Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Thailand OEM factory for footwear and bedding

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene insole manufacturer in Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene insole OEM factory Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Cushion insole OEM solution Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Innovative pillow ODM solution in Indonesia

Rockefeller University researchers have developed TrackerSci, a groundbreaking method for tracking the development and aging of brain cells, which could revolutionize the understanding of neurological diseases and aging. This technique has uncovered shifts in cell production in aging brains and has broader applications for studying cell dynamics across various organs. TrackerSci is a new tool for tracking brain cell development and aging, offering fresh insights into cellular changes over a lifetime and potential applications in various organ studies. Hospital nurseries routinely place soft bands around the tiny wrists of newborns that hold important identifying information such as name, sex, mother, and birth date. Researchers at Rockefeller University are taking the same approach with newborn brain cells—but these neonates will keep their ID tags for life, so that scientists can track how they grow and mature, as a means for better understanding the brain’s aging process. Advancements in Cell Tracking As described in a new paper in the journal Cell, the new method developed by Rockefeller geneticist Junyue Cao and his colleagues is called TrackerSci (pronounced “sky”). This low-cost, high-throughput approach has already revealed that while newborn cells continue to be produced through life, the kinds of cells being produced greatly vary at different ages. This groundbreaking work, led by co-first authors Ziyu Lu and Melissa Zhang from Cao’s lab, promises to influence not only the study of the brain but also broader aspects of aging and disease across the human body. “The cell is the basic functional unit of our body, so changes to the cell essentially underlie virtually every disease and the aging process,” says Cao, head of the Laboratory of Single-Cell Genomics and Population Dynamics. “If we can systematically characterize the different cells and their dynamics using this novel technique, we may get a panoramic view of the mechanisms of many diseases and the enigma of aging.” Rare and Powerful New cells are continuously produced in the adult mammalian brain, a critical process associated with memory, learning, and stress. They develop from progenitor cells—descendants of adult stem cells that differentiate into specialized cell types. How this process unfolds, however, has been largely unknown, both because of technological limitations and cell rarity. Finding progenitor cells in the brain is a needle-in-haystack endeavor; in mammals, they account for a mere .5 percent of all brain cells. That number drops to .1 percent in later stages of life—a downward shift due to cellular instability, a core characteristic of disease and aging. Cao studies how tissues and organs maintain stable populations of cells—a hallmark of health—so he and his team wanted to investigate how different cellular populations develop, and whether these varied neuronal cells decline in the same way or forge different paths. Tracking their cellular lifespans from birth to maturity would reveal not just differences, but also when they appeared. His lab specializes in optimizing methods for single-cell sequencing, an increasingly popular approach to analysis that homes in on the genetic expression and molecular dynamics of individual cells. Cao’s group uses combinatorial indexing, a sophisticated yet cost-effective technique that allows for the simultaneous analysis of millions of cells. This method uniquely tags cellular molecules with distinct barcodes that correlate to each cell’s unique molecular assembly. With TrackerSci, Cao and his colleagues have fine-tuned this technique even further. This enhancement enables the meticulous labeling and tracking of the dynamics of rare progenitor cells in mammalian organs. “It’s like an ID card and GPS tracker combined,” Cao says. Aging Brain: Surprising Cellular Shifts For the current study, the researchers analyzed more than 10,000 newborn progenitor cells from across entire mouse brains spanning three ages (young, mature, and elderly) with a synthetic molecule known as 5-ethynyl-2-deoxyuridine (EdU). As these newborn cells differentiated, proliferated, and dispersed, EdU continued to label their DNA, functioning like a GPS tracker. This innovative technique allowed the researchers to analyze tens of thousands of gene expressions and the chromatin landscapes of these newborn cells as they grew into families of cell types with different molecular functions. “We were able to quantify cellular proliferation and differentiation rates of many cell types across the entire brain in a single experiment, which wasn’t possible using conventional approaches,” Cao says. “Those only capture static information—the current molecular state of a cell at a single moment. But TrackerSci captures dynamic information over time. It’s like other methods take snapshots, and we shoot a film.” Some clear—and surprising—characters emerged from these movies. Most strikingly, there were radical shifts in the type of cells generated, depending on the age of the mouse. For example, the number of progenitors that become neurons, the essential communicative cells of the brain, is higher in young brains. The same is the case for a range of glial cells, which create a stable environment for neurons by ensheathing them, providing nutrients, and defending against pathogens—all important for a young, still-developing organ. The opposite is true in the elderly brain. Progenitor cells rarely become either neurons or glial cells; in fact, virtually every type of brain cell plummets. Most lost are dentate gyrus neuroblasts, which are essential for creating neurons in the hippocampus, a region linked to memory and diseases like Alzheimer’s. In comparison to the adult brain, the number of these cells drops by 16-fold in the elderly brain. Instead, immune cells and microglia, a kind of macrophage, proliferate in the aging brain. But rather than protect the brain, they convert into an inflammatory cellular state specific to aging—and these cells are produced at a higher rate. In short, the aging brain creates more of the cells that create more problems for the aging brain. The Sci’s the Limit Cao says TrackerSci could be used to track the regenerative capacity of many organs. “We’re not a brain lab,” he notes. “We also tested the protocol for profiling progenitor cells in the lung, colon, pancreas, and many different organs.” Other organs have far higher proportions of progenitor cells than brains do; newborn progenitors account for more than 20 percent of the cells in the colon, for instance. A few years ago, Cao demonstrated the potential for analyzing cell population dynamics in human fetal development by creating a cellular atlas using a similar combinatorial indexing method. TrackerSci is one of several single-sequencing techniques to recently emerge from Cao’s lab. Another, called PerturbSci-Kinetics, developed by graduate student Zihan Xu, decodes the genome-wide regulatory network that underlies RNA temporal dynamics by coupling scalable single-cell genomics with high-throughput genetic perturbations, or manipulations that can influence gene function. The method was recently described in a paper in Nature Biotechnology. Reference: “Tracking cell-type-specific temporal dynamics in human and mouse brains” by Ziyu Lu, Melissa Zhang, Jasper Lee, Andras Sziraki, Sonya Anderson, Zehao Zhang, Zihan Xu, Weirong Jiang, Shaoyu Ge, Peter T. Nelson, Wei Zhou and Junyue Cao, 28 September 2023, Cell. DOI: 10.1016/j.cell.2023.08.042

Lepraria lichens in Antarctica. Credit: Felix Grewe, Field Museum A study on Lepraria lichens found they possess genes for sexual reproduction despite being thought entirely asexual. This challenges long-held beliefs and raises questions about their reproductive strategies, offering new insights into lichen biology and evolution. The patches of lichen you’ve probably seen on tree trunks and park benches might be easy to overlook, but they are actually some of the world’s strangest living things. Often mistaken for moss, lichens are miniature ecosystems made up of a fungus and an algae or bacteria that can produce energy from sunlight, living together in a single body. They don’t seem to follow the same biological rules as many of their fellow organisms, and scientists are still discovering new things about them. Case in point: in a new study in the journal BMC Genomics, researchers were shocked to find that a type of lichen called Lepraria, long assumed to be asexual, still has the genes that govern sexual reproduction. These lichens, contrary to what scientists have thought for decades, may have secret sex lives that no one has been able to observe. Close-up photo of Lepraria lichens. Credit: Felix Grewe, Field Museum “Lepraria looks basically like greenish, grayish, brownish dust. It’s probably what you would typically think of as a lichen growing on a bench or a rock—a little mossy, but not a moss,” says Meredith Doellman, a postdoctoral researcher in the Field Museum’s Grainger Bioinformatics Center and the paper’s lead author. “Scientists have spent over 200 years looking at these things, and they swear that none of the lichens that make up the genus Lepraria ever produce any structures for sexual reproduction at all. So they assumed that these lichens are asexual.” The Role of Fungus in Lichen Reproduction Fungus forms the majority of a lichen’s body, and lichens rely on their fungal parts to reproduce. Fungi can reproduce asexually through fragmentation or budding off of the parent body, but they are also capable of sexual reproduction. Fungus sex is… complicated. The short version of it is that when the underground thread-like network of two compatible fungal parents-to-be fuse and share genetic material with each other, they come together to build an above-ground structure called a fruiting body. (Mushrooms are probably the best-known fungal fruiting bodies.) The fruiting body’s job is to disperse spores, which are like the fungal equivalent of seeds. These spores get dispersed by wind, water, and animals, eventually landing somewhere that they can grow into fungal networks and start the process anew. Sexual reproduction in lichens follows a similar pattern. “A typically sexually reproducing lichen mates with another individual and produces fruiting bodies called ascomata. These ascomata release spores into the air, and they settle down to grow into new lichens,” says Doellman. Senior author Felix Grewe collecting lichens in Antarctica. Credit: Felix Grewe, Field Museum In two centuries’ worth of examination of Lepraria lichens, scientists have never found ascomata. And while there are lots of asexual lichens in the world, Lepraria has long been considered special as an entire genus of lichens without sexual reproduction—most of the time, there’s an asexual lichen species and a sexually reproducing sister species. Lepraria, as a genus made up entirely of asexual species, appeared to be unique. This assumption led Doellman and her colleagues at the Field Museum’s research project. “We thought we had a situation where we could do some interesting comparative genomics and show that Lepraria, unlike its closest cousin, Stereocaulon, had lost the ability to have typical fungal sex,” says Doellman. Scientists at the Field Museum’s Pritzker Laboratory took DNA samples from Lepraria and Stereocaulon collected around the world, from the Chicago Botanic Gardens to Antarctica. Genomic Insights “We assembled their genomes, annotated the genes, and looked for genes that are typically known to be involved in the cellular process of meiosis that only happens during sexual reproduction. We looked for genes involved in the formation of the fruiting bodies,” says Doellman. “We expected to see that in Lepraria, these genes would be degenerating, no longer functional, or missing entirely. But instead, we found the entire complement, and they all appeared to be intact, functional, and almost exactly like their sisters in Stereocaulon.” The evidence for sexual reproduction in Lepraria upends years of scientific observations. “I was very, very surprised,” says Felix Grewe, director of the Field Museum’s Grainger Bioinformatics Center and the paper’s senior author. “No lichenologist in the world would ever assume that these lichens have sex, and yet they have the genes for it.” While the researchers found that Lepraria has the genes associated with sexual reproduction, they still haven’t found fruiting bodies. “If they occur, they’re very rare. They found a good way to hide from us,” says Grewe. Another potential explanation is that Lepraria do indeed only reproduce asexually, but they’ve retained the genes for sex because those genes are useful for something else. “It’s possible that they are doing something like sexual reproduction, but isn’t. Some sort of parasexual reproduction where they still recombine genetic information, but in a different way,” says Doellman. “For future research, we could look to see if there are different types of mating happening, and we could look at the genetics of Lepraria on a population level to see if it’s consistent with asexual reproduction.” The mystery of Lepraria’s sex life could help illuminate the bigger picture of lichens’ identity as a partnership between a fungus and algae or bacteria that can perform photosynthesis. For a fungal spore to grow into a new fungus, it needs to land in a hospitable environment. For a lichen spore to grow into a new lichen, it both needs to land in a hospitable environment and capture the photosynthetic algae or bacteria that it requires for nourishment. (For most if not all lichens, the fungal partner has evolved such that it can no longer survive on its own without a photosynthetic partner to feed it.) Sexual reproduction, then, is a risk for lichens. It can have a big pay-off, in terms of genetic diversity and evolutionary potential, hence why just about every known lichen does it. But if the lichen spores don’t land in an environment where they can readily pick up a photosynthetic buddy, then they’re in trouble. “I see the advantage for a lichen to reproduce asexually by splitting off from the parent. You may not be able to spread as far, but you get to take your photosynthetic partner along,” says Grewe. “But there are other advantages to sexual reproduction. There’s a lot of work showing that the cellular processes involved with sex contribute to the long-term stability of the genome, things like repairing breaks in genetic code.” While it’s still not clear how Lepraria uses its unexpectedly sexy genes, this study is “another piece of the puzzle to understand how lichens work,” says Grewe. These humble, dust-like organisms could help scientists develop a better understanding of genes, sex, and evolution itself. Reference: “Rethinking asexuality: the enigmatic case of functional sexual genes in Lepraria (Stereocaulaceae)” by Meredith M. Doellman, Yukun Sun, Alejandrina Barcenas-Peña, H. Thorsten Lumbsch and Felix Grewe, 26 October 2024, BMC Genomics. DOI: 10.1186/s12864-024-10898-8

Sharks rely on magnetic fields for their long-distance journeys across the sea. Sea turtles are known for relying on magnetic signatures to find their way across thousands of miles to the very beaches where they hatched. Now, researchers reporting in the journal Current Biology on May 6, 2021, have some of the first solid evidence that sharks also rely on magnetic fields for their long-distance forays across the sea. “It had been unresolved how sharks managed to successfully navigate during migration to targeted locations,” said Save Our Seas Foundation project leader Bryan Keller, also of Florida State University Coastal and Marine Laboratory. “This research supports the theory that they use the earth’s magnetic field to help them find their way; it’s nature’s GPS.” Researchers had known that some species of sharks travel over long distances to reach very specific locations year after year. They also knew that sharks are sensitive to electromagnetic fields. As a result, scientists had long speculated that sharks were using magnetic fields to navigate. But the challenge was finding a way to test this in sharks. “To be honest, I am surprised it worked,” Keller said. “The reason this question has been withstanding for 50 years is because sharks are difficult to study.” This image shows an overhead shot of bonnetheads in the holding tank. Credit: Bryan Keller Keller realized the needed studies would be easier to do in smaller sharks. They also needed a species known for returning each year to specific locations. He and his colleagues settled on bonnetheads (Sphyrna tiburo). “The bonnethead returns to the same estuaries each year,” Keller said. “This demonstrates that the sharks know where ‘home’ is and can navigate back to it from a distant location.” The question then was whether bonnetheads managed those return trips by relying on a magnetic map. To find out, the researchers used magnetic displacement experiments to test 20 juvenile, wild-caught bonnetheads. In their studies, they exposed sharks to magnetic conditions representing locations hundreds of kilometers away from where the sharks were actually caught. Such studies allow for straightforward predictions about how the sharks should subsequently orient themselves if they were indeed relying on magnetic cues. This video is footage from an experimental trial, where the bonnethead’s swimming behavior is affected by the magnetic field it is experiencing. Credit: Bryan Keller If sharks derive positional information from the geomagnetic field, the researchers predicted northward orientation in the southern magnetic field and southward orientation in the northern magnetic field, as the sharks attempted to compensate for their perceived displacement. They predicted no orientation preference when sharks were exposed to the magnetic field that matched their capture site. And, it turned out, the sharks acted as they’d predicted when exposed to fields within their natural range. The researchers suggest that this ability to navigate based on magnetic fields may also contribute to the population structure of sharks. The findings in bonnetheads also likely help to explain impressive feats by other shark species. For instance, one great white shark was documented to migrate between South Africa and Australia, returning to the same exact location the following year. This figure shows how the experiment assessed the ability of bonnethead sharks to use the Earth’s magnetic field to navigate. Credit: Keller et al./Current Biology “How cool is it that a shark can swim 20,000 kilometers round trip in a three-dimensional ocean and get back to the same site?” Keller asked. “It really is mind blowing. In a world where people use GPS to navigate almost everywhere, this ability is truly remarkable.” In future studies, Keller says he’d like to explore the effects of magnetic fields from anthropogenic sources such as submarine cables on sharks. They’d also like to study whether and how sharks rely on magnetic cues not just during long-distance migration but also during their everyday behavior. Reference: “Map-like use of Earth’s magnetic field in sharks” by Bryan A. Keller, Nathan F. Putman, R. Dean Grubbs, David S. Portnoy and Timothy P. Murphy, 6 May 2021, Current Biology. DOI: 10.1016/j.cub.2021.03.103 This work was supported by the Save Our Seas Foundation and the Florida State University Coastal and Marine Laboratory.

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