Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Thailand flexible graphene product manufacturing

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene cushion OEM factory in Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow OEM for wellness brands Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China insole ODM for global brands

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand insole ODM for global brands

New research by the Braingeneers using 3D brain models shows that certain neurons, once thought to have fixed identities, can actually change types in response to their environment. This discovery challenges long-held beliefs and opens new possibilities for understanding brain development and disorders. Using in-vitro models of a specific type of brain cell, scientists have demonstrated that neurons can transform from one type to another. Neurons are specialized brain cells responsible for transmitting signals throughout the body. For a long time, scientists believed that once neurons develop from stem cells into a specific subtype, their identity remains fixed, regardless of changes in their surrounding environment. However, new research from the Braingeneers, a collaborative team of scientists from UC Santa Cruz and UC San Francisco, challenges this long-held belief. In a study published in iScience, the Braingeneers report that neuronal subtype identity may be more flexible than previously thought. The team used cerebral organoids, 3D models of brain tissue, to investigate how neurons develop and adapt. Their findings offer new insights into how different neuron subtypes influence brain function and may play a role in neurodevelopmental disorders. “This goes against this idea that neuronal identity is completely stable,” said Mohammed Mostajo-Radji, a research scientist at the UC Santa Cruz Genomics Institute and the paper’s lead author. “It’s making all of us rethink how neurons are actually made and maintained, and the influence of the environment in this process.” First-of-their-kind models There are two main types of neurons in the cerebral cortex, the outermost layer of the brain: excitatory, which make up 80% of neurons, or inhibitory, the remaining 20%. Of inhibitory neurons in the cerebral cortex, the majority (60%) are parvalbumin-positive neurons. These inhibitory cells have control over plasticity in the brain, affecting the time period in which a person has the ability to learn a new language without an accent, or enhance other senses after the loss of one. They are also recognized to be involved in many neurodevelopmental disorders, including autism and schizophrenia. This paper shows that the scientists were able to create a large number of parvalbumin-positive neurons in the living models in the lab, the first instance when scientists were able to produce more than just a small amount of these cells. These brain cells were transplanted into and cultured within cerebral organoids, and the researchers believe the 3D structure which more closely mimics the brain, may have been key to the breakthrough. A computer rendering of a parvalbumin-positive neuron, which researchers were able to produce in large quantities for the first time in in-vitro models. Credit: UC Santa Cruz “I think part of the answer is that it does not work if you try 2D models,” Mostajo-Radji said. “We provide what I believe is the first evidence that you need a 3D environment. It might challenge us to think about what other cell types we still can’t make in-vitro, and if that’s because we always thought everything could be done in 2D, but actually they need a 3D environment.” The ability to produce and maintain these parvalbumin-positive neurons in the lab opens the door for a wide range of research into these important cell types. Scientists could learn more about their role in neurodevelopmental disease and the brain as a whole. “When thinking about assembling brain models, missing this cell type is actually quite critical,” Mostajo-Radji said. “Now, we can make a more realistic model of the brain.” Changing identity Next, to further challenge the idea that these cells have a fixed identity, the researchers investigated how the external environment around subtypes of neurons can affect the cell’s identity. To do so, they took another kind of inhibitory neuron, called somatostatin neurons, and added them to the 3D organoid model. They observed that in these conditions, some somatostatin neurons transitioned into parvalbumin-positive neurons. While they are not sure the exact genetic and environmental conditions that enabled the transition, just knowing that this change can occur in living cells in the lab opens up the possibility that the processes could be happening in the brain as well. “It’s possible that this process of changing identity might actually happen naturally in the brain,” Mostajo-Radji said. “We don’t know that yet, but maybe there is a process in which this has actually been observed in the brain, but overlooked. It’s an exciting window we should explore, and some other labs around the country are starting to think the same way.” While they have some initial ideas about which genetic pathways might be at play, the researchers want to further explore what factors are responsible for enabling this fluidity of neuronal identity. The researchers also want to further investigate the excitatory cells to find out how they influence the fate of the inhibitory cells. Reference: “Fate plasticity of interneuron specification” by Mohammed A. Mostajo-Radji, Walter R. Mancia Leon, Arnar Breevoort, Jesus Gonzalez-Ferrer, Hunter E. Schweiger, Julian Lehrer, Li Zhou, Matthew T. Schmitz, Yonatan Perez, Tanzila Mukhtar, Ash Robbins, Julia Chu, Madeline G. Andrews, Frederika N. Sullivan, Dario Tejera, Eric C. Choy, Mercedes F. Paredes, Mircea Teodorescu, Arnold R. Kriegstein, Arturo Alvarez-Buylla and Alex A. Pollen, 27 March 2025, iScience. DOI: 10.1016/j.isci.2025.112295 UC Santa Cruz researchers involved in this research include: Jesus Gonzalez-Ferrer, Hunter Schweiger, Julian Lehrer, Frederika Sullivan, Ash Robbins, Eric Choy, and Associate Professor of Electrical and Computer Engineering Mircea Teodorescu.

The illustration represents a reconstruction of the steppe mammoths that preceded the woolly mammoth, based on the genetic knowledge we now have from the Adycha mammoth. Credit: Beth Zaiken/CPG Million-Year-Old Mammoth DNA Sequenced An international team led by researchers at the Centre for Palaeogenetics in Stockholm has sequenced DNA recovered from mammoth remains that are up to 1.2 million years old. The analyses show that the Columbian mammoth that inhabited North America during the last ice age was a hybrid between the woolly mammoth and a previously unknown genetic lineage of mammoth. In addition, the study provides new insights into when and how fast mammoths became adapted to cold climate. These findings are published today (February 17, 2021) in Nature. Around one million years ago there were no woolly or Columbian mammoths, as they had not yet evolved. This was the time of their predecessor, the ancient steppe mammoth. Researchers have now managed to analyze the genomes from three ancient mammoths, using DNA recovered from mammoth teeth that had been buried for 0.7-1.2 million years in the Siberian permafrost. This is the first time that DNA has been sequenced and authenticated from million-year-old specimens, and extracting the DNA from the samples was challenging. The scientists found that only minute amounts of DNA remained in the samples and that the DNA was degraded into very small fragments. “This DNA is incredibly old. The samples are a thousand times older than Viking remains, and even pre-date the existence of humans and Neanderthals,” says senior author Love Dalén, a Professor of evolutionary genetics at the Centre for Palaeogenetics in Stockholm. The age of the specimens was determined using both geological data and the molecular clock. Both these types of analyses showed that two of the specimens are more than one million years old, whereas the third is roughly 700 thousand years old and represents one of the earliest known woolly mammoths. An Unexpected Origin of the Columbian Mammoth Analyses of the genomes showed that the oldest specimen, which was approximately 1.2 million years old, belonged to a previously unknown genetic lineage of mammoth. The researchers refer to this as the Krestovka mammoth, based on the locality where it was found. The results show that the Krestovka mammoth diverged from other Siberian mammoths more than two million years ago. “This came as a complete surprise to us. All previous studies have indicated that there was only one species of mammoth in Siberia at that point in time, called the steppe mammoth. But our DNA analyses now show that there were two different genetic lineages, which we here refer to as the Adycha mammoth and the Krestovka mammoth. We can’t say for sure yet, but we think these may represent two different species,” says the study’s lead author Tom van der Valk. Love Dalén and co-lead author Patrícia Pečnerová with a mammoth tusk on Wrangel Island. Credit: Gleb Danilov The researchers also suggest that it was mammoths that belonged to the Krestovka lineage that colonized North America some 1.5 million years ago. In addition, the analyses show that the Columbian mammoth that inhabited North America during the last ice age was a hybrid. Roughly half of its genome came from the Krestovka lineage and the other half from the woolly mammoth. “This is an important discovery. It appears that the Columbian mammoth, one of the most iconic Ice Age species of North America, evolved through a hybridization that took place approximately 420 thousand years ago,” says co-lead author Patrícia Pečnerová. Evolution and Adaptation in the Woolly Mammoth The second million-year-old genome, from the Adycha mammoth, appears to have been ancestral to the woolly mammoth. The researchers could therefore compare its genome with the genome from one of the earliest known woolly mammoths that lived 0.7 million years ago, as well as with mammoth genomes that are only a few thousand years old. This made it possible to investigate how mammoths became adapted to a life in cold environments and to what extent these adaptations evolved during the speciation process. Krestovka specimen tooth. Credit: CPG The analyses showed that gene variants associated with life in the Arctic, such as hair growth, thermoregulation, fat deposits, cold tolerance and circadian rhythms, were already present in the million-year-old mammoth, long before the origin of the woolly mammoth. These results indicate that most adaptations in the mammoth lineage happened slowly and gradually over time. “To be able to trace genetic changes across a speciation event is unique. Our analyses show that most cold adaptations were present already in the ancestor of the woolly mammoth, and we find no evidence that natural selection was faster during the speciation process,” says co-lead author David Díez-del-Molino. Future Research The new results open the door for a broad array of future studies on other species. About one million years ago was a period when many species expanded across the globe. This was also a time period of major changes in climate and sea levels, as well as the last time that Earth’s magnetic poles changed places. Because of this, the researchers think that genetic analyses on this time scale have great potential to explore a wide range of scientific questions. “One of the big questions now is how far back in time we can go. We haven’t reached the limit yet. An educated guess would be that we could recover DNA that is two million years old, and possibly go even as far back as 2.6 million. Before that, there was no permafrost where ancient DNA could have been preserved,” says Anders Götherström, a professor in molecular archaeology and joint research leader at the Centre for Palaeogenetics. Reference: “Million-year-old DNA sheds light on the genomic history of mammoths” by Tom van der Valk, Patrícia Pečnerová, David Díez-del-Molino, Anders Bergström, Jonas Oppenheimer, Stefanie Hartmann, Georgios Xenikoudakis, Jessica A. Thomas, Marianne Dehasque, Ekin Sağlıcan, Fatma Rabia Fidan, Ian Barnes, Shanlin Liu, Mehmet Somel, Peter D. Heintzman, Pavel Nikolskiy, Beth Shapiro, Pontus Skoglund, Michael Hofreiter, Adrian M. Lister, Anders Götherström and Love Dalén, 17 February 2021, Nature. DOI: 10.1038/s41586-021-03224-9 The study is the result of an international collaboration that has involved 22 scientists from nine countries. In addition to researchers from the Centre for Palaeogenetics, a joint research center funded by Stockholm University and the Swedish Museum of Natural History, the study also includes researchers from the Russian Academy of Sciences, the Natural History Museum and The Crick Institute in the United Kingdom, UC Santa Cruz in the USA, Potsdam University in Germany, China Agricultural University, the Middle East Technical University in Turkey, the Arctic University of Norway, and the University of Copenhagen in Denmark.

In a recent UCLA study, researchers discovered that “dormant” cone cells in degenerating retinas still function, providing hope for preserving near-normal daytime vision in patients with irreversible retinal blindness. “Dormant” cone photoreceptors continue to drive retinal activity for vision. New University of California, Los Angeles (UCLA) research in mice suggests that “dormant” cone photoreceptors in the degenerating retina are not dormant at all, but continue to function, producing responses to light and driving retinal activity for vision. The cells in the retina that produce the visual experience are rods and cones. Rods are active in dim light and cones in daylight. Mutations in rods that cause them to die trigger most inherited retinal degeneration. Cones can remain alive after nearly all the rods die, but they retract key parts of the cells and appear “dormant.” But while past literature suggested that dormant cells were not functional, and earlier attempts to record from them revealed no light-driven activity, the new study indicates for the first time that the cells are still viable. Furthermore, downstream signals recorded from the retina show that visual processing is not as compromised as may be expected. The authors say their findings demonstrate that therapeutic interventions to protect these cells, or enhance their sensitivity, have the capability to preserve nearly normal daytime vision. Inner Retina Adaptation “While the sensitivity of the cones was about 100-1000 fold less than normal, we were surprised to find that that the drop-off in sensitivity for the ganglion cells that project to the brain was much less,” said senior author Alapakkam Sampath, the Grace and Walter Lantz Endowed Chair in Ophthalmology at the UCLA Jules Stein Eye Institute and professor at the David Geffen School of Medicine at UCLA. “It seems that adaptational mechanisms in the inner retina might be trying to minimize the sensitivity difference to preserve robust signaling in the ganglion cells — this is consistent with what we know about the brain. Homeostatic mechanisms that respond to injury and disease typically cover up the deficiency. That is why it is hard to detect neurological problems until the deficiency becomes very severe.” The study was published recently in the peer-reviewed journal, Current Biology. “While the sensitivity of the cones was about 100-1000 fold less than normal, we were surprised to find that that the drop-off in sensitivity for the ganglion cells that project to the brain was much less,” said senior author Alapakkam Sampath. Credit: Miranda Scalabrino The investigators examined membrane properties of cones in mice following the degeneration of rods. The patch clamp recording method is a laboratory technique for studying currents in living cells while controlling the cell’s membrane potential, or membrane voltage. These single cell recordings can establish key features of the cell’s activity, including the presence of specific membrane currents, whether the cell has light responses, and whether they might connect to downstream neurons in the retina. In addition, the investigators used multi-electrode array recordings that establish the activity of all retinal ganglion cells, and that can show the ganglion cell’s ability to respond to visual stimuli that vary in spatial location over time. These recordings revealed that the remaining cones in a retina where the rods have mostly degenerated were still functional. Although the anatomic specializations that are responsible for generating the light response — or phototransduction — and the synaptic connection to downstream cells were missing, these functions remained with less sensitivity than normal. These cells still display many of the features of normal cones, including a similar resting membrane potential, a normal synaptic Ca2+ current, and light responses even though they no longer have the part of the cell that was traditionally thought needed for the light response. Furthermore, the ganglion cells retain their ability to respond to visual stimuli with similar spatial and temporal sensitivity. Implications for Restoring Vision “These important results may suggest a future path forward for patients with conditions thought to be causing irreversible retinal blindness, as photoreceptor or cone viability in tissue was previously thought to be irreparably damaged,” said Dr. Steven Schwartz, Ahmanson chair in ophthalmology at the David Geffen School of Medicine at UCLA, and professor and Retina Division chief at the UCLA Jules Stein Eye Institute. The next step for researchers is to establish the extent to which the neuroprotection or enhancement of the dormant cones will allow the rescue of vision in various forms of blindness. Reference: “Cones and cone pathways remain functional in advanced retinal degeneration” by Erika M. Ellis, Antonio E. Paniagua, Miranda L. Scalabrino, Mishek Thapa, Jay Rathinavelu, Yuekan Jiao, David S. Williams, Greg D. Field, Gordon L. Fain and Alapakkam P. Sampath, 27 March 2023, Current Biology. DOI: 10.1016/j.cub.2023.03.007 The researchers were supported by grants from the National Eye Institute (R01EY033035, R01EY027442, R01EY27193, R01EY001844, R01EY27193 and EY29817), a fellowship of the UCLA EyeSTAR program of the UCLA Department of Ophthalmology, a BrightFocus Foundation Postdoctoral Fellowship, an unrestricted grant from Research to Prevent Blindness USA to the UCLA Department of Ophthalmology and National Eye Institute Core Grant (P30) EY00311 to the Jules Stein Eye Institute. The study’s other authors are Dr. Erika Ellis, Antonio Paniagua, Yuekan Jiao, David Williams, Gordon Fain, all of UCLA; and Miranda Scalabrino, Mishek Thapa, Jay Rathinavelu and Greg Field, all of Duke University. The Field laboratory has recently moved to the UCLA Jules Stein Eye Institute. The authors declare no competing interests.

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