Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Customized sports insole ODM Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Flexible manufacturing OEM & ODM Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Memory foam pillow OEM factory Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand OEM/ODM hybrid insole services

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.PU insole OEM production in Thailand

A study suggests predicting climate change’s impact on host-pathogen interactions will become harder as temperatures rise and extreme weather events increase. Temperature variation affects pathogens and their hosts in distinct ways, and these organisms are influenced by the type of variation and the average background temperature it is applied to. Temperature fluctuations such as heatwaves can have very different effects on infection rates and disease outcomes depending on the average background temperature, says a report published on February 15, 2022, in eLife. The study suggests it will be increasingly difficult to predict the consequences of climate change on host-pathogen interactions as global temperatures rise and extreme weather events become more common. Effects of Temperature on Host-Pathogen Interactions Infectious diseases have profound ecological effects on human, agricultural, and wildlife populations. It is well known that interactions between pathogens and their hosts are sensitive to changes in temperature. But what is less well understood is how sudden and extreme temperature variation affects this relationship and how this influences overall infection rates and disease outcomes. “Climate change is predicted to increase not only average temperatures but also temperature fluctuations and the frequency and intensity of extreme weather events,” explains co-first author Pepijn Luijckx, William C. Campbell Lecturer in Parasite Biology, Trinity College Dublin, Ireland. “Yet although studies have quantified the effects of rising average temperatures on host and pathogen traits, the influence of variable temperature regimes such as heatwaves remains largely unknown.” Spores of the water flea parasite Ordospora colligata. Credit: Dieter Ebert Luijckx and the team examined the effects of different temperatures on various traits in a host organism – a small crustacean called Daphnia magna – and its known gut parasite, Odospora colligata. Transmission of the parasite is representative of classic environmental transmission, similar to that seen with diseases such as SARS-CoV-2 and cholera. The team looked at how the organisms responded to three distinct temperature regimes: a constant temperature, and two variable regimes, with daily fluctuations of +/- 3°C (5.4°F) and three-day heatwaves of 6°C (10.8°F) above ambient temperature. They then measured the crustacean’s lifespan, fertility, infection status and the number of parasite spores within their gut. Next, they processed the data into a statistical model to compare the impact of the three different temperature regimes. Parasite Response to Heatwaves and Background Temperatures The team found that daily fluctuations of temperature reduced the infectivity and spore burden of the parasite compared to those kept at the constant average temperature. However, by contrast, the infectivity of parasites after a heatwave was almost the same as the infectivity of those maintained at the constant temperature. Moreover, the number of spores in the crustacean host increased following the three-day ‘heatwave’ when the background constant temperature was 16°C (61°F), but this burden was reduced at higher temperatures. This suggests that the effects of temperature variation differ depending on the average background temperature and whether this is close to the optimum temperature for the parasite. Host fitness and reproductive success were generally reduced in the crustacean exposed to either the parasite spores or when experiencing variable temperatures. The difference between the host and pathogen responses suggest that under some circumstances the parasites were able to withstand the sudden change in heat better than their hosts. “Our findings show that temperature variation alters the outcome of host-pathogen interactions in complex ways. Not only does temperature variation affect different host and pathogen traits in a distinct way, but the type of variation and the average temperature to which it is applied also matter,” concludes Luijckx. “This means that changing patterns of climate variation, superimposed on shifts in mean temperatures due to global warming, may have profound and unanticipated effects on disease dynamics.” Reference: “Alternate patterns of temperature variation bring about very different disease outcomes at different mean temperatures” by Charlotte Kunze, Pepijn Luijckx, Andrew L Jackson and Ian Donohue, 15 February 2022, eLife. DOI: 10.7554/eLife.72861 Institute for Chemistry and Biology of the Marine Environment [ICBM], Carl von Ossietzky University of Oldenburg, Germany; Department of Zoology, School of Natural Sciences, Trinity College Dublin, Ireland Alongside Pepijn Luijckx, the research team includes co-first author Charlotte Kunze (Carl von Ossietzky University of Oldenburg, Germany, and Trinity College Dublin), Andrew Jackson and Ian Donohue (both Trinity College Dublin). Their study was funded by Science Foundation Ireland and the Irish Research Council.

Scientists discovered how microbes build protein nanowires, enabling breakthroughs in energy, pollution control, and methane reduction. Credit: Yale University Yale researchers uncovered the molecular machinery behind nanowire assembly in microbes, enabling advances in electricity production, pollution mitigation, and methane reduction. Almost all living organisms breathe oxygen to remove excess electrons generated during the conversion of nutrients into energy. However, many microbes that play a crucial role in mitigating pollution and climate change lack access to oxygen. Instead, these bacteria—found buried underground or deep beneath oceans—have evolved a unique method of expelling electrons. They “breathe” minerals in the soil using tiny protein filaments known as nanowires. Unveiling the Machinery Behind Nanowires In previous research, a team led by Nikhil Malvankar, Associate Professor of Molecular Biophysics and Biochemistry at Yale’s Microbial Sciences Institute, showed that nanowires are made up of a chain of heme molecules, just like hemoglobin in our blood, thrust into the environment to move electrons. To leverage the power of these microbes, however, scientists need to know how those nanowires are assembled. The Yale team led by Cong Shen has now discovered the machinery that assembles the nanowires, making practical applications possible. Of the 111 heme proteins, only three are known to polymerize to become nanowires. Not only did the team identify the surrounding machinery that makes it possible for these proteins to become nanowires, but they also demonstrated that changing some of the machinery’s components can accelerate nanowire reproduction and bacterial growth. This is an important next step in engineering bacteria to efficiently produce electricity, clean pollutants from water, and lower atmospheric methane levels. Reference: “A widespread and ancient bacterial machinery assembles cytochrome OmcS nanowires essential for extracellular electron transfer” by Cong Shen, Aldo I. Salazar-Morales, Wonhyeuk Jung, Joey Erwin, Yangqi Gu, Anthony Coelho, Kallol Gupta, Sibel Ebru Yalcin, Fadel A. Samatey and Nikhil S. Malvankar, 15 January 2025, Cell Chemical Biology. DOI: 10.1016/j.chembiol.2024.12.013

A new paper from the UChicago Pritzker School of Molecular Engineering, University of Houston Chemical Engineering Department and Chicago Center for the Origins of Life suggests rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived. Credit: UChicago Pritzker School of Molecular Engineering / Peter Allen, Second Bay Studios A new study indicates that rainwater may have helped early RNA structures develop into protocells by forming protective barriers around them, aiding in their evolution into complex life forms. A fundamental question about the origin of life is how droplets of RNA floating around the primordial soup turned into the membrane-protected packets of life we call cells. Now, a team of researchers from the University of Chicago’s Pritzker School of Molecular Engineering (UChicago PME), the University of Houston’s Chemical Engineering Department, and the UChicago Chemistry Department have proposed a solution. In a new study published Science Advances, UChicago PME postdoctoral researcher Aman Agrawal and his co-authors – including UChicago PME Dean Emeritus Matthew Tirrell and Nobel Prize-winning biologist Jack Szostak – show how rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived. “This is a distinctive and novel observation,” Tirrell said. University of Houston Prof. Alamgir Karim first suggested rain as a possible source of distilled water that would have existed in the era when protocells first formed. Credit: University of Houston Protocell Stability Challenge The research looks at “coacervate droplets” – naturally occurring compartments of complex molecules like proteins, lipids, and RNA. The droplets, which behave like drops of cooking oil in water, have long been eyed as a candidate for the first protocells. But there was a problem. It wasn’t that these droplets couldn’t exchange molecules between each other, a key step in evolution, the problem was that they did it too well, and too fast. Any droplet containing a new, potentially useful pre-life mutation of RNA would exchange this RNA with the other RNA droplets within minutes, meaning they would quickly all be the same. There would be no differentiation and no competition – meaning no evolution. And that means no life. “If molecules continually exchange between droplets or between cells, then all the cells after a short while will look alike, and there will be no evolution because you are ending up with identical clones,” Agrawal said. UChicago Pritzker School of Molecular Engineering postdoctoral researcher Aman Agrawal discusses his coacervate droplet research with Nobel Prize laureate Jack Szostak of the Chicago Center for the Origins of Life. Agrawal began his research at the University of Houston initially unaware of its possible implications for life’s early formation. Credit: UChicago Pritzker School of Molecular Engineering / John Zich Collaborative Research and RNA’s Role Life is by nature interdisciplinary, so Szostak, the director of UChicago’s Chicago Center for the Origins of Life, said it was natural to collaborate with both UChicago PME, UChicago’s interdisciplinary school of molecular engineering, and the chemical engineering department at the University of Houston. “Engineers have been studying the physical chemistry of these types of complexes – and polymer chemistry more generally – for a long time. It makes sense that there’s expertise in the engineering school,” Szostak said. “When we’re looking at something like the origin of life, it’s so complicated and there are so many parts that we need people to get involved who have any kind of relevant experience.” In the early 2000s, Szostak started looking at RNA as the first biological material to develop. It solved a problem that had long stymied researchers looking at DNA or proteins as the earliest molecules of life. “It’s like a chicken-egg problem. What came first?” Agrawal said. “DNA is the molecule which encodes information, but it cannot do any function. Proteins are the molecules which perform functions, but they don’t encode any heritable information.” Researchers like Szostak theorized that RNA came first, “taking care of everything” in Agrawal’s words, with proteins and DNA slowly evolving from it. “RNA is a molecule which, like DNA, can encode information, but it also folds like proteins so that it can perform functions such as catalysis as well,” Agrawal said. RNA was a likely candidate for the first biological material. Coacervate droplets were likely candidates for the first protocells. Coacervate droplets containing early forms of RNA seemed a natural next step. Fluorescence microscopy image of three coexisting populations of stable coacervate protocells. The protocells contain long single-stranded RNAs, labeled with green, red, and blue fluorescent dyes. The absence of any intermixing of colors suggests that the exchange of RNA between the stable protocells is restricted. Credit: UChicago Pritzker School of Molecular Engineering / Aman Agrawal Discovery of RNA Stability in Rainwater That is until Szostak poured cold water on this theory, publishing a paper in 2014 showing that RNA in coacervate droplets exchanged too rapidly. “You can make all kinds of droplets of different types of coacervates, but they don’t maintain their separate identity. They tend to exchange their RNA content too rapidly. That’s been a long-standing problem,” Szostak said. “What we showed in this new paper is that you can overcome at least part of that problem by transferring these coacervate droplets into distilled water – for example, rainwater or freshwater of any type – and they get a sort of tough skin around the droplets that restricts them from exchanging RNA content.” Although the exact chemical composition of both the early pre-biological molecules and early rain remain lost to time, the new paper from UChicago Pritzker School of Molecular Engineering postdoctoral researcher Aman Agrawal outlines how such a transition could have occurred. “While the chemistry would be a little bit different, the physics will remain the same,” Agrawal said. Credit: UChicago Pritzker School of Molecular Engineering / Aman Agrawal Bridging Engineering and Biology Agrawal started transferring coacervate droplets into distilled water during his PhD research at the University of Houston, studying their behavior under an electric field. At this point, the research had nothing to do with the origin of life; it was just studying fascinating material from an engineering perspective. “Engineers, particularly Chemical and Materials, have good knowledge of how to manipulate material properties such as interfacial tension, role of charged polymers, salt, pH control, etc.,” said University of Houston Prof. Alamgir Karim, Agrawal’s former thesis advisor and a senior co-author of the new paper. “These are all key aspects of the world popularly known as ‘complex fluids’ – think shampoo and liquid soap.” Agrawal wanted to study other fundamental properties of coacervates during his PhD. It wasn’t Karim’s area of study, but Karim had worked decades earlier at the University of Minnesota under one of the world’s top experts – Tirrell, who later became the founding dean of the UChicago Pritzker School of Molecular Engineering. During a lunch with Agrawal and Karim, Tirrell brought up how the research into the effects of distilled water on coacervate droplets might relate to the origin of life on Earth. Tirrell asked where distilled water would have existed 3.8 billion years ago. “I spontaneously said ‘rainwater!’ His eyes lit up and he was very excited at the suggestion,” Karim said. “So, you can say it was a spontaneous combustion of ideas or ideation!” Tirrell brought Agrawal’s distilled water research to Szostak, who had recently joined the University of Chicago to lead what was then called the Origins of Life Initiative. He posed the same question he had asked Karim. “I said to him, ‘Where do you think distilled water could come from in a prebiotic world?’” Tirrell recalled. “And Jack said exactly what I hoped he would say, which was rain.” From left, Nobel Prize laureate Jack Szostak of the Chicago Center for the Origins of Life, UChicago Pritzker School of Molecular Engineering postdoctoral researcher Aman Agrawal and UChicago PME Dean Emeritus Matthew Tirrell are behind a new paper proposing that raindrops helped droplets of biological materials floating in the primordial soup form the first protocell walls. Credit: UChicago Pritzker School of Molecular Engineering / John Zich Implications for Prebiotic Evolution Working with RNA samples from Szostak, Agrawal found that transferring coacervate droplets into distilled water increased the time scale of RNA exchange – from mere minutes to several days. This was long enough for mutation, competition, and evolution. “If you have protocell populations that are unstable, they will exchange their genetic material with each other and become clones. There is no possibility of Darwinian evolution,” Agrawal said. “But if they stabilize against exchange so that they store their genetic information well enough, at least for several days so that the mutations can happen in their genetic sequences, then a population can evolve.” Initially, Agrawal experimented with deionized water, which is purified under lab conditions. “This prompted the reviewers of the journal who then asked what would happen if the prebiotic rainwater was very acidic,” he said. Real-world Testing and Future Directions Commercial lab water is free from all contaminants, has no salt, and lives with a neutral pH perfectly balanced between base and acid. In short, it’s about as far from real-world conditions as a material can get. They needed to work with a material more like actual rain. “We simply collected water from rain in Houston and tested the stability of our droplets in it, just to make sure what we are reporting is accurate,” Agrawal said. In tests with the actual rainwater and with lab water modified to mimic the acidity of rainwater, they found the same results. The meshy walls formed, creating the conditions that could have led to life. The chemical composition of the rain falling over Houston in the 2020s is not the rain that would have fallen 750 million years after the Earth formed, and the same can be said for the model protocell system Agrawal tested. The new paper proves that this approach of building a meshy wall around protocells is possible and can work together to compartmentalize the molecules of life, putting researchers closer than ever to finding the right set of chemical and environmental conditions that allow protocells to evolve. “The molecules we used to build these protocells are just models until more suitable molecules can be found as substitutes,” Agrawal said. “While the chemistry would be a little bit different, the physics will remain the same.” Reference: “Did the exposure of coacervate droplets to rain make them the first stable protocells?” by Aman Agrawal, Aleksandar Radakovic, Anusha Vonteddu, Syed Rizvi, Vivian N. Huynh, Jack F. Douglas, Matthew V. Tirrell, Alamgir Karim and Jack W. Szostak, 21 August 2024, Science Advances. DOI: 10.1126/sciadv.adn9657

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