Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan graphene material ODM factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan athletic insole OEM production plant

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Customized sports insole ODM Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Cushion insole OEM solution Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia anti-bacterial pillow ODM design

This cross-section of a mouse heart (red) shows how well the gene therapy delivered sodium ion channel genes (cyan) to the target heart cells after researchers injected a virus with the genes into the mouse veins. Credit: Tianyu Wu, Duke University First approach to promote electrical excitation of heart cells in live mammals could lead to new gene therapy treatments for a wide range of heart diseases. Biomedical engineers at Duke University have demonstrated a gene therapy that helps heart muscle cells electrically activate in live mice. The first demonstration of its kind, the approach features engineered bacterial genes that code for sodium ion channels and could lead to therapies to treat a wide variety of electrical heart diseases and disorders. The results appeared online on February 2, 2022, in the journal Nature Communications. Long-lasting Effects on Heart Functionality “We were able to improve how well heart muscle cells can initiate and spread electrical activity, which is hard to accomplish with drugs or other tools,” said Nenad Bursac, professor of biomedical engineering at Duke. “The method we used to deliver genes in heart muscle cells of mice has been previously shown to persist for a long time, which means it could effectively help hearts that struggle to beat as regularly as they should.” Sodium-ion channels are proteins in the outer membranes of electrically excitable cells, such as heart or brain cells, that transmit electrical charges into the cell. In the heart, these channels tell muscle cells when to contract and pass the instruction along so that the organ pumps blood as a cohesive unit. Damaged heart cells, however, whether from disease or trauma, often lose all or part of their ability to transmit these signals and join the effort. Cardiac arrhythmias occur when heart muscle cells do not uniformly transmit electrical signals to pump blood in a cohesive, orderly fashion. The left video shows arrhythmic cells in tachycardia chaos, whereas the right video shows cells treated with the new gene therapy behaving normally, as they are much more difficult to push out of their regular heart beat activity. Credit: Tianyu Wu, Duke University One approach researchers can take to restore this functionality is gene therapy. By delivering the genes responsible for creating sodium channel proteins, the technique can produce more ion channels in the diseased cells to help boost their activity. In mammals, sodium channel genes are unfortunately too large to fit within the viruses currently used in modern gene therapies in humans. To skirt this issue, Bursac and his laboratory instead turned to smaller genes that code for similar sodium ion channels in bacteria. While these bacterial genes are different than their human counterparts, evolution has conserved many similarities in the channel design since multi-cellular organisms diverged from bacteria hundreds of millions of years ago. Successful Testing in Mouse Models Several years ago, Hung Nguyen, a former doctoral student in Bursac’s laboratory who now works for Fujifilm Diosynth Biotechnologies, mutated these bacterial genes so that the channels they encode could become active in human cells. In the new work, current doctoral student Tianyu Wu further optimized the content of the genes and combined them with a “promoter” that exclusively restricts channel production to heart muscle cells. The researchers then tested their approach by delivering a virus loaded with the bacterial gene into veins of a mouse to spread throughout the body. “We worked to find where the sodium ion channels were actually formed, and, as we hoped, we found that they only went into the working muscle cells of the heart within the atria and ventricles,” Wu said. “We also found that they did not end up in the heart cells that originate the heartbeat, which we also wanted to avoid.” This detailed image of a single mouse heart muscle cell shows its cell membrane expressing the new sodium ion channel genes (magenta) after researchers delivered the therapy through an injection into the mouse veins. Credit: Tianyu Wu, Duke University This gene therapy approach only delivers extra genes within a cell; it does not attempt to cut out, replace, or rewrite the existing DNA in any way. Scientists believe these types of delivered genes make proteins while floating freely within the cell, making use of the existing biochemical machinery. Previous research with this viral gene delivery approach suggests the transplanted genes should remain active for many years. As a proof of concept, tests on cells in a laboratory setting suggest that the treatment improves electrical excitability enough to prevent human abnormalities like arrhythmias. Within live mice, the results demonstrate that the sodium ion channels are active in the hearts, showing trends toward improved excitability. However, further tests are needed to measure how much of an improvement is made on the whole-heart level, and whether it is enough to rescue electrical function in damaged or diseased heart tissue to be used as a viable treatment. Future Directions and Potential Impact Moving forward, the researchers have already identified different bacterial sodium channel genes that work better in preliminary benchtop studies. The team is also working with the laboratories of Craig Henriquez, professor of biomedical engineering at Duke, and Andrew Landstrom, director of the Duke Pediatric Research Scholars Program, to test the ability of these genes to restore heart functionality in mouse models that mimic human heart diseases. “I think this work is really exciting,” Bursac said. “We have been harnessing what nature made billions of years ago to help humans with modern-day disease.” Reference: “Engineered Bacterial Voltage-Gated Sodium Channel Platform for Cardiac Gene Therapy” by Hung X. Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, Michael Tian, Andrew P. Landstrom, Craig Henriquez and Nenad Bursac, 2 February 2022. Nature Communications. DOI: 10.1038/s41467-022-28251-6 This work was supported by the National Institutes of Health (HL134764, HL132389, HL126524, 1U01HL143336-01), the Duke Translating Duke Health Initiative, and the American Heart Association Predoctoral Fellowship (829638).

Fish fecal pellets collected from the Santa Barbara Channel off California. Credit: Grace Saba Fish Waste Plays Major Role in Ocean Carbon Sink New research has shown that carbon in feces, respiration, and other excretions from fishes make up about 16% of the total carbon that sinks below the ocean’s upper layers. Ecosystems provide a huge range of benefits and services to humans – one of these is the extraction of carbon dioxide from the atmosphere and its burial either in sediments or in the deep ocean. Now a team of scientists lead by Dr. Grace Saba at Rutgers University and including Dr. Clive Trueman from Southampton have amalgamated their existing knowledge to estimate the contribution of fish to the global export of carbon. Dr. Trueman, Associate Professor in Marine Ecology at the University of Southampton who was part of the research team said, “Measuring the amount of carbon that is captured and stored by different kinds of animals and plants is very important as we try to reduce the total amount of carbon dioxide in the Earth’s atmosphere.  Disrupting ecosystems that actively store carbon could reverse some of the progress made in reducing carbon emissions. Similarly, protecting these natural carbon capture and storage services maintains our planet’s self-regulating systems.” “Marine fishes can capture carbon through feeding and then export that carbon to the deep ocean as they excrete. Understanding just how much carbon is pooed into the deep ocean by fishes is challenging, however.  Scientists argue about the number of fishes present in the world’s ocean, exactly where they live, how much they eat, and how much, and where, they poo.” he explained. Phytoplankton and Feces Fuel the Biological Pump Carbon dioxide absorbed by the ocean is taken up by phytoplankton (algae), small single-celled plants at the ocean’s surface. Through an important process called the biological pump, this organic carbon can go from the surface to ocean depths when algal material or fecal pellets from fishes and other organisms sink. The daily migration of fishes to and from the depths also contributes organic carbon particles, along with excreted and respired material. Another factor is the mixing of ocean waters. Better data on this key part of the Earth’s biological pump will help scientists understand the impact of climate change and seafood harvesting on the role of fishes in carbon flux, according to this study, published in the journal Limnology & Oceanography. Carbon flux means the movement of carbon in the ocean, including from the surface to the deep sea – the focus of this study. “Our study is the first to review the impact that fishes have on carbon flux,” said lead author Dr. Saba, an assistant professor in the Center for Ocean Observing Leadership at Rutgers University, New Brunswick. “Our estimate of the contribution by fish – about 16 percent – includes a large uncertainty, and scientists can improve it with future research. Forms of carbon from fish in ocean waters where sunlight penetrates – up to about 650 feet (200 meters) deep –include sinking fecal pellets, inorganic carbon particles, dissolved organic carbon and respired carbon dioxide. My guess is that fecal carbon from fish is 15 to 20 percent of the total carbon they release, similar to some zooplankton.” “Moreover, carbon that makes its way below the sunlit layer become sequestered, or stored, in the ocean for hundreds of years or more, depending on the depth and location where organic carbon is exported,” Saba said. “This natural process results in a sink that acts to balance the sources of carbon dioxide.” Reference: “Toward a better understanding of fish‐based contribution to ocean carbon flux” by Grace K. Saba, Adrian B. Burd, John P. Dunne, Santiago Hernández-León, Angela H. Martin, Kenneth A. Rose, Joseph Salisbury, Deborah K. Steinberg, Clive N. Trueman, Rod W. Wilson and Stephanie E. Wilson, 17 February 2021, Limnology and Oceanography. DOI: 10.1002/lno.11709 Scientists at multiple institutions contributed to the study, funded by the National Science Foundation’s Ocean Carbon and Biogeochemistry Program.

Immunofluorescence staining of human pluripotent stem cell-derived axioloids. Credit: Alev Lab (ASHBi/Kyoto University) ASHBi Researchers Have Helped Uncover the Secrets of the Human Body’s Plan Michelangelo’s David captures the beauty of the human form, but scientists have been baffled for over 100 years by how this perfect body structure develops. This mystery has been hard to unravel due to technical limitations and ethical issues surrounding research on human embryos. However, now, work published in Nature by an international team of scientists led by Dr. Cantas Alev, at the Institute for the Advanced Study of Human Biology (ASHBi) in Kyoto University, has uncovered using their own mallet and chisel –a petri dish and induced pluripotent stem cells (iPSCs)– how the early stages of the human body plan are established. Segmentation and the Role of Somites Similar to other organisms within the animal kingdom, the human body consists of repetitive anatomical units or segments – a prominent example being the vertebrae of the human spine. The most primitive version of such segments in the human embryo, known as somites, arise from an embryonic tissue called presomitic mesoderm (PSM) and contribute to the formation of various structures including cartilage, bone, skin, and skeletal muscle. Graphical abstract of the paper. Credit: Alev Lab (ASHBi/Kyoto University) / Misaki Ouchida While previous work by Alev and colleagues reconstituted the so-called segmentation clock, a molecular oscillator and dynamic ‘wave’ of gene expression required for the proper formation of human somites (somitogenesis), it could not recapitulate the complex three-dimensional (3-D) morphological and structural changes occurring during human body-axis development. In their new study, Alev and co-workers, using a cocktail consisting of human iPSCs-derived cells and Matrigel –a viscous gel compound enriched with extracellular matrix components– have now generated a 3-D model that can recapitulate the development of our early body plan in a dish, which they coined ‘axioloids’. “(Our) axioloids capture, not only the oscillatory nature of the segmentation clock but also the molecular as well as the 3-D morphological and structural characteristics observed during the process of segmentation and somitogenesis,” says Alev. Vitamin A’s Role in Somitogenesis By taking a bottom-up approach in their experimental design, Alev and his team identified a previously unappreciated functional role for retinoids, more commonly known as vitamin A and its derivatives, during somite formation. “Our bottom-up approach was critical to unraveling the role of retinoids during somitogenesis. It is likely that many researchers missed this essential role because vitamin A is a common supplement that usually gets included into culture media” comments Alev. When Alev’s axioloids were compared to actual human embryos, they revealed “remarkable similarities to Carnegie Stage 9-12 human embryos, which is known to be a critical stage during human development where organs such as the brain and heart start forming” explains Alev. Applications for Congenital Spine Disease Research Lastly, using iPSCs containing mutations commonly associated with congenital spine disease, Alev and co-authors demonstrated that axioloids can be instrumental in delineating how these mutations contribute to the pathogenesis of such diseases. Alev comments, “our (bottom-up) approach of generating axioloids have not only allowed us to uncouple fundamental biological processes, such as cell morphology and cell states, but it allowed us to determine how mutations contribute to spine disease” and he continues, “we also anticipate similar strategies will become increasingly necessary in order to understand better the etiology and pathology of other diseases.” Reference: “Reconstituting human somitogenesis in vitro” by Yoshihiro Yamanaka, Sofiane Hamidi, Kumiko Yoshioka-Kobayashi, Sirajam Munira, Kazunori Sunadome, Yi Zhang, Yuzuru Kurokawa, Rolf Ericsson, Ai Mieda, Jamie L. Thompson, Janet Kerwin, Steven Lisgo, Takuya Yamamoto, Naomi Moris, Alfonso Martinez-Arias, Taro Tsujimura and Cantas Alev, 21 December 2022, Nature. DOI: 10.1038/s41586-022-05649-2

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