Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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High-performance insole OEM Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam pillow ODM development service

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Memory foam pillow OEM factory China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand OEM insole and pillow supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene-infused pillow ODM Vietnam

Reconstructions of some Meso–Cenozoic brachiopods, showing adaptations to certain environments. Credit: Shunyi Shi A new study indicates that despite significant evolutionary innovations post-extinction, brachiopods failed to match the species diversity of molluscs, challenging assumptions about their adaptive success and shedding light on the complexities of biodiversity evolution. Researchers from the University of Bristol, the Open University, and the China University of Geosciences have discovered that while brachiopods were evolving in new directions, this did not lead to an increase in the number of species. The findings, published in Nature Ecology & Evolution, shed light on some core principles of the evolution of modern biodiversity. In current oceans, mollusks such as clams, oysters, and snails are hugely diverse, with over 50,000 species, whereas brachiopods are rare by comparison with only 394 species known. But this was not always the case. The team found that brachiopods were evolving new shell shapes and ecological behaviors following the end-Permian mass extinction which compromised their numbers. “In the Palaeozoic, from 540 to 250 million years ago, brachiopods ruled the seabed,” said Dr Zhen Guo of the China University of Geosciences, who led the study. “Brachiopods are sometimes called lamp shells, and they generally sit on the sea floor, filtering tiny food particles from seawater. Most of them are quite small–you could hold twenty of them in your hands; but others were big and thick-shelled and lived a long time. Their shells were anything from circular to widely stretched and they had either smooth shells or carried deep ridges and troughs.” Impact of the Permian Extinction “The brachiopods were hit very hard by the end-Permian mass extinction 252 million years ago,” said Professor Michael Benton of the University of Bristol’s School of Earth Sciences, a collaborator. “The group could have disappeared completely, and indeed from that point, mollusks just became more and more successful. For a long time, it was thought that the brachiopods remained rare because the survivors were stuck in just a few modes of life.” Dr Tom Stubbs of the Open University added: “In fact, the post-extinction brachiopods were innovating and trying new modes of life. One group, the terebratulids, were diversifying their body shapes and ecological functions from the end of the Permian to the present day, but their diversity did not increase.” Triassic brachiopod fossils; right: Recent brachiopod shells. Credit: Zhen Guo “This was quite unexpected,” said Professor Zhong-Qiang Chen of the China University of Geosciences. “Brachiopods were far from failures after the end-Permian extinction. They were evolving in new directions and exploring new modes of life, just as the mollusks were at the same time. But this did not turn into evolutionary success in terms of the number of species. Despite their bursts of evolution in form and function, they could not spread widely, and the exact reason remains unclear.” The new study is based on an analysis of a database of more than 1000 genera of brachiopods from the past 250 million years. For each genus, the analysts recorded dozens of measurements of the overall shape of the shells, their external sculpture, and internal anatomy. These features were analyzed together to provide measurements of the overall diversity of shapes for each major brachiopod group at each point in time. This measure of ‘diversity of shape’, usually called disparity, could then be compared from point to point in time to show a measure of shape innovation, and it can be compared with counts of the numbers of species or genera through the same time spans. “Our study took a huge amount of effort,” concluded Zhen Guo. “But it’s important to understand modern biodiversity in terms of the processes that lie behind it. “If we simply look at modern brachiopods, we have no understanding of their rich past history and how innovative they have been in evolutionary terms. But our discovery that disparity and diversity are decoupled in brachiopod history is new and unexpected. Brachiopods were pretty inventive in evolving new shell forms, but it did not translate into many new species.” Reference: “Morphological innovation did not drive diversification in Mesozoic–Cenozoic brachiopods” by Zhen Guo, Michael J. Benton, Thomas L. Stubbs and Zhong-Qiang Chen, 25 July 2024, Nature Ecology & Evolution. DOI: 10.1038/s41559-024-02491-9

A zooplankton (Daphnia dentifera) infected by the fungal parasite Metschnikowia bicuspidate. The microscopic fungal spores filling the body as visible as black fuzzy spots. Credit: Tara Stewart Merrill Whether it’s plankton exposed to parasites or people exposed to pathogens, a host’s initial immune response plays an integral role in determining whether infection occurs and to what degree it spreads within a population, new CU Boulder research suggests. The findings, published on May 13, 2021, in The American Naturalist, provide valuable insight for understanding and preventing the transmission of disease within and between animal species. From parasitic flatworms transmitted by snails into humans in developing nations, to zoonotic spillover events from mammals and insects to humans—which have caused global pandemics like COVID-19 and West Nile virus—an infected creature’s immune response is a vital variable to consider in calculating what happens next.     “One of the biggest patterns that we’re seeing in disease ecology and epidemiology is the fact that not all hosts are equal,” said Tara Stewart Merrill, lead author of the paper and a postdoctoral fellow in ecology. “In infectious disease research, we want to build host immunity into our understanding of how disease spreads.”  A zooplankton (Daphnia dentifera) not infected by fungal parasite Metschnikowia bicuspidate. Credit: Tara Stewart Merrill Invertebrates are common vectors for disease, which means they can transmit infectious pathogens between humans or from animals to humans. Vector-borne diseases, like malaria, account for almost 20% of all infectious diseases worldwide and are responsible for more than 700,000 deaths each year. Yet epidemiological studies have rarely considered invertebrate immunity and recovery in creatures that are vectors for human disease. They assume that once exposed to a pathogen, the invertebrate host will become infected.  But what if it was possible for invertebrates to fight off these diseases, and break the link in the chain that passes them on to humans? While observing a tiny species of zooplankton (Daphnia dentifera) throughout its lifecycle and exposure to a fungal parasite (Metschnikowia bicuspidata), the researchers saw this potential in action. Some of the plankton were good at stopping fungal spores from entering their bodies, and others cleared the infection within a limited window of time after ingesting the spores. “Our results show that there are several defenses that invertebrates can use to reduce the likelihood of infection, and that we really need to understand those immune defenses to understand infection patterns,” said Stewart Merrill. Tara Stewart Merrill. Credit: Loren Merrill Unexpected recovery  Stewart Merrill started this work in her first year as a doctoral student at the University of Illinois, studying this little plankton and its collection of defenses. It’s a gruesome process if the plankton fails to ward off the parasite: Its fungal spores attack the plankton’s gut, fill its body and grow until they are released when the host finally dies.  But she noticed something that had not been recorded before: Some of the doomed plankton recovered. Several years later, she has found that when faced with identical levels of exposure, the success or failure of these infections depends on the strength of the host’s internal defenses during this early limited window of opportunity.  Based on their observations of these individual outcomes, the researchers developed a simple probabilistic model for measuring host immunity that can be applied across wildlife systems, with important applications for diseases transmitted to humans by invertebrates.   “When immune responses are good, they act as a filter that reduces transmission,” said Stewart Merrill. “But any environmental change that degrades immunity can actually amplify transmission, because it will let all of that exposure go through and ultimately become infectious.”  It’s a model that can also apply to COVID-19, as research from CU Boulder has shown that not all hosts are the same in transmitting the coronavirus, and exposure does not directly determine infection.   COVID-19 is also believed to be the result of a zoonotic spillover, an infection that moved from animals into people, and similar probabilistic models could be advantageous in predicting the occurrence and spread of future spillover events, said Stewart Merrill.  Understanding prevention of infection  Stewart Merrill hopes that a better understanding of infections in a simple animal like plankton can be applied more broadly to invertebrates that matter for human health.  In Africa, Southeast Asia, as well as South and Central America, 200 million people suffer from infections caused by schistosomes—invertebrates more commonly known as parasitic flatworms. They cause illness and death, and significant economic and public health consequences, so much so that the World Health Organization considers them the second-most socioeconomically devastating parasitic disease after malaria.  They’re just one of many neglected tropical diseases transmitted to people by invertebrate hosts such as snails, mosquitoes and biting flies. These diseases infect a large portion of a population but occur in areas with low levels of sanitation that don’t have the economic resources to address those diseases, said Stewart Merrill.  Schistosomes live in freshwater environments that people use for their drinking water, laundry and bathing. So even though there are treatments, the next day a person can easily get reinfected just by accessing the water they need. By better understanding how the flatworms themselves succumb to or fight off infection, scientists like Stewart Merrill help us get closer to stopping the chain of transmission into humans.  “We really need to work on understanding prevention of infection, and what that risk is in those aquatic systems, rather than just cures for infection,” she said.  The good news is we can learn from the same invertebrates which infect us. In invertebrate hosts that suffer or die from their infections, there is a good incentive to learn how to build an immune response and fight it off. Some snails have even shown the ability to retain an immunological memory: If they get infected once and survive, then they might never get infected again.  “If we can better understand how the environment shapes those defenses, we could predict into the future how environmental changes might amplify or suppress risk of transmission to people,” said Stewart Merrill.  Reference: “Host controls of within-host disease dynamics: insight from an invertebrate system” by Tara Stewart Merrill, Zoi Rapti and Carla E Cáceres, 13 May 2021, The American Naturalist. DOI: 10.1086/715355 Additional authors on this paper include Zoi Rapti and Carla Cáceres at the University of Illinois.

Artwork depicting various sequences of single-stranded DNA being cleaved by distinct bacterial homologs of the novel Ssn enzyme family.  Credit: Ella Maru Studio An INRS research team has identified a new family of enzymes that can make precise cuts in single-stranded DNA. A few years ago, the introduction of CRISPR technology marked a significant breakthrough in the scientific community. Derived from a component of the bacterial immune system, CRISPR enables precise cuts in double-stranded DNA, allowing scientists to modify specific genes in plants, animals, and humans. This precision has made CRISPR a leading tool in the development of treatments for both inherited and acquired diseases. More recently, Professor Frédéric Veyrier and his team at the Institut national de la recherche scientifique (INRS) have developed a new genetic tool based on a family of enzymes known as Ssn. Unlike CRISPR, this tool targets and cuts only single-stranded DNA, offering a new level of specificity in genetic editing. The results of their work were recently published in the journal Nature Communications. This major breakthrough sheds light on a crucial genetic mechanism that could revolutionize a multitude of biotechnology applications. A form of DNA with a key role Single-stranded DNA is less common than double-stranded DNA. It is often found in some viruses and plays a key role in certain biological processes, such as cell replication or repair. Single-stranded DNA is also used in many technologies (sequencing, gene editing, molecular diagnostics, nanotechnology). To date, no endonuclease – enzyme that cuts DNA – has been described as exclusively targeting a single-stranded DNA sequence, which has constituted a barrier to the development of technologies based on this type of DNA. Now, for the first time in a laboratory, Professor Veyrier’s team has identified a family of enzymes capable of cutting a specific sequence in single-stranded DNA: the family of Ssn endonucleases. To achieve this, the research team at INRS’s Armand-Frappier Santé Biotechnologie Research Centre first characterized a new family of endonucleases part of the GIY-YIG superfamily called Ssn. More specifically, researchers focused on one of these enzymes in the bacterium Neisseria meningitidis, also known as the meningococcus. The enzyme targeted in the study is crucial to the exchange and alteration of genetic material, which influences evolution. “In studying it, we found that it recognizes a specific sequence that is found in many instances in its genome and plays a key role in the natural transformation of the bacterium. This interaction directly influences the dynamics of the bacterial genome,” explains Professor Veyrier, a specialist in genomic bacteriology and evolution. In addition to this fundamental discovery, INRS’s research scientists identified thousands of other similar enzymes. “We demonstrated that they are able to recognize and specifically cut their own single-stranded DNA sequence. Thousands of enzymes therefore have this property with their own specificity,” adds Alex Rivera-Millot, a postdoctoral fellow on Professor Veyrier’s team and co-first author of the study. An undeniable asset for health research These results, which represent a new tool for DNA recognition and exchange, are significant. They pave the way to many novel applications in biology and medicine. On the one hand, understanding this mechanism could help better control the bacteria in question and the associated infections. On the other, the discovery of enzymes specific to single-stranded DNA makes it possible to develop more precise and efficient genetic manipulation tools. This could namely improve methods of gene editing, DNA detection, and molecular diagnosis. These enzymes could also be used to detect and manipulate DNA in various medical and industrial applications, such as pathogen detection or genetic manipulation for medical and therapeutic purposes. All of these avenues hold significant promise for addressing many health issues. Currently, there is a patent pending for the results of this work. Reference: “Discovery of the widespread site-specific single-stranded nuclease family Ssn” by Martin Chenal, Alex Rivera-Millot, Luke B. Harrison, Ahmed S. Khairalla, Cecilia Nieves, Ève Bernet, Mansoore Esmaili, Manel Belkhir, Jonathan Perreault and Frédéric J. Veyrier, 10 March 2025, Nature Communications. DOI: 10.1038/s41467-025-57514-1 This work was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Research (CIHR) and the Fonds de recherche du Québec – Santé (FRQS).

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