Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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One-stop OEM/ODM solution provider Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Ergonomic insole ODM support Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene insole OEM factory Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China insole ODM service provider

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Eco-friendly pillow OEM manufacturer China

Overlapping gene enhancers challenge the modular model, revealing complex genome regulation with evolutionary implications. The findings from the University of Bonn and LMU Munich challenge previous assumptions. Certain sequences in the genome regulate the activation or deactivation of genes. These regulatory elements, known as enhancers, were traditionally believed to occupy distinct locations on the DNA. As a result, enhancers controlling the same gene but activating it in different parts of the body were thought to operate independently, separated from one another along the genome. A recent study from the University of Bonn and the LMU Munich challenges this idea. The findings are also important because gene switches are thought to play a central role in evolution. The study has been published in the journal Science Advances. The blueprint of plant and animal forms is encoded in their DNA. But only a small part of the genome – about two percent in mammals – contains genes, the instructions for making proteins. The rest largely controls when and where these genes are active: how many of their transcripts are produced, and thus how many proteins are made from these transcripts. Some of these regulatory sequences, called ‘enhancers’, work like dimmer switches used to modulate the light in our living room. Indeed, they specifically increase the expression of a particular gene, where and when this gene is required. Genes controlling morphology often respond to several independent enhancers, each determining the expression of the gene in a different body part. Enhancers controlling Drosophila coloration Until now, enhancers were thought to be modular. The term implies that each enhancer occupies an isolated stretch of DNA. “We have shown, however, that this is not absolutely true,” explains Mariam Museridze. She is a PhD student at the Bonn Institute of Organismic Biology in the group of Prof. Dr. Nicolas Gompel and the first author of the study. Gompel is also a member of the Transdisciplinary Research Area (TRA) ‘Life & Health’ at the University of Bonn. The images show the abdomen of flies in which a specific enhancer region has been modified. Depending on how much and which part of the region is modified, different areas of the pigment pattern change. This shows that the region contains several non-modular enhancers (blue = strong gene expression; red = weak gene expression). Credit: Mariam Museridze / Universität Bonn The researchers studied how a gene called yellow is regulated in the fruit fly Drosophila. This gene causes the insect to produce the brownish pigment melanin. There are a number of enhancers that control the activity of yellow. One of them, for example, is responsible for the pigmentation of the maggots’ teeth, while another is responsible for the formation of the striped pattern on the fly’s abdomen. “We have taken a closer look at two of these enhancers,” says Museridze. The first controls the formation of color pattern on the wings, while the second controls the coloring of the head, thorax ,and abdomen. Both are active at the same time during the fly’s metamorphosis. The team discovered that the body enhancer is not, as expected, located in a different region of DNA from the wing enhancer. Instead, there are extensive regions of DNA that belong to both gene switches, i.e. they influence the pigmentation of both the wing and the body. The results suggest that the architecture of regulatory sequences in the genome is much more complex than previously thought. This has far-reaching implications for how traits change during evolution. According to current knowledge, enhancers play a key role in this process. Enhancers as an evolutionary playground This is because many proteins are so important to an organism that a mutation in their gene (i.e., the DNA sequence that contains the instructions for building the protein) would cause serious problems or even certain death. As a result, genes that control body shape, such as the number of wings or legs, rarely change over the course of evolution. Enhancers offer a way out of this dilemma: when they mutate, the activity of the corresponding gene changes, but only in a specific tissue and at a specific time. “The cost of mutating an enhancer is therefore often lower than the cost of mutating the gene directly,” says Mariam Museridze. This makes it easier for new traits to emerge during evolution. It is like baking a cake: If you mix eggs, flour, milk, and sugar, you can get completely different types of dough, depending on the mixing ratio. In this metaphor, the enhancers would be responsible for the quantity of ingredients, not the type of ingredients. A genetic mutation is like accidentally replacing one ingredient with something completely different – for example, using sawdust instead of flour. The result will certainly not taste very good. A mutation in an enhancer, on the other hand, would change the amount of flour. “If enhancers are not as modular as we thought, this means that mutations in them can have much broader effects,” says Museridze. This means that such a mutation could affect the amount of several ingredients at the same time. However, it is also possible that the enhancers retain their independence and continue to control the amount of a single ingredient, even though their sequences are interwoven and shared. “We now want to investigate these possibilities in more detail,” explains Professor Gompel. “We also want to find out how general our findings are and how this affects our understanding of evolutionary mechanisms.” Reference: “Entangled and non-modular enhancer sequences producing independent spatial activities” by Mariam Museridze, Stefano Ceolin, Bettina Mühling, Srishti Ramanathan, Olga Barmina, Pallavi Santhi Sekhar and Nicolas Gompel, 20 November 2024, Science Advances. DOI: 10.1126/sciadv.adr9856 Prof Gompel and his research group began their study at the LMU Munich and completed it at the University of Bonn. The University of California at Davis, USA, was also involved in the research. The study was funded by the German Research Foundation (DFG) and the LMU Munich.

The study examined plankton in freshwater ponds exposed to seven years of experimental warming. Credit: University of Exeter Rising temperatures could reduce the efficiency of food chains and threaten the survival of larger animals, new research shows. Scientists measured the transfer of energy from single-celled algae (phytoplankton) to small animals that eat them (zooplankton). The study — by the University of Exeter and Queen Mary University of London, and published in the journal Nature — found that 4°C (7.2°F) of warming reduced energy transfer in the plankton food webs by up to 56%. Warmer conditions increase the metabolic cost of growth, leading to less efficient energy flow through the food chain and ultimately to a reduction in overall biomass. Underappreciated Impact of Global Warming “These findings shine a light on an under-appreciated consequence of global warming,” said Professor Gabriel Yvon-Durocher, of the Environment and Sustainability Institute on Exeter’s Penryn Campus in Cornwall. “Phytoplankton and zooplankton are the foundation of food webs that support freshwater and marine ecosystems that humans depend on. “Our study is the first direct evidence that the cost of growth increases in higher temperatures, limiting the transfer of energy up a food chain.” Professor Mark Trimmer, of Queen Mary University of London, said: “If the effects we find in this experiment are evident in natural ecosystems, the consequences could be profound. “The impact on larger animals at the top of food chains — which depend on energy passed up from lower down the food chain — could be severe. More research is needed.” “In general, about 10% of energy produced on one level of a food web makes it up to the next level,” said Dr. Diego Barneche, of the Australian Institute of Marine Science and the Oceans Institute at the University of Western Australia. “This happens because organisms expend a lot of energy on a variety of functions over a lifetime, and only a small fraction of the energy they consume is retained in biomass that ends up being eaten by predators. Warming Distorts Metabolism and Growth Balance “Warmer temperatures can cause metabolic rates to accelerate faster than growth rates, which reduces the energy available to predators in the next level up the food web.” The study measured nitrogen transfer efficiency (a proxy for overall energy transfer) in freshwater plankton that had been exposed to a seven-year-long outdoor warming experiment in the UK. Reference: “Warming impairs trophic transfer efficiency in a long-term field experiment” by Diego R. Barneche, Chris J. Hulatt, Matteo Dossena, Daniel Padfield, Guy Woodward, Mark Trimmer and Gabriel Yvon-Durocher, 1 March 2021, Nature. DOI: 10.1038/s41586-021-03352-2 Funding came from the AXA Research Fund, the Natural Environment Research Council and the European Research Council.

Scanning was completed both during Time 1 and Time 2 (approximately 1.5 years later) in each of the 5 age groups (6-year-olds, 10-year-olds, 14-year-olds, 16-year-olds, and 18+-year-olds). Credit: Zacharopoulos G, et al., 2021, PLOS Biology, CC-BY 4.0 Glutamate and GABA in the brain have reverse relationships with math ability, which switch during development. The neurotransmitters GABA and glutamate have complementary roles — GABA inhibits neurons, while glutamate makes them more active. Published today (July 22nd, 2021) in PLOS Biology, researchers led by Roi Cohen Kadosh and George Zacharopoulos from the University of Oxford show that levels of these two neurotransmitters in the intraparietal sulcus of the brain can predict mathematics ability. The study also found that the relationships between the two neurotransmitters and arithmetic fluency switched as children developed into adults. Levels of brain excitement/inhibition are thought to be related to learning, especially during critical periods. However, little is known about how they are related to complex learning that can take place over decades. To address this issue, the researchers measured the levels of GABA and glutamate in 255 people, ranging from 6-year-olds to university students. The participants also took two math achievement tests, and their performance on the arithmetic problems were correlated with the GABA and glutamate levels. The team found that among young people, higher GABA levels in the left intraparietal sulcus of the brain (a fold in the top, left, back part of the brain) were associated with greater math fluency, while the reverse was true for glutamate. In adults, the results were almost exactly opposite; low GABA concentrations were related to greater math fluency, and again, the reverse was true for glutamate. Because the participants were tested twice about 1.5 years apart, the researchers were also able to show that neurotransmitter levels at the time of the first test could predict math achievement at the later date. Much of what we know about GABA, glutamate, and learning comes from rodent experiments in the lab, which cannot say anything directly about natural school-based skills such as mathematics that develop over time. This longitudinal study in humans will help researchers better understand the relationship between learning and brain plasticity, particularly during critical periods that might span years. Cohen Kadosh adds, “Our finding of developmental switches in the link between GABA and glutamate and academic achievement highlights a general, unknown principle of plasticity. In contrast to previous studies on humans or animals that focused on narrower developmental stages, our cross-sectional-longitudinal study suggests that the link between plasticity and brain excitation and inhibition across different stages is unlikely to be immutable. Our findings have also important implications for the development of brain-based interventional programs, which we hope to examine in the future.” Reference: “Predicting learning and achievement using GABA and glutamate concentrations in human development” by George Zacharopoulos, Francesco Sella, Kathrin Cohen Kadosh, Charlotte Hartwright, Uzay Emir and Roi Cohen Kadosh, 22 July 2021, PLOS Biology. DOI: 10.1371/journal.pbio.3001325 The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z). This work was supported by the European Research Council (Learning&Achievement 338065) (RCK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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