Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan flexible graphene product manufacturing factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan neck support pillow OEM factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ESG-compliant OEM manufacturer in Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene cushion OEM factory in Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Innovative insole ODM solutions in Taiwan

Mitochondria are small, dynamic organelles found in the cells of most eukaryotic organisms. They are often referred to as the “powerhouses of the cell” because they generate the majority of a cell’s supply of adenosine triphosphate (ATP), which is used as a source of chemical energy. A New Study Sheds Light on the Organization of Proteins Within Mitochondria Mitochondria, the “powerhouses” of cells, play a crucial role in the energy production of organisms and are involved in various metabolic and signaling processes. Researchers from the University Hospital Bonn and the University of Freiburg have now gained a systematic understanding of the organization of proteins within mitochondria. The protein map of mitochondria represents a critical foundation for further exploring the functions of these cellular powerhouses, and holds implications for disease understanding. The new research has recently been published in the prestigious journal Nature. Mitochondria are essential components of cells and are surrounded by a double membrane that separates them from the rest of the cell. They produce the majority of the energy needed to sustain these activities. Beyond energy production, mitochondria play key roles in metabolism and signaling, serving as a surface for inflammation processes and programmed cell death. Model of the quality control mechanism for removing arrested proteins from the mitochondrial entry gate. Credit: Schulte et al., 2023 Nature Defects in mitochondria lead to numerous diseases, especially of the nervous system. Therefore, the molecular understanding of mitochondrial processes is of the highest relevance for basic medical research. The molecular workers in the cell are usually proteins. Mitochondria can contain around 1,000 or more different proteins. To execute functions, several of these molecules often work together and form a protein machine, also called a protein complex. Proteins also interact in the execution and regulation of molecular processes. Yet little is known about the organization of mitochondrial proteins in such complexes. Precision in the Analysis of Dynamic Protein Machines The research groups of Prof. Thomas Becker and Dr. Fabian den Brave at the UKB, together with the research groups of Prof. Bernd Fakler, Dr. Uwe Schulte, and Prof. Nikolaus Pfanner at the University of Freiburg, have created a high-resolution image of the organization of proteins in protein complexes, known as MitCOM. This involved a specific method known as complexome profiling to record the fingerprints of individual proteins at an unprecedented resolution. MitCOM reveals the organization into protein complexes of more than 90 percent of the mitochondrial proteins from baker’s yeast. This allows to the identification of new protein-protein interactions and protein complexes – important information for further studies. Quality Control in the Mitochondrial Entry Gate TOM as an Example Researchers at UKB in cooperation with Collaborative Research Center 1218 “Regulation of cellular function by mitochondria,” have shown how this dataset can be used to elucidate new processes. Mitochondria import 99 percent of their proteins from the liquid portion of the cell, known as cytosol. In this process, a protein machinery called the TOM complex enables the uptake of these proteins through the membrane into the mitochondria. However, it is largely unclear how proteins are removed from the TOM complex when they get stuck during the transport process. To elucidate this, the team led by Prof. Becker and Dr. den Brave used information from the MitCOM dataset. It was shown that non-imported proteins are specifically tagged for cellular degradation. Research by Ph.D. student Arushi Gupta further revealed a pathway by which these tagged proteins are subsequently targeted for degradation. Understanding these processes is important because defects in protein import can lead to cellular damage and neurological diseases. “The example from our study demonstrates the great potential of the MitCOM dataset to elucidate new mechanisms and pathways. Thus, this map of proteins represents an important source of information for further studies that will help us to understand the functions and origin of the cell’s powerhouse,” says Prof. Becker, director of the Institute of Biochemistry and Molecular Biology at UKB. Reference: “Mitochondrial complexome reveals quality-control pathways of protein import” by Uwe Schulte, Fabian den Brave, Alexander Haupt, Arushi Gupta, Jiyao Song, Catrin S. Müller, Jeannine Engelke, Swadha Mishra, Christoph Mårtensson, Lars Ellenrieder, Chantal Priesnitz, Sebastian P. Straub, Kim Nguyen Doan, Bogusz Kulawiak, Wolfgang Bildl, Heike Rampelt, Nils Wiedemann, Nikolaus Pfanner, Bernd Fakler and Thomas Becker, 25 January 2023, Nature. DOI: 10.1038/s41586-022-05641-w

Researchers at the Francis Crick Institute have uncovered the influence of pregnancy hormones, specifically estrogen and progesterone, on the brains of female mice, leading to heightened parental instincts even before birth. The findings suggest potential long-term brain changes due to pregnancy and raise the possibility of similar brain changes in human pregnancies due to the same hormonal interactions. Researchers at the Francis Crick Institute have shown that pregnancy hormones ‘rewire’ the brain to prepare mice for motherhood. Their findings, published on October 5 in the journal Science, show that both estrogen and progesterone act on a small population of neurons in the brain to switch on parental behavior even before offspring arrive. These adaptations resulted in stronger and more selective responses to pups. It is well known that while virgin female rodents do not show much interaction with pups, mothers spend most of their time looking after their young. It was thought that hormones released when giving birth are most crucial for this onset of maternal behavior. But earlier research also showed that rats who have given birth by Caesarean section, and virgin mice exposed to pregnancy hormones, still display this maternal behaviour, suggesting that hormone changes already during pregnancy may be more important. Mechanics of Hormonal Impact on Neurons In the current study, the researchers found that female mice indeed showed increased parental behavior during late pregnancy, and that exposure to pups wasn’t necessary for this change in behavior. They found that a population of nerve cells (galanin-expressing neurons) in an area of the brain called the medial preoptic area (MPOA) in the hypothalamus, associated with parenting, was impacted by estrogen and progesterone. Brain recordings showed that estrogen simultaneously reduced the baseline activity of these neurons and made them more excitable, whereas progesterone rewired their inputs, by recruiting more synapses (sites of communication between neurons). Making these neurons insensitive to hormones completely removed the onset of parental behavior during pregnancy. Mice failed to show parental behavior even after giving birth, suggesting there is a critical period during pregnancy when these hormones take effect. While some of these changes lasted for at least a month after giving birth, others seem to be permanent, suggesting pregnancy can lead to long-term rewiring of the female brain. Expert Insights Jonny Kohl, Group Leader of the State-Dependent Neural Processing Laboratory at the Crick, said: “We know that the female body changes during pregnancy to prepare for bringing up young. One example is the production of milk, which starts long before giving birth. Our research shows that such preparations are taking place in the brain, too. “We think that these changes, often referred to as ‘baby brain’, cause a change in priority – virgin mice focus on mating, so don’t need to respond to other females’ pups, whereas mothers need to perform robust parental behavior to ensure pup survival. What’s fascinating is that this switch doesn’t happen at birth – the brain is preparing much earlier for this big life change.” Rachida Ammari, postdoctoral fellow at the Crick, and first author along with PhD student Francesco Monaca, said: “We’ve demonstrated that there’s a window of plasticity in the brain to prepare for future behavioral challenges. These neurons receive a large number of inputs from elsewhere in the brain, so now we’re hoping to understand where this new information comes from.” The researchers believe the brain may also be rewired in a similar way during pregnancy in humans, as the same hormonal changes are expected to impact the same areas of the brain. This could influence parental behavior alongside environmental and social cues. Reference: “Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy” by Rachida Ammari, Francesco Monaca, Mingran Cao, Estelle Nassar, Patty Wai, Nicholas A. Del Grosso, Matthew Lee, Neven Borak, Deborah Schneider-Luftman and Johannes Kohl, 5 October 2023, Science. DOI: 10.1126/science.adi0576

Image of soil with a close-up of a bacterium and the cellular pathways involved in carbon dioxide productions. Available substrates from soil organic matter are processed through specific pathways with different amount of carbon dioxide output flux. Credit: Aristilde Lab/Northwestern University A new study aids in clarifying the role of microbes in the global carbon cycle. When soil microbes eat plant matter, the digested food follows one of two pathways. Either the microbe uses the food to build its own body, or it respires its meal as carbon dioxide (CO2) into the atmosphere. Now, a Northwestern University-led research team has, for the first time, tracked the pathways of a mixture of plant waste as it moves through bacteria’s metabolism to contribute to atmospheric CO2. The researchers discovered that microbes respire three times as much CO2 from lignin carbons (non-sugar aromatic units) compared to cellulose carbons (glucose sugar units), which both add structure and support to plants’ cellular walls. These findings help disentangle the role of microbes in soil carbon cycling — information that could help improve predictions of how carbon in soil will affect climate change. The research was recently published in the journal Environmental Science & Technology. “The carbon pool that’s stored in soil is about 10 times the amount that’s in the atmosphere,” said Northwestern University’s Ludmilla Aristilde, who led the study. “What happens to this reservoir will have an enormous impact on the planet. Because microbes can unlock this carbon and turn it into atmospheric CO2, there is a huge interest in understanding how they metabolize plant waste. As temperatures rise, more organic matter of different types will become available in the soil. That will affect the amount of CO2 that is emitted from microbial activities.” An expert in the dynamics of organics in environmental processes, Aristilde is an associate professor of civil and environmental engineering at Northwestern’s McCormick School of Engineering and is a member of the Center for Synthetic Biology and of the Paula M. Trienens Institute for Sustainability and Energy. Caroll Mendonca, a former Ph.D. candidate in Aristilde’s laboratory, is the paper’s first author. The study includes collaborators from the University of Chicago. ‘Not all pathways are created equally’ The new study builds upon ongoing work in Aristilde’s laboratory to understand how soil stores — or releases — carbon. Although previous researchers typically tracked how broken-down compounds from plant matter move individually through bacteria, Aristilde’s team instead used a mixture of these compounds to represent what bacteria are exposed to in the natural environment. Then, to track how different plant derivatives moved through a bacterium’s metabolism, the researchers tagged individual carbon atoms with isotope labels. “Isotope labeling allowed us to track carbon atoms specific to each compound type inside the cell,” Aristilde said. “By tracking the carbon routes, we were able to capture their paths in the metabolism. That is important because not all pathways are created equally in terms of producing carbon dioxide.” Sugar carbons in cellulose, for example, traveled through glycolytic and pentose-phosphate pathways. These pathways lead to metabolic reactions that convert digested matter into carbons to make DNA and proteins, which build the microbe’s own biomass. But aromatic, non-sugar carbons from lignin traveled a different route — through the tricarboxylic acid cycle. “The tricarboxylic acid cycle exists in all forms of life,” Aristilde said. “It exists in plants, microbes, animals, and humans. While this cycle also produces precursors for proteins, it contains several reactions that produce CO2. Most of the CO2 that gets respired from metabolism comes from this pathway.” Expanding the findings After tracking the routes of metabolism, Aristilde and her team performed a quantitative analysis to determine the amount of CO2 produced from different types of plant matter. After consuming a mixture of plant matter, microbes respired three times as much CO2 from carbons derived from lignin compared to carbons derived from cellulose. “Even though microbes consume these carbons at the same time, the amount of CO2 generated from each carbon type is disproportionate,” Aristilde said. “That’s because the carbon is processed via two different metabolic pathways.” In the initial experiments, Aristilde and her team used Pseudomonas putida, a common soil bacterium with a versatile metabolism. Curious to see if their findings applied to other bacteria, the researchers studied data from previous experiments in scientific literature. They found the same relationship they discovered among plant matter, metabolism, and CO2 manifested in other soil bacteria. “We propose a new metabolism-guided perspective for thinking about how different carbon structures accessible to soil microbes are processed,” Aristilde said. “That will be key in helping us predict what will happen with the soil carbon cycle with a changing climate.” Reference: “Disproportionate Carbon Dioxide Efflux in Bacterial Metabolic Pathways for Different Organic Substrates Leads to Variable Contribution to Carbon-Use Efficiency” by Caroll M. Mendonca, Lichun Zhang, Jacob R. Waldbauer and Ludmilla Aristilde, 11 June 2024, Environmental Science & Technology. DOI: 10.1021/acs.est.4c01328 The study was supported by the National Science Foundation (grant numbers CBET-1653092 and CBET-2022854).

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