Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Arch support insole OEM from China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia athletic insole OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Innovative pillow ODM solution in Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam foot care insole ODM expert

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ODM service for ergonomic pillows Taiwan

A study from the University of Cambridge reveals innate sex differences in newborns’ brains, with males displaying larger overall volumes and more white matter, while females have more grey matter, potentially due to biological influences during prenatal development. Cambridge researchers found that sex differences in brain structure exist from birth, with males having more white matter and females more grey matter, highlighting early neurodiversity. Research from the Autism Research Centre at the University of Cambridge has found that sex differences in brain structure are present from birth. On average, male infants have larger overall brain volumes than female infants. However, when accounting for total brain size, female infants tend to have significantly more grey matter, while male infants have significantly more white matter. Grey matter consists of neuron cell bodies and dendrites, playing a key role in processing and interpreting information related to sensation, perception, learning, speech, and cognition. In contrast, white matter is composed of axons—long nerve fibers that connect neurons across different brain regions, enabling communication throughout the brain. Yumnah Khan, a PhD student at the Autism Research Centre, who led the study, said: “Our study settles an age-old question of whether male and female brains differ at birth. We know there are differences in the brains of older children and adults, but our findings show that they are already present in the earliest days of life. “Because these sex differences are evident so soon after birth, they might in part reflect biological sex differences during prenatal brain development, which then interact with environmental experiences over time to shape further sex differences in the brain.” Overcoming Past Research Limitations One problem that has plagued past research in this area is sample size. The Cambridge team tackled this by analyzing data from the Developing Human Connectome Project, where infants receive an MRI brain scan soon after birth. Having over 500 newborn babies in the study means that, statistically, the sample is ideal for detecting sex differences if they are present. A second problem is whether any observed sex differences could be due to other factors, such as differences in body size. The Cambridge team found that, on average, male infants had significantly larger brain volumes than did females, and this was true even after sex differences in birth weight were taken into account. After taking this difference in total brain volume into account, at a regional level, females on average showed larger volumes in grey matter areas related to memory and emotional regulation, while males on average had larger volumes in grey matter areas involved in sensory processing and motor control. The findings of the study, the largest to date to investigate this question, are published in the journal Biology of Sex Differences. Investigating Underlying Biological Factors Dr Alex Tsompanidis who supervised the study, said: “This is the largest such study to date, and we took additional factors into account, such as birth weight, to ensure that these differences are specific to the brain and not due to general size differences between the sexes. “To understand why males and females show differences in their relative grey and white matter volume, we are now studying the conditions of the prenatal environment, using population birth records, as well as in vitro cellular models of the developing brain. This will help us compare the progression of male and female pregnancies and determine if specific biological factors, such as hormones or the placenta, contribute to the differences we see in the brain.” The researchers stress that the differences between males and females are average differences. Dr Carrie Allison, Deputy Director of the Autism Research Centre, said: “The differences we see do not apply to all males or all females, but are only seen when you compare groups of males and females together. There is a lot a variation within, and a lot of overlap between, each group.” Professor Simon Baron-Cohen, Director of the Autism Research Centre, added: “These differences do not imply the brains of males and females are better or worse. It’s just one example of neurodiversity. This research may be helpful in understanding other kinds of neurodiversity, such as the brain in children who are later diagnosed as autistic, since this is diagnosed more often in males.” Reference: “Sex Differences in Human Brain Structure at Birth” by Yumnah T. Khan, Alex Tsompanidis, Marcin A. Radecki, Lena Dorfschmidt, APEX Consortium, Topun Austin, John Suckling, Carrie Allison, Meng-Chuan Lai, Richard A. I. Bethlehem and Simon Baron-Cohen, 17 October 2024, Biology of Sex Differences. DOI: 10.1186/s13293-024-00657-5 The research was funded by Cambridge University Development and Research, Trinity College, Cambridge, the Cambridge Trust, and the Simons Foundation Autism Research Initiative. These results were obtained using data made available from the Developing Human Connectome Project funded by the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement no. [319456].

A study in East Africa has found that invasive ants are altering ecosystems by reducing tree cover, affecting lions’ ability to hunt zebras. This change forces lions to adapt by targeting more formidable prey like buffaloes. The research emphasizes the unexpected impact of small species on large ecosystems and highlights ongoing efforts to find solutions to preserve the landscape. What makes the little old ant think he can disrupt the life of an African lion? Researchers say it’s more than just high hopes. In a study published in the journal Science, a team of scientists reports that a tiny and seemingly innocuous invasive ant species is changing tree cover in an East African wildlife area, making it harder for lions, the world’s most iconic predator, to hunt its preferred prey, zebra. “These tiny invaders are cryptically pulling on the ties that bind an African ecosystem together, determining who is eaten and where,” said Todd Palmer, an ecologist and professor in the Department of Biology at the University of Florida. The study, which spans research over three decades, comprised a combination of hidden camera traps, collared lions tracked by satellites, and statistical modeling. It illustrates the complex web of interactions among ants, trees, elephants, lions, zebras and buffaloes. Mutualism Disrupted by Invasive Species The disruption begins in the acacia trees in the Ol Pejeta Nature Conservancy, an African wildlife area in central Kenya. The trees are historically protected from leaf-eating animals by a species of ant that nests in the trees’ bulbous thorns. In return for their home, the ants ferociously defend the trees from gigantic plant eaters, like elephants, giraffes and other herbivores — an arrangement ecologists call mutualism. In published studies from the early 2000s, Palmer began to unravel the complexities of this congenial relationship in East Africa between plant and animal species. The lion in East Africa changes hunting habits due to tiny ant species. Credit: Todd Palmer “Much to our surprise, we found that these little ants serve as incredibly strong defenders and were essentially stabilizing the tree cover in these landscapes, making it possible for the acacia trees to persist in a place with so many big plant-eating mammals,” Palmer said. In the latest study, however, scientists say the arrival of an invasive insect known as the “big-headed” ant (Pheidole megacephala) is setting off a chain of events that has resulted in a shift in predator-prey behavior that may further jeopardize populations of lions — a species already on the brink of endangerment. Consequences of Changing Landscapes The big-headed ants are small but voracious hunters of insects, destroying colonies of the tree-protecting ants but not defending the trees from the larger animals. Having lost their bodyguards, the acacia trees are being obliterated by elephants. The lions, which are ambush predators, rely on the tree cover to stalk and hide before pouncing on zebras. Less tree cover means lions are not as successful at ambushing their prey. “Oftentimes, we find it’s the little things that rule the world,” Palmer said. “These tiny invasive ants showed up maybe 15 years ago, and none of us noticed because they aren’t aggressive toward big critters, including people. We now see they are transforming landscapes in very subtle ways but with devastating effects.” The two images represent acacia trees both invaded and not invaded by a small ant species. Credit: Todd Palmer Making the best out of a bad situation, the lions are turning their attention to buffaloes, Palmer said. However, buffaloes are larger than zebras and hang out in groups, making them much more formidable prey. “Nature is clever, and critters like lions tend to find solutions to the problems they face,” he said, “but we don’t yet know what could result from this profound switch in the lions’ hunting strategy. We are keenly interested in following up on this story.” Research and Conservation Efforts The fieldwork in Kenya was led by the University of Wyoming doctoral candidate and Kenyan scientist Douglas Kamaru. Palmer, along with Jake Goheen, from the University of Wyoming, and Corinna Riginos, with The Nature Conservancy, were co-principal investigators on the National Science Foundation grant that funded the work. In addition to studying the phenomenon, the researchers say they also are interested in finding solutions to halt the loss of tree cover in these iconic landscapes. “These ants are everywhere, especially in the tropics and subtropics. You can find them in your backyard in Florida, and it’s people who are moving them around,” Palmer said. “We are working with land managers to investigate interventions, including temporarily fencing out large herbivores, to minimize the impact of ant invaders on tree populations.” As science continues to move toward highly advanced technologies like AI-powered data collection, Palmer said their group’s persistent focus on Kenyan wildlife has involved traditional methods over several decades, showing the staying power of boots-on-the-ground research. “There are a lot of new tools involving big data approaches and artificial intelligence that are available today,” he said, “but this study was born of driving around in Land Rovers in the mud for 30 years.” Reference: “Disruption of an ant-plant mutualism shapes interactions between lions and their primary prey” by Douglas N. Kamaru, Todd M. Palmer, Corinna Riginos, Adam T. Ford, Jayne Belnap, Robert M. Chira, John M. Githaiga, Benard C. Gituku, Brandon R. Hays, Cyrus M. Kavwele, Alfred K. Kibungei, Clayton T. Lamb, Nelly J. Maiyo, Patrick D. Milligan, Samuel Mutisya, Caroline C. Ng’weno, Michael Ogutu, Alejandro G. Pietrek, Brendon T. Wildt and Jacob R. Goheen, 25 January 2024, Science. DOI: 10.1126/science.adg1464 The study was funded by the National Science Foundation.

The University of Pittsburgh and Carnegie Mellon University scientists solved a decades-old mystery regarding how cells control their volume. Crowded rooms: How Carnegie Mellon University and the University of Pittsburgh researchers solved a cell mystery. A surreal video of stressed cells under a microscope inspired a group of kidney physiologists and biologists from the University of Pittsburgh and Carnegie Mellon University to investigate a mystery: how do cells control their volume? Their research, which was recently published in the journal Cell, shows how the researchers connected the dots on a conundrum that was initially presented three decades ago with a little bit of luck.  “We were doing live fluorescence imaging experiments that were unrelated to this study, and when we added a salt solution to the cells, the internal cytoplasmic material rapidly turned into a fluorescent lava lamp,” said Daniel Shiwarski, Ph.D., a postdoctoral research fellow at Carnegie Mellon University, describing how he and his wife, co-lead author Cary Boyd-Shiwarski, M.D., Ph.D., turned a fortuitous bit of experimentation into an unexpected finding. In this video, WNK kinases (a type of enzyme) are fluorescent and diffuse throughout the cell. When exposed to a salt solution, they coalesce into larger droplets, looking like the bright green goo in a lava lamp. This process, called “phase separation,” is how the cell knows it needs to bring both water and ions back in, returning to its original state within seconds. Credit: Boyd-Shiwarski, et al., Cell (2022) “I looked at her, and she asked me what was going on, like I was supposed to know,” he said. “And I said, ‘I have no idea, but I think it’s probably something important!’” The Mystery of Cell Volume Regulation When cells are abruptly exposed to an outside stressor, such as elevated salt or sugar levels, their volume can decrease. Early in the 1990s, scientists believed that cells regain their volume by somehow keeping track of their protein concentration, or how “crowded” the cell was. However, they were unaware of how the cell sensed crowding. From left to right: Dr. Daniel Shiwarski, Dr. Arohan Subramanya, and Dr. Cary Boyd-Shiwarski. Credit: Jake Carlson/UPMC Then, in the early 2000s, With-No-Lysine Kinases, or “WNKs,” were identified as a new type of enzyme. For years, scientists theorized that WNK kinases reversed cell shrinkage, but how they did so was unexplained. The new study solves both puzzles by revealing how WNK kinases activate the “switch” that restores cell volume to equilibrium through a process known as phase separation. Cytosol Dynamics and the Role of Phase Separation “The inside of a cell contains cytosol, and generally people think that this cytosol is diffuse, with all kinds of molecules floating around in a perfectly mixed solution,” said senior author Arohan R. Subramanya, M.D., associate professor in the Renal-Electrolyte Division at Pitt’s School of Medicine and staff physician at the VA Pittsburgh Healthcare System. “But there has been this paradigm shift in our thinking of how cytosol works. It’s really like an emulsion with a bunch of little, tiny protein clusters and droplets, and then when a stress such as overcrowding happens, they come together into big droplets that you can often see with a microscope.” Those liquid-like droplets were the “lava lamp” that Shiwarski and Boyd-Shiwarski were seeing that fateful day when they experimented with adding a salt solution to the cells. They had fluorescently tagged the WNKs, which were diffused throughout the cytosol, causing the whole cell to glow. When salt was added, the WNKs came together, forming large neon-green globules that oozed about the cell like the goo in a lava lamp. The team characterized what they were seeing as phase separation, which is when WNKs condense into droplets along with the molecules that activate the cell’s salt transporters. This step allows the cell to import both ions and water, returning the cell’s volume to its original state within seconds. Phase separation is an emerging area of interest, but whether or not this process was an important part of cell function has been controversial. “There’s a lot of people out there who don’t believe phase separation is physiologically relevant,” explained Boyd-Shiwarski, assistant professor in the Renal-Electrolyte Division at Pitt’s School of Medicine. “They think it’s something that happens in a test tube when you overexpress proteins or occurs as a pathological process but doesn’t really happen in normal healthy cells.” But over the past six years, the team conducted multiple studies using stressors similar to the fluctuations that occur within the human body to show that phase separation of the WNKs is a functional response to crowding. Cell volume recovery has implications for human health as well, Subramanya explained: “One of the reasons why we’re so excited is that the next step for us is to take this back into the kidney.” Exploring WNKs in Kidney Health and Disease Other WNKs activate salt transport within kidney tubule cells when potassium levels are low by forming specialized condensates through phase separation, called WNK bodies. Modern Western diets are often low in potassium, so while attempting to regulate cell volume, WNK bodies may contribute to salt-sensitive hypertension. While the new discovery won’t have immediate clinical applications, the team is excited to take what they’ve learned and explore the connections between WNKs, phase separation, and human health. Eventually, their work may lead to a better understanding of how to prevent strokes, high blood pressure, and potassium balance disorders. Reference: “WNK kinases sense molecular crowding and rescue cell volume via phase separation” by Cary R. Boyd-Shiwarski, Daniel J. Shiwarski, Shawn E. Griffiths, Rebecca T. Beacham, Logan Norrell, Daryl E. Morrison, Jun Wang, Jacob Mann, William Tennant, Eric N. Anderson, Jonathan Franks, Michael Calderon, Kelly A. Connolly, Muhammad Umar Cheema, Claire J. Weaver, Lubika J. Nkashama, Claire C. Weckerly, Katherine E. Querry, Udai Bhan Pandey, Christopher J. Donnelly, Dandan Sun, Aylin R. Rodan and Arohan R. Subramanya, 31 October 2022, Cell. DOI: 10.1016/j.cell.2022.09.042 The study was funded by the National Institutes of Health and the U.S. Department of Veterans Affairs.

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