Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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China OEM insole and pillow supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam custom product OEM/ODM services

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Soft-touch pillow OEM service in Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Indonesia custom neck pillow ODM

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Breathable insole ODM development Vietnam

Researchers discovered that a type of protein misfolding, non-covalent lasso entanglement, can slow the folding process, leading to unexpected patterns. Using simulations and experiments, they confirmed this mechanism in phosphoglycerate kinase (PGK), a protein with unusual folding behavior. Their findings could help inform future treatments for diseases related to protein misfolding. A new study reveals a possible protein misfolding mechanism that may resolve a long-standing mystery of why certain proteins refold into unexpected patterns. Proteins are long molecules that must fold into precise three-dimensional shapes to function properly within cells. However, this process sometimes goes wrong, resulting in misfolded proteins that can contribute to disease if not corrected. A new study by chemists at Penn State explores a possible reason why some proteins refold into unexpected patterns. The researchers identified a specific type of misfolding in which protein segments become improperly intertwined, creating an obstacle to normal folding. Correcting this misfolding requires substantial energy or extensive unfolding, which slows down the process and may explain the unusual folding patterns first observed in the 1990s. “Misfolded proteins can malfunction and lead to disease,” said Ed O’Brien, professor of chemistry in the Eberly College of Science, a co-hire of the Institute for Computational and Data Sciences at Penn State, and leader of the research team. “So, understanding the mechanisms involved in the folding process can potentially help researchers prevent or develop treatments for diseases caused by misfolding.” A research paper published on March 14 in Science Advances examines the folding kinetics of the protein phosphoglycerate kinase (PGK). The study integrates computer simulations with refolding experiments to offer a detailed analysis of the protein’s folding process. A Different Folding Pattern: The Mystery of PGK “For most proteins, we model the folding process as if there are two states, folded or unfolded,” said Yang Jiang, assistant research professor of chemistry in the Eberly College of Science at Penn State and the first author of the paper. “When we track the progression of a protein from unfolded to folded, we see a characteristic time-dependent pattern that we call the folding kinetics of the protein. Usually, the proportion of unfolded proteins goes down exponentially until essentially all of the proteins are folded, but some proteins don’t fit this pattern, and we were interested in the mechanisms that might explain this.” The unusual folding pattern of PGK was first observed experimentally over 25 years ago. Whereas most proteins fit the “two-state” model of exponential folding kinetics, the molecules of PGK followed a different pattern to reach a fully folded state. This new pattern was described as “stretched-exponential refolding kinetics,” but the structural mechanism that explained this difference remained a mystery — until now. The research team hypothesized that a recently described class of misfolding may be responsible for PGK’s deviation from the traditional two-state model of folding. A new study has described a potential mechanism that could help explain why some proteins refold in a different pattern than expected. The research showed that a type of misfolding, called non-covalent lasso entanglement, in which the proteins incorrectly intertwine their segments, can occur and create a barrier to the normal folding process. The image shows the native folded structure of the protein phosphoglycerate kinase (PGK) on the left and one of the misfolded PGK structures predicted in this study on the right, with the entangled regions highlighted in red and blue. Credit: Yang Jiang, Penn State “Non-covalent lasso entanglement is a class of misfolding we recently identified where a loop of the protein traps another segment of the protein, essentially intertwining itself incorrectly,” O’Brien said. “If a protein like PGK is more prone to this type of misfolding, it could help explain why we see the stretched-exponential refolding kinetics.” To test this hypothesis, the research team first built a computer model to simulate the folding process of PGK. Their simulations recapitulated the stretched-exponential kinetics seen in the earlier experiments. They then explored the intermediate stages of the folding process in their simulations to see if there were structural changes that could explain the stretched refolding. Simulations and Experimental Validation “We found several examples of misfolding involving entanglements,” Jiang said. “Sometimes a new entanglement formed and sometimes an entanglement that was part of the protein’s native structure failed to form. In our simulations, we could then remove these misfolding events and saw that the protein folded with the typical two-state exponential pattern.” To confirm the results of their simulation, the research team, which included experimentalist Stephen Fried and lab members at Johns Hopkins University, examined the structural variation of PGK upon refolding in experiments. They found that the misfolded states predicted in the simulations were consistent with the structural signals experimentally observed in the refolded protein. They also found that these misfolded states were long-lived, suggesting that they are a crucial component of the observed stretched-exponential folding kinetics. “Because of the nature of this type of misfolding, the protein gets stuck,” Jiang said. “The protein must backtrack in the folding process to correct the mistake, which takes time and is energetically expensive. The demonstration of this mechanism helps expand our understanding of how proteins are folded and gives an example of how it can go wrong. This is basic research, but it could eventually inform how we develop therapeutics for diseases linked to protein misfolding.” Reference: “Protein misfolding involving entanglements provides a structural explanation for the origin of stretched-exponential refolding kinetics” by Yang Jiang, Yingzi Xia, Ian Sitarik, Piyoosh Sharma, Hyebin Song, Stephen D. Fried and Edward P. O’Brien, 14 March 2025, Science Advances. DOI: 10.1126/sciadv.ads7379 In addition to Jiang, O’Brien and Fried, the research team includes graduate student Ian Sitarik and Assistant Professor of Statistics Hyebin Song at Penn State and co-first author Yingzi Xia and Piyoosh Sharma at Johns Hopkins University. Computer simulations and data analysis were carried using the Roar Collab, a high-performance computing cluster operated by the Institute for Computational and Data Sciences at Penn State. The U.S. National Science Foundation and the U.S. National Institutes of Health funded the research.

New research led by Harvard Medical School finds that single-cell organisms can exhibit habituation, suggesting these cells have complex behaviors and potentially altering our approach to cancer immunology. A new study demonstrates that even simple single-cell organisms, such as ciliates and amoebae, exhibit habituation, a basic form of learning previously thought to be exclusive to more complex beings. This revelation not only changes our understanding of cellular capabilities but also opens up possibilities for applications in cancer immunology, suggesting that our immune cells might be reprogrammed to better recognize and attack cancer cells. A dog learns to sit on command. A person tunes out the steady hum of a washing machine while engrossed in a book. The ability to learn and adapt is a cornerstone of evolution and survival. Habituation, a more modest cousin of adaptation, involves a reduced response to a stimulus after repeated exposure. Imagine needing a third espresso to achieve the same alertness that a single shot once provided. Discovering Habituation in Simple Organisms Until recently, habituation — a basic form of learning — was thought to be limited to complex organisms with brains and nervous systems, such as insects, birds, mammals, and worms. However, new research published today (November 19) in Current Biology reveals compelling evidence that even single-celled organisms like ciliates and amoebae—and even the cells within our own bodies—can exhibit habituation similar to that seen in brain-equipped creatures. The work, led by scientists at Harvard Medical School and the Centre for Genomic Regulation (CRG) in Barcelona, suggests that single cells are capable of behaviors more complex than currently appreciated. “This finding opens up an exciting new mystery for us: How do cells without brains manage something so complex?” said study senior author Jeremy Gunawardena, associate professor of systems biology in the Blavatnik Institute at HMS. He co-led the study with Rosa Martinez Corral, a former post-doctoral researcher in his lab who now leads a research group in systems and synthetic biology at CRG. The results add to a small but growing body of work on this subject. Earlier work led by Gunawardena found that a single-cell ciliate showed avoidance behavior, not unlike the actions observed in animals that encounter unpleasant stimuli. In this video, a single-cell pond dweller called Stentor roeselii exhibits markers of avoidance behavior, as reported in earlier research led by Gunawardena. The new study suggests this organism is also capable of habituation. Advanced Models Reveal Cellular Memory Instead of studying cells in a lab dish, the scientists used advanced computer modeling to analyze how molecular networks inside ciliate and mammalian cells respond to different patterns of stimulation. They found four networks that exhibit hallmarks of habituation present in animal brains. These networks shared a common feature: Each molecular network had two forms of “memory” storage that captured information learned from the environment. One memory decayed much faster than the other — a form of memory loss necessary for habituation, the researchers noted. This finding suggests that single cells process and remember information over different time spans. Implications for Understanding Learning and Cancer Studying habituation in single cells could help propel understanding of how learning in general works, the researchers said. The findings also cast the humble single-cell creatures in a new, more tantalizing light: They are not merely molecular machines packed in microscopic bodies, but they are also agents that can learn. But what about more practical applications? The researchers caution that these remain purely speculative for now. Yet one daring idea would be to apply the concept of habituation to the relationship between cancer and immunity. Tumors are notoriously good evaders of immune surveillance because they trick immune cells into viewing them as innocent bystanders. In other words, the immune cells responsible for recognizing cancer may get somehow habituated to the presence of a cancer cell — the immune cell gets used to the stimulus and no longer responds to it. “It’s akin to delusion. If we knew how these false perceptions get encoded in immune cells, we may be able to re-engineer them so that immune cells begin to perceive their environments correctly, the tumor becomes visible as malign, and they get to work,” Gunawardena said. “It is a fantasy right now, but it is a direction I would love to explore down the road.” Reference: “Biochemically plausible models of habituation for single-cell learning” by Lina Eckert, Maria Sol Vidal-Saez, Ziyuan Zhao, Jordi Garcia-Ojalvo, Rosa Martinez-Corral and Jeremy Gunawardena, 19 November 2024, Current Biology. DOI: 10.1016/j.cub.2024.10.041 Additional authors included Lina Eckert, Maria Sol Vidal-Saez, Ziyuan Zhao, and Jordi Garcia-Ojalvo. The research was supported by a doctoral fellowship 2021-FI-B-00408 from the Agència de Gestió d’Ajuts Universitaris i de Recerca from the Generalitat de Catalunya; a Harvard University Program for Research in Science and Engineering Award; the Spanish State Research Agency and FEDER Project PID2021-127311NB-I00; Spanish Ministry of Science and Innovation and the Generalitat de Catalunya; EMBO Fellowship ALTF683–2019, RYC2021-033860-I funded by MCIN/AEI/10.13039/501100011033 and by European Union NextGenerationEU/PRTR; with additional support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa (CEX2020-001049-S, MCIN/AEI/10.13039/ 501100011033) and the Generalitat de Catalunya through the CERCA program; and with funding from AFOSR Grant FA9550-22-1-0345.

CReATiNG, a new method from USC Dornsife researchers, is transforming synthetic biology by enabling easier and more cost-effective construction of synthetic chromosomes from yeast DNA. This innovation holds potential for major advances in medicine, biotechnology, and space exploration. Credit: SciTechDaily.com USC Dornsife’s CReATiNG technique revolutionizes synthetic biology by facilitating the cost-effective construction of synthetic chromosomes, promising significant advancements in various scientific and medical fields. A groundbreaking new technique invented by researchers at the USC Dornsife College of Letters, Arts and Science may revolutionize the field of synthetic biology. Known as CReATiNG (Cloning Reprogramming and Assembling Tiled Natural Genomic DNA), the method offers a simpler and more cost-effective approach to constructing synthetic chromosomes. It could significantly advance genetic engineering and enable a wide range of advances in medicine, biotechnology, biofuel production, and even space exploration. Simplifying Chromosome Construction CReATiNG works by cloning and reassembling natural DNA segments from yeast, allowing scientists to create synthetic chromosomes that can replace their native counterparts in cells. The innovative technique enables researchers to combine chromosomes between different yeast strains and species, change chromosome structures, and delete multiple genes simultaneously. Lead researcher Ian Ehrenreich, professor of biological sciences at USC Dornsife, said the method is a major improvement over current technology. “With CReATiNG, we can genetically reprogram organisms in complex ways previously deemed impossible, even with new tools like CRISPR,” he said. “This opens up a world of possibilities in synthetic biology, enhancing our fundamental understanding of life and paving the way for groundbreaking applications.” The study will be published today (December 20) in the journal Nature Communications. Synthetic Chromosomes/DNA in a test tube. A Leap Forward in Genetic Engineering The field of synthetic biology has emerged as a way for scientists to take control of living cells, such as yeast and bacteria, to better understand how they work and to enable them to produce useful compounds, such as new medicines. “Over the last decade or so, a new form of synthetic biology has emerged called synthetic genomics, which involves synthesizing whole chromosomes or entire genomes of organisms,” Ehrenreich said. “The thing about most synthetic genomics research is that it involves building chromosomes or genomes from scratch using chemically synthesized DNA pieces. This is a ton of work and extremely expensive.” However, there have been no alternatives — until now. “CReATiNG offers an opportunity to use natural pieces of DNA as parts to assemble whole chromosomes,” said Agilent postdoctoral fellow Alessandro Coradini, who was study first author. The method makes advanced genetic research more accessible by significantly lowering costs and technical barriers so scientists can unlock new solutions to some of the most pressing challenges in science and medicine today. CReATiNG Could Help Medicine, Space Exploration, and More The findings are particularly significant for their potential applications in biotechnology and medicine. CReATiNG could lead to more efficient production of pharmaceuticals and biofuels, aid in the development of cell therapies for diseases like cancer, and pave the way to methods of environmental bioremediation, such as creating bacteria that consume pollutants. The method might even extend to helping humans live for long periods in space or other harsh environments. Scientists could one day use CReATiNG to develop microorganisms or plants that could thrive in space stations or during long-distance space travel, though the researchers caution that this would require much future research. One of the most striking aspects of the study, according to the researchers, is how rearranging chromosome segments in yeast can alter their growth rates, with some modifications resulting in up to a 68% faster or slower growth. This discovery highlights the profound impact that genetic structure can have on biological function and opens up new research pathways to further explore these relationships. Reference: “Building synthetic chromosomes from natural DNA” by Alessandro L. V. Coradini, Christopher Ne Ville, Zachary A. Krieger, Joshua Roemer, Cara Hull, Shawn Yang, Daniel T. Lusk and Ian M. Ehrenreich, 20 December 2023, Nature Communications. DOI: 10.1038/s41467-023-44112-2 In addition to Ehrenreich and Coradini, authors on the study include Christopher Ne Ville, Zachary Krieger, Joshua Roemer, Cara Hull, Shawn Yang and Daniel Lusk, all of USC Dornsife. The study was supported by National Science Foundation grant 2124400, National Institutes of Health grant R35GM130381 and an Agilent Postdoctoral Fellowship.

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