Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Taiwan high-end foam product OEM/ODM

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.ESG-compliant OEM manufacturer in China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Soft-touch pillow OEM service in Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam insole OEM manufacturer

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Pillow OEM factory for wellness brands

EMBL researchers and colleagues have analyzed the effects of 144 antibiotics on our most common gut microbes. Their study substantially improves our understanding of antibiotics’ effects. It also suggests a new approach to mitigating the adverse effects of antibiotic therapy on the gut microbiome through the combination of antibiotics with a second drug. Credit: Isabel Romero Calvo/EMBL EMBL scientists pave the way for reducing the harmful side effects antibiotics have on gut bacteria. Antibiotics help us to treat bacterial infections and save millions of lives each year. But they can also harm the helpful microbes residing in our gut, weakening one of our body’s first lines of defense against pathogens and compromising the multiple beneficial effects our microbiota has for our health. Common side effects of this collateral damage of antibiotics are gastrointestinal problems and recurrent Clostridioides difficile infections. They also include long-term health problems, such as the development of allergic, metabolic, immunological, or inflammatory diseases. Researchers from the Typas group at EMBL Heidelberg, the Maier lab at the Cluster of Excellence ‘Controlling Microbes to Fight Infections’ at the University of Tübingen, and collaborators have analyzed the effects of 144 antibiotics on our most common gut microbes. The study published in the journal Nature substantially improves our understanding of antibiotics’ effects on gut microbes. It also suggests a new approach to mitigating the adverse effects of antibiotic therapy on the gut microbiome. The human gut harbors an intricate community of different microbial species as well as many viruses, collectively referred to as the gut microbiome. Together, they enable us to use nutrients more efficiently and hinder pathogenic bacteria from settling in our gut. However, when we treat a bacterial infection with antibiotics, there’s a risk of damaging the gut microbiome. “Many antibiotics inhibit the growth of various pathogenic bacteria. This broad activity spectrum is useful when treating infections, but it increases the risk that the microbes in our gut are targeted as well,” explained Lisa Maier, DFG Emmy Noether group leader at the University of Tübingen. Maier is an alumna of the Typas lab and one of the two lead authors of the study. If certain gut bacteria are harmed more than others, antibiotic therapy can lead to an imbalance in our microbiota composition, commonly referred to as dysbiosis. Diarrhea is a common short-term effect, while allergic conditions such as asthma or food allergies and obesity are possible long-term consequences. The fact that antibiotics are also active against gut microbes has been known for a long time, but their effects on the large diversity of microbes we carry in our gut had not yet been studied systematically, mostly due to technical challenges. Antibiotics help our body to get rid of bacterial infections. But they can also harm the helpful microbes in our gut. EMBL scientists studied the collateral damage antibiotics cause and found that some drugs could protect many gut bacteria from antibiotics. Credit: Isabel Romero Calvo/EMBL “So far, our knowledge of the effects of different antibiotics on individual members of our gut microbial communities has been patchy. Our study fills major gaps in our understanding of which type of antibiotic affects which types of bacteria, and in what way,” said Nassos Typas, Senior Scientist and Group Leader at EMBL Heidelberg. Building on a previous study from EMBL’s Typas, Bork, Patil, and Zeller groups, the scientists observed how each of the 144 antibiotics affected the growth and survival of up to 27 bacterial strains commonly inhabiting our guts. The researchers determined the concentrations at which a given antibiotic would affect these bacterial strains for more than 800 antibiotic–strain combinations, expanding existing datasets on antibiotic spectra in gut bacterial species by 75%. Importantly, the experiments revealed that tetracyclines and macrolides – two commonly used antibiotics families – not only stopped bacteria from growing, but also led to their death. About half of the tested gut strains did not survive treatment with these types of antibiotics. “We didn’t expect to see this effect with tetracyclines and macrolides, as these antibiotic classes were considered to have only bacteriostatic effects – which means that they stop bacterial growth, but don’t kill bacteria,” said Camille Goemans, a postdoctoral fellow in the Typas group who shares first authorship with Maier. “Our experiments show that this assumption is not true for about half of the gut microbes we studied. Doxycycline, erythromycin, and azithromycin, three commonly used antibiotics, killed several abundant gut microbial species, whereas others they just inhibited.” The selective killing of specific microbes by tetracyclines and macrolides could lead to these microbes being inadvertently lost from the gut microbiota much faster than microbes for which growth is only inhibited, as the authors showed with synthetic microbial communities. This could explain the strong microbiota shifts that some patients being treated with these antibiotics witness. There is a way of reducing the damage, though. “We have shown before that drugs interact differently across different bacterial species. We therefore explored whether a second drug could mask the harmful effects of antibiotics on abundant gut microbes, but allow antibiotics to retain their activity against pathogens. This would provide something like an antidote, which would reduce the collateral damage of antibiotics on gut bacteria,” explained Typas. The scientists combined the antibiotics erythromycin or doxycycline with a set of nearly 1,200 pharmaceuticals, to identify drugs that would save two abundant gut bacterial species from the antibiotic. Indeed, the researchers identified several non-antibiotic drugs that could rescue these gut microbes and other related species. Importantly, the combination of an antibiotic with a protective second drug did not compromise the antibiotics’ efficacy against pathogenic bacteria. Follow-up experiments indicated that this approach may be working in the context of a natural microbiome as well. With help from collaborators, the scientists showed that the combination of erythromycin with an antidote mitigated the loss of certain abundant gut bacterial species from the mouse gut. Similarly, antidote drugs protected human gut microbes from erythromycin in complex bacterial communities derived from stool samples. “Our approach that combines antibiotics with a protective antidote could open new opportunities for reducing the harmful side effects of antibiotics on our gut microbiomes,” concluded Maier. “No single antidote will be able to protect all the bacteria in our gut – especially since those differ so much across individuals. But this concept opens up the door for developing new personalized strategies to keep our gut microbes healthy.” Further research will be needed to identify the optimal combinations, dosing, and formulations for antidotes, and to exclude potential long-term effects on the gut microbiome. In the future, the new approach may help to keep our gut microbiome healthy and reduce antibiotics’ side effects in patients, without compromising the efficiency of our antibiotics as lifesavers. Reference: “Unravelling the collateral damage of antibiotics on gut bacteria” by Lisa Maier, Camille V. Goemans, Jakob Wirbel, Michael Kuhn, Claudia Eberl, Mihaela Pruteanu, Patrick Müller, Sarela Garcia-Santamarina, Elisabetta Cacace, Boyao Zhang, Cordula Gekeler, Tisya Banerjee, Exene Erin Anderson, Alessio Milanese, Ulrike Löber, Sofia K. Forslund, Kiran Raosaheb Patil, Michael Zimmermann, Bärbel Stecher, Georg Zeller, Peer Bork and Athanasios Typas, 13 October 2021, Nature. DOI: 10.1038/s41586-021-03986-2 The study was a collaborative effort, involving researchers from EMBL’s Typas, Bork, Zeller, Zimmermann, and Patil groups, as well as colleagues at the University of Tübingen, Ludwig-Maximilians-Universität München, and the Max Delbrück Center for Molecular Medicine in Berlin.

New research reveals how Cladonema jellyfish can regrow their tentacles in just a few days, highlighting the role of unique stem-like proliferative cells in this rapid regenerative process. This breakthrough offers insights into similar regenerative processes in other species. Credit: SciTechDaily.com Japanese scientists have uncovered that Cladonema jellyfish regenerate tentacles using stem-like proliferative cells, offering new insights into the blastema formation process and its evolutionary parallels in other species like salamanders. At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days — but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has remained a mystery until now. A research team based in Japan has revealed that stem-like proliferative cells — which are actively growing and dividing but not yet differentiating into specific cell types — appear at the site of injury and help form the blastema. The findings were published on December 21 in the scientific journal PLOS Biology. The jellyfish Cladonema pacificum exhibits branched tentacles that can robustly regenerate after amputation. Credit: Sosuke Fujita, The University of Tokyo “Importantly, these stem-like proliferative cells in blastema are different from the resident stem cells localized in the tentacle,” said corresponding author Yuichiro Nakajima, lecturer in the Graduate School of Pharmaceutical Sciences at the University of Tokyo. “Repair-specific proliferative cells mainly contribute to the epithelium — the thin outer layer — of the newly formed tentacle.” The resident stem cells that exist in and near the tentacle are responsible for generating all cellular lineages during homeostasis and regeneration, meaning they maintain and repair whatever cells are needed during the jellyfish’s lifetime, according to Nakajima. Repair-specific proliferative cells only appear at the time of injury. “Together, resident stem cells and repair-specific proliferative cells allow rapid regeneration of the functional tentacle within a few days,” Nakajima said, noting that jellyfish use their tentacles to hunt and feed. Resident stem cells (green) and repair-specific proliferative cells (red) contribute to tentacle regeneration in Cladonema. Credit: Sosuke Fujita, The University of Tokyo This finding informs how researchers understand how blastema formation differs among different animal groups, according to first author Sosuke Fujita, a postdoctoral researcher in the same lab as Nakajima in the Graduate School of Pharmaceutical Sciences. “In this study, our aim was to address the mechanism of blastema formation, using the tentacle of cnidarian jellyfish Cladonema as a regenerative model in non-bilaterians, or animals that do not form bilaterally — or left-right — during embryonic development,” Fujita said, explaining that the work may provide insight from an evolutionary perspective. Salamanders, for example, are bilaterian animals capable of regenerating limbs. Their limbs contain stem cells restricted to specific cell-type needs, a process that appears to operate similarly to the repair-specific proliferative cells observed in the jellyfish. “Given that repair-specific proliferative cells are analogs to the restricted stem cells in bilaterian salamander limbs, we can surmise that blastema formation by repair-specific proliferative cells is a common feature independently acquired for complex organ and appendage regeneration during animal evolution,” Fujita said. At 72 hours after amputation, the regenerating tentacle of Cladonema is fully functional. Credit: Sosuke Fujita, The University of Tokyo The cellular origins of the repair-specific proliferative cells observed in the blastema remain unclear, though, and the researchers say the currently available tools to investigate the origins are too limited to elucidate the source of those cells or to identify other, different stem-like cells. “It would be essential to introduce genetic tools that allow the tracing of specific cell lineages and the manipulation in Cladonema,” Nakajima said. “Ultimately, understanding blastema formation mechanisms in regenerative animals, including jellyfish, may help us identify cellular and molecular components that improve our own regenerative abilities.” Reference: “Distinct stem-like cell populations facilitate functional regeneration of the Cladonema medusa tentacle” by Sosuke Fujita, Mako Takahashi, Gaku Kumano, Erina Kuranaga, Masayuki Miura and Yu-ichiro Nakajima, 21 December 2023, PLOS Biology. DOI: 10.1371/journal.pbio.3002435 The research is supported by grants from the Japan Society for the Promotion of Science KAKENHI, Japan Science and Technology Agency, Japan Agency for Medical Research and Development, and Japan’s National Institute for Basic Biology collaborative research program.

Elephant shrews are more closely related to elephants than they are to shrews, according to molecular evolutionary trees. Scientists say convergent evolution is much more common than previously thought. An evolutionary tree, or phylogenetic tree, is a branching diagram showing the evolutionary relationships among various biological species based upon similarities and differences in their characteristics. Historically, this was done using their physical characteristics — the similarities and differences in various species’ anatomies. However, advances in genetic technology now enable biologists to use genetic data to decipher evolutionary relationships. According to a new study, scientists are finding that the molecular data is leading to much different results, sometimes overturning centuries of scientific work in classifying species by physical traits. Molecular Data vs. Morphology-Based Trees New research led by scientists at the Milner Center for Evolution at the University of Bath suggests that determining evolutionary trees of organisms by comparing anatomy rather than gene sequences is misleading. The study, published in the journal Communications Biology on May 31, 2022, shows that we often need to overturn centuries of scholarly work that classified living things according to how they look. “It means that convergent evolution has been fooling us — even the cleverest evolutionary biologists and anatomists — for over 100 years!” Matthew Wills Since Darwin and his contemporaries in the 19th Century, biologists have been trying to reconstruct the “family trees” of animals by carefully examining differences in their anatomy and structure (morphology). However, with the development of rapid genetic sequencing techniques, biologists are now able to use genetic (molecular) data to help piece together evolutionary relationships for species very quickly and cheaply, often proving that organisms we once thought were closely related actually belong in completely different branches of the tree. Geographic Distribution and Molecular Data Alignment For the first time, scientists at Bath compared evolutionary trees based on morphology with those based on molecular data, and mapped them according to geographical location. They found that the animals grouped together by molecular trees lived more closely together geographically than the animals grouped using the morphological trees. Matthew Wills, Professor of Evolutionary Paleobiology at the Milner Center for Evolution at the University of Bath, said: “It turns out that we’ve got lots of our evolutionary trees wrong. “For over a hundred years, we’ve been classifying organisms according to how they look and are put together anatomically, but molecular data often tells us a rather different story. “Our study proves statistically that if you build an evolutionary tree of animals based on their molecular data, it often fits much better with their geographical distribution. “Where things live – their biogeography – is an important source of evolutionary evidence that was familiar to Darwin and his contemporaries. “For example, tiny elephant shrews, aardvarks, elephants, golden moles, and swimming manatees have all come from the same big branch of mammal evolution — despite the fact that they look completely different from one another (and live in very different ways). “Molecular trees have put them all together in a group called Afrotheria, so-called because they all come from the African continent, so the group matches the biogeography.” Molecular evolutionary trees show that elephant shrews are more closely related to elephants, than they are to shrews. Credit: Danny Ye Convergent Evolution’s Impact on Phylogenetic Analysis The study found that convergent evolution – when a characteristic evolves separately in two genetically unrelated groups of organisms – is much more common than biologists previously thought. Professor Wills said: “We already have lots of famous examples of convergent evolution, such as flight evolving separately in birds, bats, and insects, or complex camera eyes evolving separately in squid and humans. “But now with molecular data, we can see that convergent evolution happens all the time – things we thought were closely related often turn out to be far apart on the tree of life. “People who make a living as lookalikes aren’t usually related to the celebrity they’re impersonating, and individuals within a family don’t always look similar — it’s the same with evolutionary trees too. “It proves that evolution just keeps on re-inventing things, coming up with a similar solution each time the problem is encountered in a different branch of the evolutionary tree. “It means that convergent evolution has been fooling us — even the cleverest evolutionary biologists and anatomists — for over 100 years!” Biogeography as a Test for Evolutionary Trees Dr. Jack Oyston, Research Associate and first author of the paper, said: “The idea that biogeography can reflect evolutionary history was a large part of what prompted Darwin to develop his theory of evolution through natural selection, so it’s pretty surprising that it hadn’t really been considered directly as a way of testing the accuracy of evolutionary trees in this way before now. “What’s most exciting is that we find strong statistical proof of molecular trees fitting better not just in groups like Afrotheria, but across the tree of life in birds, reptiles, insects, and plants too. “It being such a widespread pattern makes it much more potentially useful as a general test of different evolutionary trees, but it also shows just how pervasive convergent evolution has been when it comes to misleading us.” Reference: “Molecular phylogenies map to biogeography better than morphological ones” by Jack W. Oyston, Mark Wilkinson, Marcello Ruta and Matthew A. Wills, 31 May 2022, Communications Biology. DOI: 10.1038/s42003-022-03482-x

DVDV1551RTWW78V