Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Innovative pillow ODM solution in Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand pillow OEM manufacturer

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.PU insole OEM production in Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Arch support insole OEM factory from Taiwan

The discovery of two potential new lamprey species in California by UC Davis researchers highlights significant biodiversity and ecological importance, urging further exploration into these ancient, jawless fish. Above is a picture of a Pacific lamprey resting in a river. Credit: Jeremy Monroe, Fresh Waters Illustrated These jawless fish play a crucial role in the ecosystem. A study from the University of California, Davis, has identified two potential new species of lamprey fish in the waters of California. The research is part of a special section on native lampreys recently published in the North American Journal of Fisheries Management. The findings suggest that the ancient animal has far more diversity in California than once thought, which could have implications for managing these jawless fish. Lamprey species play a key role in the food chain as well as improving water quality and adding nutrients to waterways. “We found diversity that has never been reported,” said Ph.D. candidate Grace Auringer, who is the lead author on the journal paper. “We found two groups of fish in Napa River and Alameda Creek that are very genetically different from other samples along the West Coast.” The study found that of the eight known species in the state, some that were thought to be separate species likely are not. It recommends additional research to further define the new species. “This is a really understudied group of fish,” said Auringer, who is in the UC Davis Genomic Variation Lab. A long history Lampreys are boneless, jawless fish with eel-like bodies that date back over 350 million years, said Matthew “Mac” Campbell, a research affiliate in the lab. Larval stages last from three to nine years, with lampreys ranging from the size of a fingernail to about 6 inches long, and one species is not discernible from the next. At that stage, they are filter feeders. As they age, some lampreys become parasitic and suck blood and flesh out of prey via a circle of sharp teeth while others stop feeding entirely, likely living off stored energy. Some adult lampreys are migratory, and others are not. The lab’s research focused on 19 areas in the Sacramento-San Joaquin River Basin, San Francisco Bay, and Klamath River basin and sought to do three things: identify the species in each area, determine if current classifications accurately reflect the diversity of lamprey in California and compare the distribution of lamprey to other native fish. Staff from water and conservation districts, state agencies, and utilities visited watersheds, clipped small pieces of lamprey fins, and preserved them in ethanol for analysis at UC Davis. The researchers also received archived tissue samples from the Columbia River Inter-Tribal Fish Commission. DNA barcoding The scientists isolated a specific mitochondrial gene — cytochrome b — from those samples. Using a short section of DNA, they were able to identify the species type and the evolutionary relationships of the samples based on shared or divergent DNA sequences. “The amount of diversity that we saw is quite remarkable,” Auringer said. “This opens up endless possibilities for future study.” Lamprey populations have long been thought to be declining in the West, and the eight documented lamprey species — in the Lampetra and Entosphenus genera — in California are listed as species of special concern. “I think it’s very important to identify and learn about these unique populations before we lose them,” she said. The two newly discovered lamprey species from the research are part of the Lampetra genus, adding more complexity to the lamprey story in the state. Knowing the exact species can help refine management practices and protect the populations, as well as support ecosystems and the food web. For some Indigenous peoples, lampreys are both culturally significant and a source of nutrition. Ecosystem benefits Lamprey larvae filter and feed on algae and other organic matter, helping to improve water quality, maintain streambeds and cycle nutrients throughout the system. The migrating adults transport nutrients after spawning. And birds, fish, and some aquatic mammals feed on juvenile and adult lampreys. “Healthy trout streams in California often have lamprey, so conservation measures benefiting lamprey also benefit trout,” said Amanda “Mandi” Finger, the Genetic Variation Lab’s associate director. The research highlights the need for more study, including genomic sequencing, to better understand and define the new potential lamprey species and the rest of the population. “Maintaining lamprey species complexity and fostering resilience cannot begin without an understanding of their underlying genetic diversity,” the paper said. Pascale Goertler, who worked at the Delta Stewardship Council and is now with the state Department of Water Resources, contributed to the research. Reference: “Lampreys in California (Lampetra spp. and Entosphenus spp.): Mitochondrial phylogenetic analysis reveals previously unrecognized lamprey diversity” by Grace Auringer, Matthew A. Campbell, Pascale A. L. Goertler and Amanda J. Finger, 30 September 2023, North American Journal of Fisheries Management. DOI: 10.1002/nafm.10959 Funding for the research came from the California Sea Grant College Program Project and the California Department of Water Resources.

A new study on Mycena mushrooms shows their genomes are much larger than expected, with particular expansions in Arctic species. This suggests these mushrooms have adapted to diverse environments, supported by gene duplications and horizontal gene transfers. Mycena haematopus. Credit: Christoffer Harder Research on various Mycena mushroom species revealed unexpectedly large genomes, suggesting a genetic capacity for diverse lifestyles, notably in Arctic strains where genomes are significantly larger. The study, involving an international team and part of the 1000 Fungal Genomes project, uncovered genome expansions across all gene families, likely aiding adaptability in extreme environments. Mycena Mushroom Genomes Mycena mushrooms, also known as “bonnets,” have unexpectedly large genomes, according to a new scientific study of multiple species. The research was published today (June 27) in the journal Cell Genomics. While the mushrooms had been thought to live by degrading dead organic material alone, the discovery suggests that they may instead have a collection of genes to enable them to adapt to different lifestyles as circumstances change, according to the researchers. Interestingly, they show that certain Mycena strains living in the Arctic have some of the largest mushroom genomes ever described. Genome Expansion in Mycena Mushrooms “As a group, Mycena has simply used every possible known trick from the playbook to expand their genomes and apparently for multiple different purposes that are not obviously connected to their known, supposedly preferred lifestyle,” says Christoffer Bugge Harder. With an original base for the work at the University of Oslo, Norway, he served as the lead author of a 28-person author team from universities in seven countries. Mycena epipterygia. Credit: Arne Aronsen “Evolution tells us that non-advantageous traits tend to disappear over time, so an obvious implication is that adaptability and generalism in those large genome structures must be an advantage for these fungi,” says Francis Martin of the INRAE and the University of Lorraine in Champenoux, France. “This is despite the costs of having a large genome with lots of possibly unnecessary features that must be replicated in each cell division. This may be particularly true in an extreme environment like the Arctic, as also seen in plants.” The Role of Mycena in Ecosystems and Their Genome Sequencing The researchers set out to study Mycena based on their role as a main mushroom decomposer of litter and leaves in forest ecosystems. Despite their tiny fruiting bodies, Mycena have an important role in the global carbon cycle. This group of mushrooms had long been thought to live purely on dead organic material, but more recently it was found some species also make a living through cooperative or parasitic interactions with living plants. Mycenas are also bioluminescent—i.e., they glow in the dark—and earlier work describing the genomes of five Mycena species had investigated this phenomenon. To learn more about their direct lifestyle habits, the researchers now wanted to study a broad palette of Mycena species with different preferences for substrates. Exploring Genome Diversity in Mycena Species In the new study, they generated new genome sequences for 24 additional Mycena species and a related species now known as Atheniella floridula. The genomes were sequenced and annotated through the DOE Joint Genome Institute’s Community Science Program. The work is part of the 1000 Fungal Genomes project, which aims to explore genome diversity both across and within different groups of fungi, in this case the genus of Mycena. The species included represent six decayer categories: wood generalists, broadleaf wood decayers, grass litter generalists, broadleaf litter decayers, coniferous litter decayers, and overall litter generalists. It also included three Arctic species. They added their new genomes to 33 additional genomes from non-Mycena species. They wanted to understand how the genomes had evolved and expanded over evolutionary time and how species might differ in plant cell-wall-degrading enzymes based on their lifestyle habits. Surprising Genome Expansions and Their Evolutionary Implications They were surprised to find that Mycena showed massive genome expansions overall, affecting all gene families regardless of their expected habits. The expansion appeared to be driven by the emergence of novel genes as well as gene duplications, enlarged collections of genes that produce enzymes for degrading polysaccharides, the proliferation of transposable elements, and horizontal gene transfers from other fungal species. They also found that two species collected in the Arctic had the largest genomes by far, at a size that is two to eight times bigger than Mycena living in temperate zones. Observations of Adaptations in Arctic Mycena Species “It was a particular surprise that both that the Arctic genomes were so especially expanded on top of the general Mycena expansion—and that Mycena had horizontally transferred genes from Ascomycetes,” Harder says. “Those species are also found in temperate areas, and we cannot see conclusively from our results whether these species are large because of a specific species effect or because of an Arctic effect.” However, some Arctic plants have been shown to inflate their genomes with transposable elements or simply duplicate their entire genomes altogether compared to their close relatives in temperate areas, and it is of course tempting to suggest that a similar parallel evolution could be happening in Arctic mushrooms. “The evolutionary transition from decomposer to symbiotic fungi is generally believed to have happened in parallel in several fungal groups throughout the course of evolution millions of years ago,” says Håvard Kauserud of the University of Oslo, Norway. “However, with Mycena, we appear to be seeing this gradual process in action happening right in front of our eyes.” Reflections on Genome Sequencing and Ecological Deductions “We know from other lines of research that Mycena, contrary to many other fungi, can adopt more than one possible lifestyle. The findings suggests that these multiple possible lifestyles are reflected in their genome structures, too,” Harder says. The findings also have important implications for efforts to understand an organism’s habits from their genome sequences alone. “This serves as a reminder that one cannot always easily deduce the main ecology or lifestyle of a fungus just from sequencing their genomes,” Martin said. “This is quite important to remember in an age where DNA sequencing is becoming cheaper and cheaper and more and more ubiquitous while traditional hands-on organism knowledge is less widespread in younger generations of biologists and harder to obtain funding for.” Reference: “Extreme overall mushroom genome expansion in Mycena s.s. irrespective of plant hosts or substrate specializations” by Christoffer Bugge Harder, Shingo Miyauchi, Máté Virágh, Alan Kuo, Ella Thoen, Bill Andreopoulos, Dabao Lu, Inger Skrede, Elodie Drula, Bernard Henrissat, Emmanuelle Morin, Annegret Kohler, Kerrie Barry, Kurt LaButti, Asaf Salamov, Anna Lipzen, Zsolt Merényi, Botond Hegedüs, Petr Baldrian, Martina Stursova, Hedda Weitz, Andy Taylor, Maxim Koriabine, Emily Savage, Igor V. Grigoriev, László G. Nagy, Francis Martin and Håvard Kauserud, 27 June 2024, Cell Genomics. DOI: 10.1016/j.xgen.2024.100586

Researchers, including those from Johns Hopkins University, have successfully sequenced the Y chromosome, which is linked to male development. This breakthrough illuminates the genetic code of the Y chromosome and enhances understanding of male-specific development, fertility, and genetically-rooted diseases. The achievement, possible due to modern sequencing technologies, reveals structures of critical genes and offers the potential for personalized medicine advancements. A global team of scientists has fully sequenced the Y chromosome, enhancing our understanding of male development, fertility, and genetically-linked diseases. The chromosome associated with male development, which is the last mysterious piece of the human genome, has been fully sequenced by a team of more than 100 researchers around the world including Johns Hopkins University scientists. The achievement completes the Y chromosome’s genetic code and unveils key details that could provide a crisper picture of the role the chromosome plays in male-specific development, fertility, and genetically triggered diseases like cancer. The work was recently published in the journal Nature. “Now that we have this 100% complete sequence of the Y chromosome, we can identify and explore numerous genetic variations that could be impacting human traits and disease in a way that we weren’t able to do before,” said co-first author Dylan Taylor, a Johns Hopkins geneticist and doctoral candidate. The sequence of DNA that comprises chromosomes encodes the genes and genetic circuits that guide the development and function of all cells in living organisms. The Y chromosome has been particularly challenging to decode because of its repetitive molecular patterns, but new sequencing technology and bioinformatics algorithms allowed the team to resolve these DNA sequences. Unveiling Hidden Genetic Structures The team revealed the structures of sperm-regulating gene families and discovered 41 additional genes in the Y chromosome. They also unveiled the structures of genes thought to play significant roles in growth and functioning of the male reproductive system. “We completed the wiring diagram for all these genetic switches that get activated via the Y chromosome, many of which are critical to the genetic contributions to male development,” said author Michael Schatz, a Bloomberg Distinguished Professor in computer science, biology, and oncology at Johns Hopkins. “We are at a point where scientists can start using this map. We were previously blind to different parts of the genome and different mutations, but now that we can see the whole genome, we hope we can add new insights to the genetics of a lot of different diseases.” The Y chromosome, along with the X chromosome, is often discussed for its role in sexual development. While these chromosomes play a central role, the factors involved in human sexual development are spread across the genome and very complex, giving rise to the array of human sex characteristics found among male, female, and intersex individuals. These categories are not equivalent to gender, which is a social category. Additionally, recent work demonstrates that genes on the Y chromosome contribute to other aspects of human biology, such as cancer risk and severity. Contributions to the Genome Landscape The research was led by the National Human Genome Research Institute, part of the Telomere-to-Telomere consortium that in 2022 unveiled the complete sequence of a human genome a decades-in-the-making revelation expected to open new lines of molecular and genetic exploration. However, that work was done with two X chromosomes. Now, using a donor with both an X and a Y chromosome, the consortium built a complete blueprint of the Y chromosome and every element of its DNA. The new findings lay the foundation for high-quality genome assemblies that didn’t exist before, including for personalized genomes. “The genome is a very personal thing, it has the basic instructions for the building blocks of our development and what makes us human,” said co-author Rajiv McCoy, a Johns Hopkins assistant professor of biology. “We knew we had an incomplete picture up until now, but we can now see the entire genome from end to end for the first time.” The Johns Hopkins group compared the new Y chromosome sequence against the genetic data from thousands of people worldwide. Their analysis spotted errors in the previous reference genome, and showed how the new Y chromosome sequence will improve future studies of human DNA. They are integrating the new insights into studies of primates both to dig deeper into the evolution of the Y chromosome and to analyze clinically relevant genes that could influence personalized medicine for pancreatic cancer and other diseases. Related research: Complete Human Y Chromosome Sequence Assembled for the First Time The Full Story Behind Sequencing Humanity’s Most Elusive Chromosome Reference: “Assembly of 43 human Y chromosomes reveals extensive complexity and variation” by Pille Hallast, Peter Ebert, Mark Loftus, Feyza Yilmaz, Peter A. Audano, Glennis A. Logsdon, Marc Jan Bonder, Weichen Zhou, Wolfram Höps, Kwondo Kim, Chong Li, Savannah J. Hoyt, Philip C. Dishuck, David Porubsky, Fotios Tsetsos, Jee Young Kwon, Qihui Zhu, Katherine M. Munson, Patrick Hasenfeld, William T. Harvey, Alexandra P. Lewis, Jennifer Kordosky, Kendra Hoekzema, Human Genome Structural Variation Consortium (HGSVC), Rachel J. O’Neill, Jan O. Korbel, Chris Tyler-Smith, Evan E. Eichler, Xinghua Shi, Christine R. Beck, Tobias Marschall, Miriam K. Konkel and Charles Lee, 23 August 2023, Nature. DOI: 10.1038/s41586-023-06425-6 Funding: NIH/National Institutes of Health, National Science Foundation

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