Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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ODM pillow factory in Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene insole OEM factory Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam ODM expert for comfort products

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Custom foam pillow OEM in Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan pillow OEM manufacturing factory

Researchers uncovered an ancient ancestor of modern bread wheat by sequencing the DNA from 242 unique accessions of Aegilops tauschii collected across its native range from Turkey to Central Asia. Tracing the Impact of a Long-Lost Relative on Modern Bread Wheat Genetic detective work has uncovered an obscure ancestor of modern bread wheat, in a finding similar to uncovering a famous long-lost relative through DNA analysis in humans. In a study which appears in Nature Biotechnology researchers sequenced the DNA from 242 unique accessions of Aegilops tauschii gathered over decades from across its native range — from Turkey to Central Asia. Population genome analysis led by Dr. Kumar Gaurav from the John Innes Centre revealed the existence of a distinct lineage of Aegilops tauschii restricted to present-day Georgia, in the Caucuses region – some 500 kilometers (310 miles) from the Fertile Crescent where wheat was first cultivated – an area stretching across modern-day Iraq, Syria, Lebanon, Palestine, Israel, Jordan, and Egypt. First author of the study in Nature Biotechnology, Dr. Kumar Gaurav said, “The discovery of this previously unknown contribution to the bread wheat genome is akin to discovering the introgression of Neanderthal DNA into the out of Africa human genome. Researchers on a wild wheat relatives foraging trip in the central Zagros mountains in western Iran. Credit: Ali Mehrabi “It is most likely to have occurred through a hybridization outside the Fertile Crescent. This group of Georgian accessions form a distinct lineage that contributed to the wheat genome by leaving a footprint in the DNA.” The discovery comes via a major international collaboration to improve crops by exploring useful genetic diversity in Aegilops tauschii, a wild relative of bread wheat. The Open Wild Wheat Consortium brought together 38 research groups and researchers from 17 countries. Further research by Dr. Jesse Poland’s group at Kansas State University was published in a companion paper in Communications Biology and shows that the ancestral Aegilops tauschii DNA found in modern bread wheat includes the gene that gives superior strength and elasticity to dough. Dr. Poland said, “We were amazed to discover that this lineage has provided the best-known gene for superior dough quality.” The researchers speculate that the newly discovered lineage may have been more geographically widespread in the past, and that it may have become separated as a refugium population during the last ice-age. Reflecting on all that has come together to make this work possible, Dr Brande Wulff, corresponding author of the study, remarked, “Fifty or sixty years ago at a time when we barely understood DNA, my scientific forebears were traversing the Zagros mountains in the middle east and Syria and Iraq. They were collecting seeds, perhaps having an inkling that one day these could be used for improving wheat. Now we are so close to unlocking that potential, and for me that is extraordinarily exciting.” Deciphering Wheat’s Complex Genome Modern “hexaploid” wheat, is a complex genetic combination of different grasses with a huge genetic code, split into A, B, and D sub-genomes. Hexaploid wheat accounts for 95 percent of all cultivated wheat. Hexaploid means that the DNA contains six sets of chromosomes — three pairs of each. Through a combination of natural hybridizations and human cultivation, Aegilops tauschii provided the D-genome to modern wheat. The D-genome added the properties for making dough, and enabled bread wheat to flourish in different climates and soils. The origin of modern hexaploid bread wheat has long been the subject of intense scrutiny with archeological and genetic evidence suggesting that the first wheat was cultivated 10,000 years ago in the Fertile Crescent. Domestication, while increasing yield and increasing agronomic performance, came at the cost of a pronounced genetic bottleneck eroding genetic diversity for protective traits to be found in Aegilops tauschii such as disease resistance and heat tolerance. Analysis performed by Dr. Gaurav and the research team revealed that just 25% of the genetic diversity present in Aegilops tauschii made it into hexaploid wheat. To explore this diversity in the wild gene pool, they used a technique called association mapping to discover new candidate genes for disease and pest resistance, yield and environmental resilience. Dr. Sanu Arora, who had earlier led a study to clone disease-resistance genes from Aegilops tauschii said, “Previously we were restricted to exploring a very small subset of the genome for disease resistance, but in the current study, we have generated data and techniques to undertake an unbiased exploration of the species diversity”. Further experiments demonstrated the transfer of candidate genes for a subset of these traits into wheat using genetic transformation and conventional crossing — facilitated by a library of synthetic wheats — specially bred material which incorporates Aegilops tauschii genomes. This publicly available library of synthetic wheats captures 70 percent of the diversity present across all three known Aegilops tauschii lineages, enabling researchers to assess traits rapidly in a background of hexaploid wheats. “Our study provides an end-to-end pipeline for rapid and systematic exploration of the Aegilops tauschii gene pool for improving modern bread wheat,” says Dr. Wulff. “High molecular weight glutenin gene diversity in Aegilops tauschii demonstrates unique origin of superior wheat quality,” appears in Communications Biology. Reference: “Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement” by Kumar Gaurav, Sanu Arora, Paula Silva, Javier Sánchez-Martín, Richard Horsnell, Liangliang Gao, Gurcharn S. Brar, Victoria Widrig, W. John Raupp, Narinder Singh, Shuangye Wu, Sandip M. Kale, Catherine Chinoy, Paul Nicholson, Jesús Quiroz-Chávez, James Simmonds, Sadiye Hayta, Mark A. Smedley, Wendy Harwood, Suzannah Pearce, David Gilbert, Ngonidzashe Kangara, Catherine Gardener, Macarena Forner-Martínez, Jiaqian Liu, Guotai Yu, Scott A. Boden, Attilio Pascucci, Sreya Ghosh, Amber N. Hafeez, Tom O’Hara, Joshua Waites, Jitender Cheema, Burkhard Steuernagel, Mehran Patpour, Annemarie Fejer Justesen, Shuyu Liu, Jackie C. Rudd, Raz Avni, Amir Sharon, Barbara Steiner, Rizky Pasthika Kirana, Hermann Buerstmayr, Ali A. Mehrabi, Firuza Y. Nasyrova, Noam Chayut, Oadi Matny, Brian J. Steffenson, Nitika Sandhu, Parveen Chhuneja, Evans Lagudah, Ahmed F. Elkot, Simon Tyrrell, Xingdong Bian, Robert P. Davey, Martin Simonsen, Leif Schauser, Vijay K. Tiwari, H. Randy Kutcher, Pierre Hucl, Aili Li, Deng-Cai Liu, Long Mao, Steven Xu, Gina Brown-Guedira, Justin Faris, Jan Dvorak, Ming-Cheng Luo, Ksenia Krasileva, Thomas Lux, Susanne Artmeier, Klaus F. X. Mayer, Cristobal Uauy, Martin Mascher, Alison R. Bentley, Beat Keller, Jesse Poland and Brande B. H. Wulff, 1 November 2021, Nature Biotechnology. DOI: 10.1038/s41587-021-01058-4

Credit: Weizmann Institute of Science Without Egg, Sperm or Womb: Synthetic Mouse Embryo Models Created Solely from Stem Cells An egg meets a sperm – that’s a necessary first step in life’s beginnings. In embryonic development research, it’s also a common first step. However, in a new study published on August 1, 2022, in the journal Cell, researchers from the Weizmann Institute of Science have grown synthetic embryo models of mice outside the womb by starting solely with stem cells cultured in a petri dish. That means they are grown without the use of fertilized eggs. This method opens new horizons for studying how stem cells form various organs in the developing embryo. It may also one day make it possible to grow tissues and organs for transplantation using synthetic embryo models. A video showing a synthetic mouse embryo model on day 8 of its development; it has a beating heart, a yolk sac, a placenta, and emerging blood circulation. “The embryo is the best organ-making machine and the best 3D bioprinter – we tried to emulate what it does,” says Prof. Jacob Hanna of Weizmann’s Molecular Genetics Department, who headed the research team. Hanna explains that scientists already know how to restore mature cells to “stemness.” In fact, pioneers of this cellular reprogramming won a Nobel Prize in 2012. However, going in the opposite direction, that is, causing stem cells to differentiate into specialized body cells, not to mention form entire organs, has proved far more difficult. “Until now, in most studies, the specialized cells were often either hard to produce or aberrant, and they tended to form a mishmash instead of well-structured tissue suitable for transplantation. We managed to overcome these hurdles by unleashing the self-organization potential encoded in the stem cells.” (Left to right): Dr. Noa Novershtern, Prof. Jacob Hanna, Alejandro Aguilera-Castrejon, Shadi Tarazi and Carine Joubran. Credit: Weizmann Institute of Science Hanna’s team built on two previous advances in his lab. One was an efficient method for reprogramming stem cells back to a naïve state – that is, to their earliest stage – when they have the greatest potential to specialize into different cell types. The other, described in a scientific paper in Nature in March 2021, was the electronically controlled device the team had developed over seven years of trial and error for growing natural mouse embryos outside the womb. The device keeps the embryos bathed in a nutrient solution inside of beakers that move continuously, simulating the way nutrients are supplied by material blood flow to the placenta, and closely controls oxygen exchange and atmospheric pressure. In the earlier research, the team had successfully used this device to grow natural mouse embryos from day 5 to day 11. This is how synthetic mouse embryo models were grown outside the womb: a video showing the device in action. Continuously moving beakers simulate the natural nutrient supply, while oxygen exchange and atmospheric pressure are tightly controlled. In the new study, the team set out to grow a synthetic embryo model solely from naïve mouse stem cells that had been cultured for years in a petri dish, dispensing with the need for starting with a fertilized egg. This approach is extremely valuable because it could, to a large extent, bypass the technical and ethical issues involved in the use of natural embryos in research and biotechnology. Even in the case of mice, certain experiments are currently unfeasible because they would require thousands of embryos, whereas access to models derived from mouse embryonic cells, which grow in lab incubators by the millions, is virtually unlimited. “The embryo is the best organ-making machine and the best 3D bioprinter – we tried to emulate what it does.” Before placing the stem cells into the device, the researchers separated them into three groups. In one, which contained cells intended to develop into embryonic organs themselves, the cells were left as they were. Cells in the other two groups were pretreated for only 48 hours to overexpress one of two types of genes: master regulators of either the placenta or the yolk sac. “We gave these two groups of cells a transient push to give rise to extraembryonic tissues that sustain the developing embryo,” Hanna says. Development of synthetic embryo models from day 1 (top left) to day 8 (bottom right). All their early organ progenitors had formed, including a beating heart, an emerging blood circulation, a brain, a neural tube, and an intestinal tract. Credit: Weizmann Institute of Science Soon after being mixed together inside the device, the three groups of cells convened into aggregates, the vast majority of which failed to develop properly. But about 0.5 percent – 50 of around 10,000 – went on to form spheres, each of which later became an elongated, embryo-like structure. Since the researchers had labeled each group of cells with a different color, they were able to observe the placenta and yolk sacs forming outside the embryos and the model’s development proceeding as in a natural embryo. These synthetic models developed normally until day 8.5 – nearly half of the mouse 20-day gestation – at which stage all the early organ progenitors had formed, including a beating heart, blood stem cell circulation, a brain with well-shaped folds, a neural tube, and an intestinal tract. When compared to natural mouse embryos, the synthetic models displayed a 95 percent similarity in both the shape of internal structures and the gene expression patterns of different cell types. The organs seen in the models gave every indication of being functional. Day 8 in the life of a mouse embryo: a synthetic model (top) and a natural embryo (bottom). The synthetic models displayed a 95 percent similarity in both the shape of internal structures and the gene expression patterns of different cell types. Credit: Weizmann Institute of Science For Hanna and other stem cell and embryonic development researchers, the study presents a new arena: “Our next challenge is to understand how stem cells know what to do – how they self-assemble into organs and find their way to their assigned spots inside an embryo. And because our system, unlike a womb, is transparent, it may prove useful for modeling birth and implantation defects of human embryos.” In addition to helping reduce the use of animals in research, synthetic embryo models might in the future become a reliable source of cells, tissues, and organs for transplantation. “Instead of developing a different protocol for growing each cell type – for example, those of the kidney or liver – we may one day be able to create a synthetic embryo-like model and then isolate the cells we need. We won’t need to dictate to the emerging organs how they must develop. The embryo itself does this best.” A diagram showing the innovative method for growing synthetic mouse embryo models from stem cells – without egg, sperm or womb – developed in the laboratory of Prof. Jacob Hanna. Credit: Weizmann Institute of Science Reference: “Post-Gastrulation Synthetic Embryos Generated Ex Utero from Mouse Naïve ESCs” by Shadi Tarazi, Alejandro Aguilera-Castrejon, Carine Joubran, Nadir Ghanem, Shahd Ashouokhi, Francesco Roncato, Emilie Wildschutz, Montaser Haddad, Bernardo Oldak, Elidet Gomez-Cesar, Nir Livnat, Sergey Viukov, Dmitry Lukshtanov, Segev Naveh-Tassa, Max Rose, Suhair Hanna, Calanit Raanan, Ori Brenner, Merav Kedmi, Hadas Keren-Shaul, Tsvee Lapidot, Itay Maza, Noa Novershtern and Jacob H. Hanna, 1 August 2022, Cell. DOI: 10.1016/j.cell.2022.07.028 This research was co-led by Shadi Tarazi, Alejandro Aguilera-Castrejon, and Carine Joubran of Weizmann’s Molecular Genetics Department. Study participants also included Shahd Ashouokhi, Dr. Francesco Roncato, Emilie Wildschutz, Dr. Bernardo Oldak, Elidet Gomez-Cesar, Nir Livnat, Sergey Viukov, Dmitry Lokshtanov, Segev Naveh-Tassa, Max Rose and Dr. Noa Novershtern of Weizmann’s Molecular Genetics Department; Montaser Haddad and Prof. Tsvee Lapidot of Weizmann’s Immunology and Regenerative Biology Department; Dr. Merav Kedmi of Weizmann’s Life Sciences Core Facilities Department; Dr. Hadas Keren-Shaul of the Nancy and Stephen Grand Israel National Center for Personalized Medicine; and Dr. Nadir Ghanem, Dr. Suhair Hanna and Dr. Itay Maza of the Rambam Health Care Campus. Prof. Jacob Hanna’s research is supported by the Dr. Barry Sherman Institute for Medicinal Chemistry; the Helen and Martin Kimmel Institute for Stem Cell Research; and Pascal and Ilana Mantoux.

A major study suggests that releasing genetically selected, captive-bred Arabian leopards into the wild could significantly aid the recovery of this Critically Endangered species. Through international collaboration and extensive genetic research, scientists aim to enhance the dwindling wild populations in Oman. Research on the critically endangered Arabian leopard indicates that reintroducing carefully selected, captive-bred individuals into the wild could substantially aid in the recovery of their decreasing numbers and help prevent extinction. The authors of a major study on the Critically Endangered Arabian leopard suggest that releasing captive-bred animals, carefully chosen based on their genetic makeup, can significantly aid in the recovery of the rapidly declining wild population and help prevent their extinction. An international collaboration led by scientists from the Durrell Institute of Conservation and Ecology (DICE) at the University of Kent, University of East Anglia (UEA), University College London (UCL), Nottingham-Trent University (NTU), and the Diwan of Royal Court in Oman, surveyed the remote Dhofar mountain range of southern Oman to determine how many of Arabia’s last big cat survive. Genetic Study Findings By deploying camera traps to identify individual leopards and performing DNA analyses from wild leopard scat alongside samples from the captive population, the team estimates there could be only 51 wild leopards remaining in Oman, distributed between three isolated, genetically impoverished but distinct subpopulations. Despite revealing extremely low levels of genetic diversity in the wild leopard population in Oman, the team discovered higher levels of genetic diversity in captive leopards across the region, in particular among several individuals originating from neighboring Yemen that helped found today’s captive-breeding population. This important genetic resource has the potential for a major role in the successful recovery of the Arabian leopard. The team’s research showed that the dwindling regional wild population could most effectively be recovered through ‘genetic rescue’, namely, the introduction of offspring from captive-bred leopards — which harbor the greatest amount of genetic diversity — into the wild population. However, their predictions indicate that for genetic rescue to establish the most viable populations through leopard reintroductions, the benefit that new genes can bring needs to be carefully assessed, in particular because captive leopards may already be in-bred. The study used conservation genetic analysis at DICE, cutting-edge computer simulations developed at UEA, and extensive fieldwork in Oman, to closely examine Arabian leopard DNA and assess the risk of future extinction, as well as forecast how genetic rescue can secure the leopard’s viability. The authors say their findings, published on May 23 in Evolutionary Applications, could help other threatened species. Detailed Genetic Analysis Professor Jim Groombridge, who led the research at Kent’s DICE, explained how the genetic analysis was carried out: ‘In collaboration with the Diwan of Royal Court in Oman, we surveyed and collected leopard scats from across the Dhofar mountain range, and extracted DNA from them which we analyzed using microsatellite DNA markers to quantify genetic diversity. ‘Using the genetic information, we were able to determine the number of leopard individuals that remain in the wild. We could then compare levels of genetic diversity between the wild leopard population and those in captivity.’ Dr Hadi Al Hikmani, Arabian leopard Conservation Lead at the Royal Commission for AlUla in Saudi Arabia, described the motivation for this study: ‘The Arabian leopard is one of the world’s rarest carnivores and is extraordinarily elusive. The only way to monitor these leopards in the wild is to deploy camera traps high up across the mountain ranges where the leopards live, and to collect the scats they leave behind on the mountain passes, for DNA analysis.’ Thomas Birley, a PhD researcher at UEA who performed the computer simulations for genetic rescue, said: ‘By using the genetic information from the wild and captive populations, we were able to forecast the best plan for genetic rescue to ensure long-term viability for this Critically Endangered big cat.’ Professor Cock van Oosterhout, of the School of Environmental Sciences at UEA, added: ‘The problem is that all individuals are somehow related to each other. They are the descendants of the few ancestors that managed to survive a major population crash. Hence, it becomes virtually impossible to stop inbreeding, and this exposes ‘bad’ mutations, what we call genetic load. In turn, this can increase the mortality rate, causing further population collapse.’ ‘The genetic load poses a severe threat, but it can be alleviated by genetic rescue, and our study has projected the best way to do this. The wild population needs ‘genetic rescue’ from more genetically diverse leopards bred in captivity. These leopards are genetically more diverse, and they can help to reduce the level of inbreeding and genetic load. However, there is a risk that we could introduce other bad mutations from the captive population into the wild, so we will need a careful balance.’ Reference: “Can genetic rescue help save Arabia’s last big cat?” by Hadi Al Hikmani, Cock van Oosterhout, Thomas Birley, Jim Labisko, Hazel A. Jackson, Andrew Spalton, Simon Tollington and Jim J. Groombridge, 23 May 2024, Evolutionary Applications. DOI: 10.1111/eva.13701

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