Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Pillow OEM for wellness brands Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Thailand pillow ODM development service

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Cushion insole OEM solution Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Pillow ODM design company in China

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam high-end foam product OEM/ODM

A University of Minnesota Twin Cities-led research team studied how bacteria swim in complex fluids, providing insight into how the microorganisms move through different environments, such as their natural habitats or inside the human body. Credit: Cheng Research Group, University of Minnesota University of Minnesota researchers studied for the first time how bacteria move through fluids containing small solid particles. For years, science fiction authors have written about the idea of using microswimmers that could perform surgeries or deliver medicines to humans. Now, a team led by University of Minnesota Twin Cities researchers discovered how bacteria swim through different complex fluids and environments, such as the human body.  Their findings could help scientists develop new treatments for bacteria-causing diseases and design bacteria-based systems for delivering drugs into the human body.  The study is published in Nature, the world’s leading peer-reviewed, multidisciplinary science journal.  The University of Minnesota has a long history with swimming in fluids other than water. In 2004 Ed Cussler, then a professor in the Department of Chemical Engineering and Materials Science, compared how fast a competitive university athlete swam in water versus a thick, syrupy guar gum solution. It led to an unexpected discovery (and an IgNobel prize) that humans can swim just as fast in guar gum solutions as in water.  Almost two decades later, a multidisciplinary team at the University of Minnesota has revisited the problem, except the swimmers are now microscopic bacteria instead of university athletes. They found that bacteria swim even faster in thick solutions than in water. Bacteria Move Faster in Thick Fluids “Bacterial swimming,” as it’s commonly known in the research community, has been studied intensively by scientists since the 1960s. Previous studies have found that bacteria swim faster in thick polymer solutions, namely fluids containing polymers, which are substances made up of long chain-like molecules. Researchers have theorized that this is because the bacteria can swim through the network formed by the chain molecules and can stretch the chains to assist their propulsion. However, in this new study, the U of M team studied for the first time how bacteria move through solutions of small solid particles, instead of chain molecules. Despite vast differences in polymer and particle dynamics, they found that the bacteria still swam faster, suggesting that there must be a different explanation for how bacteria move through thick, complex fluids.  The U of M researchers have a possible answer. They believe that as the bacteria swim, the drag created from passing by particles allows their flagella—or the “tails” bacteria have that spin in order to propel them forward—to better align with their bodies, ultimately helping them move faster. A bacterial cell “wobbles” in order to propel itself forward next to a micron-sized colloid particle. Video credit: Cheng Research Group, University of Minnesota “People have been fascinated by the swimming of bacteria ever since the invention of microscopes in the 17th century, but until now, the understanding was mostly limited to simple liquids like water,” explained Shashank Kamdar, lead author on the paper, a University of Minnesota chemical engineering graduate student, and a recipient of the PPG Research Fellowship. “But it is still an open question as to how bacteria are moving in real-life situations, like through soil and fluids in their own habitats.” Understanding how bacteria move through complex, viscous environments—the human body being one—can help scientists design treatments for diseases and even use bacteria as vessels for delivering medicines to humans. Unified Understanding of Bacterial Swimming “There are several mechanisms people have used to explain this phenomenon throughout the decades, but with this study, we provide a unified understanding of what happens when bacteria swim through complex solutions,” said Xiang Cheng, senior author on the paper and an associate professor in the University of Minnesota Department of Chemical Engineering and Materials Science. “And it’s important to understand how bacteria move in a complex environment. For example, a certain type of bacteria causes stomach ulcers. Stomach lining is a viscous environment, so studying how the bacteria move in these environments is important to understanding how the disease spreads.” “In the end, we should all learn from bacteria,” Cheng added. “They keep moving forward despite opposition.” Reference: “The colloidal nature of complex fluids enhances bacterial motility” by Shashank Kamdar, Seunghwan Shin, Premkumar Leishangthem, Lorraine F. Francis, Xinliang Xu and Xiang Cheng, 30 March 2022, Nature. DOI: 10.1038/s41586-022-04509-3 In addition to Cheng and Kamdar, the team included University of Minnesota College of Science and Engineering Distinguished Professor and 3M Chair in Experiential Learning Lorraine Francis and Department of Chemical Engineering and Materials Science graduate researcher Seunghwan Shin; and Beijing Computational Science Research Center researchers Premkumar Leishangthem and Xinliang Xu. The research was supported by the National Science Foundation (NSF) and the University of Minnesota Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME).

The researchers conducted experiments on C. elegans, a roundworm with just 300 neurons, that offers a simple laboratory model for studying how an animal learns. A Multi-Dimensional Model To Explain the Learning Process of an Animal Over Time Physicists have developed a dynamic model of animal behavior that could shed light on the long-standing mysteries of associative learning, dating back to Pavlov’s famous canine experiments. The study, which was performed on the widely used laboratory organism C. elegans, was published in the Proceedings of the National Academy of Sciences (PNAS). “We showed how learned associations are not mediated by just the strength of an association, but by multiple, nearly independent pathways — at least in the worms,” says Ilya Nemenman, an Emory professor of physics and biology whose lab led the theoretical analyses for the paper. “We expect that similar results will hold for larger animals as well, including maybe in humans.” “Our model is dynamical and multi-dimensional,” adds William Ryu, an associate professor of physics at the Donnelly Centre at the University of Toronto, whose lab led the experimental work. “It explains why this example of associative learning is not as simple as forming a single positive memory. Instead, it’s a continuous interplay between positive and negative associations that are happening at the same time.” First author of the paper is Ahmed Roman, who worked on the project as an Emory graduate student and is now a postdoctoral fellow at the Broad Institute. Konstaintine Palanski, a former graduate student at the University of Toronto, is also an author. The Conditioned Reflex More than 100 years ago, Ivan Pavlov discovered the “conditioned reflex” in animals through his experiments on dogs. For example, after a dog was trained to associate a sound with the subsequent arrival of food, the dog would start to salivate when it heard the sound, even before the food appeared. About 70 years later, psychologists built on Pavlov’s insights to develop the Rescorla-Wagner model of classical conditioning. This mathematical model describes conditioned associations by their time-dependent strength. That strength increases when the conditioned stimulus (in Pavlov’s dog’s case the sound) can be used by the animal to decrease the surprise in the arrival of the unconditioned response (the food). Such insights helped set the stage for modern theories of reinforcement learning in animals, which in turn enabled reinforcement learning algorithms in artificial intelligence systems. But many mysteries remain, including some related to Pavlov’s original experiments. After Pavlov trained dogs to associate the sound of a bell with food he would then repeatedly expose them to the bell without food. During the first few trials without food, the dogs continued to salivate when the bell rang. If the trials continued long enough, the dogs “unlearned” and stopped salivating in response to the bell. The association was said to be “extinguished.” Pavlov discovered, however, that if he waited a while and then retested the dogs, they would once again salivate in response to the bell, even if no food was present. Neither Pavlov nor more recent associative-learning theories could accurately explain or mathematically model this spontaneous recovery of an extinguished association. Teasing Out the Puzzle Researchers have explored such mysteries through experiments with C. elegans. The one-millimeter roundworm only has about 1,000 cells and 300 of them are neurons. That simplicity provides scientists with a simple system to test how the animal learns. At the same time, C. elegans’ neural circuitry is just complicated enough to connect some of the insights gained from studying its behavior to more complex systems. Earlier experiments have established that C. elegans can be trained to prefer a cooler or warmer temperature by conditioning it at a certain temperature with food. In a typical experiment, the worms are placed in a petri dish with a gradient of temperatures but no food. Those trained to prefer a cooler temperature will move to the cooler side of the dish, while the worms trained to prefer a warmer temperature go to the warmer side. But what exactly do these results mean? Some believe that the worms crawl toward a particular temperature in expectation of food. Others argue that the worms simply become habituated to that temperature, so they prefer to hang out there even without a food reward. The puzzle could not be resolved due to a major limitation of many of these experiments — the lengthy amount of time it takes for a worm to traverse a nine-centimeter petri dish in search of the preferred temperature. Measuring How Learning Changes Over Time Nemenman and Ryu sought to overcome this limitation. They wanted to develop a practical way to precisely measure the dynamics of learning, or how learning changes over time. Ryu’s lab used a microfluidic device to shrink the experimental model of nine-centimeter petri dishes into four-millimeter droplets. The researchers could rapidly run experiments on hundreds of worms, each worm encased within its individual droplet. “We could observe in real time how a worm moved across a linear gradient of temperatures,” Ryu says. “Instead of waiting for it to crawl for 30 minutes or an hour, we could much more quickly see which side of the droplet, the cold side or the warm side, that the worm preferred. And we could also follow how its preferences changed with time.” Their experiments confirmed that if a worm is trained to associate food with a cooler temperature it will move to the cooler side of the droplet. Over time, however, with no food present, this memory preference seemingly decays. “We found that suddenly the worms wanted to spend more time on the warm side of the droplet,” Ryu says. “That’s surprising because why would the worms develop a different preference and even avoidance of the temperature they had come to associate with food?” Eventually, the worm begins moving back and forth between the cooler and warmer temperatures. The researchers hypothesized that the worm does not simply forget the positive memory of food associated with cooler temperatures but instead starts to negatively associate the cooler side with no food. That spurs it to head for the warmer side. Then as more time passes, it begins to form a negative association of no food with the warmer temperature, which combined with the residual positive association to the cold, makes it migrate back to the cooler one. “The worm is always learning, all the time,” Ryu explains. “There is an interplay between the drive of a positive association and a negative association that causes it to start oscillating between cold and warm.” “It’s Like When You Lose Your Keys” Nemenman’s team developed theoretical equations to describe the interactions over time between the two independent variables — the positive, or excitatory, association that drives a worm toward one temperature and the negative, or inhibitory, association that drives it away from that temperature. “The side that the worm gravitates toward depends on when exactly you take the measurements,” Nemenman explains. “It’s like when you lose your keys you may check the desk where you usually keep them first. If you don’t see them there right away, you run around different places looking for them. If you still don’t find them, you go back to the original desk figuring you just didn’t look hard enough.” The researchers repeated the experiments under different conditions. They trained the worms at different starting temperatures and starved them for different durations of time before testing their temperature preference, and the worms’ behaviors were correctly predicted by the equations. They also tested their hypothesis by genetically modifying the worms, knocking out the insulin-like signaling pathway known to serve as a negative association pathway. “We perturbed the biology in specific ways and when we ran the experiments, the worm’s behavior changed as predicted by our theoretical model,” Nemenman says. “That gives us more confidence that the model reflects the underlying biology of learning, at least in C. elegans.” The researchers hope that others will test their model in studies of larger animals across species. “Our model provides an alternative quantitative model of learning that is multi-dimensional,” Ryu says. “It explains results that are difficult, or in some cases impossible, for other theories of classical conditioning to explain.” Reference: “A dynamical model of C. elegans thermal preference reveals independent excitatory and inhibitory learning pathways” by Ahmed Roman, Konstantine Palanski, Ilya Nemenman and William S. Ryu, 20 March 2023, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2215191120 The study was funded by the Natural Sciences and Engineering Research Council of Canada, the Human Frontier Science Program, and the National Science Foundation.

The Leaf litter frog (Haddadus binotatus) emits a distress call at frequencies that humans cannot hear but predators can. Credit: Henrique Nogueira For the first time in South America, researchers recorded the use of ultrasound by a frog endemic to the Atlantic Rainforest in Brazil, which has more species of amphibians than any other country. Other frogs may use very high-frequency calls. A study reported in the journal Acta Ethologica recorded the use of ultrasound by amphibians for the first time in South America. It also describes the first documented case of the use of ultrasound for defense against predators, in a distress call of ear-piercing intensity to many animals, but inaudible to humans. “Some potential predators of amphibians, such as bats, rodents and small primates, are able to emit and hear sounds at this frequency, which humans can’t. One of our hypotheses is that the distress call is addressed to some of these, but it could also be the case that the broad frequency band is generalist in the sense that it’s supposed to scare as many predators as possible,” said Ubiratã Ferreira Souza, first author of the article. The study was part of his master’s research at the State University of Campinas’s Institute of Biology (IB-UNICAMP) in São Paulo state, Brazil, with a scholarship from FAPESP. Unveiling the Ultrasonic World of Amphibians Another hypothesis is that the scream is meant to attract another animal to attack the predator which is threatening the amphibian, in this case, the Leaf litter frog (Haddadus binotatus), a species endemic to the Brazilian Atlantic Rainforest. The researchers recorded the distress call on two occasions. When they analyzed the sound using special software, they found that it had a frequency range of 7 kilohertz (kHz) to 44 kHz. Humans cannot hear frequencies higher than 20 kHz, which are classed as ultrasound. Observations of Defensive Behaviors in Frogs While emitting its distress call, this frog makes a series of movements typical of defense against predators. It raises the front of its body, opens its mouth wide and jerks its head backward. It then partially closes its mouth and emits a call that ranges from a frequency band audible to humans (7 kHZ-20 kHz) to an inaudible ultrasound band (20 kHz-44 kHz). “In light of the fact that amphibian diversity in Brazil is the highest in the world, with more than 2,000 species described, it wouldn’t be surprising to find that other frogs also emit sounds at these frequencies,” said Mariana Retuci Pontes, a co-author of the article and a PhD candidate at IB-UNICAMP with a scholarship from FAPESP. Potential Cross-Species Ultrasonic Communication The use of this strategy by another species may have been accidentally discovered by Pontes herself. In January 2023, during a visit to the Upper Ribeira State Tourism Park (PETAR) in Iporanga, São Paulo state, Pontes saw on a rock an animal that was probably a Hensel’s big-headed frog (Ischnocnema henselii), although she did not collect the animal to identify the species precisely. Holding the frog by the legs in an attempt to take a photograph, she was surprised to find that its defensive movement and distress call closely resembled those of H. binotatus. A lancehead pit viper (Bothrops jararaca) was a few feet away, apparently confirming the hypothesis that this behavior is a response to predators. Research Evolution and Future Directions She was able to record a video but could not analyze the sound track to confirm the presence of the ultrasound frequency band. Taking hold of a frog’s legs is a move typically used by researchers to simulate an attack by a predator, according to the documentation for H. binotatus. “Both species live in leaf litter, are similar in size [between 3 cm and 6 cm], and have similar predators, so it’s possible that I. henselii also uses this distress call with ultrasound to defend itself against natural enemies,” said Luís Felipe Toledo, last author of the article and a professor at IB-UNICAMP. He is principal investigator for the project “From the natural history to the conservation of Brazilian amphibians,” supported by FAPESP. The first time Toledo suspected that H. binotatus emitted sounds at frequencies too high for humans to hear was in 2005 when he was a PhD candidate at São Paulo State University’s Institute of Biosciences (IB-UNESP) in Rio Claro. However, he was unable to verify frequencies above 20 kHz owing to limitations of the equipment available at the time. There are also recordings of ultrasound calls by three Asian amphibian species, but the frequencies concerned are used for communication between individuals of the same species. In mammals, ultrasound use is common among whales, bats, rodents and small primates. Its use by amphibians for self-defense against predators was unknown until the study by Souza et al. The researchers now plan to address a number of questions raised by the discovery, such as which predators are sensitive to the distress call, how they react to it, and whether the call is intended to scare them or to attract their natural enemies. “Could it be the case that the call is meant to attract an owl that will attack a snake that’s about to eat the frog?” Souza wondered. Reference: “Ultrasonic distress calls and associated defensive behaviors in Neotropical frogs” by Ubiratã Ferreira Souza, Guilherme Augusto-Alves, Mariana Retuci Pontes, Lucas Machado Botelho, Edélcio Muscat and Luís Felipe Toledo, 8 January 2024, acta ethologica. DOI: 10.1007/s10211-023-00435-3 The study was also supported by FAPESP via a doctoral scholarship awarded to Guilherme Augusto Alves and another project led by Toledo.

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