Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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ESG-compliant OEM manufacturer in Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Ergonomic insole ODM production factory Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow OEM for wellness brands Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China custom neck pillow ODM

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan athletic insole OEM supplier

Researchers at the HUN-REN Institute discovered that specific inhibitory neurons in the brain, known as HDB-PV neurons, play a critical role in learning from negative experiences. These neurons enhance cognitive processes and are essential for drawing attention and facilitating learning in response to aversive stimuli. Credit: SciTechDaily A neuroscience study identifies specific brain neurons that are vital for learning from negative stimuli, highlighting their potential role in mental health. We often say ‘I’m not going to do this again’ when faced with negative feedback, adverse effects, or disappointing outcomes. From these experiences, we attempt to learn. How does the brain facilitate this type of learning? Positive and negative reinforcements are crucial mechanisms within the brain’s valuation system. Neurons releasing the neurotransmitter dopamine signify outcomes that are better or worse than expected by either increasing or decreasing their activity. Meanwhile, there is growing evidence that other parts of the brain handle ‘negative’ and ‘positive’ differently. Arousal and Attention in Negative Experiences Negative experiences often provoke a significant arousal effect, activating specific parts of the neocortex. This activation helps us focus on pertinent features and learn from the experience, a concept known as ‘attention for aversive learning’. Researchers from the HUN-REN Institute of Experimental Medicine, led by Balazs Hangya, explored which brain regions and neuron types are involved in aversive learning. Their study, published in the journal Nature Communications, reveals that long-range projecting inhibitory neurons that express the protein parvalbumin (PV) in the horizontal limb of the diagonal band of Broca (HDB) play a crucial role in this process. Parvalbumin expressing axons (yellow) contact a cholinergic neuron (cyan) in the medial septum. Credit: Panna Hegedüs. From Hegedüs et al., 2024, Nature Communications. Neuron Functionality and Experimental Findings These HDB-PV neurons, known for their fast activity, convey arousing effects to the neocortex and control gamma oscillations critical for cognitive functions. Therefore, they appeared as good candidates for mediating ‘attention for aversive learning’. Hangya’s team showed that these neurons are indeed recruited by aversive events in experimental mice, like an unexpected puff of air on the face mice strive to avoid, or the odor of a fearful predator. The Effects of Aversive Events Aversive events activate a range of pathways, leading to a series of consequences in the brain. First, they promote avoidance behaviors that reduce the risk of enduring negative impacts. Second, they enhance arousal and attention by activating relevant parts of the neocortex, helping the organism cope with the situation. Third, they facilitate learning to avoid or mitigate similar future scenarios. Panna Hegedüs, the first author of the study, noted, “Learning from negative experience is a deeply rooted, ancient survival strategy. It can even override the effects of positive reinforcement.” Insights from Optogenetics Hangya’s team used a technology called optogenetics, which can render specific cell types, in this case, HDB-PV neurons, sensitive to light. These techniques enable precise activation or suppression of the activity of neurons by the timed delivery of light into the brain tissue via small optic fibers. They found that activating HDB-PV neurons did not cause avoidance behavior in mice, suggesting that this pathway is not involved in active avoidance like seeking a shelter, but more likely mediates attention and/or learning aspects induced by aversive stimuli. Indeed, when they optogenetically blocked the responses of the neurons to facial air puffs, mice failed to learn discriminating predictive auditory stimuli forecasting likely or unlikely air puffs. This experiment demonstrated that HDB-PV neurons are necessary to learn from aversive stimuli. Neural Circuits and Behavioral Responses Neurons do not act in isolation but are part of complex circuits with diverse input and output pathways. Hangya’s team, together with Gabor Nyiri and coworkers from the same institute, mapped the inputs to and outputs of HDB-PV neurons. They found that these cells integrate multiple sources of aversive information including prominent pathways from the hypothalamus and the brainstem raphe nuclei. In turn, they transmit integrated information to the so-called limbic system broadly responsible for behavioral and emotional responses, including the septo-hippocampal system important for storing and recalling episodic memories. Furthermore, the inhibitory HDB-PV cells mostly target other inhibitory neurons in these regions, thus likely relieving excitatory cells from inhibition and allowing them to be more active – a ubiquitous brain mechanism called disinhibition. Conclusion and Implications for Mental Health The study suggests that long-range inhibitory HDB-PV neurons are recruited by aversive stimuli to serve crucial associative learning functions through increasing cortical excitability at specific target areas, probably by disinhibition. Thus, at least for aversive stimuli, HDB-PV neurons might be the physical substrate of the ‘attention for learning’ concept. “The dysregulation of processing positive and negative valence can be observed in different psychiatric disorders including anxiety and depression. Therefore, it is crucial to understand how negative valence is encoded in the brain and how it contributes to learning,” Hegedüs concludes. Reference: “Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience” by Panna Hegedüs, Bálint Király, Dániel Schlingloff, Victoria Lyakhova, Anna Velencei, Írisz Szabó, Márton I. Mayer, Zsofia Zelenak, Gábor Nyiri and Balázs Hangya, 7 June 2024, Nature Communications. DOI: 10.1038/s41467-024-48755-7

Mechanical stimuli initiate the concentric propagation of intercellular calcium waves away from trichomes. Credit: Yasuomi Tada Trichomes on plant leaves sense rain as a pathogen risk, triggering immune responses via calcium waves, offering potential for enhancing crop disease resistance. While rain is essential for the survival of plants, it also contains bacteria and other pathogens which can cause them harm. So how do plants protect themselves from this threat? A recent study by Nagoya University researchers and colleagues revealed that when plants are exposed to rain, hair-like structures on the leaf surface called trichomes recognize this rain as a risk factor for causing disease and activate their immune system to prevent infections. These findings, published in the journal Nature Communications, could contribute to the development of methods to protect plants from infectious diseases caused by rain. Plants have their own immune system, just like humans and other multicellular organisms. When plants detect pathogens, they express immune-related genes to prevent themselves from being infected. Raindrops contain pathogens, such as bacteria, filamentous fungi, and viruses, and thus can cause disease in plants. With this in mind, the researchers hypothesized that plants could recognize rain as a risk factor for disease and react to protect themselves from this risk in some way. To find out how plants respond to rain, a research team led by Professor Yasuomi Tada and Assistant Professor Mika Nomoto of Nagoya University conducted a study using Arabidopsis thaliana seedlings. The team began by conducting RNA sequencing analyses to examine which genes are expressed in the leaves when they are exposed to rain. They found that several major immune-related genes are expressed in response to rain, and that these genes are regulated by immunosuppressive genes called CAMTAs (calmodulin-binding transcription activators). Since CAMTAs are controlled by calcium ions (Ca2+), the team hypothesized that rain serves to increase Ca2+ concentrations in cells. Thus, they investigated how Ca2+ levels in Arabidopsis leaves change in response to rain by introducing GCaMP3 — a gene that fluoresces green when bound to Ca2+ — into the leaves. They found that when the leaves were exposed to rain, Ca2+ levels around trichomes on leaf surfaces increased. Trichomes: Key Players in Plant Defense Mechanisms The result suggested that trichomes sense rain as a risk factor and induce calcium waves (transmission of localized increases in Ca2+ to the surrounding areas) across the leaf to inactivate the immunosuppressor CAMTA and thereby activate immune-related genes. To confirm this, they next conducted experiments in the same way using mutants of Arabidopsis which lacked trichomes, and the results showed that the propagation of calcium waves was compromised in the mutants. “From these results, we confirmed that trichomes play a role in sensing rain as a risk factor and activating immune responses,” says Professor Tada. “Our findings suggest that we may be able to artificially improve plants’ defensive capabilities against diseases at any time and for any length of time. Using this technology, we could make it possible to activate crops’ immune responses when environmental conditions are harsh enough to possibly cause disease in plants, which could result in stable crop yields.” Reference: “Mechanosensory trichome cells evoke a mechanical stimuli–induced immune response in Arabidopsis thaliana” by Mamoru Matsumura, Mika Nomoto, Tomotaka Itaya, Yuri Aratani, Mizuki Iwamoto, Takakazu Matsuura, Yuki Hayashi, Tsuyoshi Mori, Michael J. Skelly, Yoshiharu Y. Yamamoto, Toshinori Kinoshita, Izumi C. Mori, Takamasa Suzuki, Shigeyuki Betsuyaku, Steven H. Spoel, Masatsugu Toyota and Yasuomi Tada, 8 March 2022, Nature Communications. DOI: 10.1038/s41467-022-28813-8

Researchers have found that studying proteins at body temperature reveals new drug binding sites, potentially revolutionizing drug design by providing more physiologically relevant insights into protein structure. Credit: SciTechDaily.com Scientists discovered that proteins change shape at body temperature, revealing new drug binding sites. This finding, using cryo-electron microscopy, could revolutionize drug development by providing more accurate protein structures for medication design. Some proteins change their shape in response to varying temperatures, unveiling previously hidden binding sites for drugs. The findings, published in Nature, could revolutionize wide swathes of biology by fundamentally changing how protein structure is studied and leveraged for drug design. Van Andel Institute’s Juan Du, Ph.D. and Wei Lü, Ph.D led the research. Proteins generally are investigated at low temperatures to ensure their stability. However, the new study demonstrates that certain proteins are highly sensitive to temperature and change their shape when viewed at body temperature. “For a long time, the methods we’ve used to study proteins require them to be cold or frozen. But in the real world, human proteins exist and function at body temperature,” Du said. “Our study describes a new way to study proteins at body temperature and reveals that some proteins drastically alter their structures when warm, opening up new opportunities for structure-guided drug development.” The Role of Proteins in Medication Development Proteins are the molecular workhorses of the body. Their shape governs how they interact with other molecules to do their jobs. By determining protein structure, scientists can create blueprints that guide the development of more effective medications, much like locksmiths designing keys to fit into specific locks. Although it is well known that temperature affects molecular function in the body, studying proteins at physiological temperature has been technologically challenging. Today’s study by the Du and Lü laboratories details how they overcame these issues and provides scientists a roadmap for doing so in their own experiments. Proteins usually are studied at low temperatures. However, new findings from the labs of Dr. Juan Du and Dr. Wei Lu at Van Andel Institute demonstrate that certain proteins, such as TRPM4, are highly sensitive to temperature and change their shape when viewed at body temperature. This change may expose previously hidden binding sites for medications. Credit: Courtesy of the Du Lab and Lü Lab, Van Andel Institute The study focused on a protein called TRPM4, which supports heart function and metabolism, including the release of insulin. As such, TRPM4 is linked to stroke, heart disease, and diabetes, among other health conditions. To visualize TRPM4 at body temperature, the team leveraged VAI’s powerful suite of cryo-electron microscopes (cryo-EM), which allow scientists to flash freeze proteins and assemble detailed images of their structures. Rather than using a low-temperature sample, Postdoctoral Fellow Jinhong Hu, Ph.D., and colleagues in the Du and Lü laboratories heated the sample to body temperature before flash freezing it. By doing so, they found that ligands — molecules that bind to proteins — interact with totally different sites on TRPM4 at body temperature than at lower temperatures. The implications of today’s study are far-reaching and reinforce the importance of studying proteins at body temperature to ensure the identification of physiologically relevant drug-binding sites. Reference: “Physiological temperature drives TRPM4 ligand recognition and gating” by Jinhong Hu, Sung Jin Park, Tyler Walter, Ian J. Orozco, Garrett O‘Dea, Xinyu Ye, Juan Du and Wei Lü, 15 May 2024, Nature. DOI: 10.1038/s41586-024-07436-7 The cryo-EM data was collected at VAI’s Cryo-EM Core and David Van Andel Cryo-Electron Microscopy Suite. Research reported in this publication was supported by the National Heart, Lung and Blood Institute of the National Institutes of Health under award no. R01HL153219 (Lü); the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under awards no. R01NS112363 (Lü), R01NS111031 (Du) and R01NS129804 (Du); a Klingenstein-Simons Fellowship Award in Neuroscience (Du); an Alfred P. Sloan Research Fellowship in Neuroscience (Du); a Pew Scholar in Biomedical Sciences from the Pew Charitable Trusts (Du); a McKnight Scholar Award (Du); and the American Heart Association under award no. 24POST1196982 (Hu).

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