs,該老類藥極少使用,因副作用極大,我就省略在這不提。                                                                                       提示:凡和有正腎上腺素相關的藥,會影響血壓(升高或降低)增正腎上腺素受體,可調節情緒。缺點是抑制性欲、血壓可能升高。

Prozac is a SSRI

1. Selective serotonin reuptake inhibitors (SSRIs)

SSRIs increase the amount of the serotonin in your brain. Doctors often prescribe these first because they cause the fewer side effects.

2. Serotonin-norepinephrine reuptake inhibitors (SNRIs)

SNRIs increase the amount of serotonin and norepinephrine in your brain.

3. Tricyclic antidepressants

Those medications, also known as cyclic antidepressants, increase amounts of serotonin and norepinephrine. Those are like using many stones in order to hit many birds. 

4. Monoamine oxidase inhibitors (MAOIs)

serotonin , norepinephrine, and dopamine are all monoamines. MAOIs are rarely prescribed anymore because they have serious side effects.

如果服用高劑量,或是本身就有高血壓,應每天監測血壓。如果沒有高血壓,吃抗憂鬱藥三天後,要監測血壓,如果你發現血壓一下子升高,就要告知醫生或藥師,這種升高的血壓是無法逆轉 rapid rise in blood pressure is called irreversible hypertension.


If you are taking an antidepressant in higher dose or you have a history of hypertension, You need to check your blood pressure(BP). If you dont have hypertension when start to take an antidepressant, please check your BP. Let your healthcare provider knows when your BP gets out of control. It is called irreversible hypertension when rapid rise in BP happens.

當你偏頭痛時常發作,轟隆的敲打頭部,你試過很多方法,可以考慮要不要服用抗憂鬱藥,你也可以斟酌你其他的病狀。如果使用抗憂鬱藥可否一石二鳥,雙重治療。但請記住,抗憂鬱藥可用於預防偏頭痛,卻不是治療急性發作來的偏頭痛。

When you are troubled by the annoying migraines, and you have tried different treatments without improvements. Then you may consider using  antidepressants. Keep in mind that antidepressants are used to prevent migraines, not treat active ones.

抗憂鬱藥有哪些副作用呢?What are the side effects of antidepressants?


SSRI通常引起較少的副作用,因此你的醫生可能將此類型放在第一考慮。

不同類型的抗憂鬱藥略不同,常見的副作用包括:

Antidepressants can cause a varied of side effects. SSRIs normally cause the fewer side effects, so your doctor might suggest using this kind first.



* 口乾 dry mouth

* 噁心 nausea

* 緊張 nervousness

* 躁動 restlessness

* 失眠 insomnia

* 性功能障礙或射精延遲 Sexual /erectile dysfunction

許多人無法接受吃了抗憂鬱藥物後,心如止水,一點欲望都沒有

Many people can not accept it when their sexual desires disappear after taking an antidepressant.

三環類抗憂鬱藥(TCAs),包括amitriptyline可能引起的副作用:

Tricyclic antidepressants, including amitriptyline, can cause additional side effects, such as:


* 模糊視覺 blurred vision

* 便秘 constipation

* 站立時血壓低 drops in blood pressure when standing

* 尿滯留 Urinary retention

* 發睏 drowsiness

* 注意力難以集中 hard to focus

有些此類藥,切記服用後,你要試至少7天服用期,要同一個時間用,直到一周後,你再來評估此藥的優缺點,” 憂鬱症藥我吃23天都沒效?要不要繼續吃呢?“ 藥菲說:抗鬱劑需時間生效!“ 

Some of the antidepressants, please at least stay on for 7 days of trial. Take them at the same time. Recheck the outcome after 1 week of taking it.

嘗試幾種不同的藥,直到適合你,且副作用少的,這樣的程序 trials and errors 是無可避免的。

It is normal to the saying, " trials and errors."

抗憂鬱藥安全嗎?Are antidepressants safe?


通常是安全的。 但是,服用抗憂鬱藥來治療偏頭痛被認為是off label, 這意味著藥商沒有進行試驗來確保治療偏頭痛的安全性和有效性。 除非其他療法失敗,否則大多數醫生不會特別以此診斷diagnosis code開處方使用此類藥物,但是如果你有熱潮、焦慮症,你的醫生可以幫助你以此目的來治療偏頭痛。

Antidepressants are ideally safe. However, taking antidepressants to help migraines is "off-label use."  This means that antidepressant manufacturers haven’t studied the same the safety and effectiveness when it considers to treating migraines. Most doctors don’t prescribe medication for off-label use unless other treatments have failed or you have other related symptoms like depression.

Your doctor can  weigh the benefits and risks of using antidepressants for migraines for you.

血清素濃度過高症是其中之一的副作用

Serotonin Symdrome



是一種罕見但嚴重的疾病,當您的血清素太高時,身體出現症狀如體溫升高,往往這種情況就要上ER


It is rare but servere. You have to go to the ER if you have high body temperature. 

如果您已經服用了以下專用於偏頭痛的藥物,那麼請不要同時服用抗憂鬱藥:

Don’t take antidepressants if you already take any of the following medications for migraines:

* Axert 

* Imitrex

另外抗憂鬱藥和以下藥物會有不良反應,這些藥包括:

Other things that can interact with antidepressants and cause serotonin syndrome include:


* DM , dextromethorphan ,OTC感冒藥和止咳藥中的常見成分,藥菲止咳影片中提到。

  • dextromethorphan, a common ingredient in OTC cold and cough medicines in my "TearAbook" Youtube video

* 草藥補品,包括人參和聖約翰草St. John’s wort, 

  • herbal supplements, including ginseng and St. John’s wort

* 其他抗憂鬱藥併合使用,除非有醫生指示

  • other antidepressants

* 街頭藥:搖頭丸,可待因,安非它命

  • Street drugs, including ecstasy, cocaine, and amphetamines

如有以下症狀,就要上急診



Seek emergency medical treatment if you experience any of these side effects while taking antidepressants:

* 肌肉痙攣 confusion

* 發抖  tremors

* 心跳加快 Heart racing

最後還是提醒你,藥物治療偏頭痛的種類繁多,抗憂鬱劑分四大類,分別是「選擇血清素回收抑制劑(SSRIs)」,「正腎上腺素與血清素回收抑制劑(SNRI)」「三環抗鬱劑(TCA)」,MAOIs 其他」類。藥物在治療憂鬱症占重要角色,患者持續的負面情緒與生理症狀,常需要使用抗憂鬱劑來當第一線的治療。抗憂鬱藥物漸漸被廣泛使用,在了解你自己的頻繁煩人頭痛症狀外,你還有耐心試試不同方法,一旦決定服用,務必要按照時間吃,一旦想要停止服用,自己不可貿然停藥,你要漸漸降低劑量step down therapy 才不會有不良反彈反應。

Last but not the least, there are so many kinds of migraine medicine.

1. Selective serotonin reuptake inhibitors (SSRIs)

2. Serotonin-norepinephrine reuptake inhibitors (SNRIs)

3. Tricyclic antidepressants (TCAs)

4. Monoamine oxidase inhibitors (MAOIs)

It plays a crucial role to treat depression as the first therapy. When you are thinking of using antidepressants for migraines, discuss all the possibilities as above with your doctor. Once you take a SSRI,  dont stop it without a discussion of "step down therapy."

Dont wish it were easier, wish you were better. 別指望健康簡單,要靠你來保持


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