Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Breathable insole ODM development Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow ODM design company in Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Custom foam pillow OEM in Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan insole ODM for global brands

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China sustainable material ODM solutions

A tiger shark (Galeocerdo cuvier) swimming at the surface with a biologging package attached to dorsal fin. This package records temperature, swimming speed, depth, body movement and video footage. Credit: Diego Camejo (Beneath the Waves) New research from marine biologists offers answers to a fundamental puzzle that had until now remained unsolved: why are some fish warm-blooded when most are not? It turns out that while (warm-blooded) fish able to regulate their own body temperatures can swim faster, they do not live in waters spanning a broader range of temperatures. The research therefore provides some of the first direct evidence as to the evolutionary advantage of being warm-blooded as well as underlining that species in this demographic — such as the infamous white shark and the speedy bluefin tuna — are likely just as vulnerable to changing global ocean temperatures as their cold-blooded relatives. Lucy Harding, PhD Candidate in Trinity College Dublin’s School of Natural Sciences, is the first author of the associated research article, which has just been published in the journal, Functional Ecology. She said: “Scientists have long known that not all fish are cold-blooded. Some have evolved the ability to warm parts of their bodies so that they can stay warmer than the water around them, but it has remained unclear what advantages this ability provided. “Some believed being warm-blooded allowed them to swim faster, as warmer muscles tend to be more powerful, while others believed it allowed them to live in a broader range of temperatures and therefore be more resilient to the effects of ocean warming as a result of climate change.” A white shark (Carcharodon carcharias) swimming at the surface with a biologging package attached to dorsal fin. This package records temperature, swimming speed, depth, body movement and video footage. Credit: Andrew Fox Lucy and her international team of collaborators assessed these two possibilities by collecting data from wild sharks and bony fish, as well as using existing databases. By attaching biologging devices to the fins of the animals they caught, they were able to collect information such as water temperatures encountered by the fish in their habitats; the speeds at which the fish swam for most of the day; and the depths of water the fish swam in. The results showed that warm-blooded fishes swim approximately 1.6 times faster than their cold-blooded relatives, but they did not live in broader temperature ranges. Nick Payne, Assistant Professor in Zoology in Trinity’s School of Natural Sciences, said: “The faster swimming speeds of the warm-blooded fishes likely gives them competitive advantages when it comes to things like predation and migration. With predation in mind, the hunting abilities of the white shark and bluefin tuna help paint a picture of why this ability might offer a competitive advantage. “Additionally, and contrary to some previous studies and opinions, our work shows these animals do not live in broader temperature ranges, which implies that they may be equally at risk from the negative impacts of ocean warming. Findings like these — while interesting on their own — are very important as they can aid future conservation efforts for these threatened animals.” Reference: “Endothermy makes fishes faster but does not expand their thermal niche” by Lucy Harding, Andrew Jackson, Adam Barnett, Ian Donohue, Lewis Halsey, Charles Huveneers, Carl Meyer, Yannis Papastamatiou, Jayson M. Semmens, Erin Spencer, Yuuki Watanabe and Nicholas Payne, 30 June 2021, Functional Ecology. DOI: 10.1111/1365-2435.13869 The research was supported by Science Foundation Ireland.

New research reveals a hybrid cell type in the human brain that exhibits both neuronal and glial properties, capable of generating electrical signals. This finding, important for glioma and normal brain function, suggests potential prognostic value in cancer treatment. Credit: SciTechDaily.com Scientists from Baylor College have identified a new cell type in the human brain that shares properties of neurons and glia. These cells, also found in glioma tumors, are capable of firing electrical impulses, challenging the conventional belief that only neurons can do so. Discovery of New Cell Type in Human Brain Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital have uncovered a new cell type in the human brain. The study published today (September 5) in the journal Cancer Cell reveals that a third of the cells in glioma, a type of brain tumor, fire electrical impulses. Interestingly, the impulses, also called action potentials, originate from tumor cells that are part neuron and part glia, supporting the groundbreaking idea that neurons are not the only cells that can generate electric signals in the brain. The scientists also discovered that cells with hybrid neuron-glia characteristics are present in the non-tumor human brain. The findings highlight the importance of further studying the role of these newly identified cells in both glioma and normal brain function. Impact on Glioma Research and Patient Survival “Gliomas are the most common tumors of the central nervous system with an estimated 12,000 cases diagnosed each year. These tumors are universally lethal and have devastating effects on neurological and cognitive functions. Previous studies have shown that patient survival outcomes are associated with tumor proliferation and invasiveness, which are influenced by tumor intrinsic and extrinsic factors, including communication between tumor cells and neurons that reside in the brain,” said Dr. Benjamin Deneen professor and Dr. Russell J. and Marian K. Blattner Chair in the Department of Neurosurgery, director of the Center for Cancer Neuroscience, a member of the Dan L Duncan Comprehensive Cancer Center at Baylor and a principal investigator at the Jan and Dan Duncan Neurological Research Institute. Researchers have previously described that glioma and surrounding healthy neurons connect with each other and that neurons communicate with tumors in ways that drive tumor growth and invasiveness. Unveiling Electrical Activity in Cancer Cells “We have known for some time now that tumor cells and neurons interact directly,” said first author Dr. Rachel N. Curry, postdoctoral fellow in pediatrics – neuro oncology at Baylor, who was responsible for conceptualizing the project. “But one question that always lingered in my mind was, ‘Are cancer cells electrically active?’ To answer this question correctly, we required human samples directly from the operating room. This ensured the biology of the cells as they would exist in the brain was preserved as much as possible.” To study the ability of glioma cells to spike electrical signals and identify the cells that produce the signals, the team used Patch-sequencing, a combination of techniques that integrates whole-cell electrophysiological recordings to measure spiking signals with single-cell RNA-sequencing and analysis of the cellular structure to identify the type of cells. Innovative Methods and Unexpected Findings The electrophysiology experiments were conducted by research associate and co-first author Dr. Qianqian Ma in the lab of co-corresponding author associate professor of neuroscience Dr. Xiaolong Jiang. This innovative approach has not been used before to study human brain tumor cells. “We were truly surprised to find these tumor cells had a unique combination of morphological and electrophysiological properties,” Ma said. “We had never seen anything like this in the mammalian brain before.” “We conducted all these analyses on single cells. We analyzed their individual electrophysiological activity. We extracted each cell’s content and sequenced the RNA to identify the genes that were active in the cell, which tells us what type of cell it is,” Deneen said. “We also stained each cell with dyes that would visualize its structural features.” Analysis and Computational Advances in Neuroscience Integrating this vast amount of individual data required the researchers to develop a novel way to analyze it. “To define the spiking cells and determine their identity, we developed a computational tool – Single Cell Rule Association Mining (SCRAM) – to annotate each cell individually,” said co-corresponding author, Dr. Akdes Serin Harmanci, assistant professor of neurosurgery at Baylor. Broader Implications for Neuroscience and Clinical Practice “Finding that so many glioma cells are electrically active was a surprise because it goes against a strongly held concept in neuroscience that states that, of all the different types of cells in the brain, neurons are the only ones that fire electric impulses,” Curry said. “Others have proposed that some glia cells known as oligodendrocyte precursor cells (OPCs) may fire electrical impulses in the rodent brain, but confirming this in humans had proven a difficult task. Our findings show that human cells other than neurons can fire electrical impulses. Since there is an estimated 100 million of these OPCs in the adult brain, the electrical contributions of these cells should be further studied.” “Moreover, the comprehensive data analyses revealed that the spiking hybrid cells in glioma tumors had properties of both neurons and OPC cells,” Harmanci said. “Interestingly, we found non-tumor cells that are neuron-glia hybrids, suggesting that this hybrid population not only plays a role in glioma growth but also contributes to healthy brain function.” “The findings also suggest that the proportion of spiking hybrid cells in glioma may have a prognostic value,” said co-corresponding author Dr. Ganesh Rao, Marc J. Shapiro Professor and chair of neurosurgery at Baylor. “The data shows that the more of these spiking hybrid glioma cells a patient has, the better the survival outcome. This information is of great value to patients and their doctors.” Collaboration and Conclusions in Cancer and Brain Research “This work is the result of extensive equal collaboration across multiple disciplines – neurosurgery, bioinformatics, neuroscience, and cancer modeling – disciplines strongly supported by state-of-the-art groups at Baylor,” Deneen said. “The results offer an enhanced understanding of glioma tumors and normal brain function, a sophisticated bioinformatics pipeline to analyze complex cellular populations and potential prognostic implications for patients with this devastating disease.” Reference: “Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma” by Rachel N. Curry, Qianqian Ma, Malcolm F. McDonald, Yeunjung Ko, Snigdha Srivastava, Pey-Shyuan Chin, Peihao He, Brittney Lozzi, Prazwal Athukuri, Junzhan Jing, Su Wang, Arif O. Harmanci, Benjamin Arenkiel, Xiaolong Jiang, Benjamin Deneen, Ganesh Rao and Akdes Serin Harmanci, 5 September 2024, Cancer Cell. DOI: 10.1016/j.ccell.2024.08.009 Other contributors to this work include Malcolm F. McDonald, Yeunjung Ko, Snigdha Srivastava, Pey-Shyuan Chin, Peihao He, Brittney Lozzi, Prazwal Athukuri, Junzhan Jing, Su Wang, Arif O. Harmanci and Benjamin Arenkiel. The authors are affiliated with one or more of the following institutions: Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and University of Texas Health Science Center, Houston. This work was supported by grants from the NIH (R35-NS132230, R01NS124093, R01CA223388, U01CA281902, R01NS094615, 5T32HL92332-15, F31CA265156, and F99CA274700). Further support was provided by NIH Shared Instrument Grants (S10OD023469, S10OD025240, P30EY002520) and CPRIT grant RP200504.

An artist’s representation of the new Brillouin microscopy approach that allows entire light-sheets to interact with 3D biological samples. The scattered light reveals a unique optical interference signal that can be recorded with a custom-developed spectrometer, tremendously speeding up image acquisition. Credit: Daniela Velasco/EMBL A new EMBL innovation dramatically improves Brillouin microscopy, enabling faster, more efficient 3D imaging of light-sensitive samples. EMBL scientists previously developed a microscope using Brillouin scattering, a technique that analyzes how light interacts with natural thermal vibrations to reveal a material’s mechanical properties. In their latest advancement, the researchers have increased the speed and efficiency of Brillouin microscopy by approximately 1,000 times. The upgraded technique now captures an entire 10,000-pixel plane—rather than a 100-pixel line—enabling rapid 3D imaging suitable for observing living organisms in real time. A 1,000-Fold Speed Boost for Brillouin Microscopy EMBL researchers have made a major breakthrough, introducing a novel methodology that enhances microscopy capabilities for life scientists. This advancement increases the speed and throughput of Brillouin microscopy by 1,000 times, enabling more efficient imaging of light-sensitive organisms. “We were on a quest to speed up image acquisition,” said Carlo Bevilacqua, lead author of the study published in Nature Photonics and an optical engineer in EMBL’s Prevedel Team. “Over the years, we have progressed from being able to see just a pixel at a time to a line of 100 pixels, to now a full plane that offers a view of approximately 10,000 pixels.” The Science Behind Brillouin Microscopy This technology is based on a phenomenon first predicted in 1922 by French physicist Léon Brillouin. He discovered that when light interacts with a material, it exchanges energy with natural thermal vibrations, slightly shifting its frequency (or color). By analyzing the scattered light spectrum, scientists can extract valuable information about a material’s physical properties. From Single Pixels to a Full 2D Field of View Using Brillouin scattering for microscopy purposes came much later – in the early 2000s – when other technological advancements enabled scientists to measure tiny frequency shifts with high precision and sufficient throughput. This allowed them to compute mechanical properties of living biological samples. However, at that point, scientists were only able to view one pixel at a time. The process was therefore quite time-consuming, and it severely limited how the microscopy method could be used in biology. In 2022, Bevilacqua and others in the Prevedel group were able to first expand the field of view to a line, and now with this latest development, to a full 2D field of view, which also helps speed up 3D imaging. A New Era for Mechanical Imaging “Just as the development of light-sheet microscopy here at EMBL marked a revolution in light microscopy because it allowed for faster, high-resolution, and minimally phototoxic imaging of biological samples, so too does this advance in the area of mechanical or Brillouin imaging,” said Robert Prevedel, Group Leader and senior author on the paper. “We hope this new technology – with minimal light intensity – opens one more ‘window’ for life scientists’ exploration.” Reference: “Full-field Brillouin microscopy based on an imaging Fourier-transform spectrometer” by Carlo Bevilacqua, and Robert Prevedel, 20 February 2025, Nature Photonics. DOI: 10.1038/s41566-025-01619-y

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