Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Ergonomic insole ODM production factory Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene sheet OEM supplier Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China custom insole OEM supplier

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China insole ODM service provider

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand sustainable material ODM solutions

Scientists have uncovered a key function of NAD, a molecule crucial for energy and cellular repair. Mitochondria act as NAD storage units, but if drained over time, they can accelerate aging and disease. Promising treatments focus on boosting NAD levels to combat these effects. NAD, a vital molecule for cellular energy and DNA repair, plays a central role in aging and diseases like cancer and neurodegeneration. Recent research reveals how mitochondria act as reservoirs for NAD, supporting cells during increased demand. This insight opens doors to therapeutic strategies for mitigating aging and related diseases. NAD: The Molecule Essential to Life At the core of this groundbreaking discovery is a molecule called NAD, short for Nicotinamide Adenine Dinucleotide. Professor Mathias Ziegler from the Department of Biomedicine at the University of Bergen (UiB), who led the international research team behind the study, highlights its importance: “The fascinating thing about NAD is that the molecule is essential to life, as it plays critical roles in all cellular processes. Therefore, dysregulated NAD levels are involved in aging processes as well as many pathologies ranging from cancer to diabetes and neurodegenerative diseases. And the reason for this is that it holds a key position in both energy metabolism and the regulation of vital functions,” he says. How NAD Fuels Cellular Energy All bodily functions rely on energy — without it, we can’t run, breathe, or even think. Our bodies, and more specifically our cells, get this essential energy from the food we eat. Nutrients like sugars and fats are broken down and converted into a form of energy that cells use to power everything they do. “NAD is central to these conversions as it functions like a rechargeable battery. It is charged by the energy retrieved from food and passes it on to fuel all cellular activities. An important part of this energy transfer takes place in cellular structures called mitochondria, which are also referred to as the powerhouse of the cell,” Ziegler explains. Professor Mathias Ziegler. Credit: Torstein Ravnskog, UiB Aging, DNA Repair, and NAD Demand Crucially, NAD also contributes to many other vital functions throughout the cell. It serves as a chemical signal to regulate key cellular events including gene expression and DNA repair, which take place in the cell nucleus. “Interestingly, during aging, our DNA may accumulate damage which, in turn, will increase the demand for NAD molecules. Indeed, we see that cellular NAD levels decrease as we age, and it is assumed that increased DNA repair activity is one of the main reasons for this decline,” explains Ziegler. “The problem arises when the mitochondria or their NAD store are affected or tapped over extended periods of time.” But how do cells cope with the increased demand for NAD and do decreased NAD levels necessarily result in pathological conditions? To answer these questions, Ziegler and his team developed models to study how cells react to reduced NAD levels as they occur during aging. They had previously developed a method that enabled them to detect cellular NAD molecules and their distribution in living cells. In addition, they now implemented advanced analytical techniques, including high-resolution mass spectrometry, to study the cellular dynamics of NAD-dependent processes. As a result, the researchers discovered a hitherto unrecognized role of mitochondria in the maintenance of cellular NAD levels: “These organelles serve as an NAD reservoir that is filled when cells function normally, and it supplies the cell with NAD when there is an increased demand,” explains Lena Høyland, PhD student and first author of the study. Employing gene-technological methods such as CRISPR-Cas9 genome editing they were able to establish the molecular mechanisms of how mitochondria counteract cellular NAD decline. “Decreased cellular NAD levels thus appear to be generally well tolerated by the cells,” she says. “The problem, however, arises when the mitochondria or their NAD store are affected or tapped over extended periods of time. This can have fatal consequences since the cells may no longer have sufficient NAD “battery capacity” to drive vital, energy-dependent processes,” Professor Ziegler adds. Exploring NAD Supplementation in Aging Research over the past years has established that mitochondrial dysfunction and lowered cellular NAD levels represent characteristics of aging, and age-related disorders, such as dementia or neurodegenerative diseases. Based on their new findings, the team of researchers believes that excessive depletion of mitochondrial NAD might constitute a key factor leading to dysfunctional cellular powerhouses and thus aging-associated diseases. Indeed, initial clinical trials in Norway and internationally using therapeutic supplementation approaches aiming to increase NAD levels have provided encouraging results. “We are very excited about having discovered yet another mechanism potentially involved in disease development and progression,” says Høyland, and Ziegler concludes: “Our study also demonstrates the importance of basic research to identify promising targets to slow aging and to treat aging-related diseases.” The results have been published in the renowned journal Nature Metabolism and featured in a News and Views article in the same issue. Reference: “Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+” by Lena E. Høyland, Magali R. VanLinden, Marc Niere, Øyvind Strømland, Suraj Sharma, Jörn Dietze, Ingvill Tolås, Eva Lucena, Ersilia Bifulco, Lars J. Sverkeli, Camila Cimadamore-Werthein, Hanan Ashrafi, Kjellfrid F. Haukanes, Barbara van der Hoeven, Christian Dölle, Cédric Davidsen, Ina K. N. Pettersen, Karl J. Tronstad, Svein A. Mjøs, Faisal Hayat, Mikhail V. Makarov, Marie E. Migaud, Ines Heiland and Mathias Ziegler, 13 December 2024, Nature Metabolism. DOI: 10.1038/s42255-024-01174-w

A unique experiment involving gophers at Mount St. Helens has shown long-lasting benefits for ecological recovery, with significant increases in plant life and sustained soil health over 40 years. In 1980, the eruption of Mount St. Helens devastated local ecosystems, but an experimental introduction of gophers has demonstrated a long-term positive impact on the soil and plant life. Scientists observed that gophers, considered pests, could regenerate vital bacteria and fungi, significantly aiding plant recovery. Forty years later, this single-day experiment continues to show benefits, with certain areas displaying a dramatic increase in plant diversity and resilience thanks to the persistent effects on microbial communities. Mount St. Helens Eruption When Mount St. Helens erupted in 1980, the lava incinerated every living thing for miles. In an experimental effort to help the ecosystem recover, scientists introduced gophers to the scorched mountain for just 24 hours. The impact of that single day proved significant—and is still evident 40 years later. Once the ash and debris cooled, scientists hypothesized that gophers, by digging and disturbing the soil, could bring beneficial bacteria and fungi to the surface, potentially aiding in the restoration of plant and animal life. Two years after the eruption, they put this theory to the test. “They’re often considered pests, but we thought they would take old soil, move it to the surface, and that would be where recovery would occur,” explained UC Riverside’s Michael Allen. An unhappy gopher and plant near the gopher enclosure fence in 1982. Credit: Michael Allen/UCR Long-Term Effects Observed in Soil They were right. The scientists, however, did not anticipate that the effects of this brief experiment would remain evident in the soil today, in 2024. A recent paper in Frontiers in Microbiomes describes how the areas where gophers were introduced show lasting changes in fungal and bacterial communities, unlike nearby areas where gophers were never added. “In the 1980s, we were just testing the short-term reaction,” said UCR microbiologist Michael Allen. “Who would have predicted you could toss a gopher in for a day and see a residual effect 40 years later?” In 1983, Allen and Utah State University’s James McMahon helicoptered to an area where the lava had turned the land into collapsing slabs of porous pumice. At that time, there were only about a dozen plants that had learned to live on these slabs. A few seeds had been dropped by birds, but the resulting seedlings struggled. After scientists dropped a few local gophers on two pumice plots for a day, the land exploded again with new life. Six years post-experiment, there were 40,000 plants thriving on the gopher plots. The untouched land remained mostly barren. Gophers and plants thriving in the once barren area scarred by the volcanic eruption, 2012. Credit: Mike Allen/UCR Microbial Role in Plant Survival All this was possible because of what isn’t always visible to the naked eye. Mycorrhizal fungi penetrate into plant root cells to exchange nutrients and resources. They can help protect plants from pathogens in the soil, and critically, by providing nutrients in barren places, they help plants establish themselves and survive. “With the exception of a few weeds, there is no way most plant roots are efficient enough to get all the nutrients and water they need by themselves. The fungi transport these things to the plant and get carbon they need for their own growth in exchange,” Allen said. Comparative Study: Old-Growth Forests vs. Clearcut Areas A second aspect of this study further underscores how critical these microbes are to the regrowth of plant life after a natural disaster. On one side of the mountain was an old-growth forest. Ash from the volcano blanketed the trees, trapping solar radiation and causing needles on the pine, spruce, and Douglas firs to overheat and fall off. Scientists feared the loss of the needles would cause the forest to collapse. That is not what happened. “These trees have their own mycorrhizal fungi that picked up nutrients from the dropped needles and helped fuel rapid tree regrowth,” said UCR environmental microbiologist and paper co-author Emma Aronson. “The trees came back almost immediately in some places. It didn’t all die like everyone thought.” On the other side of the mountain, the scientists visited a forest that had been clearcut prior to the eruption. Logging had removed all the trees for acres, so naturally there were no dropped needles to feed soil fungi. “There still isn’t much of anything growing in the clearcut area,” Aronson said. “It was shocking looking at the old growth forest soil and comparing it to the dead area.” Learning From Nature’s Resilience These results underscore how much there is to learn about rescuing distressed ecosystems, said lead study author and University of Connecticut mycologist Mia Maltz, who was a postdoctoral scholar in Aronson’s lab at UCR when the study began. “We cannot ignore the interdependence of all things in nature, especially the things we cannot see like microbes and fungi,” Maltz said. Reference: “Microbial community structure in recovering forests of Mount St. Helens” by Emma L. Aronson, Lela V. Andrews, Hannah Freund, Hannah Shulman, Rebecca R. Hernandez, Michala Phillips and Mia R. Maltz, 22 August 2024, Frontiers in Microbiomes. DOI: 10.3389/frmbi.2024.1399416

University of Michigan researchers have discovered the protein GluK2 as the key to how mammals sense cold, a finding that could impact treatments for conditions like the cold sensitivity experienced by chemotherapy patients. Researchers at the University of Michigan have discovered the protein that enables mammals to sense cold, filling a long-standing knowledge gap in the field of sensory biology. The findings, published in Nature Neuroscience, could help unravel how we sense and suffer from cold temperature in the winter, and why some patients experience cold differently under particular disease conditions. “The field started uncovering these temperature sensors over 20 years ago, with the discovery of a heat-sensing protein called TRPV1,” said neuroscientist Shawn Xu, a professor at the U-M Life Sciences Institute and a senior author of the new research. “Various studies have found the proteins that sense hot, warm, even cool temperatures—but we’ve been unable to confirm what senses temperatures below about 60 degrees Fahrenheit.” In a2019 study, researchers in Xu’s lab discovered the first cold-sensing receptor protein in Caenorhabditis elegans, a species of millimeter-long worms that the lab studies as a model system for understanding sensory responses. Because the gene that encodes the C. elegans protein is evolutionarily conserved across many species, including mice and humans, that finding provided a starting point for verifying the cold sensor in mammals: a protein called GluK2 (short for Glutamate ionotropic receptor kainate type subunit 2). Identifying the Mammalian Cold Sensor For this latest study, a team of researchers from the Life Sciences Institute and the U-M College of Literature, Science, and the Arts tested their hypothesis in mice that were missing the GluK2 gene, and thus could not produce any GluK2 proteins. Through a series of experiments to test the animals’ behavioral reactions to temperature and other mechanical stimuli, the team found that the mice responded normally to hot, warm, and cool temperatures, but showed no response to noxious cold. GluK2 is primarily found on neurons in the brain, where it receives chemical signals to facilitate communication between neurons. But it is also expressed in sensory neurons in the peripheral nervous system (outside the brain and spinal cord). “We now know that this protein serves a totally different function in the peripheral nervous system, processing temperature cues instead of chemical signals to sense cold,” said Bo Duan, U-M associate professor of molecular, cellular, and developmental biology and co-senior author of the study. While GluK2 is best known for its role in the brain, Xu speculates that this temperature-sensing role may have been one of the protein’s original purposes. The GluK2 gene has relatives across the evolutionary tree, going all the way back to single-cell bacteria.”A bacterium has no brain, so why would it evolve a way to receive chemical signals from other neurons? But it would have great need to sense its environment, and perhaps both temperature and chemicals,” said Xu, who is also a professor of molecular and integrative physiology at the U-M Medical School. “So I think temperature sensing may be an ancient function, at least for some of these glutamate receptors, that was eventually co-opted as organisms evolved more complex nervous systems.” In addition to filling a gap in the temperature-sensing puzzle, Xu believes the new finding could have implications for human health and well-being. Cancer patients receiving chemotherapy, for example, often experience painful reactions to cold. “This discovery of GluK2 as a cold sensor in mammals opens new paths to better understand why humans experience painful reactions to cold, and even perhaps offers a potential therapeutic target for treating that pain in patients whose cold sensation is overstimulated,” Xu said. Reference: “The kainate receptor GluK2 mediates cold sensing in mice” by Wei Cai, Wenwen Zhang, Qin Zheng, Chia Chun Hor, Tong Pan, Mahar Fatima, Xinzhong Dong, Bo Duan and X. Z. Shawn Xu, 11 March 2024, Nature Neuroscience. DOI: 10.1038/s41593-024-01585-8 The research was supported by the National Institutes of Health. All procedures performed in mice were approved by the Institutional Animal Care and Use Committee and performed in accordance with the institutional guidelines.

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