Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam high-end foam product OEM/ODM

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.ESG-compliant OEM manufacturer in Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene insole OEM factory Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China orthopedic insole OEM manufacturer

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam sustainable material ODM solutions

The researchers found that chimpanzees consistently used standalone communication signals – such as vocalizations, manual gestures or facial expressions – across all ages and in different situations, but as they got older, they were more likely to combine different communication signals together. Credit: Dr. Jake Brooker A study finds that young chimpanzees combine gestures, sounds, and facial expressions as they grow, paralleling human infant communication. This research provides clues about the evolutionary origins of human language. New research suggests that young chimpanzees meld various gestures, sounds, and facial cues in a manner that echoes how communication develops in human infants. The study, led by psychologists at Durham University, suggests that these combinations of different communicative cues could potentially enhance the clarity of their messages to other chimpanzees, especially in varied contexts like play or conflict. The researchers found that this ability develops throughout infancy and adolescence. Such combined signals included combining playful open-mouth faces with laughing, touching another chimpanzee while whimpering, and baring their teeth while squeaking. The researchers say that understanding this “multimodal” form of communicating could shed important light on how communication evolved in humans and our closest ape relatives, and tell us more about how our own language skills emerge. Juvenile female chimpanzee Nancy shows a play face and laughs during rough and tumble play. The research found that as the chimpanzees got older, they were more likely to combine different communication signals together, especially when they were responding to/ avoiding aggression or were playing. Credit: Dr. Jake Brooker Their study, which also involved the University of Portsmouth, is published in the journal Animal Behaviour. Researchers observed 28 semi-wild chimpanzees, ranging in age from one to 11 years old, at the Chimfunshi Wildlife Orphanage Trust sanctuary in northern Zambia. While previous studies on apes have largely looked at different forms of communication signals in isolation (gestures, vocalizations, facial expressions), the new findings looked at how chimpanzees combined these different forms of communication to see how this developed with age and in varying circumstances. The researchers found that chimpanzees consistently used standalone communication signals – such as grunting, arm movements, or facial expressions – across all ages and in different situations. Increased Complexity in Communication with Age However, they also showed that as the chimpanzees got older, they were more likely to combine different communication signals together. The research looked at how chimpanzees combined different forms of communication to see how this developed with age and in varying social contexts. Credit: Dr. Jake Brooker This was especially the case when the chimpanzees were responding to aggression or were playing, two situations where it is important for them to make clear what they were communicating to avoid risky fallout, the researchers said. The older adolescent chimpanzees studied were also more likely to use a combination of different communication signals instead of individual gestures or expressions, especially during aggression scenarios. Research lead author Emma Doherty, a Research Postgraduate in the Department of Psychology, Durham University, said: “When we think about human language, we know that it is a combination of different types of communication such as speech, facial expressions, and gestures. “The way we communicate likely has deep evolutionary roots that are shared with some of our closest living relatives such as apes. Juvenile female Chitalu acknowledges an approaching adolescent male with a grunt vocalization and a light touch gesture as he walks by during group feeding. Credit: Emma Doherty “Our study provides evidence that the way chimpanzees communicate with increased complexity as they get older is consistent with the development of communication we see in human infants. “By studying the development of this multi-layered way of communicating among young chimpanzees we can learn more about the reasons behind this and shed light on the potential evolutionary continuity between humans and other apes.” The researchers said that more work should be carried out to observe multimodal signals in primates in the wild to further understand how the development of communication is affected by different environments. They added that studying multimodal communication – instead of observing individual communication signals in isolation – could provide better evidence of how communication develops in apes and potentially help us to understand the evolution of human communication. Multimodal Communication as a Key to Language Evolution Research corresponding author Dr. Zanna Clay, Associate Professor in the Department of Psychology, Durham University, said: “A lot of the focus of research so far into communication, both in humans and other animals, looks at individual communication signals independently, but we know humans combine these signals all the time from early infancy. “As a close relative of humans, apes give us a snapshot into how these signals could have evolved into multimodal communications, ultimately culminating in human language.” Reference: “Multimodal communication development in semiwild chimpanzees” by Emma Doherty, Marina Davila-Ross and Zanna Clay, 5 June 2023, Animal Behaviour. DOI: 10.1016/j.anbehav.2023.03.020 The research was funded by a Durham University Doctoral Scholarship, the British Association of Biological Anthropology and Osteoarchaeology, the Lucie Burgers Foundation for Comparative Behavioural Research.

A light microscopy image shows the marine haptophyte algae Braarudosphaera bigelowii with a black arrow pointing to the nitroplast organelle. Credit: Tyler Coale Modern biology textbooks assert that only bacteria can take nitrogen from the atmosphere and convert it into a form that is usable for life. Plants that fix nitrogen, such as legumes, do so by harboring symbiotic bacteria in root nodules. But a recent discovery upends that rule. In two recent papers, an international team of scientists described the first known nitrogen-fixing organelle within a eukaryotic cell. The organelle is the fourth example in the history of primary endosymbiosis — the process by which a prokaryotic cell is engulfed by a eukaryotic cell and evolves beyond symbiosis into an organelle. “It’s very rare that organelles arise from these types of things,” said Tyler Coale, a postdoctoral scholar at UC Santa Cruz and first author on one of two recent papers. “The first time we think it happened, it gave rise to all complex life. Everything more complicated than a bacterial cell owes its existence to that event,” he said, referring to the origins of the mitochondria. “A billion years ago or so, it happened again with the chloroplast, and that gave us plants,” Coale said. The third known instance involves a microbe similar to a chloroplast. The newest discovery is the first example of a nitrogen-fixing organelle, which the researchers are calling a nitroplast. A decades-long mystery The discovery of the organelle involved a bit of luck and decades of work. In 1998, Jonathan Zehr, a UC Santa Cruz distinguished professor of marine sciences, found a short DNA sequence of what appeared to be from an unknown nitrogen-fixing cyanobacterium in Pacific Ocean seawater. Zehr and colleagues spent years studying the mystery organism, which they called UCYN-A. The UC Santa Cruz research team, from left to right: Esther Mak, Jonathan Zehr, Kendra Turk-Kubo and Tyler Coale. Credit: University of California – Santa Cruz At the same time, Kyoko Hagino, a paleontologist at Kochi University in Japan, was painstakingly trying to culture a marine alga. It turned out to be the host organism for UCYN-A. It took her over 300 sampling expeditions and more than a decade, but Hagino eventually successfully grew the alga in culture, allowing other researchers to begin studying UCYN-A and its marine alga host together in the lab. For years, the scientists considered UCYN-A an endosymbiont that was closely associated with an alga. But the two recent papers suggest that UCYN-A has co-evolved with its host past symbiosis and now fits the criteria for an organelle. Organelle origins In a paper published in Cell in March, Zehr and colleagues from the Massachusetts Institute of Technology, Institut de Ciències del Mar in Barcelona, and the University of Rhode Island show that the size ratio between UCYN-A and their algal hosts is similar across different species of the marine haptophyte algae Braarudosphaera bigelowii. A soft x-ray tomography image shows B. bigelowii cell division, with the nitroplasts (UCYN-A) in cyan. Credit: Valentina Loconte The researchers use a model to demonstrate that the growth of the host cell and UCYN-A are controlled by the exchange of nutrients. Their metabolisms are linked. This synchronization in growth rates led the researchers to call UCYN-A “organelle-like.” “That’s exactly what happens with organelles,” said Zehr. “If you look at the mitochondria and the chloroplast, it’s the same thing: they scale with the cell.” But the scientists did not confidently call UCYN-A an organelle until confirming other lines of evidence. In the cover article of the journal Science, Zehr, Coale, Kendra Turk-Kubo and Wing Kwan Esther Mak from UC Santa Cruz, and collaborators from the University of California, San Francisco, the Lawrence Berkeley National Laboratory, National Taiwan Ocean University, and Kochi University in Japan show that UCYN-A imports proteins from its host cells. “That’s one of the hallmarks of something moving from an endosymbiont to an organelle,” said Zehr. “They start throwing away pieces of DNA, and their genomes get smaller and smaller, and they start depending on the mother cell for those gene products — or the protein itself — to be transported into the cell.” Tyler Coale worked on the proteomics for the study. He compared the proteins found within isolated UCYN-A with those found in the entire algal host cell. He found that the host cell makes proteins and labels them with a specific amino acid sequence, which tells the cell to send them to the nitroplast. The nitroplast then imports the proteins and uses them. Coale identified the function of some of the proteins, and they fill gaps in certain pathways within UCYN-A. “It’s kind of like this magical jigsaw puzzle that actually fits together and works,” said Zehr. In the same paper, researchers from UCSF show that UCYN-A replicates in synchrony with the alga cell and is inherited like other organelles. Changing perspectives These independent lines of evidence leave little doubt that UCYN-A has surpassed the role of a symbiont. And while mitochondria and chloroplasts evolved billions of years ago, the nitroplast appears to have evolved about 100 million years ago, providing scientists with a new, more recent perspective on organellogenesis. The organelle also provides insight into ocean ecosystems. All organisms need nitrogen in a biologically usable form, and UCYN-A is globally important for its ability to fix nitrogen from the atmosphere. Researchers have found it everywhere from the tropics to the Arctic Ocean, and it fixes a significant amount of nitrogen. “It’s not just another player,” said Zehr. The discovery also has the potential to change agriculture. The ability to synthesize ammonia fertilizers from atmospheric nitrogen allowed agriculture — and the world population — to take off in the early 20th century. Known as the Haber-Bosch process, it makes possible about 50% of the world’s food production. It also creates enormous amounts of carbon dioxide: about 1.4% of global emissions come from the process. For decades, researchers have tried to figure out a way to incorporate natural nitrogen fixation into agriculture. “This system is a new perspective on nitrogen fixation, and it might provide clues into how such an organelle could be engineered into crop plants,” said Coale. But plenty of questions about UCYN-A and its algal host remain unanswered. The researchers plan to delve deeper into how UCYN-A and the alga operate and study different strains. Kendra Turk-Kubo, an assistant professor at UC Santa Cruz, will continue the research in her new lab. Zehr expects scientists will find other organisms with evolutionary stories similar to UCYN-A, but as the first of its kind, this discovery is one for the textbooks. References: “Metabolic trade-offs constrain the cell size ratio in a nitrogen-fixing symbiosis” by Francisco M. Cornejo-Castillo, Keisuke Inomura, Jonathan P. Zehr and Michael J. Follows, 11 March 2024, Cell. DOI: 10.1016/j.cell.2024.02.016 “Nitrogen-fixing organelle in a marine alga” by Tyler H. Coale, Valentina Loconte, Kendra A. Turk-Kubo, Bieke Vanslembrouck, Wing Kwan Esther Mak, Shunyan Cheung, Axel Ekman, Jian-Hua Chen, Kyoko Hagino, Yoshihito Takano, Tomohiro Nishimura, Masao Adachi, Mark Le Gros, Carolyn Larabell and Jonathan P. Zehr, 11 April 2024, Science. DOI: 10.1126/science.adk1075

Harvard Medical School researchers have analyzed the molecular crosstalk between pain fibers in the gut and goblet cells that line the walls of the intestine. The work shows that chemical signals from pain neurons induce goblet cells to release protective mucus that coats the gut and shields it from damage. The findings show that intestinal pain is not a mere detection-and-signaling system, but plays a direct protective role in the gut. Credit: Chiu Lab/Harvard Medical School What if Pain Is More Than Just a Mere Alarm Bell? New research in mice illuminates how pain neurons shield the gut from damage. Pain is one of evolution’s most effective mechanisms for detecting injury and letting us know that something is wrong. It acts as a warning system, telling us to stop and pay attention to our body. But what if pain is more than just a mere alarm signal? What if pain is in itself a form of protection? A new study led by researchers at Harvard Medical School suggests that may well be the case in mice. The surprising research reveals that pain neurons in the mouse gut regulate the presence of protective mucus under normal conditions and stimulate intestinal cells to release more mucus during states of inflammation. The study was published on October 14 in the journal Cell. The work describes the steps of a complex signaling cascade, demonstrating that pain neurons engage in direct crosstalk with mucus-containing gut cells, known as goblet cells. Goblet cells arise from pluripotent stem cells and get their name from their cup-like appearance that resembles a goblet. Their main function is to secrete mucin and create a protective mucus layer. Goblet cells are also believed to have a role in the regulation of the immune system. “It turns out that pain may protect us in more direct ways than its classic job to detect potential harm and dispatch signals to the brain. Our work shows how pain-mediating nerves in the gut talk to nearby epithelial cells that line the intestines,” said study senior investigator Isaac Chiu. “This means that the nervous system has a major role in the gut beyond just giving us an unpleasant sensation and that it’s a key player in gut barrier maintenance and a protective mechanism during inflammation.” Chiu is an associate professor of immunobiology in the Blavatnik Institute at HMS.  A Direct Conversation Our intestines and airways are studded with goblet cells. Named for their cup-like appearance, goblet cells contain gel-like mucus made of proteins and sugars that acts as protective coating that shields the surface of organs from abrasion and damage. The new research found that intestinal goblet cells release protective mucus when triggered by direct interaction with pain-sensing neurons in the gut. In a set of experiments, the researchers observed that mice lacking pain neurons produced less protective mucus and experienced changes in their intestinal microbial composition — an imbalance in beneficial and harmful microbes known as dysbiosis. To clarify just how this protective crosstalk occurs, the scientists analyzed the behavior of goblet cells in the presence and in the absence of pain neurons. They found that the surfaces of goblet cells contain a type of receptor, called RAMP1, that ensures the cells can respond to adjacent pain neurons, which are activated by dietary and microbial signals, as well as mechanical pressure, chemical irritation or drastic changes in temperature. The experiments further showed that these receptors connect with a chemical called CGRP, released by nearby pain neurons, when the neurons are stimulated. These RAMP1 receptors, the researchers found, are also present in both human and mouse goblet cells, thus rendering them responsive to pain signals. Experiments further showed that the presence of certain gut microbes activated the release of CGRP to maintain gut homeostasis. “This finding tells us that these nerves are triggered not only by acute inflammation, but also at baseline,” Chiu said. “Just having regular gut microbes around appears to tickle the nerves and causes the goblet cells to release mucus.” This feedback loop, Chiu said, ensures that microbes signal to neurons, neurons regulate the mucus, and the mucus keeps gut microbes healthy. In addition to microbial presence, dietary factors also played a role in activating pain receptors, the study showed. When researchers gave mice capsaicin, the main ingredient in chili peppers known for its ability to trigger intense, acute pain, the mice’s pain neurons got swiftly activated, causing goblet cells to release abundant amounts of protective mucus. By contrast, mice lacking either pain neurons or goblet cell receptors for CGRP were more susceptible to colitis, a form of gut inflammation. The finding could explain why people with gut dysbiosis may be more prone to colitis. When researchers gave pain-signaling CGRP to animals lacking pain neurons, the mice experienced rapid improvement in mucus production. The treatment protected mice against colitis even in the absence of pain neurons. The finding demonstrates that CGRP is a key instigator of the signaling cascade that leads to the secretion of protective mucus. “Pain is a common symptom of chronic inflammatory conditions of the gut, such as colitis, but our study shows that acute pain plays a direct protective role as well,” said study first author Daping Yang, a postdoctoral researcher in the Chiu Lab. A Possible Downside to Suppressing Pain The team’s experiments showed that mice lacking pain receptors also had worse damage from colitis when it occurred. Given that pain medications are often used to treat patients with colitis, it may be important to consider the possible detrimental consequences of blocking pain, the researchers said. “In people with inflammation of the gut, one of the major symptoms is pain, so you might think that we’d want to treat and block the pain to alleviate suffering,” Chiu said. “But some part of this pain signal could be directly protective as a neural reflex, which raises important questions about how to carefully manage pain in a way that does not lead to other harms.” Additionally, a class of common migraine medications that suppress the secretion of CGRP may damage gut barrier tissues by interfering with this protective pain signaling, the researchers said. “Given that CGRP is a mediator of goblet cell function and mucus production, if we are chronically blocking this protective mechanism in people with migraine and if they are taking these medications long-term, what happens?” Chiu said. “Are the drugs going to interfere with the mucosal lining and people’s microbiomes?” Goblet cells have multiple other functions in the gut. They provide a passage for antigens — proteins found on viruses and bacteria that initiate a protective immune response by the body — and they produce antimicrobial chemicals that protect the gut from pathogens. “One question that arises from our current work is whether pain fibers also regulate these other functions of goblet cells,” Yang said. Another line of inquiry, Yang added, would be to explore disruptions in the CGRP signaling pathway and determine whether malfunctions are at play in patients with genetic predisposition to inflammatory bowel disease. Reference: “Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection” by Daping Yang, Amanda Jacobson, Kimberly A. Meerschaert, Joseph Joy Sifakis, Meng Wu, Xi Chen, Tiandi Yang, Youlian Zhou, Praju Vikas Anekal, Rachel A. Rucker, Deepika Sharma, Alexandra Sontheimer-Phelps, Glendon S. Wu, Liwen Deng, Michael D. Anderson, Samantha Choi, Dylan Neel, Nicole Lee, Dennis L. Kasper, Bana Jabri, Jun R. Huh, Malin Johansson, Jay R. Thiagarajah, Samantha J. Riesenfeld and Isaac M. Chiu, 14 October 2022, Cell. DOI: 10.1016/j.cell.2022.09.024 Co-authors included Amanda Jacobson, Kimberly Meerschaert, Joseph Sifakis, Meng Wu, Xi Chen, Tiandi Yang, Youlian Zhou, Praju Vikas Anekal, Rachel Rucker, Deepika Sharma, Alexandra Sontheimer-Phelps, Glendon Wu, Liwen Deng, Michael Anderson, Samantha Choi, Dylan Neel, Nicole Lee, Dennis Kasper, Bana Jabri, Jun Huh, Malin Johansson, Jay Thiagarajah, and Samantha Riesenfeld. The work was supported by the National Institutes of Health (grants R01DK127257, R35GM142683, P30DK034854, and T32DK007447); the Food Allergy Science Initiative; the Kenneth Rainin Foundation; and the Digestive Diseases Research Core Center under grant P30 DK42086 at the University of Chicago. Jacobson is an employee of Genentech Inc.; Chiu serves on scientific advisory boards of GSK Pharmaceuticals and Limm Therapeutics. His lab receives research support from Moderna Inc. and Abbvie/Allergan Pharmaceuticals.

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