Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan flexible graphene product manufacturing

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Customized sports insole ODM Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Smart pillow ODM manufacturing factory Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Customized sports insole ODM factory Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ESG-compliant OEM manufacturer in China

Researchers have found that plants can potentially control the genetics of their root symbionts. Plants Tweak Their Fungi Partners’ Genes To Grow Better Researchers from the University of Ottawa have discovered that plants may be able to control the genetics of their intimate root symbionts – the organism with which they live in symbiosis – thereby providing a better understanding of their growth. In addition to having a significant impact on all terrestrial ecosystems, their discovery may lead to improved eco-friendly agricultural applications. We talked to research lead Nicolas Corradi, Associate Professor in the Department of Biology and Research Chair in Microbial Genomics at the University of Ottawa, and lead author Vasilis Kokkoris, Postdoctoral Fellow in the Corradi Lab, to learn more about their recent study published in the journal Current Biology. Can you tell us more about your findings? Nicolas Corradi: “We have uncovered a fascinating genetic regulation between plants and their microbial symbionts, known as Arbuscular Mycorrhizal Fungi (AMF). AMF are plant obligate symbionts that grow within the plant roots and help their hosts to grow better and be more resistant to environmental stressors. AMF genetics have long been mysterious; while typical cells carry one nucleus, the cells of AMF carry thousands of nuclei that can be genetically diverse. How these nuclei communicate with each other and whether the plants can control their relative abundance has been a total mystery. Each spore contains hundreds of nuclei. The image was generated using confocal microscopy. The bright spots within the spores represent nuclei labeled with fluorescent dye. Images are color-coded along z-axis for depth recognition, with white and red colors being closer to the observer while blue colors being the furthest. Each image is the result of approximately 300 z-stacks (0.35um intervals). Credit: University of Ottawa/ Microscope Laboratory (Ottawa-RDC, Agriculture and Agri-Food Canada) Our work provides insights into this unique genetic condition:  1- We demonstrate that the host plant symbiont influences the relative abundance of thousands of co-existing nuclei carried by their fungal symbionts. 2- We find evidence that co-existing nuclei of different genetic backgrounds cooperate, rather than compete with one another thus potentially maximizing growth benefits for both the fungi and their plant partners.” How did you come to these conclusions?  Vasilis Kokkoris: “We implemented a novel molecular approach accompanied by advanced microscopy and mathematical modeling. Every single AMF spore carries hundreds of nuclei (see image). By analyzing single spores, we were able to quantify the genetics of thousands of nuclei and define their relative abundance in different fungal strains and across plant species. To ensure that we accurately analyze single nuclei, we used advanced microscopy to visualize and count the nuclei in the spores. Lastly, we used mathematical modeling to prove that the observed abundance of nuclear genotypes we identified cannot be a product of luck but instead is the result of a driven cooperation between them. To better understand what is regulating the AMF nuclei we grew different AMF strains with different hosts and found that plants have control of the relative abundance of the fungal nuclei.” What are the impacts of your discovery? Nicolas Corradi: “For many years, AMF have been considered to be genetic peculiarities and far away from model organisms. Inconsistencies are commonly observed in plant-AMF experiments. For example, growing the same fungal strain with different plants can lead to drastically different plant yields. For a long time, this variance in plant growth was blamed on the AMF mysterious genetics. Our research provides an answer as we demonstrate that the genetics of these fungi, and their effect on plant growth, can be manipulated by plants thus explaining the reason for the observed variability on plant growth. From an environmental standpoint, this new knowledge allows for a better understanding of how plants can influence the genetics of their symbiotic partners, thus influencing entire terrestrial ecosystems. From an economic standpoint, it opens doors to improved sustainable agricultural applications.” Reference: “Host identity influences nuclear dynamics in arbuscular mycorrhizal fungi” by Vasilis Kokkoris, Pierre-Luc Chagnon, Gökalp Yildirir, Kelsey Clarke, Dane Goh, Allyson M. MacLean, Jeremy Dettman, Franck Stefani and Nicolas Corradi, 4 February 2021, Current Biology. DOI: 10.1016/j.cub.2021.01.035 ​The research was led by the Corradi Lab, at the University of Ottawa and was conducted at the University of Ottawa and the Agriculture and Agri-Food Canada (AAFC). Two members of the Corradi lab, uOttawa PhD student Gökalp Yildirir and recent graduate Kelsey Clarke, also contributed to this study. The other co-authors include Dr. Pierre-Luc Chagnon, Assistant Professor in the Department of Biological Sciences at the University of Montreal, Dr. Allyson M MacLean, Assistant Professor in the Department of Biology at the University of Ottawa and her MSc student Dane Goh, and Dr. Jeremy Dettman and Dr. Franck Stefani from the Agriculture and Agri-food Canada (Ottawa Research and Development Centre).

Researchers at Monash University have discovered the critical role of the protein IKAROS in immune cell development, offering new insights into cancer therapy and the potential for reevaluating existing drugs targeting this protein for improved treatment options. IKAROS code cracked: insight into an essential protein for immune cell development and protection against pathogens and cancer. In a scientific breakthrough that aids our understanding of the internal wiring of immune cells, researchers at Monash University in Australia have cracked the code behind IKAROS, an essential protein for immune cell development and protection against pathogens and cancer. This disruptive research, led by the eminent Professor Nicholas Huntington of Monash University’s Biomedicine Discovery Institute, is poised to reshape our comprehension of gene control networks and its impact on everything from eye color to cancer susceptibility and the design of novel therapies. Impact on Natural Killer Cells and Cancer Therapeutics The study, published today (January 5) in Nature Immunology, promises pivotal insights into the mechanisms safeguarding us against infections and cancers. When the transcription factor Ikaros/Ikzf1 was deliberately obstructed, be it in preclinical models or humans, the once-mighty activity of Natural Killer (NK) cells, our immune system’s frontline warriors, plummeted. Loss of this transcription factor in NK cells resulted in widespread dysregulation of NK cell development and function, preventing their ability to recognize and kill virus-infected cells and clear metastatic tumor cells from circulation. Aiolos/Ikzf3 and Helios/Ikzf2, related family members were found to partially compensate for the loss of Ikaros, as such when multiple IKZF-family members were inhibited, NK cells underwent rapid death. Mechanistically, Aiolos and Ikaros were found to directly bind and activate most members of the JUN/FOS family, transcription factors known for their essential roles in human embryo development and tissue function. This discovery opens the door to the prospect of potential novel cancer therapeutics. NK cells, our first line of defense against pathogens and internal threats like cancers, could be fortified by therapies enhancing their killing prowess by targeting IKAROS and JUN/FOS biology. FDA-Approved Drugs and Future Therapeutic Potential Professor Huntington notes that drugs targeting IKAROS/AIOLOS have already received approval from the US Food and Drug Administration (FDA) and local Therapeutic Goods Administration (TGA) for the treatment of B cell malignancy “but until now we haven’t understood how these drugs work, armed with this new information it could be possible to develop novel drugs targeting these complexes which may offer differentiated pharmacology and therapeutic index for treating disease,” he said. Importantly on this front, Professor Huntington’s team was able to show that IKAROS had a conserved role in healthy B cells and thus potentially B cell cancers. Reference: “IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development” by Wilford Goh, Harrison Sudholz, Momeneh Foroutan, Sebastian Scheer, Aline Pfefferle, Rebecca B. Delconte, Xiangpeng Meng, Zihan Shen, Robert Hennessey, Isabella Y. Kong, Iona S. Schuster, Christopher E. Andoniou, Melissa J. Davis, Soroor Hediyeh-Zadeh, Fernando Souza-Fonseca-Guimaraes, Ian A. Parish, Paul Beavis, Daniel Thiele, Michael Chopin, Mariapia A. Degli-Esposti, Joe Cursons, Axel Kallies, Jai Rautela, Stephen L. Nutt and Nicholas D. Huntington, 5 January 2024, Nature Immunology. DOI: 10.1038/s41590-023-01718-4

The tiny roundworm C.elegans is the focus of a new study examining 3’UTRs. These short segments of RNA play a critical role in the regulation of genes. The resulting map, the product of 20 years of research, is the most complete dataset of its kind for any animal, and will help advance basic understanding of mechanisms of gene regulation critical in human health and disease. Credit: Graphic by Jason Drees A new study investigates the mechanisms of gene regulation. Researchers at Arizona State University have made a major breakthrough in understanding gene regulation in living organisms. The study, recently published in the journal Nucleic Acids Research, highlights the crucial role of specific RNA fragments in the small, transparent roundworm Caenorhabditis elegans (C. elegans). The study provides a detailed map of the 3’UTR regions of RNA in C. elegans. 3’UTRs (untranslated regions) are segments of RNA involved in gene regulation. The new map is a valuable tool for scientists studying how DNA genes are switched on and off after they are transcribed into RNA. Using this data, scientists can make improved predictions of how small RNA molecules (miRNAs) interact with genes to control their activity. The researchers also explored crucial regions of the 3’UTRs that help in processing and regulating RNA molecules. By studying the genetic material in this model organism, researchers are gaining deeper insights into the mysteries of gene behavior, shedding light on fundamental biological processes essential to human health and disease. “This monumental work represents a culmination of 20 years of hard work. We finally have the complete picture of how genes are formed in higher organisms,” says Marco Mangone, corresponding author of the new study. “With this complete dataset, we can now pinpoint and study all the regulatory and processing elements within these gene sections. These elements determine the duration of gene expression, their specific locations within cells, and the level of expression required.” Genes are only half the story Genes are segments of DNA that contain the blueprints for an astonishing diversity of life on Earth. However, part of the secret to this versatility lies not in the genes themselves but in how their effects are delicately fine-tuned. Genes provide the instructions for making proteins, which play essential roles in building and repairing cells and tissues, speeding up chemical reactions, and defending the body against pathogens. Marco Mangone is a researcher in the Biodesign Virginia G. Piper Center for Personalized Diagnostics and a professor in the School of Life Sciences at ASU. Credit: The Biodesign Institute at Arizona State University To produce proteins, genes require an intermediary molecule called RNA. During this process, DNA is first copied into RNA, which acts as a bridge between the DNA template and the resulting proteins. Although our DNA genome is fixed from birth, RNA provides the body with enormous flexibility by regulating how genes are expressed. Once genetic instructions are transcribed from DNA into messenger RNA (mRNA), specialized segments of the mRNA — the 3’UTRs — can regulate how the proteins are produced. 3’UTRs are sections of RNA located at the end of a messenger RNA molecule. They help to govern how and when proteins are made by controlling the stability and efficiency of the mRNA. This regulation allows for dynamic responses to environmental changes and enables control over protein production, which is essential for adapting to various physiological needs. 3’UTRs reconsidered Initially, noncoding RNAs like 3’UTRs were regarded as nonessential genetic fragments because they themselves do not code for proteins. However, recent research reveals that they are crucial for modifying gene behavior and influencing mRNA stability, localization, and translation efficiency. Translation refers to the process of converting RNA into proteins composed of sequences of amino acids. 3’UTRs are an integral part of a sophisticated and highly adaptable system of checks and balances on protein production. Additionally, these RNA regulatory elements often contain binding sites for other elements responsible for protein regulation, including microRNAs and RNA-binding proteins. Despite their importance, scientists previously knew little about them. The new study addresses this gap by mapping out 3’UTRs for nearly all genes in C. elegans, providing the most complete map of its kind for any animal. A window into gene function and disease C. elegans is a small, transparent nematode that is one of the most extensively studied model organisms in biological research. Its significance lies in its simplicity, short life cycle, and well-mapped genetic structure. The organism shares many essential biological pathways with humans, making it invaluable for studying gene function, development, and disease processes. Its transparent body allows researchers to observe cellular processes in real-time, and its genetic composition enables the precise manipulation of genes. These characteristics make C. elegans a powerful tool for uncovering fundamental mechanisms of biology that are often conserved across species, including humans. The study found that the process of switching between different 3’UTRs is less common in C. elegans than previously thought. This challenges earlier beliefs and highlights the complexity of gene regulation. Using the new data, scientists updated predictions for how microRNAs interact with genes. The insights gained from the new study have far-reaching implications for human health. Problems with gene control can lead to diseases like cancer, diabetes, and neurological disorders. By providing a detailed map of 3’UTRs and their regulatory elements, the research offers new insights that could lead to better treatments and therapies. The new dataset produced in the study will be a key resource for scientists studying genetics and human health. The ASU team plans to continue their research to further explore how these regulatory elements work and their critical influence on gene control. Reference: “A comprehensive analysis of 3′UTRs in Caenorhabditis elegans” by Emma Murari, Dalton Meadows, Nicholas Cuda and Marco Mangone, 25 June 2024, Nucleic Acids Research. DOI: 10.1093/nar/gkae543

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