Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Taiwan OEM/ODM hybrid insole services

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Custom foam pillow OEM production factory in Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Private label insole and pillow OEM Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene-infused pillow ODM Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Eco-friendly pillow OEM manufacturer Thailand

Anxious individuals utilize a less suitable section of the forebrain when making decisions in socially challenging situations compared to non-anxious people, according to a recent study of brain scans. This difference in brain activity can lead anxious people to avoid social situations, hindering their ability to learn from such experiences. In socially challenging situations, individuals with anxiety tend to utilize a different part of the forebrain compared to those without anxiety. In socially challenging situations, individuals with anxiety tend to utilize a different region of the forebrain than those without anxiety. This can be seen in brain scans, as shown by the research of Bob Bramson and Sjoerd Meijer at the Donders Institute of Radboud University. For example, an anxious and a non-anxious person both run into someone whom they’ve been in love with for quite some time. Both of them find this tense and both would like to ask the person out on a date. But do you walk up to that person? Or do you pretend not to see them to avoid embarrassment? Whereas the non-anxious person can put aside this emotion and choose behavior that allows them to approach the potential lover, this is much more difficult for an anxious person. Bramson: “Anxious people use a less suitable section of the forebrain for this control. It’s more difficult for them to choose alternative behavior, so they avoid social situations more often.” Decisions like this demand a balancing act between a possible threat and a reward, a decision that non-anxious people make in the prefrontal cortex. Researchers at Radboud University have now shown that socially anxious people use a different section in the forebrain for decisions like this. Brain Scans Bramson and Meijer studied brain scans to see what happens in anxious and non-anxious people in a simulated social situation. “Our trial subjects were shown happy and angry faces and had to first move a joystick towards the happy face and away from the angry face. At a certain point they had to do the reverse: move towards an angry face and away from a happy face. This demands control over our automatic tendency to avoid negative situations.” Anxious people proved to perform just as well as non-anxious people in this simple task, but the scans showed that a completely different section of the brain was active. “In non-anxious people, we often see that, during emotional control, a signal is sent from the foremost section of the prefrontal cortex to the motor cortex, the section of the brain that directs your body to act. In anxious people, a less efficient section of that foremost section is used.” Other scans showed that the reason for this is probably because the ‘correct’ section becomes overstimulated in anxious people. “This could explain why anxious people find it difficult to choose alternative behavior and thus avoid social situations. The disadvantage of this is that they never learn that social situations aren’t as negative as they think.” Treating Anxiety For the first time, brain scans have now shown that the forebrain of anxious people works differently from that of non-anxious people with regard to control of emotional behavior. The researchers think that the results could be used to develop new treatments for people with anxiety. Reference: “Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex” by Bob Bramson, Sjoerd Meijer, Annelies van Nuland, Ivan Toni and Karin Roelofs, 12 August 2023, Nature Communications. DOI: 10.1038/s41467-023-40666-3

Researchers at the University of Cologne discovered that stick insects’ depressor muscle neurons are uniquely excited in a rhythmic pattern, challenging the belief that all motor neurons are uniformly activated by central pattern generators. This finding highlights the specialized neural control required for stabilizing walking movements. A recent study conducted by researchers at the University of Cologne has shed light on how nerve cells (neurons) that regulate the movement of leg muscles in stick insects operate in a rhythmic manner. The team discovered that the neurons responsible for triggering the depressor muscle in the leg exhibit a rhythmic activation pattern, which is distinct from the activation patterns of neurons associated with other leg muscles. So far, it has been assumed that all of these so-called motor neurons are activated in the same way by central neural networks. The study was published under the title ‘The synaptic drive of central pattern-generating networks to leg motor neurons of a walking insect is motor neuron pool specific’ in the journal Current Biology. Understanding Central Pattern Generators The UoC research team investigates the neural foundations of motion generation in animals, in particular those underlying locomotor activities such as walking. For this purpose, the team led by Professor Dr Ansgar Büschges analyses insects, among other arguments, as the requirements for the nervous system regarding the generation and control of walking movements are very similar across the animal kingdom. In many animals, for example, there are networks in the central nervous system that form the basis for the generation of rhythmic activity patterns for many forms of movements, whether for rhythmic locomotor activity such as running, swimming, crawling, and flying or for vegetative functions such as breathing. These highly specialized networks are referred to as central pattern generators (CPGs). They generate the rhythmic motor activity of the muscles for movement in interaction with information from sensory organs, neurons called proprioceptors; proprioceptors report movements and inform the central nervous system. In the case of walking, they are located on and in the insect’s legs. The networks do this by activating the so-called motor neurons that innervate the muscles. So far, it was assumed that such CPGs have the same influence on all motor neurons they target. In their new study, Angelina Ruthe, Dr Charalampos Mantziaris, and Professor Büschges disproved this assumption about the locomotor activity of insects. New Insights from Stick Insect Research In their experiments, the scientists pharmacologically activated the CPGs in the central nervous system of the stick insect Carausius morosus and investigated their influence on the motor neurons that innervate its leg muscles. They found that all motor neuron groups of the leg muscles, except one, receive identical drive from the networks: rhythmic inhibitory signals from the CPGs. Only the motor neurons, which innervate the depressor muscle of the leg, are controlled by phasic excitatory drive. Interestingly, the leg depressor muscle is precisely the muscle of the insect that is responsible for generating leg stance during any walking situation – regardless of whether the animal runs up or down horizontally, on the ceiling, or on a branch. “The rhythmic excitation and thus the specific activation of this motor neuron pool by the CPGs could serve to ensure the exact timing of the contraction of the depressor muscle and thus the start of the stance phase and its stabilization,” explained Professor Büschges. Reference: “The synaptic drive of central pattern-generating networks to leg motor neurons of a walking insect is motor neuron pool specific” by Angelina Ruthe, Charalampos Mantziaris and Ansgar Büschges, 1 February 2024, Current Biology. DOI: 10.1016/j.cub.2024.01.026 The study was funded by the German Research Foundation (DFG).

The first entirely complete sequence of a human genome, covering every chromosome from end to end without gaps and with unparalleled accuracy, is now available. Parts of the human genome now available to study for the first time are important for understanding genetic diseases, human diversity, and evolution. The first truly complete sequence of a human genome, covering each chromosome from end to end with no gaps and unprecedented accuracy, is now accessible through the UCSC Genome Browser and is described in six papers published today (March 31, 2022) in Science. Since the first working draft of a human genome sequence was assembled at UC Santa Cruz in 2000, genomics research has led to enormous advances in our understanding of human biology and disease. Nevertheless, crucial regions accounting for some 8% of the human genome have remained hidden from scientists for over 20 years due to the limitations of DNA sequencing technologies. Karen Miga, assistant professor of biomolecular engineering at UC Santa Cruz, and Adam Phillippy at the National Human Genome Research Institute (NHGRI) organized an international team of scientists—the Telomere-to-Telomere (T2T) Consortium—to fill in the missing pieces. Their efforts have now paid off. The new reference genome, called T2T-CHM13, adds nearly 200 million base pairs of novel DNA sequences, including 99 genes likely to code for proteins and nearly 2,000 candidate genes that need further study. It also corrects thousands of structural errors in the current reference sequence. The gaps now filled by the new sequence include the entire short arms of five human chromosomes and cover some of the most complex regions of the genome. These include highly repetitive DNA sequences found in and around important chromosomal structures such as the telomeres at the ends of chromosomes and the centromeres that coordinate the separation of replicated chromosomes during cell division. The new sequence also reveals previously undetected segmental duplications, long stretches of DNA that are duplicated in the genome and are known to play important roles in evolution and disease. “These parts of the human genome that we haven’t been able to study for 20-plus years are important to our understanding of how the genome works, genetic diseases, and human diversity and evolution,” Miga said. It took almost twice as long to finish the last 8% of the human genome as it did to sequence the first 92%. New laboratory and computational technologies finally enabled Miga and her colleagues to overcome obstacles such as highly repetitive DNA sequences in order to fill in the remaining gaps. Credit: NHGRI Many of the newly revealed regions have important functions in the genome even if they do not include active genes. “There is a profound advantage to seeing the whole genome as a complete system. It puts us in a position to unravel how that system works,” said David Haussler, director of the UC Santa Cruz Genomics Institute. “We’ve gotten an enormous understanding of human biology and disease from having roughly 90 percent of the human genome, but there were many important aspects that lay hidden, out of view of science, because we did not have the technology to read those portions of the genome. Now we can stand at the top of the mountain and see all of the landscape below and get a complete picture of our human genetic heritage.” The T2T genome sequence, representing the finished CHM13 genome plus the recently finished T2T Y chromosome (CHM13 includes an X but not a Y chromosome), is now a new reference genome in the UCSC Genome Browser. The T2T sequence is fully annotated in the browser, providing an efficient way for scientists to access and visualize a wealth of information associated with genes and other elements of the genome. “We wanted to put the information out in a way that is accessible and familiar to researchers so they can begin to build on it and use all the tools and resources the browser provides,” Miga explained. Karen Miga, assistant professor of biomolecular engineering at UC Santa Cruz, co-led the Telomere-to-Telomere (T2T) Consortium, which has released the first complete, gapless assembly of a human genome sequence. Credit: Photo by Carolyn Lagattuta The new T2T reference genome will complement the standard human reference genome, known as Genome Reference Consortium build 38 (GRCh38), which had its origins in the publicly funded Human Genome Project and has been continually updated since the first draft in 2000. Building Towards a Human Pangenome Reference “We’re adding a second complete genome, and then there will be more,” explained Haussler. “The next phase is to think about the reference for humanity’s genome as not being a single genome sequence. This is a profound transition, the harbinger of a new era in which we will eventually capture human diversity in an unbiased way.” The T2T Consortium has now joined with the Human Pangenome Reference Consortium, which aims to create a new “human pangenome reference” based on the complete genome sequences of 350 individuals. “Pangenomics is about capturing the diversity of the human population, and it’s also about ensuring we’ve captured the whole genome properly,” said Benedict Paten, associate professor of biomolecular engineering at UCSC, a coauthor of the T2T papers, and a leader of the pangenomics effort. “Without having a map of these difficult-to-sequence regions of the genome across multiple individuals, then we’re missing a huge amount of the variation present in our population. T2T sets us up to look across hundreds of genomes from telomere to telomere. It’s going to be great!” The standard reference genome (GRCh38) does not represent any one individual but was assembled from multiple donors. Merging them into one linear sequence created artificial structures in the sequence. The Human Pangenome Project will make it possible to compare newly sequenced genomes to multiple complete genomes representing a range of human ancestries. Improving Genetic Variant Analysis with the T2T Genome An important outcome of the new T2T sequence is enabling more accurate assessments of genetic variants. When human genomes are sequenced for clinical studies to understand the role of genetic variants in disease or to study genetic diversity within and between human populations, they are nearly always analyzed by aligning the sequencing results with the reference genome for comparison. The T2T variant team documented major improvements in identifying and interpreting genetic variants using the new T2T sequence compared to the standard human reference genome. “The new human genome is incredibly accurate at the base level, allowing us to flag hundreds of thousands of variants that had been misinterpreted by mapping them to the standard reference. Many of these new variants are in genes known to contribute to disease. We can now spot those because we have a more complete and accurate reference genome,” Miga said. Miga’s research has focused on satellite DNA, the long stretches of repetitive DNA sequences found mostly in and around telomeres and centromeres. The centromeres separate each chromosome into a short arm and a long arm and hold duplicated chromosomes together prior to cell division. “The centromeres play a critical role in how chromosomes segregate properly during cell division, and we’ve known for some time now that they are misregulated in all kinds of human diseases. But we’ve never been able to study them at the sequence level,” Miga said. “By far the largest portion of new sequences added to the reference are centromere satellite DNAs. For the first time, we can study ‘base-by-base’ the sequences that define the centromere and can start to understand how it works.” Long-Read Sequencing Technologies Powering the T2T Effort “Long-read” DNA sequencing technologies, such as the nanopore sequencing pioneered at UC Santa Cruz, were essential tools for the T2T Consortium. Two long-read sequencing datasets—high fidelity reads (HiFi data from PacBio systems) and extremely long reads that routinely reach lengths greater than 100,000 base pairs (ultra-long data from Oxford Nanopore devices)—enabled T2T researchers to span repetitive regions and develop strategies to ensure that the assembly was highly accurate. Miten Jain and other UCSC Genomics Institute researchers helped establish the ultra-long read protocol. UC Santa Cruz has a long history of leadership in genomics, starting with a seminal meeting in 1985 to discuss the sequencing of the human genome organized at UCSC by then-Chancellor Robert Sinsheimer. Haussler was invited to join the public Human Genome Project in 1999, and his team played a crucial role in its completion. At the time, James Kent, now a research scientist at the Genomics Institute and director of the UCSC Genome Browser project, was a UCSC graduate student. He wrote the code that assembled the first working draft of the human genome from data obtained by the International Human Genome Sequencing Consortium, and UCSC posted the draft online for the whole world to access. Kent then created the UCSC Genome Browser, still the most widely used platform to access the human genome. The UC Santa Cruz Genomics Institute has continued to be at the forefront of genomics research and plays a leading role in the T2T and pangenomics efforts. “The T2T work reflects the sustained and dedicated efforts of many people at UC Santa Cruz and elsewhere. Karen Miga has been working hard to get real centromere sequences into the human genome assemblies for a decade, and this has finally come to fruition!” said Kent. “I’m very excited to see this work combined with efforts to get telomere-to-telomere sequences from other human ancestries. We are moving quickly towards a truly complete representation of the human genome.” Reference: “The complete sequence of a human genome” by Sergey Nurk, Sergey Koren, Arang Rhie, Mikko Rautiainen, Andrey V. Bzikadze, Alla Mikheenko, Mitchell R. Vollger, Nicolas Altemose, Lev Uralsky, Ariel Gershman, Sergey Aganezov, Savannah J. Hoyt, Mark Diekhans, Glennis A. Logsdon, Michael Alonge, Stylianos E. Antonarakis, Matthew Borchers, Gerard G. Bouffard, Shelise Y. Brooks, Gina V. Caldas, Nae-Chyun Chen, Haoyu Cheng, Chen-Shan Chin, William Chow, Leonardo G. de Lima, Philip C. Dishuck, Richard Durbin, Tatiana Dvorkina, Ian T. Fiddes, Giulio Formenti, Robert S. Fulton, Arkarachai Fungtammasan, Erik Garrison, Patrick G. S. Grady, Tina A. Graves-Lindsay, Ira M. Hall, Nancy F. Hansen, Gabrielle A. Hartley, Marina Haukness, Kerstin Howe, Michael W. Hunkapiller, Chirag Jain, Miten Jain, Erich D. Jarvis, Peter Kerpedjiev, Melanie Kirsche, Mikhail Kolmogorov, Jonas Korlach, Milinn Kremitzki, Heng Li, Valerie V. Maduro, Tobias Marschall, Ann M. McCartney, Jennifer McDaniel, Danny E. Miller, James C. Mullikin, Eugene W. Myers, Nathan D. Olson, Benedict Paten, Paul Peluso, Pavel A. Pevzner, David Porubsky, Tamara Potapova, Evgeny I. Rogaev, Jeffrey A. Rosenfeld, Steven L. Salzberg, Valerie A. Schneider, Fritz J. Sedlazeck, Kishwar Shafin, Colin J. Shew, Alaina Shumate, Ying Sims, Arian F. A. Smit, Daniela C. Soto, Ivan Sovic, Jessica M. Storer, Aaron Streets, Beth A. Sullivan, Françoise Thibaud-Nissen, James Torrance, Justin Wagner, Brian P. Walenz, Aaron Wenger, Jonathan M. D. Wood, Chunlin Xiao, Stephanie M. Yan, Alice C. Young, Samantha Zarate, Urvashi Surti, Rajiv C. McCoy, Megan Y. Dennis, Ivan A. Alexandrov, Jennifer L. Gerton, Rachel J. O’Neill, Winston Timp, Justin M. Zook, Michael C. Schatz, Evan E. Eichler, Karen H. Miga and Adam M. Phillippy, 31 March 2022, Science. DOI: 10.1126/science.abj6987 Miga is a co-corresponding author of the main Science paper, “The complete sequence of a human genome,” along with Adam Phillippy at NHGRI and Evan Eichler at the University of Washington. She is also a co-corresponding author of the papers on “Complete genomic and epigenetic maps of human centromeres” and “Epigenetic patterns in a complete human genome,” and a coauthor of the papers on “Segmental duplications and their variation in a complete human genome,” “A complete reference genome improves analysis of human genetic variation,” and “From telomere to telomere: the transcriptional and epigenetic state of human repeat elements.” Other researchers at the UC Santa Cruz Genomics Institute who are coauthors of the papers include Benedict Paten, Mark Diekhans, Erik Garrison (now at University of Tennessee Health Science Center), Marina Haukness, Miten Jain, and Kishwar Shafin. This work was supported by the National Institutes of Health.

DVDV1551RTWW78V