Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam OEM/ODM hybrid insole services

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.ODM ergonomic pillow solution factory Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Smart pillow ODM manufacturer Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Orthopedic pillow OEM solutions Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia graphene product OEM service

If you feel like your dog gets you in a way that most other animals don’t, you’re right. New research comparing dog puppies to human-reared wolf pups offers some clues to how dogs’ unusual people-reading skills came to be. Credit: canine.org, Jared Lazarus You can snuggle wolf pups all you want, they still won’t ‘get’ you quite like your dog. You know your dog gets your gist when you point and say “go find the ball” and he scampers right to it. This knack for understanding human gestures may not seem impressive, but it’s actually a complex cognitive ability that is rare in the animal kingdom. Our closest relatives, the chimpanzees, can’t do it. And the dogs’ closest relative, the wolf, can’t either, according to a new Duke University-led study published on July 12, 2021, in the journal Current Biology. More than 14,000 years of hanging out with us has done a curious thing to the minds of dogs. They have what are known as “theory of mind” abilities, or mental skills allowing them to infer what humans are thinking and feeling in some situations. The study, a comparison of 44 dog and 37 wolf puppies who were between 5 and 18 weeks old, supports the idea that domestication changed not just how dogs look, but their minds as well. At the Wildlife Science Center in Minnesota, wolf puppies were first genetically tested to make sure they were not wolf — dog hybrids. The wolf puppies were then raised with plenty of human interaction. They were fed by hand, slept in their caretakers’ beds each night, and received nearly round-the-clock human care from just days after birth. In contrast, the dog puppies from Canine Companions for Independence lived with their mother and littermates and had less human contact. Then the canines were tested. In one test, the researchers hid a treat in one of two bowls, then gave each dog or wolf puppy a clue to help them find the food. In some trials, the researchers pointed and gazed in the direction the food was hidden. In others, they placed a small wooden block beside the right spot — a gesture the puppies had never seen before — to show them where the treat was hidden. The results were striking. Even with no specific training, dog puppies as young as eight weeks old understood where to go, and were twice as likely to get it right as wolf puppies the same age who had spent far more time around people. Seventeen out of 31 dog puppies consistently went to the right bowl. In contrast, none out of 26 human-reared wolf pups did better than a random guess. Control trials showed the puppies weren’t simply sniffing out the food. Even more impressive, many of the dog puppies got it right on their first trial. Absolutely no training necessary. They just get it. It’s not about which species is “smarter,” said first author Hannah Salomons, a doctoral student in Brian Hare’s lab at Duke. Dog puppies and wolf puppies proved equally adept in tests of other cognitive abilities, such as memory, or motor impulse control, which involved making a detour around transparent obstacles to get food. It was only when it came to the puppies’ people-reading skills that the differences became clear. “There’s lots of different ways to be smart,” Salomons said. “Animals evolve cognition in a way that will help them succeed in whatever environment they’re living in.” Other tests showed that dog puppies were also 30 times more likely than wolf pups to approach a stranger. “With the dog puppies we worked with, if you walk into their enclosure they gather around and want to climb on you and lick your face, whereas most of the wolf puppies run to the corner and hide,” Salomons said. And when presented with food inside a container that was sealed so they could no longer retrieve it, the wolf pups generally tried to solve the problem on their own, whereas the dog puppies spent more time turning to people for help, looking them in the eye as if to say: “I’m stuck can you fix this?” Senior author Brian Hare says the research offers some of the strongest evidence yet of what’s become known as the “domestication hypothesis.” Somewhere between 12,000 and 40,000 years ago, long before dogs learned to fetch, they shared an ancestor with wolves. How such feared and loathed predators transformed into man’s best friend is still a bit of a mystery. But one theory is that, when humans and wolves first met, only the friendliest wolves would have been tolerated and gotten close enough to scavenge on the human’s leftovers instead of running away. Whereas the shyer, surlier wolves might go hungry, the friendlier ones would survive and pass on the genes that made them less fearful or aggressive toward humans. The theory is that this continued generation after generation, until the wolf’s descendants became masters at gauging the intentions of people they interact with by deciphering their gestures and social cues. “This study really solidifies the evidence that the social genius of dogs is a product of domestication,” said Hare, professor of evolutionary anthropology at Duke. It’s this ability that makes dogs such great service animals, Hare said. “It is something they are really born prepared to do.” Much like human infants, dog puppies intuitively understand that when a person points, they’re trying to tell them something, whereas wolf puppies don’t. “We think it indicates a really important element of social cognition, which is that others are trying to help you,” Hare said. “Dogs are born with this innate ability to understand that we’re communicating with them and we’re trying to cooperate with them,” Salomons said. Reference: “Cooperative Communication with Humans Evolved to Emerge Early in Domestic Dogs” Hannah Salomons, Kyle Smith, Megan Callahan-Beckel, Margaret Callahan, Kerinne Levy, Brenda S. Kennedy, Emily Bray, Gitanjali E. Gnanadesikan, Daniel J. Horschler, Margaret Gruen, Jingzhi Tan, Philip White, Evan MacLean and Brian Hare, 12 July 2021, Current Biology. DOI: 10.1016/j.cub.2021.06.051 This research was supported by the Office of Naval Research (N00014- 16-12682), the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (NIH-1Ro1HD097732) and the AKC Canine Health Foundation (#2700).

Caltech neuroscientists’ recent research on mounting behavior in mice uncovers a complex interplay between love and anger in the mouse brain. This study sheds light on how the mammalian brain controls emotions and may hold potential insights into human behavior. Mounting in mice can signal love or dominance. Two brain regions act like a switch, controlling emotional behavior based on social context. Mounting behavior, that awkward thrusting motion dogs sometimes do against your leg, is usually associated with sexual arousal in animals, but this is not always the case. New research by Caltech neuroscientists that explores the motivations behind mounting behavior in mice finds that sometimes there is a thin line between love and hate (or anger) in the mouse brain. The research, which appears in the journal Nature, was conducted in the lab of David Anderson, the Seymour Benzer Professor of Biology, Tianqiao and Chrissy Chen Institute for Neuroscience Leadership Chair, an investigator with the Howard Hughes Medical Institute, and director of the Tianqiao and Chrissy Chen Institute for Neuroscience. “Our lab is interested in understanding how social behaviors and underlying emotional states are controlled by the brain,” explains lead author Tomomi Karigo, a postdoctoral scholar at Caltech. “While we were studying social behaviors in mice, we sometimes noticed that male mice would mount other males, in a way similar to how they would mount females,” Karigo says. It was unclear whether these male mice tried to mate with a male because they simply mistook it for a female or if they knew it was a male but intended to establish dominance over it. The researchers hoped to understand whether a male mouse mounting another male mouse reflects a different intent than a mouse mounting a female mouse, and how mounting behavior is regulated in the brain. To find out, the researchers first recorded videos of males mounting both male and female mice. Using machine learning, a type of software that learns and adapts through experience, they analyzed the videos to see whether there was anything different in the mounting behavior that was exhibited toward a male versus that toward a female mouse. The machine-learning analysis revealed no obvious difference in the mechanics of the mounting behavior. The researchers then looked for other clues in the mounting males’ behavior that might differentiate female-focused versus male-focused mounting. Ultrasonic Clues and Fighting Behavior One clue was that male mice appear to “sing” to females while mating with them. These songs, known as ultrasonic vocalizations, are too high-pitched for humans to hear, but can be picked up with a special microphone. Karigo and the team found that mounting mice sing only to female mice, not to males. In addition, when a male is mounting another male, the two animals usually end up fighting after a short period of mounting. This does not happen in the case of a female mounting partner. These results suggested that mounting behavior toward a female has a different meaning than mounting behavior toward a male. Specifically, mounting toward a male is probably the expression of dominance or mild anger (aggressive mounting) and not a reproductive (or so-called affiliative) behavior. Next, the researchers explored which brain regions are responsible for each type of mounting behavior. When a male mouse mounted male or female mice, the researchers observed neural activity in an area of its brain called the hypothalamus, which controls, among other things, hunger, thirst, metabolism, and defensive behaviors. In particular, two regions of the hypothalamus seemed to be involved: the medial preoptic area (MPOA) and the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl). The MPOA showed high levels of activity when the male mouse was mounting, and singing to, a female; conversely, the VMHvl showed high levels of activity when the male mouse was mounting, but not singing to, a male. Distinct Neurons, Distinct Behaviors The team then took a closer look at the activity of individual neurons in the MPOA and VMHvl. They found that distinct groups of neurons were activated during reproductive mounting and aggressive mounting, in each brain region. In addition, the researchers discovered that they could train a computer to correctly predict whether the mounting was sexual or aggressive, based purely on the pattern of neuronal activity in these two regions. The researchers then tested to see if those brain regions actually controlled the two mounting behaviors, or if activity in the regions was simply correlated with the behaviors. They did this using a technique called optogenetic stimulation, in which light is used to trigger the firing of neurons. By directing the light to specific areas of the brain, researchers can induce neuronal activity there, and thus induce behaviors. When the researchers presented a female mouse to a male mouse, the male mouse began to sing and mate with a female. But when the researchers stimulated the male’s VMHvl, the male stopped singing and started to show aggressive mounting behavior toward the female. Conversely, if a male mouse was engaging in aggressive behaviors toward another male and the researchers stimulated its MPOA, the aggressive mouse would stop fighting, begin to sing, and attempt to mate with the other male. A Seesaw of Love and Hate Karigo and Anderson liken this to a seesaw of love and hate. Activity in the MPOA tilts the seesaw toward love, while activity in the VMHvl tilts it toward hate (or aggression). “In this study, we used mounting behavior as an entry point to understand the underlying neural mechanisms that control emotional or motivational states,” Karigo says. She says their findings advance our understanding of how the mouse brain, and more broadly the mammalian brain, works to control emotions, and she adds that they may one day help us to better understand human behaviors. The paper describing their findings, titled, “Distinct hypothalamic control of same- and opposite-sex mounting behavior in mice,” was published online by Nature on December 2, 2020. Co-authors are Ann Kennedy, formerly of Caltech and now at the Feinberg School of Medicine at Northwestern University; neurobiology graduate students Bin Yang and Mengyu Liu of Caltech; Derek Tai, formerly a research assistant at Caltech and now at the Touro University Nevada College of Osteopathic Medicine; Iman A. Wahle (BS ’20), a Schmidt Scholar at Caltech; and David J. Anderson. Reference: “Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice” by Tomomi Karigo, Ann Kennedy, Bin Yang, Mengyu Liu, Derek Tai, Iman A. Wahle and David J. Anderson, 2 December 2020, Nature. DOI: 10.1038/s41586-020-2995-0 CaltechAUTHORS: 20200909-142458487 Funding for the research was provided by the National Institutes of Health, the Simons Collaboration on the Global Brain Foundation, the Howard Hughes Medical Institute and the Tianqiao and Chrissy Chen Institute for Neuroscience, of which Anderson is the director.

Researchers at the University of Connecticut found that extra-cellular vesicles (EVs) in human cells can transport bacterial products to other cells, impacting health. This discovery, which elucidates how bacterial elements enter cells, has significant implications for understanding immune responses and cellular communication. Credit: SciTechDaily.com It’s well known that bacterial products can get inside human cells; Now, researchers can finally explain how. Messenger bubbles produced by human cells can pick up bacterial products and deliver them to other cells, University of Connecticut researchers report in the journal Nature Cell Biology. The discovery may explain a key mechanism by which bacteria, whether friendly or infectious, affect our health. The Function of Extra-Cellular Vesicles (EVs) Extra-cellular vesicles (EVs) are like a postal service for our cells. Cells produce the EVs, tiny bubbles with a water-resistant shell made of fatty substances called lipids, and send them into the bloodstream. When another cell comes across an EV, it takes it inside itself and opens it up. Inside the EVs are usually molecules that act as messages informing the receiving cell’s behavior or growth. An Unexpected Discovery Now, University of Connecticut School of Medicine immunologists Puja Kumari, Vijay Rathinam, and colleagues report that EVs do something else, entirely unexpected. The walls of an EV can pick up pieces of bacteria, which usually have a lipid section that easily slips into the lipid walls of the EV. The EV then brings the bacterial products along with its other contents inside of whichever human cell snags it. “We found EVs patrol the circulation for systemic microbial products and alert an immune surveillance network inside the cell,” says Kumari, a postdoctoral researcher in the Rathinam lab. Solving a Cellular Mystery This solves a longstanding mystery. Researchers knew that our cells have receptors inside of them that detect bacterial products. But they didn’t know how those bacterial products actually got inside of our cells. “We understood which microbial products go into circulation,” says Rathinam, an associate professor in the department of immunology. The products can come from infectious bacteria invading, or they can come from friendly bacteria, for example, the ones that live in our intestines. When the receptors inside of cells detect them, the signals from bacteria can help the gut, immune system, and even brain function properly. Or they can cause cells to explode themselves and cause inflammation, depending on the type of bacteria and the product involved. “But we didn’t know how microbial products reaching the blood from harmful or friendly bacteria go from outside the cell to inside the cell,” Rathinam says. Proving the Transport Mechanism To show that EVs were actually transporting the bacterial pieces and bringing them into cells, Kumari, Rathinam, and their colleagues did a series of experiments. First, they injected green-labeled LPS, a product made by bacteria, into mice. After about an hour, they found the green LPS on EVs in the mice’s blood. Second, when they transferred these EVs with green LPS to another group of mice, they found green LPS inside the cells in the recipient mice, setting off inflammation. Although they have not yet tried the experiments with microbial products other than LPS, they suspect a similar thing would happen. “We think this has a role in normal physiology as well as in infections. Microbial products from microbiota in the gut are released into circulation, and are important for the body. EVs may have a good, beneficial role in that,” says Rathinam. Reference: “Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis” by Puja Kumari, Swathy O. Vasudevan, Ashley J. Russo, Skylar S. Wright, Víctor Fraile-Ágreda, Dylan Krajewski, Evan R. Jellison, Ignacio Rubio, Michael Bauer, Atsushi Shimoyama, Koichi Fukase, Yuanpeng Zhang, Joel S. Pachter, Sivapriya Kailasan Vanaja and Vijay A. Rathinam, 16 November 2023, Nature Cell Biology. DOI: 10.1038/s41556-023-01269-8 This research was funded by the National Institutes of Health.

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