Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan anti-bacterial pillow ODM design

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene cushion OEM factory in Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Latex pillow OEM production in Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.One-stop OEM/ODM manufacturing factory and solution provider

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand custom product OEM/ODM services

Recent research on tardigrades uncovers a complex genetic basis for their extreme resilience, challenging previous assumptions about their ecological adaptations and pointing to independent evolutionary events in their anhydrobiosis capability. Tardigrades may be nature’s ultimate survivors. While these tiny, nearly translucent animals are easily overlooked, they represent a diverse group that has successfully colonized freshwater, marine, and terrestrial environments on every continent, including Antarctica. Commonly known as “water bears”, these unusual creatures may be among the most resilient organisms on the planet thanks to their unparalleled ability to survive extreme conditions, with various species being resistant to drought, high doses of radiation, low oxygen environments, and both high and low temperatures and pressures. While numerous genes have been suggested to contribute to this extremotolerance, a comprehensive understanding of the origins and history of these unique adaptations has remained elusive. In a new study published in Genome Biology and Evolution, scientists at Keio University Institute for Advanced Biosciences, the University of Oslo Natural History Museum, and the University of Bristol reveal a surprisingly intricate network of gene duplications and losses associated with tardigrade extremotolerance, highlighting the complex genetic landscape that drives modern tardigrade ecology. Understanding Tardigrade Gene Families As one form of extremotolerance, tardigrades can survive almost complete desiccation by entering a dormant state called anhydrobiosis (i.e., life without water), which allows them to reversibly halt their metabolism. Multiple tardigrade-specific gene families were previously found to be associated with anhydrobiosis. Three of these gene families are referred to as cytosolic, mitochondrial, and secretory abundant heat soluble proteins (CAHS, MAHS, and SAHS, respectively) based on the cellular location in which the proteins are expressed. Some tardigrades appear to possess a variant pathway that involves two families of abundant heat-soluble proteins first identified in the tardigrade Echiniscus testudo and usually referred to as EtAHS alpha and beta. A photograph of the tardigrade Ramazzottius varieornatus, in the center of a phylogeny of CAHS, the largest of the six desiccation-related protein families analyzed in this study. Credit: Kazuharu Arakawa, Keio Institute of Advanced Biosciences Tardigrades also possess stress resistance genes that can be found in animals more broadly, such as the meiotic recombination 11 (MRE11) gene, which has been implicated in desiccation tolerance in other animals. Unfortunately, since the identification of these gene families, limited information has been available from most tardigrade lineages, making it difficult to draw conclusions on their origins, history, and ecological implications. Investigating Tardigrade Evolution To better shed light on the evolution of tardigrade extremotolerance, the authors of the new study—James Fleming, Davide Pisani, and Kazuharu Arakawa—identified sequences from these six gene families across 13 tardigrade genera, including representatives from both of the major tardigrade lineages, the Eutardigrades, and Heterotardigrades. Their analysis revealed 74 CAHS, 8 MAHS, 29 SAHS, 22 EtAHS alpha, 18 EtAHS beta, and 21 MRE11 sequences, allowing them to build the first tardigrade phylogenies for these gene families. As resistance to desiccation is likely to have emerged as an adaptation to terrestrial environments, the authors assumed that they would find a link between gene duplications and losses in these gene families and habitat changes within tardigrades. “When we began the work, we expected to find that each clade would be clearly grouped around ancient duplications, with few independent losses. That would help us easily tie them to an understanding of modern habitats and ecology,” says the study’s lead author, James Fleming. “It’s an intuitive hypothesis,” he continues, “that the evolution of the duplications of these desiccation-related genes should, in theory, contain remnants of the ecological history of these organisms, although, in reality, this turned out to be overly simplistic.” Instead, the authors were surprised by the sheer number of independent duplications of heat-soluble genes, which painted a much more complex picture of anhydrobiosis-related gene evolution. Notably, however, there was no clear link between strongly anhydrobiotic species and the number of anhydrobiosis-related genes a species possessed. “What we found was far more exciting,” says Fleming, “a complex network of independent gains and losses that does not necessarily correlate to modern terrestrial species ecologies.” Independent Adaptations in Tardigrade Lineages Despite the lack of a relationship between gene duplications and tardigrade ecology, the study did provide crucial insight into the major transitions that led to the acquisition of anhydrobiosis. The distinct distributions of gene families across the two major groups of tardigrades—CAHS, MAHS, and SAHS in the Eutardigrades and EtAHS alpha and beta in the Heterotardigrades—suggest that two independent transitions from marine to limno-terrestrial environments occurred within tardigrades, once in the Eutardigrade ancestor and once within the Heterotardigrades. This research marks a significant step forward in our understanding of the evolution of anhydrobiosis in tardigrades. It also provides a foundation for future studies into tardigrade extremotolerance, which will require the continued development of genomic resources from more diverse tardigrade lineages. “We, unfortunately, have no representatives from several important families, such as the Isohypsibiidae, and this does limit how firmly we can stand by our conclusions,” notes Fleming. “With more freshwater and marine tardigrade samples, we will be better able to appreciate the adaptations of terrestrial members of the group.” Unfortunately, some tardigrades can be especially elusive, presenting a major obstacle to such studies. As an example, Tanarctus bubulubus, one of Fleming’s favorite tardigrades, is too small to see with the naked eye and is found only in sediment in the North Atlantic at depths of around 150 m. “Hopefully,” says Fleming, “large-scale sequencing initiatives through the Earth Biogenome Project will steadily bridge this gap in our understanding, and it’s an effort I’m excited to see continue.” Reference: “The Evolution of Temperature and Desiccation-Related Protein Families in Tardigrada Reveals a Complex Acquisition of Extremotolerance” by James F Fleming, Davide Pisani and Kazuharu Arakawa, 29 November 2023, Genome Biology and Evolution. DOI: 10.1093/gbe/evad217

Reconstruction of the earliest ichthyosaur and the 250-million-year-old ecosystem found on Spitsbergen. Credit: Illustration by Esther van Hulsen Geochemical analysis of ichthyosaur fossils from Spitsbergen rewrites the evolutionary history of marine reptiles, pushing their origins back before the end-Permian mass extinction. For nearly 190 years, scientists have searched for the origins of ancient sea-going reptiles from the Age of Dinosaurs. Now a team of Swedish and Norwegian paleontologists has discovered remains of the earliest known ichthyosaur or ‘fish-lizard’ on the remote Arctic island of Spitsbergen. Ichthyosaurs were an extinct group of marine reptiles whose fossils have been recovered worldwide. They were amongst the first land-living animals to adapt to life in the open sea, and evolved a ‘fish-like’ body shape similar to modern whales. Ichthyosaurs were at the top of the food chain in the oceans while dinosaurs roamed the land, and dominated marine habitats for over 160 million years. Computed tomography image and cross-section showing internal bone structure of vertebrae from the earliest ichthyosaur. Credit: Øyvind Hammer and Jørn Hurum According to the textbooks, reptiles first ventured into the open sea after the end-Permian mass extinction, which devastated marine ecosystems and paved the way for the dawn of the Age of Dinosaurs nearly 252 million years ago. As the story goes, land-based reptiles with walking legs invaded shallow coastal environments to take advantage marine predator niches that were left vacant by this cataclysmic event. Over time, these early amphibious reptiles became more efficient at swimming and eventually modified their limbs into flippers, developed a ‘fish-like’ body shape, and started giving birth to live young; thus, severing their final tie with the land by not needing to come ashore to lay eggs. The new fossils discovered on Spitsbergen are now revising this long-accepted theory. Close to the hunting cabins on the southern shore of Ice Fjord in western Spitsbergen, Flower’s valley cuts through snow-capped mountains exposing rock layers that were once mud at the bottom of the sea around 250 million years ago. A fast-flowing river fed by snow melt has eroded away the mudstone to reveal rounded limestone boulders called concretions. These formed from limey sediments that settled around decomposing animal remains on the ancient seabed, subsequently preserving them in spectacular three-dimensional detail. Paleontologists today hunt for these concretions to examine the fossil traces of long-dead sea creatures. Fossil-bearing rocks on Spitsbergen that produce the earliest ichthyosaur remains. Credit: Benjamin Kear During an expedition in 2014, a large number of concretions were collected from Flower’s valley and shipped back to the Natural History Museum at the University of Oslo for future study. Research conducted with The Museum of Evolution at Uppsala University has now identified bony fish and bizarre ‘crocodile-like’ amphibian bones, together with 11 articulated tail vertebrae from an ichthyosaur. Unexpectedly, these vertebrae occurred within rocks that were supposedly too old for ichthyosaurs. Also, rather than representing the textbook example of an amphibious ichthyosaur ancestor, the vertebrae are identical to those of geologically much younger larger-bodied ichthyosaurs, and even preserve internal bone microstructure showing adaptive hallmarks of fast growth, elevated metabolism, and a fully oceanic lifestyle. Revising the Timeline of Ichthyosaur Evolution Geochemical testing of the surrounding rock confirmed the age of the fossils at approximately two million years after the end-Permian mass extinction. Given the estimated timescale of oceanic reptile evolution, this pushes back the origin and early diversification of ichthyosaurs to before the beginning of the Age of Dinosaurs; thereby forcing a revision of the textbook interpretation and revealing that ichthyosaurs probably first radiated into marine environments prior to the extinction event. Excitingly, the discovery of the oldest ichthyosaur rewrites the popular vision of Age of Dinosaurs as the emergence timeframe of major reptile lineages. It now seems that at least some groups predated this landmark interval, with fossils of their most ancient ancestors still awaiting discovery in even older rocks on Spitsbergen and elsewhere in the world. The paper is published in the prestigious international life sciences journal Current Biology. Reference: “Earliest Triassic ichthyosaur fossils push back oceanic reptile origins” by Benjamin P. Kear, Victoria S. Engelschiøn, Øyvind Hammer, Aubrey J. Roberts and Jørn H. Hurum, 13 March 2023, Current Biology. DOI: 10.1016/j.cub.2022.12.053

PRINT, a new gene therapy technique, employs bird-derived retrotransposons to insert whole genes into a safe zone of the human genome, offering a complementary approach to CRISPR-Cas9 by potentially enabling the treatment of diseases without the risk of gene disruption or cancer. Credit: SciTechDaily.com Retrotransposons can insert new genes into a “safe harbor” in the genome, complementing CRISPR gene editing. The recent greenlighting of a CRISPR-Cas9 treatment for sickle cell disease underscores the efficacy of gene editing technologies in deactivating genes to heal inherited illnesses. However, the capability to integrate entire genes into the human genome as replacements for faulty or harmful ones remains unachievable. A new technique that employs a retrotransposon from birds to insert genes into the genome holds more promise for gene therapy, since it inserts genes into a “safe harbor” in the human genome where the insertion won’t disrupt essential genes or lead to cancer. Retrotransposons, or retroelements, are pieces of DNA that, when transcribed to RNA, code for enzymes that copy RNA back into DNA in the genome — a self-serving cycle that clutters the genome with retrotransposon DNA. About 40% of the human genome is made up of this “selfish” new DNA, though most of the genes are disabled, so-called junk DNA. The new technique, called Precise RNA-mediated INsertion of Transgenes, or PRINT, leverages the ability of some retrotransposons to efficiently insert entire genes into the genome without affecting other genome functions. PRINT would complement the recognized ability of CRISPR-Cas technology to disable genes, make point mutations, and insert short segments of DNA. A description of PRINT, which was developed in the laboratory of Kathleen Collins, a professor of molecular and cell biology at the University of California, Berkeley, was recently published in the journal Nature Biotechnology. PRINT involves the insertion of new DNA into a cell using delivery methods similar to those used to ferry CRISPR-Cas9 into cells for genome editing. For PRINT, one piece of delivered RNA encodes a common retroelement protein called R2 protein, which has multiple active parts, including a nickase — an enzyme that binds and nicks double-stranded DNA — and reverse transcriptase, the enzyme that generates the DNA copy of RNA. The other RNA is the template for the transgene DNA to be inserted, plus gene expression control elements — an entire autonomous transgene cassette that R2 protein inserts into the genome, Collins said. Retrotransposons found in the genomes of the white-throated sparrow and the zebra finch are shown to safely shepherd transgenes into the human genome, providing a gene therapy approach complementary to CRISPR-Cas9 gene editing. Credit: Briana Van Treeck, UC Berkeley A key advantage of using R2 protein is that it inserts the transgene into an area of the genome that contains hundreds of identical copies of the same gene — each coding for ribosomal RNA, the RNA machine that translates messenger RNA (mRNA) into protein. With so many redundant copies, when the insertion disrupts one or a few ribosomal RNA genes, the loss of the genes won’t be missed. Putting the transgene into a safe harbor avoids a major problem encountered when inserting transgenes via a human virus vector, which is the common method today: The gene is often inserted randomly into the genome, disabling working genes or messing with the regulation or function of genes, potentially leading to cancer. “A CRISPR-Cas9-based approach can fix a mutant nucleotide or insert a little patch of DNA — sequence fixing. Or you can just knock out a gene function by site-specific mutagenesis,” said Collins, who holds the Walter and Ruth Schubert Family Chair. “We’re not knocking out a gene function. We’re not fixing an endogenous gene mutation. We’re taking a complementary approach, which is to put into the genome an autonomously expressed gene that makes an active protein —to add back a functional gene as a deficit bypass. It’s transgene supplementation instead of mutation reversal. To fix loss-of-function diseases that arise from a panoply of individual mutations of the same gene, this is great.” ‘The real winners were from birds’ Many hereditary diseases, such as cystic fibrosis and hemophilia, are caused by a number of different mutations in the same gene, all of which disable the gene’s function. Any CRISPR-Cas9-based gene editing therapy would have to be tailored to a person’s specific mutation. Gene supplementation using PRINT could instead deliver the correct gene to every person with the disease, allowing each patient’s body to make the normal protein, no matter what the original mutation. Many academic labs and startups are investigating the use of transposons and retrotransposons to insert genes for gene therapy. One popular retrotransposon under study by biotech companies is LINE-1 (Long INterspersed Element-1), which in humans has duplicated itself and some hitchhiker genes to cover about 30% of the genome, though fewer than 100 of our genome’s LINE-1 retrotransposon copies are functional today, a minuscule fraction of the genome. Collins, along with UC Berkeley postdoctoral colleague Akanksha Thawani and Eva Nogales, UC Berkeley Distinguished Professor in the Department of Molecular and Cell Biology and a Howard Hughes Medical Institute investigator, published a cryoelectron microscopy structure of the enzyme protein encoded by the LINE-1 retroelement on Dec. 14 in the journal Nature. That study made it clear, Collins said, that the LINE-1 retrotransposon protein would be hard to engineer to safely and efficiently insert a transgene into the human genome. But previous research demonstrating that genes inserted into the repetitive, ribosomal RNA encoding region of the genome (the rDNA) get expressed normally suggested to Collins that a different retroelement, called R2, might work better for safe transgene insertion. Because R2 is not found in humans, Collins and senior researcher Xiaozhu Zhang and postdoctoral fellow Briana Van Treeck, both from UC Berkeley, screened R2 from more than a score of animal genomes, from insects to the horseshoe crab and other multicellular eukaryotes, to find a version that was highly targeted to rDNA regions in the human genome and efficient at inserting long lengths of DNA into the region. “After chasing dozens of them, the real winners were from birds,” Collins said, including the zebra finch and the white-throated sparrow. While mammals do not have R2 in their genomes, they do have the binding sites needed for R2 to effectively insert as a retroelement — likely a sign, she said, that the predecessors to mammals had an R2-like retroelement that somehow got kicked out of the mammalian genome. In experiments, Zhang and Van Treeck synthesized mRNA-encoding R2 protein and a template RNA that would generate a transgene with a fluorescent protein expressed by an RNA polymerase promoter. These were cotransfected into cultured human cells. About half the cells lit up green or red due to fluorescent protein expression under laser light, demonstrating that the R2 system had successfully inserted a working fluorescent protein into the genome. Further studies showed that the transgene did indeed insert into the rDNA regions of the genome and that about 10 copies of the RNA template could be inserted without disrupting the protein-manufacturing activity of the rDNA genes. A giant ribosome biogenesis center Inserting transgenes into rDNA regions of the genome is advantageous for reasons other than it gives them a safe harbor. The rDNA regions are found on the stubby arms of five separate chromosomes. All of these stubby arms huddle together to form a structure called the nucleolus, in which DNA is transcribed into ribosomal RNA, which then folds into the ribosomal machinery that makes proteins. Within the nucleolus, rDNA transcription is highly regulated, and the genes undergo quick repairs, since any rDNA breaks, if left to propagate, could shut down protein production. As a result, any transgene inserted into the rDNA region of the genome would be treated with kid gloves inside the nucleolus. “The nucleolus is a giant ribosome biogenesis center,” Collins said. “But it’s also a really privileged DNA repair environment with low oncogenic risk from gene insertion. It’s brilliant that these successful retroelements — I’m anthropomorphizing them — have gone into the ribosomal DNA. It’s multicopy, it’s conserved, and it’s a safe harbor in the sense that you can disrupt one of these copies and the cell doesn’t care.” This makes the region an ideal place to insert a gene for human gene therapy. Collins admitted that a lot is still unknown about how R2 works and that questions remain about the biology of rDNA transcription: How many rDNA genes can be disrupted before the cell cares? Because some cells turn off many of the 400+ rDNA genes in the human genome, are these cells more susceptible to side effects of PRINT? She and her team are investigating these questions, but also tweaking the various proteins and RNAs involved in retroelement insertion to make PRINT work better in cultured cells and primary cells from human tissue. The bottom line, though, is that “it works,” she said. “It’s just that we have to understand a little bit more about the biology of our rDNA in order to really take advantage of it.” Reference: “Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci” by Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate and Kathleen Collins, 20 February 2024, Nature Biotechnology. DOI: 10.1038/s41587-024-02137-y Other co-authors of the Nature Biotechnology paper are UC Berkeley graduate students Connor Horton, Jeremy McIntyre, Sarah Palm, and Justin Shumate. The work was supported by the National Institutes of Health (F32 GM139306, DP1 HL156819, T32 GM07232) and the Shurl and Kay Curci Foundation. Collins has filed for patents on PRINT, and co-founded a company, Addition Therapeutics, to develop PRINT further as a gene therapy.

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