Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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High-performance insole OEM China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Private label insole and pillow OEM Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Customized sports insole ODM Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM service for ergonomic pillows China

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam orthopedic insole OEM manufacturer

New research has uncovered significant age-related changes in lipid metabolism across different organs and sexes in mice, highlighting the accumulation of specific lipids produced by gut bacteria. The findings, which also include the identification of a gene causing sex differences in the kidneys, could improve our understanding of age-related diseases like Alzheimer’s and atherosclerosis. This research provides a foundation for future studies on the human lipidome and microbiome, potentially leading to targeted treatments for these conditions. Credit: RIKEN RIKEN Center researchers have found key age-related changes in mice’s lipid metabolism, potentially improving treatments for age-related diseases. Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have identified multiple age-related alterations in lipid metabolism in mice, affecting various organs and differing by sex. Notably, they observed a systemic accumulation of specific lipids originating from gut bacteria as the mice aged. Additionally, the study revealed a sex-related difference in the kidneys and identified a gene linked to this variation. Published in Nature Aging, these findings could enhance our understanding of chronic age-related diseases such as Alzheimer’s, atherosclerosis, kidney disease, and cancer. Lipids, often in the form of fats or oils, are essential molecules for storing energy in our bodies, among other things. In addition, lipids act as signaling molecules and as components of cell membranes. Metabolism—the breakdown of biomolecules such as lipids and sugars into their component parts—slows down as we age, which helps explain why it’s easier to gain weight, and more difficult to lose it, as we get older. Although this has been known for over 50 years, how changes in lipid metabolism in particular affects lifespan and health remain unclear. In their recent study, Hiroshi Tsugawa and his team at RIKEN IMS reasoned that before this question can be fully answered, we need to know what the actual changes are, in great detail. Only then can scientists begin looking for links between aging lipid metabolism and human health. Toward this end, they used mice to develop an atlas of age-related changes in lipid metabolites. By using a cutting-edge technique to take multiple snapshots of the mouse lipidome—all lipid metabolites present in a biological sample—the researchers found that BMP-type lipids increased with age in the kidneys, liver, lungs, muscles, spleen, and small intestine of the mice. These lipids play key roles in cholesterol transport and the breakdown of biomolecules within cellular recycling centers called lysosomes. Age-related lysosomal damage might result in cells making more BMPs, which could lead to further metabolic changes, such as increasing cholesterol derivatives in the kidney. Gut Bacteria and Lipid Changes The researchers also investigated the impact of gut bacteria on the lipidome, discovering that while gut bacteria produced many structurally unique lipids, only sulfonolipids increased with age in the liver, kidney, and spleen. In fact, no other group of lipid metabolites from gut bacteria were even detected in these peripheral tissues. “As this kind of lipid is known to be involved in regulating immune responses, the next phase of our research will involve testing the gut bacteria-derived sulfonolipids to determine their structure and physiological functions,” says Tsugawa. The researchers also found age-related sex differences in the mouse lipidome, particularly in the kidneys, with levels of the lipid metabolite galactosylceramide being higher in older male mice than in older females. This discrepancy was attributed to increased expression of the UGT8 gene in male mice. Understanding sex-specific metabolic differences like this could shed light on susceptibility to age-related diseases in humans. “Our research has comprehensively characterized the changes in the lipidome that occur in the mouse with aging. In doing so, we have created at atlas that will serve as an important global resource,” says Tsugawa. “Next, we must extend this type of study to the human lipidome and microbiome.” The findings highlight the importance of understanding how lipid metabolism changes as we age, and the potential of targeting the lipidome when designing treatments for age-related diseases. Reference: “A lipidome landscape of aging in mice” by Hiroshi Tsugawa, Tomoaki Ishihara, Kota Ogasa, Seigo Iwanami, Aya Hori, Mikiko Takahashi, Yutaka Yamada, Naoko Satoh-Takayama, Hiroshi Ohno, Aki Minoda and Makoto Arita, 12 April 2024, Nature Aging. DOI: 10.1038/s43587-024-00610-6

The researchers found that chimpanzees consistently used standalone communication signals – such as vocalizations, manual gestures or facial expressions – across all ages and in different situations, but as they got older, they were more likely to combine different communication signals together. Credit: Dr. Jake Brooker A study finds that young chimpanzees combine gestures, sounds, and facial expressions as they grow, paralleling human infant communication. This research provides clues about the evolutionary origins of human language. New research suggests that young chimpanzees meld various gestures, sounds, and facial cues in a manner that echoes how communication develops in human infants. The study, led by psychologists at Durham University, suggests that these combinations of different communicative cues could potentially enhance the clarity of their messages to other chimpanzees, especially in varied contexts like play or conflict. The researchers found that this ability develops throughout infancy and adolescence. Such combined signals included combining playful open-mouth faces with laughing, touching another chimpanzee while whimpering, and baring their teeth while squeaking. The researchers say that understanding this “multimodal” form of communicating could shed important light on how communication evolved in humans and our closest ape relatives, and tell us more about how our own language skills emerge. Juvenile female chimpanzee Nancy shows a play face and laughs during rough and tumble play. The research found that as the chimpanzees got older, they were more likely to combine different communication signals together, especially when they were responding to/ avoiding aggression or were playing. Credit: Dr. Jake Brooker Their study, which also involved the University of Portsmouth, is published in the journal Animal Behaviour. Researchers observed 28 semi-wild chimpanzees, ranging in age from one to 11 years old, at the Chimfunshi Wildlife Orphanage Trust sanctuary in northern Zambia. While previous studies on apes have largely looked at different forms of communication signals in isolation (gestures, vocalizations, facial expressions), the new findings looked at how chimpanzees combined these different forms of communication to see how this developed with age and in varying circumstances. The researchers found that chimpanzees consistently used standalone communication signals – such as grunting, arm movements, or facial expressions – across all ages and in different situations. Increased Complexity in Communication with Age However, they also showed that as the chimpanzees got older, they were more likely to combine different communication signals together. The research looked at how chimpanzees combined different forms of communication to see how this developed with age and in varying social contexts. Credit: Dr. Jake Brooker This was especially the case when the chimpanzees were responding to aggression or were playing, two situations where it is important for them to make clear what they were communicating to avoid risky fallout, the researchers said. The older adolescent chimpanzees studied were also more likely to use a combination of different communication signals instead of individual gestures or expressions, especially during aggression scenarios. Research lead author Emma Doherty, a Research Postgraduate in the Department of Psychology, Durham University, said: “When we think about human language, we know that it is a combination of different types of communication such as speech, facial expressions, and gestures. “The way we communicate likely has deep evolutionary roots that are shared with some of our closest living relatives such as apes. Juvenile female Chitalu acknowledges an approaching adolescent male with a grunt vocalization and a light touch gesture as he walks by during group feeding. Credit: Emma Doherty “Our study provides evidence that the way chimpanzees communicate with increased complexity as they get older is consistent with the development of communication we see in human infants. “By studying the development of this multi-layered way of communicating among young chimpanzees we can learn more about the reasons behind this and shed light on the potential evolutionary continuity between humans and other apes.” The researchers said that more work should be carried out to observe multimodal signals in primates in the wild to further understand how the development of communication is affected by different environments. They added that studying multimodal communication – instead of observing individual communication signals in isolation – could provide better evidence of how communication develops in apes and potentially help us to understand the evolution of human communication. Multimodal Communication as a Key to Language Evolution Research corresponding author Dr. Zanna Clay, Associate Professor in the Department of Psychology, Durham University, said: “A lot of the focus of research so far into communication, both in humans and other animals, looks at individual communication signals independently, but we know humans combine these signals all the time from early infancy. “As a close relative of humans, apes give us a snapshot into how these signals could have evolved into multimodal communications, ultimately culminating in human language.” Reference: “Multimodal communication development in semiwild chimpanzees” by Emma Doherty, Marina Davila-Ross and Zanna Clay, 5 June 2023, Animal Behaviour. DOI: 10.1016/j.anbehav.2023.03.020 The research was funded by a Durham University Doctoral Scholarship, the British Association of Biological Anthropology and Osteoarchaeology, the Lucie Burgers Foundation for Comparative Behavioural Research.

Muscle membrane-derived Giant Plasma Membrane Vesicles (GPMVs). These isolated large membrane units, coupled with advanced microscopy applications, enabled a close analysis of the architecture of the otherwise difficult-to-study cell membrane lipid bilayer, giving insight into an unknown pathological mechanism of a recently discovered, severe human inherited disease. Credit: Cikes/IMBA. Researchers linked enzyme PCYT2 depletion to accelerated muscle aging and degeneration in mice, demonstrating its conserved importance across vertebrates. Innovative lipid analysis methods revealed new therapeutic possibilities for improving muscle health in aging and rare diseases. The most widespread reason for frailty in hereditary diseases and aging is muscle degeneration, which could stem from a lack of a crucial enzyme in the lipid biosynthesis pathway. A team of researchers at the Austrian Academy of Sciences’ Institute of Molecular Biotechnology (IMBA) has studied how the enzyme PCYT2 influences muscle health in disease and aging using laboratory mouse models. The results of their study were recently published in the journal Nature Metabolism. The degeneration of muscles in inherited diseases and aging is a global concern affecting hundreds of millions of people. The decline of skeletal muscles, which serve as the body’s source of protein, leads to a condition known as frailty, characterized by overall physiological deterioration. A research team led by Domagoj Cikes at the Institute of Molecular Biotechnology (IMBA) and Josef Penninger at IMBA and the University of British Columbia (UBC) have now revealed the crucial role played by the enzyme PCYT2 in muscle health. PCYT2 is known as the bottleneck enzyme in a major synthesis pathway of ethanolamine-derived phospholipids, the phosphatidylethanolamines (PEs). Based on patient data and using laboratory mouse and zebrafish models, they show that mutations affecting PCYT2, or its reduced activity, are conserved hallmarks of muscle degeneration across vertebrates. Specifically, they demonstrate that PCYT2 deficiency in muscles affects mitochondrial function and the physicochemical properties of the myofiber membrane. Josef Penninger and Domagoj Cikes. Credit: IMBA Membrane Rigidity, Aging, and Conservation in Vertebrates Lipids are ubiquitously present in biological membranes and are present at particularly high concentrations in the membranes of nerve cells and neural tissues. Following reports that PE-based molecules enhance the membrane rigidity of liposomes, Domagoj Cikes, the study’s co-corresponding author and a former postdoctoral researcher in the Penninger lab at IMBA, hypothesized that this lipid species may play an important role in tissues subjected to constant shear stress, such as muscle tissue. “This assumption prompted me to selectively deplete PCYT2 in muscle tissues of animal models and study the outcome. In parallel, clinicians reported patient cases of mutations affecting PCYT2. The patients presented a condition called complex hereditary spastic paraplegia, a severe, multi-symptomatic disease characterized by leg muscle weakness, stiffness, and muscle wasting that worsened with time. However, given that the disease was just recently discovered, the underlying pathophysiological biology is vastly unknown,” says Cikes. The researchers demonstrated that the levels of functional PCYT2 are linked to human muscle health and affect the muscle tissues of mice and zebrafish. The mouse models in particular showed striking and severe phenotypes of muscle growth retardation and quick deterioration upon PCYT2 depletion. They noted that this phenotype of fast deterioration in the mouse models resembled accelerated aging. Thus, Cikes and colleagues showed that PCYT2 plays a conserved role in vertebrates. Muscle membrane-derived Giant Plasma Membrane Vesicles (GPMVs). Credit: Cikes/IMBA PEs are also abundant in mitochondrial membranes. Therefore, the researchers examined how PCYT2 depletion in muscle tissues affects mitochondrial membrane homeostasis and found that PCYT2 depletion indeed altered mitochondrial function and muscle energetics. However, a mitochondrial therapeutic approach was not sufficient to rescue the phenotype in mice. “This prompted us to think that there must be an additional mechanism driving the pathology,” says Cikes. Indeed, the team showed that the organization of the cell membrane lipid bilayer played an additional role. “This represents a novel pathophysiological mechanism that might also be present in other lipid-related disorders,” says Cikes. In addition, the team demonstrated that PCYT2 activity decreased during aging in humans and mice. Using a targeted delivery technique of active PCYT2, the scientists were able to rescue muscle weakness in PCYT2-depleted mouse models and improve muscle strength in old mice. Technical Advances To Understand the Biology and Pathophysiology Having linked muscle health in vertebrates with PEs and muscle membrane composition, the researchers studied the role of lipid species in biological membranes. As biological work with lipids is particularly challenging, they also needed to think of ways to advance the available research applications. By adapting a technique developed by Kareem Elsayad at the Vienna BioCenter Core Facilities (VBCF) to measure tissue stiffness using Brillouin Light Scattering (BLS), the researchers were able to examine the physical properties of biological membranes. With this technique, the team demonstrated a considerable decrease in membrane surface stiffness when PCYT2 was depleted in mouse muscles. “In addition, our current work makes another leap forward in the field of lipid biology, as we were able to peek into the lipid bilayer of cell membranes and examine the local properties of structural lipids,” says Cikes. The technique is based on isolating Giant Plasma Membrane Vesicles (GPMVs) from biological tissues and studying the physicochemical properties and geometry of the membrane bilayer by means of an intercalating dye. This approach allows the scientists to examine how well the lipids in the bilayer are matched and whether they observe gaps, hydrophilic components, and leakages through the membrane. The Biology of Lipids – Crucial, yet Understudied “Current knowledge on the biology of lipids is largely over-simplified. The whole lipid field is summarized into a handful of molecular families, such as cholesterols, triglycerides, phospholipids, and fatty acids. It is a vast and unexplored molecular universe where the function of most species in health and disease is unknown.” says Cikes. By shedding light on the central effect of a lipid biosynthesis pathway in muscle health, Cikes and the team wish to highlight the importance and discovery potential of lipid research. “Our current work demonstrates a fundamental, specific, and conserved role of PCYT2-mediated lipid synthesis in vertebrate muscle health and allows us to explore novel therapeutic avenues to improve muscle health in rare diseases and aging,” concludes Penninger. Reference: “PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing” by Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Torma Ferenc, Michael Orthofer, Rebecca Yarwood, Leonhard X. Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J. F. Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S. Chamberlain, Marica Bakovic, Siddharth Banka and Josef M. Penninger, 20 March 2023, Nature Metabolism. DOI: 10.1038/s42255-023-00766-2 Josef Penninger was the founding director of IMBA and is currently the director of the Life Sciences Institute at the University of British Columbia (UBC), Vancouver, Canada.

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