Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan neck support pillow OEM

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene sheet OEM supplier Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ESG-compliant OEM/ODM production factory in Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam OEM insole and pillow supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan pillow OEM manufacturer

Researchers at Kyoto University have discovered that talin proteins play a crucial role in cell migration and mechanosensing by dynamically stretching to connect cellular matrices, challenging existing beliefs about cellular force transmission. Credit: SciTechDaily.com Talin’s springy role in force transmission and dynamic cellular bridging. Cell biology has possibly never jumped to the next level in the same way. In multicellular organisms, cell migration and mechanosensing are essential for cellular development and maintenance. These processes rely on talin, the key focal adhesion — or FA — protein, central in connecting adjacent cellular matrices and enabling force transmission between them. Talins are commonly considered fully extended at FAs between actin filaments — or F-actin — and the anchor-like integrin receptor. Contradicting Prevailing Notions However, a research team led by Kyoto University previously observed that the actin network constantly moves over FAs as a single unit: a unique phenomenon contradicting prevailing notions. “This begs the question: how does talin manage to simultaneously maintain the intercellular connection while transmitting force?” asks corresponding author Sawako Yamashiro at KyotoU’s Graduate School of Life Sciences. Most significantly, the team’s results reveal a new mode of force transmission in which dynamic molecular stretching bridges the extracellular matrix and flowing F-actin moving at different speeds. This discovery underscores the necessity of molecular elasticity and random coupling for sufficiently transmitting force. Dynamic molecular stretching bridges the extracellular matrix and flowing F-actin moving at different speeds. On a human scale, this phenomenon can be visualized as a super flexible anime character, gripping onto a train passing at around 50 km/h. Credit: KyotoU/Sawako Yamashiro A New Model of Force Transmission “On a human scale, this phenomenon can be visualized as a super flexible anime character. He is gripping onto a train passing at around 50 km/h,” illustrates Yamashiro. The train represents the flowing F-actin, while a station platform is the substrate. The superhero plays the talin FA protein that would either be carried away unstretched or remain on the substrate. “Occasionally, however, when both ends of talin are firmly anchored, it gets stretched by the pull because some parts of this protein can unfold like a spring,” explains Yamashiro. Aided by intracellular fluorescent talin single-molecule imaging, Yamashiro’s team observed and calculated that approximately 4% of the talin links the F-actin and the substrate via an elastic transient clutch. In contrast, the remaining majority are bound to either end. Revising Molecular Roles These findings also call for revising the role of molecular unfolding, updating the traditional view that it functions as a mechanosensor and a shock absorber when molecules unfold under external force. “However, our results suggest that molecular unfolding facilitates the transmission of force rather than absorbing it,” says coauthor Dimitrios Vavylonis at Lehigh University. “We can expect further use of intracellular single-molecule microscopy to witness other possible intra- and extra-cellular superheroic behaviors, such as talin’s elastic transient clutch,” concludes coauthor Naoki Watanabe, also at KyotoU’s Graduate School of Life Sciences. Reference: “Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin” by Sawako Yamashiro, David M. Rutkowski, Kelli Ann Lynch, Ying Liu, Dimitrios Vavylonis and Naoki Watanabe, 20 December 2023, Nature Communications. DOI: 10.1038/s41467-023-44018-z

Stanford’s study reveals the mechanics behind skin sensations post-cleansing and moisturizing, offering insights for improved skincare product development and potential applications in wearable tech communication. A new study from Stanford University reveals the neurological mechanism behind the perception of skin tightness. Stanford researchers have uncovered the mechanism behind the feeling of skin tightness experienced after washing with a cleanser and subsequent relief with moisturizing. Their study, published in PNAS Nexus, demonstrates how mechanical changes in the skin’s outermost layer can lead to these sensations. Using their insights, they developed a predictive model that closely matched human trial feedback. This research not only offers new avenues for skincare product development but also potential applications in wearable technology that can communicate through mechanical skin changes. Understanding Skin Sensations When we wash our face with a cleanser, our skin can start to feel tight. With the application of a favorite moisturizer, that feeling often goes away. This perception of our skin might seem subjective, but researchers at Stanford recently revealed the mechanism behind these feelings. Their work, published today, September 26, in PNAS Nexus, demonstrates how mechanical changes at the outer surface of our skin translate into sensations and provides a quantitative approach for determining how people will perceive their skin after using a moisturizer or cleanser. “This work provides a new understanding of how products affect the physical properties of our skin, which includes not just skin health, but also skin sensorial perception. That’s a significant advance,” said Reinhold Dauskardt, the Ruth G. and William K. Bowes Professor in Stanford’s Department of Materials Science and Engineering. “It provides a whole new understanding of how to design those formulations.” Mechanism and Experimentation Our skin is the largest organ in our body and it’s constantly exposed to the environment around us. The outermost layer of our skin – the stratum corneum – acts as a barrier to keep out unwanted chemicals and bacteria and to keep in moisture. When we use a harsh cleanser, it strips away some of the lipids that hold in moisture, causing the stratum corneum to contract. A good moisturizer increases the water content of the stratum corneum, causing it to swell. Dauskardt and his colleagues predicted that the mechanical forces created by this shrinking or swelling propagate through the skin to reach mechanoreceptors – sensory receptors that turn mechanical force into neurological signals – below the epidermis, which then fire off signals to the brain that we interpret as a feeling of skin tightness. To test their theory, the researchers studied the effects of nine different moisturizing formulas and six different cleansers on donor skin samples from three locations on the human body – cheek, forehead, and abdomen. They measured changes in the stratum corneum in the lab and then fed that information into a sophisticated model of human skin to predict the signals that the mechanoreceptors would send. “We were able to rank the different formulations in terms of what subjects should say about the sensorial perception of their skin,” Dauskardt said. The predictions from their analysis lined up almost perfectly with what people reported in human trials for each formula. Collaborators at L’Oréal Research and Innovation recruited 2,000 women in France to assess the nine moisturizers and 700 women in China to assess the six cleansers. The participants ranked their perceived feelings of skin tightness after using the formula they were given. “We plotted what we were predicting against what human subjects were telling us, and it all fell on a straight line. In other words, we were predicting exactly what they were telling us,” Dauskardt said. “It was an absolutely remarkable correlation with a very high statistical significance.” Shaping New Developments The ability to understand and predict how people will feel after using a skin treatment could help cosmetics companies improve their formulations before bringing in people to test them. And with such a detailed model of how mechanical stresses are transferred through skin layers, these methods could potentially be used to evaluate more than just the feeling of tightness, Dauskardt said. “It provides a framework for the development of new products,” Dauskardt said. “If you’re doing anything to the outer layer of the skin that’s causing it to change its strain state and its stress state, then we can tell you how that information is transmitted and how it will be understood and reported by consumers.” Dauskardt is also looking to apply this new understanding to the development of wearable devices. For example, if we know how our brains interpret minute changes in skin tension, we might be able to harness that mechanism to send intentional signals. In the same way that a person reading braille translates sensations on their fingertip into words, a device creating tiny mechanical changes on our skin might be able to convey information. “What we’ve done is reveal how mechanical information gets from the outer stratum corneum layer down to the neurons much lower in the skin layers,” Dauskardt said. “So now, can we communicate through human skin? Can we build a device to provide information to someone non-verbally, non-visually, using our understanding of these mechanisms? That’s one of the areas we’re very interested in.” Reference: “Sensory neuron activation from topical treatments modulates the sensorial perception of human skin” by Ross Bennett-Kennett, Joseph Pace, Barbara Lynch, Yegor Domanov, Gustavo S Luengo, Anne Potter and Reinhold H Dauskardt, 26 September 2023, PNAS Nexus. DOI: 10.1093/pnasnexus/pgad292 Dauskardt is a member of Stanford Bio-X , the Cardiovascular Institute, the Wu Tsai Human Performance Alliance, and the Wu Tsai Neurosciences Institute, and an affiliate of the Precourt Institute for Energy and the Stanford Woods Institute for the Environment. Additional Stanford co-authors of this research include doctoral students Ross Bennett-Kennett and Joseph Pace. Other co-authors are from L’Oréal Research and Innovation. This work was funded by L’Oréal Research and Innovation.

CRISPR illustration. Credit: National Institutes of Health Multiplexed gene activation system allows for four to six times the activation capacity of current CRISPR technology, with simultaneous activation of up to seven genes at once. In new research published in Nature Plants, Yiping Qi, associate professor of Plant Science at the University of Maryland (UMD), introduces a new and improved CRISPR 3.0 system in plants, focusing on gene activation instead of traditional gene editing. This third-generation CRISPR system focuses on multiplexed gene activation, meaning that it can boost the function of multiple genes simultaneously. According to the researchers, this system boasts four to six times the activation capacity of current state-of-the-art CRISPR technology, demonstrating high accuracy and efficiency in up to seven genes at once. While CRISPR is more often known for its gene editing capabilities that can knock out genes that are undesirable, activating genes to gain functionality is essential to creating better plants and crops for the future. “While my lab has produced systems for simultaneous gene editing [multiplexed editing] before, editing is mostly about generating loss of function to improve the crop,” explains Qi. “But if you think about it, that strategy is finite, because there aren’t endless genes that you can turn off and actually still gain something valuable. Logically, it is a very limited way to engineer and breed better traits, whereas the plant may have already evolved to have different pathways, defense mechanisms, and traits that just need a boost. Through activation, you can really uplift pathways or enhance existing capacity, even achieve a novel function. Instead of shutting things down, you can take advantage of the functionality already there in the genome and enhance what you know is useful.” In his new paper, Qi and his team validated the CRISPR 3.0 system in rice, tomatoes, and Arabidopsis (the most popular model plant species, commonly known as rockcress). The team showed that you can simultaneously activate many kinds of genes, including faster flowering to speed up the breeding process. But this is just one of the many advantages of multiplexed activation, says Qi. “Having a much more streamlined process for multiplexed activation can provide significant breakthroughs. For example, we look forward to using this technology to screen the genome more effectively and efficiently for genes that can help in the fight against climate change and global hunger. We can design, tailor, and track gene activation with this new system on a larger scale to screen for genes of importance, and that will be very enabling for discovery and translational science in plants.” Since CRISPR is usually thought of as “molecular scissors” that can cut DNA, this activation system uses deactivated CRISPR-Cas9 that can only bind. Without the ability to cut, the system can focus on recruiting activation proteins for specific genes of interest by binding to certain segments of DNA instead. Qi also tested his SpRY variant of CRISPR-Cas9 that greatly broadens the scope of what can be targeted for activation, as well as a deactivated form of his recent CRISPR-Cas12b system to show versatility across CRISPR systems. This shows the great potential of expanding for multiplexed activation, which can change the way genome engineering works. “People always talk about how individuals have potential if you can nurture and promote their natural talents,” says Qi. “This technology is exciting to me because we are promoting the same thing in plants – how can you promote their potential to help plants do more with their natural capabilities? That is what multiplexed gene activation can do, and it gives us so many new opportunities for crop breeding and enhancement.” Reference: “CRISPR–Act3.0 for highly efficient multiplexed gene activation in plants” by Changtian Pan, Xincheng Wu, Kasey Markel, Aimee A. Malzahn, Neil Kundagrami, Simon Sretenovic, Yingxiao Zhang, Yanhao Cheng, Patrick M. Shih and Yiping Qi, 24 June 2021, Nature Plants. DOI: 10.1038/s41477-021-00953-7 This work is funded by the National Science Foundation, Award #1758745 and #2029889.

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