Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Pillow ODM design company in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan custom insole OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Breathable insole ODM development China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan graphene sports insole ODM

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam custom product OEM/ODM services

MIT researchers have discovered a gene linked to cognitive resilience in the elderly. Environmental enrichment, they find, appears to activate the MEF2 protein, which controls a genetic program in the brain that promotes resilience to declines related to Alzheimer’s and age-related dementia. Credit: MIT News, iStockphoto The findings may help explain why some people who lead enriching lives are less prone to Alzheimer’s and age-related dementia. Many people develop Alzheimer’s or other forms of dementia as they get older. However, others remain sharp well into old age, even if their brains show underlying signs of neurodegeneration. Among these cognitively resilient people, researchers have identified education level and amount of time spent on intellectually stimulating activities as factors that help prevent dementia. A new study by MIT researchers shows that this kind of enrichment appears to activate a gene family called MEF2, which controls a genetic program in the brain that promotes resistance to cognitive decline. The researchers observed this link between MEF2 and cognitive resilience in both humans and mice. The findings suggest that enhancing the activity of MEF2 or its targets might protect against age-related dementia. “It’s increasingly understood that there are resilience factors that can protect the function of the brain,” says Li-Huei Tsai, director of MIT’s Picower Institute for Learning and Memory. “Understanding this resilience mechanism could be helpful when we think about therapeutic interventions or prevention of cognitive decline and neurodegeneration-associated dementia.” Tsai is the senior author of the study, which was published on November 3, 2021, in Science Translational Medicine. The lead authors are recent MIT PhD recipient Scarlett Barker and MIT postdoctoral fellow and Boston Children’s Hospital physician Ravikiran (Ravi) Raju. Protective effects A large body of research suggests that environmental stimulation offers some protection against the effects of neurodegeneration. Studies have linked education level, type of job, number of languages spoken, and amount of time spent on activities such as reading and doing crossword puzzles to higher degrees of cognitive resilience. The MIT team set out to try to figure out how these environmental factors affect the brain at the neuronal level. They looked at human datasets and mouse models in parallel, and both tracks converged on MEF2 as a critical player. MEF2 is a transcription factor that was originally identified as a factor important for cardiac muscle development, but later was discovered to play a role in neuron function and neurodevelopment. In two human datasets comprising slightly more than 1,000 people altogether, the MIT team found that cognitive resilience was highly correlated with expression of MEF2 and many of the genes that it regulates. Many of those genes encode ion channels, which control a neuron’s excitability, or how easily it fires an electrical impulse. The researchers also found, from a single-cell RNA-sequencing study of human brain cells, that MEF2 appears to be most active in a subpopulation of excitatory neurons in the prefrontal cortex of resilient individuals. To study cognitive resilience in mice, the researchers compared mice who were raised in cages with no toys, and mice placed in a more stimulating environment with a running wheel and toys that were swapped out every few days. As they found in the human study, MEF2 was more active in the brains of the mice exposed to the enriched environment. These mice also performed better in learning and memory tasks. When the researchers knocked out the gene for MEF2 in the frontal cortex, this blocked the mice’s ability to benefit from being raised in the enriched environment, and their neurons became abnormally excitable. “This was particularly exciting as it suggested that MEF2 plays a role in determining overall cognitive potential in response to variables in the environment,” Raju says. The researchers then explored whether MEF2 could reverse some of the symptoms of cognitive impairment in a mouse model that expresses a version of the tau protein that can form tangles in the brain and is linked with dementia. If these mice were engineered to overexpress MEF2 at a young age, they did not show the usual cognitive impairments produced by the tau protein later in life. In these mice, neurons overexpressing MEF2 were less excitable. “A lot of human studies and mouse model studies of neurodegeneration have shown that the neurons become hyperexcitable in early stages of disease progression,” Raju says. “When we overexpressed MEF2 in a mouse model of neurodegeneration, we saw that it was able to prevent this hyperexcitability, which might explain why they performed cognitively better than control mice.” Enhancing resilience The findings suggest that enhancing MEF2 activity could help to protect against dementia; however, because MEF2 also affects other types of cells and cellular processes, more study is needed to make sure that activating it wouldn’t have adverse side effects, the researchers say. The MIT team now hopes to further investigate how MEF2 becomes activated by exposure to an enriching environment. They also plan to examine some of the effects of the other genes that MEF2 controls, beyond the ion channels they explored in this study. Such studies could help to reveal additional targets for drug treatments. “You could potentially imagine a more targeted therapy by identifying a subset or a class of effectors that is critically important for inducing resilience and neuroprotection,” Raju says. Reference: “MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration” by Scarlett J. Barker, Ravikiran M. Raju, Noah E.P. Milman, Jun Wang, Jose Davila-Velderrain, Fatima Gunter-Rahman, Cameron C. Parro, P. Lorenzo Bozzelli, Fatema Abdurrob, Karim Abdelaal, David A. Bennett, Manolis Kellis and Li-Huei Tsai, 3 November 2021, Science Translational Medicine. DOI: 10.1126/scitranslmed.abd7695 The research was funded by the Glenn Center for Biology of Aging Research, the National Institute of Aging, the Cure Alzheimer’s Fund, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Researchers are developing a detailed wiring diagram of the motor circuits in fruit flies’ central nervous systems. This connectome reveals the complex coordination between the nerves controlling leg and wing movements. Insights from recent studies highlight the complexity of motor neurons and their role in diverse movements like flying and walking, providing a basis for further research on neural circuit functionality. (Artist’s concept.) Credit: SciTechDaily Studies on fruit flies are shedding light on the complex neural coordination of movements, enhancing our understanding of motor neuron functionality. Scientists are developing a wiring diagram of the motor circuits in fruit flies’ central nervous system that control their muscles. This diagram, which is called a connectome, has already provided insights into the complex coordination between the nerves controlling leg and wing movements. Complexity in Simple Creatures While fruit flies seem like simple creatures, the researchers said their motor system contains “an unexpected level of complexity.” “A typical fly motor neuron receives thousands of synapses from hundreds of presynaptic premotor neurons,” the scientists observed. “This number is on par with the scale of synaptic integration in pyramidal cells of the rodent cortex.” An anatomical reconstruction of motor neurons that control muscles of the fruit fly leg and wing. Credit: Tyler Sloan/Quorometrix Studio New Studies on Motor Coordination Two new papers published in the scientific journal Nature have revealed the latest findings in this area, advancing our understanding of how the central nervous system in animals coordinates individual muscles to facilitate a variety of behaviors. Animation of the anatomical reconstruction of various nervous system structures involved in take-off and flight in a female fruit fly. Motor Neuron Efficiency and Adaptability Fruit flies use their legs for numerous activities such as leaping, walking, grooming, fighting, and courtship. They can also adapt their gait to navigate terrains like house plants, walls, damp surfaces, ceilings – and even insect-scale treadmills. All such movements, from postural reflexes that enable a fly to hold its position steady, to traversing obstacles or changing flight direction, originate through electrical signals from motor neurons. These signals are conducted through threadlike projections from the motor neuron to stimulate muscles. A fly’s six legs are managed by just 60 to 70 motor neurons, the researchers pointed out. In a cat, they noted, about 600 motor neurons supply a single feline calf muscle. Only 29 motor neurons govern the power and steering muscles of a fruit fly wing. In comparison, a hummingbird’s pectoral muscle is supplied by 2,000 motor neurons. Although the fly’s motor neurons are few, it performs remarkable aerial and terrestrial feats. An anatomical reconstruction of the ventral nerve cord of a female fruit fly. Credit: Tyler Sloan/Quorometrix Studio Wiring Logic of Premotor Circuits The scientists explained that motor units are composed of a single motor neuron and the muscle fibers that it can excite. Various motor units, activated in different combinations and sequences, collaborate to achieve a myriad of movement behaviors. The scientists in the two studies were interested in the wiring logic of premotor circuits. They wanted to understand how a fly’s nervous system coordinates motor units to accomplish varied tasks. Detailed Mapping and Synaptic Architecture One of the studies employed automated tools, machine learning, cell-type annotation, and electron microscopy to identify 14,600 neuronal cell bodies and about 45 million synapses (signal-transmission junctions) in the ventral nerve cord of a female fruit fly. The ventral nerve cord in flies is analogous to the spinal cord in vertebrates. The scientists subsequently applied deep learning to automatically reconstruct the anatomy of the neurons and their connections throughout the female fly. Motor Neurons and Muscle Activation in Flight The researchers used sophisticated methods to map the muscles targeted by leg and wing motor neurons. They determined which motor neurons in the female adult nerve cord connectome connect to individual muscles in the front leg and wing. From there, they created an atlas of the circuits that coordinate the fly’s leg and wing movements during take-off and flight motor initiation. To get into the air, the fly’s middle legs extend to jump and its front legs flex for departure. This is very roughly like a taxiing airliner retracting its wheels after leaving the ground or a wading heron tucking its spindly legs to keep them out of the way as it rushes into the sky. The scientists also found that some muscle fibers in adult flies are innervated by several motor neurons. This also occurs in the larval stage of the fruit fly and locusts. While some mammals have multiple innervations of nerve fibers as newborns, these usually disappear by adulthood. Multiple innervations might offer more flexibility and explain why an insect’s limbs can operate with precision despite having so few motor neurons. Functional and Evolutionary Insights from Fly Connectomics The scientists also examined the fly’s wing motor system, which has roughly three sections grouped by function: powering the wing flapping, steering the insect, and adjusting wing motion. The investigation of the connectivity of the premotor neurons enabled the researchers to compare the organization of premotor circuits for two types of limbs. The leg and the wing in fruit flies each have a distinct evolution and biomechanics. Implications and Future Directions of Connectome Research Connectomes are allowing scientists to produce new theories on how neural circuits function, and to debunk some false notions. The scientists mentioned that the recent community effort to develop the fruit fly connectome has led to one of the first synapse-level wiring diagrams for any limbed animal. They hope that additional connectomes will allow researchers to compare neural wiring across individuals. The anticipated reconstruction of a male fruit fly central nerve cord might illuminate differences between sexes. References: “Connectomic reconstruction of a female Drosophila ventral nerve cord” by Anthony Azevedo, Ellen Lesser, Jasper S. Phelps, Brandon Mark, Leila Elabbady, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Avinash Khandelwal, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Andrew Cook, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey Schneider-Mizell, Derrick Brittain, Chris S. Jordan, Michael Dickinson, Alexandra Pacureanu, H. Sebastian Seung, Thomas Macrina, Wei-Chung Allen Lee and John C. Tuthill, 26 June 2024, Nature. DOI: 10.1038/s41586-024-07389-x “Synaptic architecture of leg and wing premotor control networks in Drosophila” by Ellen Lesser, Anthony W. Azevedo, Jasper S. Phelps, Leila Elabbady, Andrew Cook, Durafshan Sakeena Syed, Brandon Mark, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey Schneider-Mizell, Derrick Brittain, Chris S. Jordan, Thomas Macrina, Michael Dickinson, Wei-Chung Allen Lee and John C. Tuthill, 26 June 2024, Nature. DOI: 10.1038/s41586-024-07600-z The research was supported by a Searle Scholar Award, Klingenstein-Simons Fellowship, Pew Biomedical Scholar Award, McKnight Scholar Award, Sloan Research Fellowship, New York Stem Cell Foundation, University of Washington Innovation Award, Genise Goldenson Award, National Institutes of Health Grants U19NS104655, RO1MH177808.

A study conducted by Penn State entomologists evaluated the effectiveness of various insects in potentially controlling spotted lanternfly populations. Credit: Penn State, edited Spotted lanternflies have wreaked havoc on U.S. agriculture since their arrival in 2014, but Penn State researchers may have found unlikely allies: native insect predators. A new study reveals that stink bugs and mantises can effectively consume the pests, suggesting a more eco-friendly alternative to chemical pesticides. Native Predators Offer New Hope Insect predators already present in the United States may help reduce spotted lanternfly populations and lessen the need for chemical pesticides, according to new research from Penn State. Conducted by entomologists in Penn State’s College of Agricultural Sciences and published in Arthropod-Plant Interactions, the study assessed how effective different insect species are at preying on the invasive pest. Since its first detection in the U.S. in 2014, the spotted lanternfly has spread to at least 18 states, causing serious damage to vineyards, orchards, and the nursery industry. Soldier Bugs and Mantises Show Promise Researchers found that spined soldier bugs, a predatory stink bug native to North America, and both Carolina and Chinese mantises were especially effective at feeding on spotted lanternflies. The findings suggest that supporting populations of these natural predators could offer a sustainable, strategic method for controlling the pest. “Our study shows that several native and naturalized predators can consume spotted lanternflies effectively,” said lead researcher and doctoral candidate Anne Johnson, who conducted the study with Kelli Hoover, professor of entomology. “By leveraging natural enemies already in the environment, we hope to develop a sustainable, low-impact approach to managing this invasive species that will complement other control methods.” Beyond Chemicals: A Biological Alternative Johnson noted that current management efforts rely heavily on insecticides, which pose risks of resistance development and unintended harm to beneficial organisms. Biological control, which relies on natural enemies to regulate pest populations, presents a more sustainable alternative for long-term spotted lanternfly management, she said. In the spotted lanternfly’s native range of southeastern Asia, several predators, including parasitic wasps, keep the pest in check. However, importing and releasing new species to the U.S. as a control measure requires numerous environmental impact studies — currently underway by the U.S. Department of Agriculture and University researchers — and regulatory approval. Both can take years, Hoover said. Other predator species, especially those in the U.S., could offer an extra control layer. However, the researchers wondered if the situation might be more complex than it seems. The Tree of Heaven’s Toxic Defense “The spotted lanternfly’s ability to sequester toxins from its preferred host, the tree of heaven, raises concerns about its vulnerability to predators,” Johnson said. “We hypothesized that the spotted lanternfly might harness the tree’s bitter-tasting chemical compounds as a defense mechanism that could protect them against predation.” Johnson and Hoover tested 10 generalist predators — spined soldier bugs, praying mantises, wheel bugs, lady beetles, and lacewings. In the experiments, predators were placed in enclosures with either 25 lanternfly nymphs or 10 adults for up to one week. Standouts Among the Tested Predators Among the tested predators, the spined soldier bugs and two praying mantis species were the most effective at reducing lanternfly populations in controlled settings, regardless of the lanternflies’ life stage. Eight-spined soldier bugs, which hunt and attack prey as a group, consistently consumed all lanternflies — regardless of life stage — within three to four days. Additionally, the scientists observed that the predators would consume spotted lanternflies regardless of whether they had fed on tree of heaven or alternative host plants. “These findings are fascinating because they suggest that natural predators could be incorporated into integrated pest management strategies,” Johnson said. “By conserving and encouraging populations of these beneficial insects, we may be able to reduce the use of chemical controls.” Community Science Sparks New Insights The study builds on earlier community science initiatives documenting native insects preying on spotted lanternflies. From 2020 to 2022, Johnson invited the public to share photos of birds and insects feeding on spotted lanternflies via Facebook. She received nearly 2,000 reports, giving scientists clues about which predators to evaluate. While their research is promising, Hoover and Johnson stressed that this is not an end-all solution. They said the next leg of their research will involve field experiments to determine the efficacy of predators against spotted lanternflies in an open system without enclosures. A Piece of the Larger Puzzle “While these insects could help keep spotted lanternfly populations in check someday, we recognize that their impact may be limited by consistent presence of sufficient prey and the use of insecticides that can also kill these generalist predators,” Hoover said. “Therefore, they should be considered part of a broader integrated pest management strategy rather than a standalone solution.” Johnson said additional management options are outlined in Penn State Extension’s Spotted Lanternfly Management Guide, which can be downloaded from the extension website. Reference: “Predation of spotted lanternfly (Lycorma delicatula) by generalist arthropod predators in North America” by Anne E. Johnson, Sara Hermann and Kelli Hoover, 1 March 2025, Arthropod-Plant Interactions. DOI: 10.1007/s11829-025-10138-0 Sara Hermann, Tombros Early Career Professor and assistant professor of arthropod ecology and trophic interactions at Penn State, collaborated on the research and co-authored the paper. A U.S. Department of Agriculture McIntire-Stennis grant, a Northeast Sustainable Agriculture Research and Education grant, the USDA National Institute of Food and Agriculture’s Specialty Crop Research Initiative, and the Pennsylvania Department of Agriculture supported this research.

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