Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Soft-touch pillow OEM service in China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.One-stop OEM/ODM solution provider Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Cushion insole OEM solution Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Breathable insole ODM innovation factory Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China insole ODM service provider

Scientists in India discovered a new lizard species, Cnemaspis vangoghi, in the Southern Western Ghats, named for its resemblance to Van Gogh’s The Starry Night. The finding highlights the rich biodiversity and unique habitat characteristics of Tamil Nadu’s Srivilliputhur area. Credit: Akshay Khandekar You’ve probably seen nature depicted in art, but how often do you see an artwork hiding in nature? When they saw the back of a lizard in the Southern Western Ghats, a group of scientists from the Thackeray Wildlife Foundation in India were reminded of Van Gogh’s The Starry Night. As soon as they figured out it was a new species, it was only apt to name it in honor of the famous painter. “Cnemaspis vangoghi is named for Dutch painter Vincent Van Gogh (1853–1890) as the striking coloration of the new species is reminiscent of one of his most iconic paintings, The Starry Night,” explains Ishan Agarwal, who took part in the study to describe the new lizard. Males of the species have a yellow head and forebody and light blue spots on the back and they live among rocks and occasionally buildings and trees. From left to right: Akshay Khandekar, Tejas Thackeray, Swapnil Pawar, Ishan Agarwal, Satpal Gangalmale, Vivek Waghe. Credit: Khandekar et al. Expedition Findings and Biodiversity Together with his fellow researchers Akshay Khandekar and Tejas Thackeray, they found the new species during an expedition in April 2022 to the Southern Western Ghats in Tamil Nadu, India. Now, they have published their findings in the peer-reviewed journal ZooKeys. “Tamil Nadu is an exceptionally biodiverse state and we expect to name well over 50 new species of lizards by the time we are done [with our expeditions]!” Ishan Agarwal says. “I also had more than 500 tick bites during that summer trip, with the highest densities in the low-elevation, dry forests of Srivilliputhur, where the new species are found,” he adds. Cnemaspis vangoghi is a small-sized gecko that can reach 3,4 cm in length. It was described as new to science together with another species of its genus, Cnemaspis sathuragiriensis, named for its type locality the Sathuragiri Hills. “The two new species are distributed in low elevation (250–400 m asl.), deciduous forests of Srivilliputhur, and add to the five previously known endemic vertebrates from Srivilliputhur-Megamalai Tiger Reserve, Tamil Nadu, India,” Ishan Agarwal explains. They are diurnal and mainly active during the cool hours of the early morning and evening, found largely on rocks. So far, they have only been found in very restricted localities, “an interesting case of micro-endemism in low-elevation species,” he notes. Reference: “Two new species of the Cnemaspis galaxia complex (Squamata, Gekkonidae) from the eastern slopes of the southern Western Ghats” by Akshay Khandekar, Tejas Thackeray and Ishan Agarwal, 27 March 2024, ZooKeys. DOI: 10.3897/zookeys.1196.117947

Zika virus uses the ANKLE2 protein to replicate and evade immune defenses, posing a unique threat by crossing the placenta and impacting fetal brain development. Zika virus, infamous for causing microcephaly, manipulates a host protein called ANKLE2 to assist its replication, which also affects brain development. This process differs from other mosquito-borne viruses like dengue and yellow fever, as Zika uniquely crosses the placental barrier to harm fetuses. Zika Virus and Microcephaly: A Dangerous Connection The mosquito-borne Zika virus is infamous for causing microcephaly, a birth defect where abnormal brain development leads to an unusually small head. A recent study published today (January 13) in mBio reveals that Zika exploits a host protein called ANKLE2 — critical for brain development — to enhance its own reproduction. Unlike most related viruses, Zika can cross the placenta, leading to potentially devastating effects during pregnancy. “It’s a case of Zika being in the wrong place at the wrong time,” explained Priya Shah, associate professor in the departments of Microbiology and Molecular Genetics and of Chemical Engineering at the University of California, Davis and senior author on the paper. ANKLE2: The Host Protein Hijacked by Zika The study also found that other mosquito-borne viruses, like dengue and yellow fever, use ANKLE2 in a similar way. This breakthrough opens up new possibilities for developing vaccines or treatments targeting these viruses. Viruses carry only a limited set of instructions in their own genetic material, so to reproduce they rely on taking over host cell proteins and functions. Shah’s laboratory studies these interactions between virus and host. Shah and her research team previously found that a Zika virus protein called NS4A interacts with ANKLE2 in host cells. Working in Drosophila fruit flies, they showed that this could lead to microcephaly. ANKLE2 is known to be involved in brain development in the fetus, but is found in cells throughout the body. Forming Virus Factories In the new study, led by recent Ph.D. graduate Adam Fishburn, Shah’s team grew the Zika virus in human cells. Knocking out the ANKLE2 gene in these cells reduced the ability of the Zika virus to grow. In Zika-infected cells, ANKLE2 clusters in pockets around the endoplasmic reticulum, a network used for protein production within the cell. Viral NS4A interacts with ANKLE2 to form pockets off the endoplasmic reticulum that act as virus factories, Shah said. Bringing all the components to make viruses in one place makes replication more efficient and also helps hide the virus from the immune system. A Clever Hiding Strategy for Viral Replication “Our current model is that ANKLE2 is really important, but not essential, for forming these replication pockets,” Shah said. Our cells are well equipped to fight off these viruses, but only if they can find them, Fishburn said. “Zika and related viruses have evolved strategies to hide themselves in these replication pockets to avoid detection. We believe that ANKLE2 is hijacked to help facilitate this process, and without it the pockets don’t form as well and the immune system can keep virus replication in check,” Fishburn said. Mosquito and Human Hosts: A Shared Target Working with Claudia Rückert at the University of Nevada, Reno, they found that Zika virus also uses ANKLE2 when it infects mosquito cells, meaning that this interaction is important in both human and insect hosts. Finally, they showed that NS4A from other, related mosquito-borne viruses, including dengue virus and yellow fever virus, interacts with ANKLE2 in the same way. This all suggests that NS4A/ANKLE2 interaction is important for replication across a broad group of mosquito-borne viruses, opening possible routes to new drugs and vaccines for these diseases. Why Zika Virus Causes Microcephaly While Others Don’t If much more common viruses like dengue virus also target ANKLE2, why don’t they also cause the microcephaly seen in Zika virus infection? It’s probably all down to location. Zika virus is unusual in that it can cross the placenta and enter the fetus, where ANKLE2 is known to play a big role in brain development. Most other viruses are kept out of the fetus by the placental barrier. Reference: “Microcephaly protein ANKLE2 promotes Zika virus replication” by Adam T. Fishburn, Cole J. Florio, Thomas N. Klaessens, Brian Prince, Neil A. B. Adia, Nicholas J. Lopez, Nitin Sai Beesabathuni, Sydney S. Becker, Liubov Cherkashchenko, Sophia T. Haggard Arcé, Vivian Hoang, Traci N. Shiu, R. Blake Richardson, Matthew J. Evans, Claudia Rückert and Priya S. Shah, 13 January 2025, mBio. DOI: 10.1128/mbio.02683-24 The work was supported by grants from the National Institutes of Health and the W. M. Keck Foundation. Additional authors on the paper are: Cole Florio, Thomas Klaessens, Neil Alvin Adia, Nicholas Lopez, Nitin Sai Beesabathuni, Sydney Becker, Liubov Cherkaschenko, Sophia Haggard Arcé, Vivian Hoang and Traci Shiu at UC Davis; Brian Prince, University of Nevada, Reno; and Blake Richardson and Matthew Evans at Icahn School of Medicine at Mount Sinai, New York.

B chromosomes, studied in rye by the IPK Leibniz Institute, manipulate cell division via “chromosome drive.” Using advanced sequencing, researchers identified five candidate genes, including DCR28, a key regulator. Their findings provide new insights into chromosome biology and genetic disease mechanisms. B chromosomes manipulate cell division for survival, and new research identifies key genes, including DCR28, involved in this process in rye. Supernumerary B chromosomes, unlike standard A chromosomes, are not essential for the normal growth and development of organisms. As of 2024, B chromosomes have been identified in nearly 3,000 species across all eukaryotic phyla. While low numbers of B chromosomes typically have no noticeable selective impact, higher numbers can lead to phenotypic abnormalities and decreased fertility. To avoid elimination, many B chromosomes influence cell division in their favor and increase their copy number in the process. This phenomenon is called chromosome drive. The “selfish” B chromosomes, therefore, only become active when their existence is at stake and not for the benefit of the plant. Challenges in Studying B Chromosome Drive Drive mechanisms in B chromosome systems have been studied in many species and contexts using various technologies, from classical genetics to cytogenetics. But despite being an ideal test case to study the underlying mechanisms of the chromosome drive, B chromosome research has only slowly been able to capitalize on the data explosion of the DNA sequencing boom: B chromosomes are highly structurally complex, repetitive, and multitudinous, all of which make them resistant to pseudomolecule-level chromosome assembly, especially before recent developments in the area of long-read sequencing. As such, gene-level insight into the specific mechanisms that control chromosome drive is severely limited, and specific gene candidates implicated in this phenomenon have not been identified so far. Breakthrough in Rye B Chromosome Research To identify the drive-controlling factor(s) on the rye B chromosome, an international research team led by the IPK Leibniz Institute first narrowed down the size of the drive-control region. Next, the researchers used long DNA reads and assembled the rye B chromosome into a single ~430 Mb-long pseudomolecule and performed a detailed transcriptome analysis. “Using a newly-assembled B chromosome pseudomolecule, we identified five candidate genes whose role as moderators of chromosome drive is supported by additional studies,” explains Jianyong Chen, first author of the study. “The DCR28 gene, which is presumably responsible for regulating this process, stood out,” emphasizes Prof. Andreas Houben, head of IPK’s research group “Chromosome Structure and Function.” Furthermore, it was shown that the B chromosome originated from fragments of all seven rye standard A chromosomes. These findings could also be helpful for research into genetic diseases that are based on the unequal distribution of chromosomes. Reference: “The genetic mechanism of B chromosome drive in rye illuminated by chromosome-scale assembly” by Jianyong Chen, Jan Bartoš, Anastassia Boudichevskaia, Anna Voigt, Mark Timothy Rabanus-Wallace, Steven Dreissig, Zuzana Tulpová, Hana Šimková, Jiří Macas, Gihwan Kim, Jonas Buhl, Katharina Bürstenbinder, Frank R. Blattner, Jörg Fuchs, Thomas Schmutzer, Axel Himmelbach, Veit Schubert and Andreas Houben, 8 November 2024, Nature Communications. DOI: 10.1038/s41467-024-53799-w

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