Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Innovative insole ODM solutions in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia insole ODM design and production

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam pillow OEM manufacturer

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.PU insole OEM production in Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Eco-friendly pillow OEM manufacturer China

The loss of the protein pigment epithelium-derived factor, the study discovered, is a driver of aging-related changes in the retina. Mice without a protective protein in their eyes have symptoms resembling age-related macular degeneration. According to a recent National Eye Institute (NEI) study in mice, loss of the protein pigment epithelium-derived factor (PEDF), which protects retinal support cells, may promote age-related changes in the retina. Age-related retinal diseases, such as age-related macular degeneration (AMD), can cause blindness since the retina is the light-sensitive tissue at the back of the eye. The new information could help develop medicines to stop AMD and other aging conditions of the retina. The research was published in the International Journal of Molecular Sciences. NEI is part of the National Institutes of Health. “People have called PEDF the ‘youth’ protein because it is abundant in young retinas, but it declines during aging,” said Patricia Becerra, Ph.D., chief of NEI’s Section of Protein Structure and Function and senior author of the study. “This study showed for the first time that just removing PEDF leads to a host of gene changes that mimic aging in the retina.” PEDF’s Impact on Photoreceptors and the Retinal Pigment Epithelium (RPE) The retina is made up of layers of cells that work together to recognize and interpret light signals, which the brain utilizes to produce vision. The retina’s light-sensing photoreceptors are located atop a layer of support cells called the retinal pigment epithelium (RPE). When photoreceptors detect light, the RPE nourishes them and recycles “outer segments,” which get used up and their tips shed each time photoreceptors detect light. RPE from mice without Serpin1 accumulate more lipids than wild-type mice. Super-resolution confocal microscopy of RPE tissue from wild-type (upper) and Serpin1-null (lower) mice. Detailed images on the right are magnified regions of the RPE tissue imaged on the left (dotted square area). RPE cell boundaries are stained in red, and accumulated lipids are stained in green. Credit: Ivan Rebustini, NEI Photoreceptor cells lose the capacity to create new segments and subsequently lose the ability to detect light if the RPE is unable to supply recycled components of older outer segment tips back to them. And without the nutrients that the RPE supplies, photoreceptors die. Senescence (aging) or death of RPE cells in the retina causes vision loss in individuals with AMD or certain types of retinal dystrophies. PEDF and Its Role in Lipid Breakdown and Outer Segment Recycling Previous research from Becerra’s team and other groups have shown that PEDF shields retinal cells, protecting against both cellular damage and abnormal blood vessel growth in the retina. RPE cells produce and secrete the PEDF protein. The protein then binds to its receptor, PEDF-R, which is also expressed by RPE cells. Binding by PEDF stimulates PEDF-R to break down lipid molecules, key components of the cell membranes that enclose photoreceptor outer segments and other cellular compartments. This breakdown step is a key part of the outer segment recycling process. And while researchers have known that PEDF levels drop in the retina during the aging process, it was not clear whether this loss of PEDF was causing, or merely correlated with, age-related changes in the retina. To examine the retinal role of PEDF, Becerra and colleagues studied a mouse model that lacks the PEDF gene (Serpin1). The researchers examined the cellular structure of the retina in the mouse model, finding that the RPE cell nuclei were enlarged, which may indicate changes in how the cells’ DNA is packed. The RPE cells also had turned on four genes associated with aging and cellular senescence, and levels of the PEDF receptor were significantly below normal. Finally, unprocessed lipids and other photoreceptor outer segment components had accumulated in the RPE layer of the retina. Similar changes in gene expression and defects in RPE metabolism are found in the aging retina. The Connection Between PEDF Loss and Aging in the Retina “One of the most striking things was this reduction in the PEDF receptor on the surface of the RPE cells in the mouse lacking the PEDF protein,” said the study’s lead author, Ivan Rebustini, Ph.D., a staff scientist in Becerra’s lab. “It seems there’s some sort of feedback-loop involving PEDF that maintains the levels of PEDF-R and lipid metabolism in the RPE.” While at first glance, the retinas of these PEDF-negative mice appear normal, these new findings suggest that PEDF is playing a protective role that helps the retina weather trauma and aging-related wear and tear. “We always wondered if loss of PEDF was driven by aging, or was driving aging,” said Becerra. “This study, especially with the clear link to altered lipid metabolism and gene expression, indicates the loss of PEDF is a driver of aging-related changes in the retina.” Reference: “PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE” by Ivan T. Rebustini, Susan E. Crawford and S. Patricia Becerra, 13 July 2022, International Journal of Molecular Sciences. DOI: 10.3390/ijms23147745 The study was funded by the National Eye Institute.

Waveform visualizations of sound production of three species described by one of the project collaborators, Amalis Riera, during the work of Riera et al., 2018 and Riera et al., 2020. Scientists have developed an extensive inventory of underwater species known or suspected to produce sound. This groundbreaking work documents over 22,000 species, challenging the notion that aquatic life is predominantly silent and significantly advancing marine and aquatic sciences. Scientists looking to uncover the mysteries of the underwater world have more valuable information at their fingertips thanks to an international team that has produced an inventory of species confirmed or expected to produce sound underwater. Led by Audrey Looby from the University of Florida Department of Fisheries and Aquatic Sciences, the Global Library of Underwater Biological Sounds working group collaborated with the World Register of Marine Species to document 729 aquatic mammals, other tetrapods, fishes, and invertebrates that produce active or passive sounds. In addition, the inventory includes another 21,911 species that are considered to likely produce sounds. Video of red drum (Sciaenops ocellatus; named for their characteristic drumming sounds produced during reproductive behavior) in the Discovery Room of the Nature Coast Biological Station. With more than 70% of the Earth’s surface covered in water, most of the planet’s habitats are aquatic, and there is a misconception that most aquatic organisms are silent. The newly published comprehensive digital database on what animals are known to make sounds is the first of its kind and can revolutionize marine and aquatic science, the researchers said. Video of fish auditioning in a tank environment. Credit: Amalis Riera “Eavesdropping on underwater sounds can reveal a plethora of information about the species that produce them and is useful for a variety of applications, ranging from fisheries management, invasive species detection, improved restoration outcomes, and assessing human environmental impacts,” said Looby, who also co-created FishSounds, which offers a comprehensive, global inventory of fish sound production research. A nest-building Plainfin Midshipman filmed by Mackenzie Woods while conducting her thesis research in Washington. The team’s research, “Global Inventory of Species Categorized by Known Underwater Sonifery,” will be published today (December 18) in the journal Scientific Data and involved 19 authors from six countries, funding from the Richard Lounsbery Foundation and centuries of scientific effort to document underwater sounds. A nest-building Plainfin Midshipman filmed by Mackenzie Woods while conducting her thesis research in Washington. “Understanding how marine species interact with their environments is of global importance, and this data being freely available is a major step toward that goal,” said Kieran Cox, a member of the research team and a National Science and Engineering Research Council of Canada fellow. Video with sounds of Amazon River Dolphin, Inia geoffrensis, recorded in the Pacaya-Samiria National Reserve, Peru during the work of Rountree et al. 2022. Most people are familiar with whale or dolphin sounds but are often surprised to learn that many fishes and invertebrates use sounds to communicate, too, Looby said. “Our dataset helps demonstrate how widespread underwater sound production really is across a variety of animals, but also that we still have a lot to learn,” she said. Reference: “Global inventory of species categorized by known underwater sonifery” by Audrey Looby, Christine Erbe, Santiago Bravo, Kieran Cox, Hailey L. Davies, Lucia Di Iorio, Youenn Jézéquel, Francis Juanes, Charles W. Martin, T. Aran Mooney, Craig Radford, Laura K. Reynolds, Aaron N. Rice, Amalis Riera, Rodney Rountree, Brittnie Spriel, Jenni Stanley, Sarah Vela and Miles J. G. Parsons, 18 December 2023, Scientific Data. DOI: 10.1038/s41597-023-02745-4

Researchers from the University of Copenhagen have discovered that Caribbean box jellyfish, previously believed to be simple creatures, possess advanced learning abilities despite their basic nervous system. Credit: Jan Bielecki Jellyfish are more advanced than once thought. A new study from the University of Copenhagen has demonstrated that Caribbean box jellyfish can learn at a much more complex level than ever imagined – despite only having one thousand nerve cells and no centralized brain. The finding changes our fundamental understanding of the brain and could enlighten us about our own mysterious brains. After more than 500 million years on Earth, the immense evolutionary success of jellyfish is undeniable. Still, we’ve always thought of them as simple creatures with very limited learning abilities. The prevailing opinion is that more advanced nervous systems equate with more advanced learning potential in animals. Jellyfish and their relatives, collectively known as cnidarians, are considered to be the earliest living animals to develop nervous systems and to have fairly simple nervous systems and no centralized brain. For more than a decade, neurobiologist Anders Garm has been researching box jellyfish, a group of jellyfish commonly known for being among the world’s most poisonous creatures. But these lethal jellies are interesting for another reason as well: it turns out that they are not quite as simple as once believed. And this shakes our entire understanding of what simple nervous systems are capable of. A Caribbean box jellyfish. Black dots embedded low on the bell are the animal’s visual sensory and learning center called rhopalia. Credit: Jan Bielecki “It was once presumed that jellyfish can only manage the simplest forms of learning, including habituation – i.e., the ability to get used to a certain stimulation, such as a constant sound or constant touch. Now, we see that jellyfish have a much more refined ability to learn, and that they can actually learn from their mistakes. And in doing so, modify their behavior,” says Anders Garm, an associate professor at the University of Copenhagen’s Department of Biology. One of the most advanced attributes of a nervous system is the ability to change behavior as a result of experience – to remember and learn. The research team, headed by Jan Bielecki of Kiel University and Anders Garm, set out to test this ability in box jellyfish. The findings have just been published in the journal Current Biology. About Tripedalia cystophora Box jellyfish are a class of jellyfish known for being among the most poisonous animals in the world. They use their venom to catch fish and large shrimp. Tripedalia cystophora has a somewhat milder venom and feeds on tiny copepods. Box jellyfish do not have a centralized brain like most animals. Instead, they have four parallel brain-like structures, with approximately holds a thousand nerve cells in each. A human brain has approximately 100 billion nerve cells. Box jellyfish have twenty four eyes distributed among their four brain-like structures. Some of these eyes are image forming, providing box jellyfish with more complex vision than other types of jellyfish. To find their way through murky mangroves, four of Tripedalia cystophora’s eyes look up through the surface of the water and navigate using the mangrove canopies. Tripedalia cystophora is one of the smallest box jellyfish species, with a body of only about one centimeter in diameter. It lives in the Caribbean Sea and Central Indo-Pacific. Unlike many jellyfish species, Tripedalia cystophora actually mates as the male captures the female with its tentacles. A female’s eggs are then fertilized in their gut system, where they also develop into larvae. A Thousand Nerve Cells Are More Capable Than Once Thought The scientists studied the Caribbean box jellyfish, Tripedalia cystophora, a fingernail-sized medusa that lives in Caribbean mangrove swamps. Here, they use their impressive visual system including 24 eyes to hunt for tiny copepods among mangrove roots. While making for a good hunting grounds, the web of roots is also a dangerous place for soft-bodied jellies. So, as the small box jellyfish approach the mangrove roots, they turn and swim away. Should they veer too soon, they won’t have enough time to catch any copepods. But if they turn too late, they risk bumping into the root and damaging their gelatinous bodies. Thus, assessing distances is crucial for them. And here, contrast is the key, as the researchers discovered: “Our experiments show that contrast, i.e., how dark the root is in relation to the water, is used by the jellyfish to assess distances to roots, which allows them to swim away at just the right moment. Even more interesting is that the relationship between distance and contrast changes on a daily basis due to rainwater, algae, and wave action,” says Anders Garm, who continues: “We can see that as each new day of hunting begins, box jellyfish learn from the current contrasts by combining visual impressions and sensations during evasive maneuvers that fail. So, despite having a mere one thousand nerve cells – our brains have roughly 100 billion – they can connect temporal convergences of various impressions and learn a connection – or what we call associative learning. And they actually learn about as quickly as advanced animals like fruit flies and mice.” The new research results break with previous scientific perceptions of what animals with simple nervous systems are capable of: “For fundamental neuroscience, this is pretty big news. It provides a new perspective on what can be done with a simple nervous system. This suggests that advanced learning may have been one of the most important evolutionary benefits of the nervous system from the very beginning,” says Anders Garm. Caribbean box jellyfish lives and feeds among underwater mangrove roots. Credit: Anders Gram How They Did It The researchers replicated mangrove swamp conditions in the laboratory, where box jellyfish were placed in a behavioral arena. Here, the researchers manipulated jellyfish behavior by changing the contrast conditions to see what effect this had on their behavior. They learned that jellyfish learning takes place through failed evasions. That is, they learn from misinterpreting contrast and bumping into roots. Here they combined the visual impression and mechanical shock they got whenever they bumped into a root – and in doing so, learned when to veer away. “Our behavioral experiments demonstrate that three to five failed evasive maneuvers are enough to change the jellyfish’s behavior so that they no longer hit the roots. It is interesting that this is roughly the same repetition rate that a fruit fly or mouse needs to learn,” says Anders Garm. The learning was further verified through electrophysiology and classical conditioning experiments, which also showed where in the jellyfish’s nervous system the learning takes place. Seeking the Brain Cells Where Memory Is Housed The scientists have also shown where the learning is happening in these box jellyfish. This has given them unique opportunities to now study the precise changes that occur in a nerve cell when it is involved in advanced learning. “We hope that this can become a supermodel system for looking at cellular processes in the advanced learning of all sorts of animals. We are now in the process of trying to pinpoint exactly which cells are involved in learning and memory formation. Upon doing so, we will be able to go in and look at what structural and physiological changes occur in the cells as learning takes place,” says Anders Garm. If the research team is able to pinpoint the exact mechanisms in jellyfish involved in learning, the next step will be to find out whether it applies specifically to jellies or if it can be found in all animals. “Eventually, we will look for the same mechanisms in other animals, to see if this is how memory works in general,” says the researcher. This kind of groundbreaking knowledge could be used for a wealth of purposes, according to Anders Garm: “Understanding something as enigmatic and immensely complex as the brain is in itself an absolutely amazing thing. But there are unimaginably many useful possibilities. One major problem in the future will undoubtedly be various forms of dementia. I don’t claim that we are finding the cure for dementia, but if we can gain a better understanding of what memory is, which is a central problem in dementia, we may be able to lay a building block to better understand the disease and perhaps counteract it,” concludes the researcher. The study will be published today (September 22) in the scientific journal Current Biology. Reference: “Associative learning in the box jellyfish Tripedalia Cystophora” by Jan Bielecki, Sofie Katrine Dam Nielsen, Gösta Nachman and Anders Garm, 22 September 2023, Current Biology. DOI: 10.1016/j.cub.2023.08.056 The study was conducted by Jan Bielecki from Kiel University and Anders Garm, Sofie Katrine Dam Nielsen, and Gösta Nachman from the Department of Biology, University of Copenhagen.

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