Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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China custom product OEM/ODM services

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China ergonomic pillow OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Insole ODM factory in Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene sheet OEM supplier factory Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.PU insole OEM production factory in Taiwan

Scripps Research scientists have developed a simpler method to add new amino acids to proteins using four-nucleotide codons, creating novel peptides with potential applications in drug discovery and beyond. Credit: SciTechDaily.com Scripps Research scientists have created a method using four-nucleotide codons to incorporate non-canonical amino acids into proteins, expanding protein engineering possibilities without requiring genome-wide edits. This method has been tested in creating new peptides and holds potential for applications in various fields. In every introductory biology class, it’s a fundamental concept: proteins are made from combinations of 20 distinct amino acids, arranged in various sequences like words. However, researchers aiming to engineer biological molecules with novel functions have long found these 20 building blocks restrictive. As a result, they have sought ways to incorporate new components—known as non-canonical amino acids—into proteins. Now, scientists at Scripps Research have designed a new paradigm for easily adding non-canonical amino acids to proteins. Their approach, described in Nature Biotechnology on September 11, 2024, revolves around using four RNA nucleotides—rather than the typical three—to encode each new amino acid. A New Approach to Protein Engineering “Our goal is to develop proteins with tailored functions for applications in fields spanning bioengineering to drug discovery,” says senior author Ahmed Badran, PhD, an assistant professor of chemistry at Scripps Research. “Being able to incorporate non-canonical amino acids into proteins with this new method gets us closer to that goal.” For a cell to produce any given protein, it must translate a strand of RNA into a string of amino acids. Every three nucleotides of RNA, called a codon, correspond to one amino acid. But many amino acids have more than one possible codon; for instance, RNA reading the sequences UAU and UAC both correspond to the amino acid tyrosine. It’s the job of small molecules called transfer RNAs (tRNAs) to link each amino acid to its corresponding codons. Examples of the >100 macrocycles generated in this study. Colored components represent new-to-nature amino acids that were incorporated into either peptide. Credit: Scripps Research Recently, researchers aiming to add completely new amino acids to a protein have created strategies to reassign a codon. For instance, the UAU codon could be linked to a new amino acid by changing the tRNA for UAU; this would result in UAU being read by the cell as corresponding to a building block other than tyrosine. But at the same time, every instance of UAU in the cell’s genome would need to become UAC, in order to prevent the new amino acid from being integrated into thousands of other proteins where it doesn’t belong. “Creating free codons by whole genome recoding can be a powerful strategy, but it can also be a challenging undertaking since it requires considerable resources to build new genomes,” says Badran. “For the organism itself, it can be difficult to predict how such codon changes influence genome stability and host protein production.” Introducing Four-Nucleotide Codons Badran and his colleagues wanted to create an efficient plug-and-play strategy that would only incorporate the chosen non-canonical amino acid(s) into specific sites in a target protein, without disrupting the cell’s normal biology or requiring the entire genome to be edited. That meant using tRNA that wasn’t already assigned to an amino acid. Their solution: a four-nucleotide codon. The team knew that in a few situations—such as bacteria quickly adapting to resist drugs—four-nucleotide codons had naturally evolved. So, in their new work, the researchers studied what caused cells to use a codon with four nucleotides rather than three. They discovered that the identities of the sequences nearby to the four-base codon were critical—frequently used codons enhanced how the cell could read a four-nucleotide codon to incorporate a non-canonical amino acid. Badran’s group then tested whether they could alter the sequence of a single gene so that it had a new four-nucleotide codon that would be correctly used by the cell. The method worked: When the researchers surrounded a target site with three-letter, frequently used codons and maintained sufficient levels of the four-nucleotide tRNA, the cell incorporated any new amino acid that was attached to the corresponding four-letter tRNA. The research team repeated the experiment with 12 different four-nucleotide codons and then used the technique to design more than 100 new cyclic peptides—called macrocycles—with up to three non-canonical amino acids in each. “These cyclic peptides are reminiscent of bioactive small molecules that one might find in nature,” says Badran. “By capitalizing on the programmability of protein synthesis and the diversity of building blocks accessible by this approach, we can create new-to-nature small molecules that will have exciting applications in drug discovery.” Benefits of the New Method He adds that, compared with previous approaches to non-canonical amino acid incorporation, this new method is easy to use since it involves altering only one gene rather than a cell’s entire genome. Additionally, more non-canonical amino acids could be used in a single protein since there are more possible four-nucleotide codons than three-nucleotide ones. “Our results suggest that one can now easily and effectively incorporate non-canonical amino acids at diverse sites in a wide array of proteins,” says Badran. “We’re excited about these possibilities for our ongoing work and to provide this capability to the broader community.” He notes that the technique could be used to re-engineer existing proteins—or create entirely new ones—that have utility in a range of sectors, including medicine, manufacturing and chemical sensing. Reference: “Efficient genetic code expansion without host genome modifications” by Alan Costello, Alexander A. Peterson, David L. Lanster, Zhiyi Li, Gavriela D. Carver and Ahmed H. Badran, 11 September 2024, Nature Biotechnology. DOI: 10.1038/s41587-024-02385-y This work was supported by funding from the National Institutes of Health (DP5-OD024590), the Research Corporation for Science Advancement, the Sloan Foundation (G-2023-19625), the Thomas Daniel Innovation Fund (627163_1), an Abdul Latif Jameel Water and Food Systems Lab Grand Challenge Award (GR000141-S6241), a Breakthrough Energy Explorer Grant (GR000056), the Foundation for Food & Agriculture Research (28-000578), a Homeworld Collective Garden Grant (GR000129), the Army Research Office (81341- BB-ECP), the Hope Funds for Cancer Research (HFCR-23-03-01), a Skaggs-Oxford Scholarship and a Fletcher Jones Foundation Fellowship.

New research has demonstrated that seaweed, long used as an indicator of coral reef health, may be providing misleading information. The study, which analyzed data from over 1,200 oceanic sites, suggests that different species of macroalgae react differently to contamination, potentially obscuring signs of reef stress and misdirecting conservation efforts. New research shows that seaweed is an unreliable indicator of reef health, as different species respond uniquely to environmental stress, potentially obscuring human impact. Scientists have been using seaweed as an indicator of coral reef health for decades. But what if the seaweed was misleading them? New University of British Columbia research reveals it was, and scientists need new ways to determine whether human activity is harming a particular reef. “This is especially critical today, given that reefs globally are threatened by climate-driven stressors,” said Dr. Sara Cannon, a postdoctoral fellow at the UBC Institute for the Oceans and Fisheries and the study’s lead author. Local Species Behave Differently Seaweed belongs to a group of organisms called macroalgae. Macroalgae at the ocean’s surface has long served as a proxy for reef health, because it is relatively quick and easy to measure. Since the 1970s, scientists have assumed that local human impacts increase macroalgae while simultaneously damaging underlying reefs. However, the study just published in Global Change Biology looked at data from over 1,200 sites in the Indian and Pacific Oceans over a 16-year period and revealed that this approach is misleading and may even have hidden signs of reef stress. For example, macroalgae coverage depends heavily on the species growing in a particular area. Sargassum is less likely to grow in water contaminated by agricultural runoff, but Halimeda will thrive. In both cases, a reef will suffer. The global research team concluded that using macroalgae coverage as an indicator of local human impacts can actually obscure how much our actions are harming reefs, and cause scientists to misidentify the reefs most in need of intervention. Reference: “Macroalgae exhibit diverse responses to human disturbances on coral reefs” by Sara E. Cannon, Simon D. Donner, Angela Liu, Pedro C. González Espinosa, Andrew H. Baird, Julia K. Baum, Andrew G. Bauman, Maria Beger, Cassandra E. Benkwitt, Matthew J. Birt, Yannick Chancerelle, Joshua E. Cinner, Nicole L. Crane, Vianney Denis, Martial Depczynski, Nur Fadli, Douglas Fenner, Christopher J. Fulton, Yimnang Golbuu, Nicholas A. J. Graham, James Guest, Hugo B. Harrison, Jean-Paul A. Hobbs, Andrew S. Hoey, Thomas H. Holmes, Peter Houk, Fraser A. Januchowski-Hartley, Jamaluddin Jompa, Chao-Yang Kuo, Gino Valentino Limmon, Yuting V. Lin, Timothy R. McClanahan, Dominic Muenzel, Michelle J. Paddack, Serge Planes, Morgan S. Pratchett, Ben Radford, James Davis Reimer, Zoe T. Richards, Claire L. Ross, John Rulmal Jr., Brigitte Sommer, Gareth J. Williams and Shaun K. Wilson, 5 April 2023, Global Change Biology. DOI: 10.1111/gcb.16694

Congrio colorado (Genypterus chilensus) cusk-eels swim around a tubeworm mound near a methane seep. These fish — a commercially important fish highly valued in Chile — have been observed around reefs and soft-bottom mangrove ecosystems, but the importance of chemosynthetic ecosystems in sustaining their populations has not been previously observed. Credit: ROV SuBastian / Schmidt Ocean Institute An international team charts four previously unnamed underwater canyons, investigates nearly 20 methane seep ecosystems thriving in complete darkness, and discovers a stunning array of otherworldly creatures, including potential new species. An international team of scientists aboard the Schmidt Ocean Institute’s research vessel R/V Falkor (too) recently surveyed nearly 20 methane seeps, including several newly discovered sites, and explored four submarine canyon systems that had never before been seen by humans. Their findings revealed a rich abundance of marine life off the Chilean coast, including approximately 60 potentially new species thriving in diverse ecosystems. Among the discoveries were commercially valuable fish swimming in methane seep areas. The 55-day expedition traversed the Chilean coastline, from Valparaíso to Punta Arenas, exploring ocean habitats from central to southern Chile. This groundbreaking cruise was the first in the region to employ a remotely operated vehicle (ROV) to transmit real-time imagery. It was co-led by Dr. Jeffrey Marlow of Boston University (USA), Dr. Patricia Esquete of the University of Aveiro (Portugal), and Dr. Eulogio Soto of the University of Valparaíso (Chile). The team utilized advanced techniques, including sonar-based bubble mapping, bathymetric mapping, and in situ methane concentration measurements, to map the canyons and locate methane seeps. The expedition featured researchers from Chile, the United States, Portugal, Norway, Germany, the Netherlands, Spain, and Italy, marking a highly collaborative international effort. The Importance of Methane Seeps Methane seeps are chemosynthetic environments where methane bubbles up from the seafloor, feeding microbes that, in turn, support an array of life. While clues from water chemistry measurements and images from camera tows taken on previous expeditions to the region suggested the presence of some seeps off of Chile, many sites had not been fully surveyed and sampled before. In addition, several seep sites were entirely new to science. Some were in shallow waters, others in deep waters; some were in rocky areas, others were in sediment. “I was most impressed by how different the methane seeps in this area are from those we’ve studied in North America — and how distinct the sites we visited were from one day to the next,” said Marlow, a microbial ecologist who served as the expedition’s chief scientist. “The fact that we came across so many seeps in such a relatively small area suggests that they’re pervasive along the Chilean coast, serving as hubs for biodiversity and elemental cycling on a vast scale.” One observation the team was particularly impressed by was abundant red cusk-eels called congrio colorado (Genypterus chilensus) — a commercially important fish that is highly valued in Chile — swimming in and around an 892-square-meter (9600-square-foot) tubeworm mound near a methane seep. Poet and Nobel Laureate Pablo Neruda celebrated this iconic Chilean fish; upon returning to the country from exile in 1954, he wrote an ode to the eel as a celebration of his home country and life. While these fish have been observed around reefs and soft-bottom mangrove ecosystems, there has been little documentation of their behavior swimming near methane seeps. Scientists require further research to understand the species’ relationship with methane seeps and to determine if these environments are essential to sustaining their populations. “These exploratory expeditions are incredible — and essential — opportunities for the science community to improve our understanding of the planet,” said Esquete. “After extensive sampling, we suspect our team has found at least 60 species new to science and will be working over the next few years to confirm this.” Unveiling Submarine Canyons and Extraordinary Discoveries The team explored four unnamed submarine canyons in southern Chile for the first time, mapping them to a high resolution. The largest of the canyons is approximately 2000 square kilometers (770 square miles) and the deepest is over 3000 meters deep (1.86 miles). Submarine canyons are critical ecosystems that connect land to the open ocean. The rocky canyon walls provide structures for habitat-building animals like glass sponges and deep-sea corals, which support species from tiny bristle stars to octopuses. An additional methane seep was discovered in one of the canyons near Chile’s triple junction, a place on the seafloor where three tectonic plates meet. Other notable observations included large congregations of Humboldt Squid feeding near the seeps, a sighting of a glowing anglerfish scientists are still working to identify, massive chemosynthetic clam beds, and a shimmering polychaete worm that garnered the attention of millions on social media during the expedition. “This expedition is yet another example of the tremendous value of bringing together cross-disciplinary science teams and cutting-edge technology to little-known regions of our global Ocean,” said Dr. Jyotika Virmani, executive director of Schmidt Ocean Institute. “The diverse marine life swimming contentedly in this geologically interesting ecosystem was beautiful to watch — a strong reminder that what is out of sight should perhaps not be out of mind.”

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