Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

ODM pillow factory in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene-infused pillow ODM Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Arch support insole OEM from Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Private label insole and pillow OEM Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand insole ODM for global brands

MIT biologists have found a possible explanation for the Warburg effect, first seen in cancer cells in the 1920s and named after Otto Warburg, pictured. Credit: Image: Digital collage by Jose-Luis Olivares; cancer image courtesy of Dr. Cecil Fox, NCI; Warburg photo courtesy of NIH MIT study sheds light on the longstanding question of why cancer cells get their energy from fermentation. In the 1920s, German chemist Otto Warburg discovered that cancer cells don’t metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative pathway, which is much less efficient. MIT biologists have now found a possible answer to this longstanding question. In a study appearing in Molecular Cell, they showed that this metabolic pathway, known as fermentation, helps cells to regenerate large quantities of a molecule called NAD+, which they need to synthesize DNA and other important molecules. Their findings also account for why other types of rapidly proliferating cells, such as immune cells, switch over to fermentation.  “This has really been a hundred-year-old paradox that many people have tried to explain in different ways,” says Matthew Vander Heiden, an associate professor of biology at MIT and associate director of MIT’s Koch Institute for Integrative Cancer Research. “What we found is that under certain circumstances, cells need to do more of these electron transfer reactions, which require NAD+, in order to make molecules such as DNA.” Vander Heiden is the senior author of the new study, and the lead authors are former MIT graduate student and postdoc Alba Luengo PhD ’18 and graduate student Zhaoqi Li. Inefficient Metabolism Fermentation is one way that cells can convert the energy found in sugar to ATP, a chemical that cells use to store energy for all of their needs. However, mammalian cells usually break down sugar using a process called aerobic respiration, which yields much more ATP. Cells typically switch over to fermentation only when they don’t have enough oxygen available to perform aerobic respiration. MIT researchers have shown that cancer cells’ demand for NAD+ drives them to switch to a wasteful metabolic process called fermentation. Credit: Courtesy of the researchers Since Warburg’s discovery, scientists have put forth many theories for why cancer cells switch to the inefficient fermentation pathway. Warburg originally proposed that cancer cells’ mitochondria, where aerobic respiration occurs, might be damaged, but this turned out not to be the case. Other explanations have focused on the possible benefits of producing ATP in a different way, but none of these theories have gained widespread support. In this study, the MIT team decided to try to come up with a solution by asking what would happen if they suppressed cancer cells’ ability to perform fermentation. To do that, they treated the cells with a drug that forces them to divert a molecule called pyruvate from the fermentation pathway into the aerobic respiration pathway. They saw, as others have previously shown, that blocking fermentation slows down cancer cells’ growth. Then, they tried to figure out how to restore the cells’ ability to proliferate, while still blocking fermentation. One approach they tried was to stimulate the cells to produce NAD+, a molecule that helps cells to dispose of the extra electrons that are stripped out when cells make molecules such as DNA and proteins. When the researchers treated the cells with a drug that stimulates NAD+ production, they found that the cells started rapidly proliferating again, even though they still couldn’t perform fermentation. This led the researchers to theorize that when cells are growing rapidly, they need NAD+ more than they need ATP. During aerobic respiration, cells produce a great deal of ATP and some NAD+. If cells accumulate more ATP than they can use, respiration slows and production of NAD+ also slows. “We hypothesized that when you make both NAD+ and ATP together, if you can’t get rid of ATP, it’s going to back up the whole system such that you also cannot make NAD+,” Li says. Therefore, switching to a less efficient method of producing ATP, which allows the cells to generate more NAD+, actually helps them to grow faster. “If you step back and look at the pathways, what you realize is that fermentation allows you to generate NAD+ in an uncoupled way,” Luengo says. Solving the Paradox The researchers tested this idea in other types of rapidly proliferating cells, including immune cells, and found that blocking fermentation but allowing alternative methods of NAD+ production enabled cells to continue rapidly dividing. They also observed the same phenomenon in nonmammalian cells such as yeast, which perform a different type of fermentation that produces ethanol. “Not all proliferating cells have to do this,” Vander Heiden says. “It’s really only cells that are growing very fast. If cells are growing so fast that their demand to make stuff outstrips how much ATP they’re burning, that’s when they flip over into this type of metabolism. So, it solves, in my mind, many of the paradoxes that have existed.” The findings suggest that drugs that force cancer cells to switch back to aerobic respiration instead of fermentation could offer a possible way to treat tumors. Drugs that inhibit NAD+ production could also have a beneficial effect, the researchers say. Reference: “Increased demand for NAD+ relative to ATP drives aerobic glycolysis” by Alba Luengo, Zhaoqi Li, Dan Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do, Raphael Ferreira, Adi Naamati, Ahmed Ali, Caroline A. Lewis, Craig J. Thomas, Stefani Spranger, Nicholas J. Matheson and Matthew G. Vander Heiden, 30 December 2020, Molecular Cell. DOI: 10.1016/j.molcel.2020.12.012 The research was funded by the Ludwig Center for Molecular Oncology, the National Science Foundation, the National Institutes of Health, the Howard Hughes Medical Institute, the Medical Research Council, NHS Blood and Transplant, the Novo Nordisk Foundation, the Knut and Alice Wallenberg Foundation, Stand Up 2 Cancer, the Lustgarten Foundation, and the MIT Center for Precision Cancer Medicine.

Southern right whales, like this mother and calf, can live for 130 years or more – almost twice as long as previously understood. Credit: Els Vermeulen Right whales can live over 130 years, but North Atlantic right whales average only 22 years due to human threats. The study underscores the importance of older whales in teaching survival skills and predicts slow recovery of populations, potentially spanning centuries. New research published in Science Advances reveals that right whales can live over 130 years—nearly twice as long as previously believed. This remarkable longevity aligns with that of their relatives, the bowhead whales, which are known for their exceptional lifespans. Scientists collaborating with Indigenous subsistence hunters in Utqiaġvik conducted chemical analyses of harvested bowhead whales, confirming they can live for over 200 years. Adding to this evidence, hunters have occasionally found 19th-century harpoon tips embedded in bowhead whales caught during modern hunts. Right whales, which are much more closely related to bowhead whales than any other species, appear to exhibit similar lifespans. Like bowheads, right whales filter feed through baleen and migrate seasonally to give birth. Whalers considered them the “right” whales to hunt due to their thick blubber, which caused them to float when killed. Photo Identification Data on Right Whales The current study examined four decades of data collected by photo identification programs tracking individual whales from two species: the Southern right whale, which lives in the oceans south of the equator, and the critically endangered North Atlantic right whale, found along the Atlantic coast of North America. Researchers used the data to construct survivorship curves — graphs that show the proportion of a population that survives to each age — similar to those used by insurance companies to calculate human life expectancies. Analysis revealed that Southern right whales, once thought to live only 70 to 80 years, can exceed lifespans of 130 years, with some individuals possibly reaching 150 years. In contrast, the study found the average lifespan of the North Atlantic right whale is just 22 years, with very few individuals surviving past the age of 50. According to University of Alaska Fairbanks associate professor Greg Breed, the stark contrast in lifespans between these two closely related species is primarily due to human impacts. Breed is the study’s lead author. “North Atlantic whales have unusually short lifespans compared to other whales, but this isn’t because of intrinsic differences in biology, and they should live much longer,” he said. “They’re frequently tangled in fishing gear or struck by ships, and they suffer from starvation, potentially linked to environmental changes we don’t fully understand.” Historical Underestimations of Whale Longevity Breed has spent years studying marine mammals, including seals, certain species of which can live up to 50 years, and narwhals, with lifespans of a century or more. He noted that a lack of data on whale aging led to significant underestimations of their lifespans in the past. “We didn’t know how to age baleen whales until 1955, which was the very end of industrial whaling,” Breed said. “By the time we figured it out, there weren’t many old whales left to study. So we just assumed they didn’t live that long.” The study has important implications for conservation efforts. “To attain healthy populations that include old animals, recovery might take hundreds of years,” Breed said. “For animals that live to be 100 or 150 and only give birth to a surviving calf every 10 years or so, slow recovery is to be expected.” The study also underscores the importance of cultural knowledge among whale populations. “There’s a growing recognition that recovery isn’t just about biomass or the number of individuals. It’s about the knowledge these animals pass along to the next generation,” Breed said. “That knowledge isn’t just genetic — it’s cultural and behavioral. Older individuals teach survival skills. Younger animals learn by observing and copying the strategies of the older ones.” The loss of older individuals disrupts this critical transfer of knowledge and can impair the survival of the young. Breed and his colleagues intend to extend their research to other whale populations and predict whether other whale species currently thought to live around 80 years may also have much longer lifespans. They hope to learn more about how whaling affected the number of old individuals in current whale populations and predict when their numbers will recover to pre-whaling levels. Reference: “Extreme longevity may be the rule not the exception in Balaenid whales” by Greg A. Breed, Els Vermeulen and Peter Corkeron, 20 December 2024, Science Advances. DOI: 10.1126/sciadv.adq3086

The rediscovered volcano mouse, thought to be extinct. Credit: (c) Danny Balete, Field Museum A small mouse rediscovered on a volcano that erupted 30 years ago provides hope for wildlife conservation in the Philippines. In June 1991, Mount Pinatubo, a volcanic peak on the Philippine Island of Luzon, literally blew its top. It was the second-most powerful volcanic eruption of the 20th century, ten times stronger than Mount Saint Helens, and its effects were devastating. Lava and ash spewed into the surrounding environment in the Zambales Mountains, pooling in layers up to 600 feet (180 meters) thick in the valleys. Following the eruption, powerful typhoons and monsoon rains triggered landslides and ash flows that continued for many months. Eight hundred people lost their lives, and the lush forests that covered the mountain prior to the eruption were destroyed or severely damaged. Rediscovering a Forgotten Mouse In recent years, scientists returned to the region to survey the surviving mammal populations, and in a new paper in the Philippine Journal of Science, the team announced the rediscovery of a species of mouse that had long been feared to be extinct. “When Pinatubo blew up, probably the last thing on anyone’s mind was that a little species of mouse was thought to live only on that one mountain, and might well have become extinct as a result. What we’ve learned subsequently really blew us away,” says Larry Heaney, the Negaunee Curator of Mammals at Chicago’s Field Museum and one of the paper’s authors. Ecosystem surrounding Mount Pinatubo, recovering after the eruption in 1990. Credit: (c) Danny Balete, Field Museum In early 2011 and again in 2012, twenty years after the eruption, Field Museum researcher Danilo (Danny) Balete went to Mt. Pinatubo to study its mammal fauna. Over the course of several months, Balete and his team of field assistants (including local men from the Aeta tribe) surveyed the mammals on the mountain, from the bottom to near the top where the forest had been devastated by the eruption. “Most of our field work on Luzon and elsewhere in the Philippines has been in natural forested habitats where mammals are most common,” says Eric Rickart, Curator of Vertebrates at the Natural History Museum of Utah and lead author on the paper, “but Danny couldn’t pass up an opportunity to see how mammals were faring on Mt. Pinatubo.” There were no surveys of the mammals on Mt. Pinatubo prior to the eruption. However, specimens housed in the US National Museum of Natural History provided some records from lower elevations around the mountain. “Most of these early records were for common species of bats collected in the 1950s,” says Heaney, “but one specimen was particularly intriguing-a small rodent that became the type specimen, and only example, of a new species described in 1962 as Apomys sacobianus, the Pinatubo volcano mouse.” Danny Balete, the researcher who led the fieldwork for this study, now deceased. Credit: (c) Field Museum Challenging Conditions, Unlikely Habitats Conditions on Mt. Pinatubo were very harsh, and the survey work by Balete’s team was both grueling and dangerous. Even after 20 years, evidence of the eruption was everywhere. The landscape was very unstable due to the constantly eroding ash and lahar deposits that made working in the steep terrain hazardous. It also greatly slowed the process of plant succession. Vegetation was a sparse mix of native and non-native plants, dense stands of grass (including bamboo), shrubs, low-growing vines, and few trees-all the characteristics of early stage second-growth habitat. It was a far cry from the old-growth tropical forest that covered the mountain before the eruption. Field surveys of small non-flying mammals elsewhere on Luzon have revealed that old-growth forests contain a great variety of native species and few, if any, non-native “pest” species of rats. But in heavily disturbed second-growth habitats, particularly areas near croplands, the reverse is the case-non-native rats are most abundant, and there are only a few hardy native species. “We thought the work on Pinatubo would confirm this general pattern, so we expected to see few if any of the native species,” says Rickart. A specific motivation for the Pinatubo survey was to discover the fate of Apomys sacobianus, the Pinatubo volcano mouse. “After the eruption of Pinatubo, we looked for this mouse on other peaks in the Zambales Mountains but failed to find it,” notes Heaney, “suggesting a very limited geographic distribution for the species. We thought the volcano might be the only place this mouse lived.” And based on expectations from islands elsewhere, at the time it seemed possible that the species might have been lost because of the eruption. However, the survey of Pinatubo produced some very surprising results – a total of 17 species were documented, including eight bats, seven rodents (five native and two non-native species), and even two large mammals (wild pig and deer). Contrary to expectations, non-native rats were not at all common and were restricted to areas near Aeta croplands where such agricultural pests are often most abundant. Despite the fact that all areas surveyed supported sparse, scrubby second-growth vegetation rather than forest, native rodents were abundant everywhere. Resilience of the Volcano Mouse Most surprising of all, the most abundant species, overwhelmingly, was the volcano mouse Apomys sacobianus. Far from being wiped out by the eruption, this species was thriving in this greatly disturbed landscape along with other native species that also have a high tolerance for disturbance. “For some time, we’ve known that many of the small mammals of the Philippines can tolerate habitat disturbance, both natural and human-caused,” Rickart says, “but most of them are geographically widespread, not locally endemic species which usually are viewed by conservation biologists as highly vulnerable.” As Mt. Pinatubo recovers from the damage done by the eruption, the forests will return and other species of mammals will move in. “Mt. Pinatubo could be a wonderful place to establish a long-term project to monitor habitat recovery and community re-assembly following the eruption,” says Rickart, “such information would be helpful in efforts to regenerate the many areas that have been deforested by people.” After completing the Mt. Pinatubo mammal survey, Danny Balete returned to the Field Museum where he organized specimens and data from the survey, made some early notes for an eventual publication, and then set them aside to finish later. After he suddenly died in 2017 at age 56, Rickart and Heaney say that they picked up and completed the study as a tribute to Balete, who is now recognized as one of the most important figures in Philippine biodiversity science for his extensive research contributions, mentoring of younger colleagues, and promoting enjoyment of nature throughout the Philippines. “Knowing that a species once thought to be vulnerable, even feared to be extinct, is actually thriving is the finest tribute to Danny that we can imagine,” adds Heaney.

DVDV1551RTWW78V