Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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PU insole OEM production in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Insole ODM factory in Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia insole ODM service provider

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China insole ODM design and production

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ODM pillow for sleep brands Thailand

Salk Institute scientists are studying ways to accelerate the regeneration of muscle tissue, using a combination of molecular compounds that are often used in stem-cell research. Salk Institute research reveals clues about molecular changes underlying muscle loss tied to aging. One of the many effects of aging is loss of muscle mass, which contributes to disability in older people. To counter this loss, scientists at the Salk Institute are studying ways to accelerate the regeneration of muscle tissue, using a combination of molecular compounds that are commonly used in stem-cell research. In a study published on May 25, 2021, in the journal Nature Communications, the investigators showed that using these compounds increased the regeneration of muscle cells in mice by activating the precursors of muscle cells, called myogenic progenitors. Although more work is needed before this approach can be applied in humans, the research provides insight into the underlying mechanisms related to muscle regeneration and growth and could one day help athletes, as well as aging adults, regenerate tissue more effectively. “Loss of these progenitors has been connected to age-related muscle degeneration,” says Salk Professor Juan Carlos Izpisua Belmonte, the paper’s senior author. “Our study uncovers specific factors that are able to accelerate muscle regeneration, as well as revealing the mechanism by which this occurred.” Induction of Yamanaka factors (OKSM) in muscle fibers increases the number of myogenic progenitors. Top, control; bottom, treatment. Red-pink color is Pax7, a muscle stem-cell marker. Blue indicates muscle nuclei. Credit: Salk Institute The compounds used in the study are often called Yamanaka factors after the Japanese scientist who discovered them. Yamanaka factors are a combination of proteins (called transcription factors) that control how DNA is copied for translation into other proteins. In lab research, they are used to convert specialized cells, like skin cells, into more stem-cell-like cells that are pluripotent, which means they have the ability to become many different types of cells. “Our laboratory previously showed that these factors can rejuvenate cells and promote tissue regeneration in live animals,” says first author Chao Wang, a postdoctoral fellow in the Izpisua Belmonte lab. “But how this happens was not previously known.” Muscle regeneration is mediated by muscle stem cells, also called satellite cells. Satellite cells are located in a niche between a layer of connective tissue (basal lamina) and muscle fibers (myofibers). In this study, the team used two different mouse models to pinpoint the muscle stem-cell-specific or niche-specific changes following the addition of Yamanaka factors. They focused on younger mice to study the effects of the factors independent of age. In the myofiber-specific model, they found that adding the Yamanaka factors accelerated muscle regeneration in mice by reducing the levels of a protein called Wnt4 in the niche, which in turn activated the satellite cells. By contrast, in the satellite-cell-specific model, Yamanaka factors did not activate satellite cells and did not improve muscle regeneration, suggesting that Wnt4 plays a vital role in muscle regeneration. According to Izpisua Belmonte, who holds the Roger Guillemin Chair, the observations from this study could eventually lead to new treatments by targeting Wnt4. “Our laboratory has recently developed novel gene-editing technologies that could be used to accelerate muscle recovery after injury and improve muscle function,” he says. “We could potentially use this technology to either directly reduce Wnt4 levels in skeletal muscle or to block the communication between Wnt4 and muscle stem cells.” The investigators are also studying other ways to rejuvenate cells, including using mRNA and genetic engineering. These techniques could eventually lead to new approaches to boost tissue and organ regeneration. Reference: “In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche” by Chao Wang, Ruben Rabadan Ros, Paloma Martinez-Redondo, Zaijun Ma, Lei Shi, Yuan Xue, Isabel Guillen-Guillen, Ling Huang, Tomoaki Hishida, Hsin-Kai Liao, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Pedro Guillen-Garcia, Pradeep Reddy and Juan Carlos Izpisua Belmonte, 25 May 2021, Nature Communications. DOI: 10.1038/s41467-021-23353-z Other authors included: Ruben Rabadan Ros, Paloma Martinez Redondo, Zaijun Ma, Lei Shi, Yuan Xue, Isabel Guillen-Guillen, Ling Huang, Tomoaki Hishida, Hsin-Kai Liao, Concepcion Rodriguez Esteban, and Pradeep Reddy of Salk; Estrella Nuñez Delicado of Universidad Católica San Antonio de Murcia in Spain; and Pedro Guillen Garcia of Clinica CEMTRO in Spain. The work was funded by NIH-NCI CCSG: P30 014195, the Helmsley Trust, Fundacion Ramon Areces, Asociación de Futbolistas Españoles (AFE), Fundacion Pedro Guillen, Universidad Católica San Antonio de Murcia (UCAM), the Moxie Foundation and CIRM (GC1R-06673-B).

The upper panel shows non-Rabl configuration. Centromeres in magenta dispersed in nuclei in green. The lower panel shows Rabl configuration. Centromeres unevenly distributed in nuclei. Credit: Sachihiro Matsunaga, The University of Tokyo Biologists Uncover Mechanism That Shapes Centromere Distribution Since the 1800s, scientists have noted the configuration of centromeres, a special chromosomal region that is vital for cell division, in the cell nucleus. However, up until now, the determining mechanisms and the biological significance of centromere distribution were poorly understood. Recently, researchers proposed a two-step regulatory mechanism that shapes centromere distribution. Their findings also indicate that centromere configuration in the nucleus plays a role in maintaining genome integrity. The results were published today (August 1, 2022) in the journal Nature Plants. The study was led by researchers from the University of Tokyo and their collaborators. Special chromosomal domains known as centromeres are pulled to the opposite ends of the cell during the process of cell division. After cell division is complete and the cell nucleus is constructed, centromeres are spatially distributed in the nucleus. If the distribution of centromeres pulled to the two poles remains unchanged, the cell nucleus will have centromeres grouped at just one side of the nucleus. This uneven distribution of centromeres is called Rabl configuration, after Carl Rabl, the 19th-century cytologist. Some species’ nuclei show a dispersed distribution of centromeres instead. This is known as non-Rabl configuration. “The biological function and molecular mechanism of the Rabl or non-Rabl configuration has been a mystery across the centuries,” said corresponding author Sachihiro Matsunaga, professor at the University of Tokyo’s Graduate School of Frontier Sciences. “We successfully revealed the molecular mechanism to construct the non-Rabl configuration.” The uneven distribution of centromeres (magenta) in nuclei (green). Credit: Sachihiro Matsunaga, The University of Tokyo The scientists studied the plant Arabidopsis thaliana, known also as thale cress and a specimen that is known to have non-Rabl configuration, and its mutant form that had a Rabl configuration. Through their work, they found that protein complexes known as condensin II (CII) and protein complexes known as the linker of nucleoskeleton and cotoskeleton (LINC) complex work together to determine centromere distribution during cell division. “The centromere distribution for non-Rabl configuration is regulated independently by the CII– LINC complex and a nuclear lamina protein known as CROWDED NUCLEI (CRWN),” Matsunaga said. Two-Step Regulatory Mechanism of Centromere Scattering The first step of the two-step regulatory mechanism of centromere distribution that the researchers uncovered was that the CII-LINC complex mediates the scattering of centromeres from late anaphase to telophase — two phases at the end of cell division. The second step of the process is that the CRWNs stabilize the scattered centromeres on nuclear lamina within the nucleus. Next, to explore the biological significance, the researchers analyzed the gene expression in A. thaliana and in its Rabl-structure mutant. Because a change in the spatial arrangement of centromeres also changes the spatial arrangement of genes, the researchers expected to find differences in gene expression, but this hypothesis proved to be incorrect. However, when DNA damage stress was applied, the mutant grew organs at a slower rate than the normal plant. “This suggests that precise control of centromere spatial arrangement is required for organ growth in response to DNA damage stress, and there is no difference in tolerance to DNA damage stress between organisms with the non-Rabl and Rabl,” Matsunaga said. “This suggests that the appropriate spatial arrangement of DNA in the nucleus regardless of Rabl configuration is important for stress response.” According to Matsunaga, the next steps are to identify the power source that changes the spatial arrangement of specific DNA regions and the mechanism that recognizes specific DNA. “Such findings will lead to the development of technology for artificially arranging DNA in the cell nucleus in an appropriate spatial arrangement,” he said. “It is expected that this technology will make it possible to create stress-resistant organisms, as well as to impart new properties and functions by altering the spatial arrangement of DNA rather than editing its nucleotide sequence.” Reference: “Two-step regulation of centromere distribution by condensin II and the nuclear envelope proteins” by Takuya Sakamoto, Yuki Sakamoto, Stefan Grob, Daniel Slane, Tomoe Yamashita, Nanami Ito, Yuka Oko, Tomoya Sugiyama, Takumi Higaki, Seiichiro Hasezawa, Maho Tanaka, Akihiro Matsui, Motoaki Seki, Takamasa Suzuki, Ueli Grossniklaus and Sachihiro Matsunaga, 1 August 2022, Nature Plants. DOI: 10.1038/s41477-022-01200-3

A male gorilla chest beating. Credit: Jordi Galbany / Dian Fossey Gorilla Fund The chest beats given by adult male gorillas reliably indicate their body size. Gorillas usually stand bipedally and rapidly beat their chests with cupped hands in rapid succession. Chest beating is a unique sound because is it not a vocalization, like frogs croaking, but rather it is a form of gestural communication that can be both heard and seen. The emanating drumming sound can be heard over one kilometer (3,300 feet) away. The presumed function of gorilla chest beats is to attract females and intimidate rival males. Researchers recorded chest beats and used a technique called photogrammetry to non-invasively measure the body size of adult male wild mountain gorillas monitored by the Dian Fossey Gorilla Fund in Volcanoes National Park, Rwanda. They found that larger males emitted chest beats with lower peak frequencies than smaller ones. In other words, chest beats conveyed information regarding the body size of the chest beater. Silverback chest beating. Credit: Dian Fossey Gorilla Fund “The gorilla chest beat is one of those iconic sounds from the animal kingdom, so it is great that we have been able to show that body size is encoded in these spectacular displays,” says Edward Wright, the first author of the study from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. Body size is a key attribute in many animals as it often reflects fighting or competitive ability. Previous research by this team showed that larger males were more socially dominant and more successful in terms of reproduction than smaller males. “Conducting this study was challenging because the chest beats are relatively short in duration and we needed to be in the right place at the right time to obtain the sound recordings, as well as staying clear from these large powerful animals,” says co-author Eric Ndayishimiye, research assistant with the Dian Fossey Gorilla Fund. Silverback chest beating during an inter-group interaction. Credit: Dian Fossey Gorilla Fund Rival males are likely to attend to the body size information transmitted in chest beats as it allows them to assess the competitive ability of the chest beater, this will help them decide whether to initiate, escalate, or retreat in aggressive contests with them. Females on the other hand, are likely to use this information in their choice of potential mates. Interestingly, the researchers also found a great deal of variation among males in both the number of beats comprised in a chest beat as well as the duration of the chest beat. “This hints at the possibility that chest beats may have individual signatures, but further study is needed to test this,” says Wright. Reference: “Chest beats as an honest signal of body size in male mountain gorillas (Gorilla beringei beringei)” by Edward Wright, Sven Grawunder, Eric Ndayishimiye, Jordi Galbany, Shannon C. McFarlin, Tara S. Stoinski and Martha M. Robbins, 8 April 2021, Scientific Reports. DOI: 10.1038/s41598-021-86261-8

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