Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam graphene material ODM solution

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Insole ODM production factory in Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow OEM for wellness brands Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan insole ODM full-service provider factory

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Custom graphene foam processing Vietnam

New research shows that prolonged, intense cognitive work causes potentially toxic byproducts to build up in the part of the brain known as the prefrontal cortex. Mental fatigue is caused by glutamate buildup in the brain after prolonged thinking, making rest crucial for recovery. It goes without saying that hard physical labor wears you out, but what about hard mental labor? Sitting around thinking hard for hours also makes one feel worn out. Now, scientists have new evidence to explain why this is. Based on their findings, the reason you feel mentally exhausted (as opposed to drowsy) from intense thinking isn’t all in your head. Their studies show that when intense cognitive work is prolonged for several hours, it causes potentially toxic byproducts to build up in the part of the brain known as the prefrontal cortex. According to the researchers, this in turn alters your control over decisions, so you shift toward low-cost actions requiring no effort or waiting as cognitive fatigue sets in. The research was reported on August 11 in the journal Current Biology. “Influential theories suggested that fatigue is a sort of illusion cooked up by the brain to make us stop whatever we are doing and turn to a more gratifying activity,” says Mathias Pessiglione of Pitié-Salpêtrière University in Paris, France. “But our findings show that cognitive work results in a true functional alteration—accumulation of noxious substances—so fatigue would indeed be a signal that makes us stop working but for a different purpose: to preserve the integrity of brain functioning.” Pessiglione and colleagues, including first author of the study Antonius Wiehler, wanted to understand what mental fatigue really is. While machines can compute continuously, the brain cannot. They wanted to discover why. They suspected the reason had to do with the need to recycle potentially toxic substances that originate from neural activity. To look for evidence to support this theory, they used magnetic resonance spectroscopy (MRS) to monitor brain chemistry over the course of a workday. They studied two groups of people: those who needed to think hard and those who had relatively simple cognitive tasks. Glutamate and Its Role in Mental Fatigue They saw signs of fatigue, including reduced pupil dilation, only in the group doing hard mental work. Those in that group also exhibited in their choices a change toward options proposing rewards at short delay with minimal effort. Critically, they also had higher levels of glutamate in synapses of the brain’s prefrontal cortex. Together with earlier evidence, the scientists say it supports the hypothesis that glutamate accumulation makes further activation of the prefrontal cortex more costly, such that cognitive control is more difficult after a mentally tough workday. So, is there some way to overcome this limitation of our brain’s ability to think hard? “Not really, I’m afraid,” Pessiglione said. “I would employ good old recipes: rest and sleep! There is good evidence that glutamate is eliminated from synapses during sleep.” There may be other practical implications of the findings. For example, the researchers say, monitoring of prefrontal metabolites could help to detect severe mental fatigue. Such an ability may help adjust work agendas to avoid burnout. Pessiglione also advises people to avoid making important decisions when they’re tired. In future studies, the researchers hope to learn why the prefrontal cortex seems especially susceptible to glutamate accumulation and fatigue. They’re also curious to learn whether the same markers of fatigue in the brain may predict recovery from health conditions, such as cancer or depression. Reference: “A neuro-metabolic account of why daylong cognitive work alters the control of economic decisions” by Antonius Wiehler, Francesca Branzoli, Isaac Adanyeguh, Fanny Mochel and Mathias Pessiglione, 11 August 2022, Current Biology. DOI: 10.1016/j.cub.2022.07.010

By engineering “programmable” embryo-like models, scientists can now study early development without real embryos. Stem cells, guided by CRISPR, self-organize into structures that mirror natural processes, offering insights into fertility and genetic disorders. Credit: Ali Shariati/ UC Santa Cruz, edited Scientists have found a way to study early embryonic development without real embryos. Using CRISPR, they programmed stem cells to self-organize into structures mimicking early embryos. The cells show remarkable, collective behavior, almost as if they instinctively “know” what to do. This breakthrough allows researchers to explore genetic influences on development, reproductive challenges, and potential fertility treatments—all without using actual embryos. Unlocking the Earliest Mysteries of Life The earliest moments after fertilization, when a sperm cell meets an egg, remain one of biology’s greatest mysteries. Scientists from various fields are fascinated by how a single cell develops into a complex organism. In many animals, this transformation occurs inside the protective environment of the uterus, making direct observation difficult. As a result, researchers struggle to fully understand what can go wrong during early development and how external factors might prevent embryo formation. Engineering Embryos Without Embryos To overcome these challenges, scientists at UC Santa Cruz have engineered cellular models that replicate the first few days of embryonic development, without using actual embryos. Using CRISPR-based techniques, they guide stem cells to self-organize into “programmable” embryo-like structures, known as embryoids. These lab-grown cell assemblies are not true embryos but closely mimic key aspects of early development, providing a powerful tool for studying genetic and environmental influences on embryonic formation. Their findings were published today (March 20) in Cell Stem Cell, a leading journal in stem cell research. “We as scientists are interested in recreating and repurposing natural phenomena, such as formation of an embryo, in the dish to enable studies that are otherwise challenging to do with natural systems,” said Ali Shariati, assistant professor of biomolecular engineering and the study’s senior author. “We want to know how cells organize themselves into an embryo-like model, and what could go wrong when there are pathological conditions that prevent an animal from successfully developing.” Cell Co-Development: A More Natural Approach Shariati is an expert in stem cell engineering, a field that uses stem cells — unspecialized cells that can form any type of cell such as gut or brain cells — to study and solve biological and health problems. This project, led by UCSC postdoctoral scholar Gerrald Lodewijk and biomolecular engineering alumna and current Caltech graduate student Sayaka Kozuki, used mouse stem cells that are commonly grown in the lab to guide them to form basic building blocks of the embryo. Programmable cellular models of embryos, known as embryoids, allow scientists to mimic the first few day of embryonic development. Credit: Ali Shariati/ UC Santa Cruz CRISPR Technology: A Revolutionary Tool The team used a version of CRISPR technology known as an epigenome editor, which does not cut DNA but instead modifies how it is expressed. They targeted regions of the genome known to be involved in the development of an early embryo. This allowed them to control which genes were activated, and induce the creation of main types of cells needed for early development. “We use the stem cells, which are like a blank canvas, and use them to induce different cell types using our CRISPR tools,” Lodewijik said. This method had the advantage of allowing different cell types to “co-develop,” which more closely resembles the natural embryo formation than the chemical approaches other scientists have used to develop different cell types. “These cells co-develop together, just like they would in an actual embryo, and establish that history of being neighbors,” Shariati said. “We do not change their genome or expose them to specific signaling molecules, but rather activate the existing genes.” Self-Organizing Cells: A Remarkable Discovery The team found that 80% of the stem cells organize themselves into a structure that mimics the most basic form of an embryo after a few days, and most undergo gene activation that reflects the development process that occurs in living organisms. “The similarity is remarkable in the way the cells organize themselves, as well as the molecular composition,” Shariati said. “[The cells require] very little input from us — it’s as if the cells already know what to do, and we just give them a little bit of guidance.” The researchers observed that the cells showed a collective behavior in moving and organizing together. “Some of them start doing this rotational migration, almost like the collective behavior of birds or other species,” Shariati said. “Through this collective behavior and migration they can form these fascinating embryonic patterns.” “Programmable” Models for Developmental Research Having an accurate baseline model that reflects a living organisms’ early embryo could allow scientists to better study and learn how to treat developmental disorders or mutations. “These models have a more complete representation of what’s going on in early stages of development, and can capture the background,” Lodewijik said. The CRISPR programming not only allows the scientists to activate the genes at the beginning of the experimentation process, but also enables them to activate or modify genes important for other parts of development. This allows the embryo models to be “programmable,” meaning they can be relatively easily influenced with a high level of control to target and test the impact of multiple genes as the embryo model develops, illuminating which have deleterious effects when turned on or off. As an example, the researchers demonstrated how certain tissues form or are hindered during early development, but their methods could be used to study a wide range of genes and their cascading effects on the cell types. “I think this is the pioneering work of this study — the programmability and that we don’t rely on extrinsic factors to do this, but rather have a lot of control inside the cell,” Shariati said. The researchers are interested in how this approach might be used to study other species, allowing for a look into their embryo formation without ever using their actual embryos. A Window Into Fertility Challenges This research could allow for the study of the bottlenecks that lead reproduction to fail in early stages. Among mammals, humans have more reproduction challenges in that human embryos often fail to implant or establish the correct early organizational form. Understanding why this is the case could help make progress toward improving human fertility. Reference: “Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming” by Gerrald A. Lodewijk, Sayaka Kozuki, Clara J. Han, Benjamin R. Topacio, Seungho Lee, Lily Nixon, Abolfazl Zargari, Gavin Knight, Randolph Ashton, Lei S. Qi and S. Ali Shariati, 20 March 2025, Cell Stem Cell. DOI: 10.1016/j.stem.2025.02.015

A 3D illustration of Bacillus anthracis, the spore-forming bacteria that cause anthrax. Harvard Medical School researchers have found a cellular sensor that enables bacterial spores to sense nutrients and awaken from dormancy. This discovery could help prevent dangerous dormant bacteria from causing outbreaks. Research provides answers to the long-standing mystery of bacterial spores, illuminating new paths for disease prevention. Inert, sleeping bacteria — or spores — can survive for years, even centuries, without nutrients, resisting heat, UV radiation, antibiotics, and other harsh chemicals. How spores spring back to life has been a century-long mystery. New research identifies how sensor proteins revive dormant bacteria. Discovery opens new routes to combat spore resistance to antibiotics and sterilization. Findings can inform novel strategies to prevent infections and food spoilage. Solving a riddle that has confounded biologists since bacterial spores — inert, sleeping bacteria — were first described more than 150 years ago, researchers at Harvard Medical School have discovered a new kind of cellular sensor that allows spores to detect the presence of nutrients in their environment and quickly spring back to life. It turns out that these sensors double as channels through the membrane and remain closed during dormancy but rapidly open when they detect nutrients. Once open, the channels allow electrically charged ions to flow out through the cell membrane, setting in motion the shedding of protective spore layers and the switching on of metabolic processes after years — or even centuries — of dormancy. The team’s findings, published recently in the journal Science, could help inform the design of ways to prevent dangerous bacterial spores from lying dormant for months, even years, before waking up again and causing outbreaks. “This discovery solves a puzzle that’s more than a century old,” said study senior author David Rudner, professor of microbiology in the Blavatnik Institute at HMS. “How do bacteria sense changes in their environment and take action to break out of dormancy when their systems are almost completely shut down inside a protective casing?” How Sleeping Bacteria Come Back to Life To survive adverse environmental conditions, some bacteria go into dormancy and become spores, with biological processes put on hold and layers of protective armor around the cell. These biologically inert mini fortresses allow bacteria to wait out periods of famine and shield themselves from the ravages of extreme heat, dry spells, UV radiation, harsh chemicals, and antibiotics. For more than a century, scientists have known that when the spores detect nutrients in their environment, they rapidly shed their protective layers and reignite their metabolic engines. Although the sensor that enables them to detect nutrients was discovered almost 50 years ago, the means of delivering the wake-up signal, and how that signal triggers bacterial revival remained a mystery. In most cases, signaling relies on metabolic activity and often involves genes encoding proteins to make specific signaling molecules. However, these processes are all shut off inside a dormant bacterium, raising the question of how the signal induces the sleeping bacteria to wake up. In this study, Rudner and team discovered that the nutrient sensor itself assembles into a conduit that opens the cell back up for business. In response to nutrients, the conduit, a membrane channel, opens, allowing ions to escape from the spore interior. This initiates a cascade of reactions that allow the dormant cell to shed its protective armor and resume growth. The scientists used multiple avenues to follow the twists and turns of the mystery. They deployed artificial intelligence tools to predict the structure of the intricately folded sensor complex, a structure made of five copies of the same sensor protein. They applied machine learning to identify interactions between subunits that make up the channel. They also used gene-editing techniques to induce bacteria to produce mutant sensors as a way to test how the computer-based predictions played out in living cells. “The thing that I love about science is when you make a discovery and suddenly all these disparate observations that don’t make sense suddenly fall into place,” Rudner said. “It’s like you’re working on a puzzle, and you find where one piece goes and suddenly you can fit six more pieces very quickly.” Rudner described the process of discovery in this case as a series of confounding observations that slowly took shape, thanks to a team of researchers with diverse perspectives working together synergistically. Along the way, they kept making surprising observations that confused them, hints that suggested answers that didn’t seem like they could possibly be true. Stitching the Clues Together One early clue emerged when Yongqiang Gao, an HMS research fellow in the Rudner lab, was conducting a series of experiments with the microbe Bacillus subtilis, commonly found in soil and a cousin to the bacterium that causes anthrax. Gao introduced genes from other bacteria that form spores into B. subtilis to explore the idea that the mismatched proteins produced would interfere with germination. Much to his surprise, Gao found that in some cases the bacterial spores reawakened flawlessly with a set of proteins from a distantly related bacterium. Lior Artzi, a postdoctoral fellow in the lab at the time of this research, came up with an explanation for Gao’s finding. What if the sensor was a kind of receptor that acts like a closed gate until it detects a signal, in this case a nutrient like a sugar or an amino acid? Once the sensor binds to the nutrient, the gate pops open, allowing ions to flow out of the spore. In other words, the proteins from distantly related bacteria would not need to interact with mismatched B. subtilis spore proteins, but instead simply respond to changes in the electric state of the spore as ions begin to flow. Rudner was initially skeptical of this hypothesis because the receptor didn’t fit the profile. It had almost none of the characteristics of an ion channel. But Artzi argued the sensor might be made up of multiple copies of the subunit working together in a more complex structure. AI Has Entered the Chat Another postdoc, Jeremy Amon, an early adopter of AlphaFold, an AI tool that can predict the structure of proteins and protein complexes, was also studying spore germination and was primed to investigate the nutrient sensor. The tool predicted that a particular receptor subunit assembles into a five-unit ring known as a pentamer. The predicted structure included a channel down the middle that could allow ions to pass through the spore’s membrane. The AI tool’s prediction was just what Artzi had suspected. Gao, Artzi, and Amon then teamed up to test the AI-generated model. They worked closely with a third postdoc, Fernando Ramírez-Guadiana and the groups of Andrew Kruse, HMS professor of biological chemistry and molecular pharmacology, and computational biologist Deborah Marks, HMS associate professor of systems biology. They engineered spores with altered receptor subunits predicted to widen the membrane channel and found the spores awoke in the absence of nutrient signals. On the flip side, they generated mutant subunits that they predicted would narrow the channel aperture. These spores failed to open the gate to release ions and awake from stasis in the presence of ample nutrients to coax them out of dormancy. In other words, a slight deviation from the predicted configuration of the folded complex could leave the gate stuck open or shut, rendering it useless as a tool for waking up the dormant bacteria. Implications for Human Health and Food Safety Understanding how dormant bacteria spring back into life is not just an intellectually tantalizing puzzle, Rudner said, but one with important implications for human health. A number of bacteria that are capable of going into deep dormancy for stretches of time are dangerous, even deadly pathogens: The powdery white form of weaponized anthrax is a made up of bacterial spores. Another dangerous spore-forming pathogen is Clostridioides difficile, which causes life-threatening diarrhea and colitis. Illness from C. difficile typically occurs after use of antibiotics that kill many intestinal bacteria but are useless against dormant spores. After treatment, C. difficile awakens from dormancy and can bloom, often with catastrophic consequences. Eradicating spores is also a central challenge in food-processing plants because the dormant bacteria can resist sterilization due to their protective armor and dehydrated state. If sterilization is unsuccessful, germination and growth can cause serious foodborne illness and massive financial losses. Understanding how spores sense nutrients and rapidly exit dormancy can enable researchers to develop ways to trigger germination early, making it possible to sterilize the bacteria, or block germination, keeping the bacteria trapped inside their protective shells, unable to grow, reproduce, and spoil food or cause disease. Reference: “Bacterial spore germination receptors are nutrient-gated ion channels” by Yongqiang Gao, Jeremy D. Amon, Lior Artzi, Fernando H. Ramírez-Guadiana, Kelly P. Brock, Joshua C. Cofsky, Deborah S. Marks, Andrew C. Kruse and David Z. Rudner, 27 April 2023, Science. DOI: 10.1126/science.adg9829 Additional authors include Kelly Brock and Joshua Cofsky, of HMS. Support for this work comes from the National Institutes of Health grants GM086466, GM127399, GM122512, AI171308 (DZR), AI164647 (DZR, ACK, DSM) and funds from the Harvard Medical School Dean’s Initiative. Amon was funded by National Institutes of Health grant F32GM130003. Artzi was a Simons Foundation fellow of the Life Sciences Research Foundation.

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