Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Breathable insole ODM development Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene insole OEM factory Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China pillow OEM manufacturer

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Eco-friendly pillow OEM factory Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene-infused pillow ODM factory Taiwan

Confocal microscopic image shows mesenchymal stem cells (green) captured within nanovials (pink). The nanovial technology was developed by UCLA’s Dino Di Carlo and colleagues. Credit: Shreya Udani/UCLA UCLA stem cell scientists ID surprise genetic instructions for boosting protein secretion, with big implications for biotech and cell therapy. Mesenchymal stem cells, found in bone marrow, secrete therapeutic proteins that could potentially help regenerate damaged tissue. A UCLA study examining these cells challenges the conventional understanding of which genetic instructions prompt the release of these therapeutic proteins. The findings could help advance both regenerative medicine research and the laboratory production of biologic treatments already in use. Expanding Horizons in Antibody-Based Medicine Today, medicines based on antibodies — proteins that fight infection and disease — are prescribed for everything from cancer to COVID-19 to high cholesterol. The antibody drugs are supplied by genetically engineered cells that function as tiny protein-producing factories in the laboratory. Meanwhile, researchers have been targeting cancer, injuries to internal organs, and a host of other ailments with new strategies in which similarly engineered cells are implanted directly into patients. These biotechnology applications rely on the principle that altering a cell’s DNA to produce more of the genetic instructions for making a given protein will cause the cell to release more of that protein. Challenging Established Biological Principles However, a groundbreaking study from UCLA challenges this long-held belief, at least in the case of a specific stem cell type. The researchers examined mesenchymal stem cells, which reside in bone marrow and can self-renew or develop into bone, fat or muscle cells. Mesenchymal cells secrete a protein growth factor called VEGF-A, which plays a role in regenerating blood vessels and which scientists believe may have the potential to repair damage from heart attacks, kidney injuries, arterial disease in limbs, and other conditions. Surprising Findings in Stem Cell Research When the researchers compared the amount of VEGF-A that each mesenchymal cell released with the expression of genes in the same cell that code for VEGF-A, the results were surprising: Gene expression correlated only weakly with the actual secretion of the growth factor.   The scientists identified other genes better correlating with growth factor secretion, including one that codes for a protein found on the surface of some stem cells. Isolating stem cells with that protein on their surface, the team cultivated a population that secreted VEGF-A prolifically and kept doing so days later. Implications for Biotechnology and Medicine The findings, published on December 11 in the journal Nature Nanotechnology, suggest that a fundamental assumption in biology and biotechnology may be up for reconsideration, said co-corresponding author Dino Di Carlo, the Armond and Elena Hairapetian Professor of Engineering and Medicine at the UCLA Samueli School of Engineering. “The central dogma has been, you have instructions in the DNA, they’re transcribed to RNA, and then the RNA is translated into protein,” said Di Carlo, who is also a member of UCLA’s California NanoSystems Institute and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. “Based on this, many scientists assumed that if you had more RNA, you’d have more protein, and then more protein released from the cell. We questioned that assumption. “It seems we can’t assume that if a gene is expressed at higher levels, there will be higher secretion of the corresponding protein. We found a clear example where that doesn’t happen, and it opens up a lot of new questions.” The results could help make the manufacturing of antibody-based treatments more efficient and define new cellular treatments that would be more effective. Knowing the right genetic switches to flip could enable the engineering or selection of extraordinarily productive cells for making or delivering therapies. Breakthroughs in Single-Cell Analysis The UCLA study was conducted using standard lab equipment augmented with a technology invented by Di Carlo and his colleagues: nanovials, microscopic bowl-shaped hydrogel containers, each of which captures a single cell and its secretions. Leveraging a new nanovial-enabled analytic method, the scientists were able to connect the amount of VEGF-A released by each one of 10,000 mesenchymal stem cells to an atlas mapping tens of thousands of genes expressed by that same cell. “The ability to link protein secretion to gene expression on the single-cell level holds great promise for the fields of life science research and therapeutic development,” said Kathrin Plath, a UCLA professor of biological chemistry, a member of the Broad Stem Cell Research Center and a co-corresponding author of the study. “Without it, we couldn’t have arrived at the unexpected results we found in this study. Now we have an exciting opportunity to learn new things about the mechanisms underpinning the basic processes of life and use what we learn to advance human health.” New Avenues in Therapeutic Development While activation of the genetic instructions for VEGF-A displayed little correlation with release of the protein, the researchers identified a cluster of 153 genes with strong links to VEGF-A secretion. Many of them are known for their function in blood vessel development and wound healing; for others, their function is currently unknown. One of the top matches encodes a cell-surface protein, IL13RA2, whose purpose is poorly understood. Its exterior location made it simpler for the scientists to use it as a marker and separate those cells from the others. Cells with IL13RA2 showed 30% more VEGF-A secretion than cells that lacked the marker. In a similar experiment, the researchers kept the separated cells in culture for six days. At the end of that time, cells with the marker secreted 60% more VEGF-A compared to cells without it. Potential Impact on Clinical Applications Although therapies based on mesenchymal stem cells have shown promise in laboratory studies, clinical trials with human participants have shown many of these new options to be safe but not effective. The ability to sort for high VEGF-A secreters using IL13RA2 may help turn that tide. “Identifying a subpopulation that produces more, and markers associated with that population, means you can separate them out very easily,” Di Carlo said. “A very pure population of cells that’s going to produce high levels of your therapeutic protein should make a better therapy.” Nanovials are available commercially from Partillion Bioscience, a company co-founded by Di Carlo that started up at the CNSI’s on-campus incubator, Magnify. Reference: “Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq” by Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath and Dino Di Carlo, 11 December 2023, Nature Nanotechnology. DOI: 10.1038/s41565-023-01560-7 The first author of the study is Shreya Udani, who earned a doctorate from UCLA in 2023. Other co-authors, all affiliated with UCLA, are staff scientist Justin Langerman; Doyeon Koo, who earned a doctorate in 2023; graduate students Sevana Baghdasarian and Citradewi Soemardy; undergraduate Brian Cheng; Simran Kang, who earned a bachelor’s degree in 2023; and Joseph de Rutte, who earned a doctorate in 2020 and is a co-founder and CEO of Partillion. The study was supported by the National Institutes of Health and a Stem Cell Nanomedicine Planning Award funded jointly by the CNSI and the Broad Stem Cell Research Center.

Electron microscopy image of DNA origami rotor arms, which are the faint orange “L’s” attached to the purple tracking particles. Credit: Image courtesy of Julene Madariaga Marcos DNA origami helps scientists observe CRISPR in action, paving the way for more precise genome editing. CRISPR gene editing has transformed research, but it is not perfect, and can sometimes target unintended genes. To watch CRISPR enzymes respond to different genes, Leipzig University researchers developed a new method using DNA origami and were able to measure their response to matched and mismatched gene sequences. The remarkable genetic scissors called CRISPR/Cas9, the discovery that won the 2020 Nobel Prize in Chemistry, sometimes cut in places that they are not designed to target. Though CRISPR has completely changed the pace of basic research by allowing scientists to quickly edit genetic sequences, it works so fast that it is hard for scientists to see what sometimes goes wrong and figure out how to improve it. Julene Madariaga Marcos, a Humboldt postdoctoral fellow, and colleagues in the lab of Professor Ralf Seidel at Leipzig University in Germany, found a way to analyze the ultra-fast movements of CRISPR enzymes, which will help researchers understand how they recognize their target sequences in hopes of improving the specificity. Madariaga Marcos will present the research on Tuesday, February 23 at the 65th Annual Meeting of the Biophysical Society. To use CRISPR enzymes to edit gene sequences, scientists can tailor them to target a specific sequence within the three billion DNA base pairs in the human genome. During target recognition CRISPR enzymes untwist the DNA strands to find a sequence that is complementary to CRISPR’s attached RNA sequence. But sometimes the RNA matches to DNA sequences that are not quite complementary. To troubleshoot this unintended match, scientists need to be able to observe how CRISPR is acting along individual DNA base pairs, but the process is fast and difficult to observe. DNA Origami: A Creative Tool for Molecular Observation To measure CRISPR’s actions on an ultra-fast timescale, Madariaga Marcos and colleagues turned to DNA origami, which uses special DNA sequences to form complex three-dimensional nanostructures instead of a simple double helix. DNA origami has applications in drug delivery, nanoelectronics, and even art. Using DNA origami, they built rotor arms out of DNA so that they could watch with a high-speed camera on a microscope the untwisting of the DNA by CRISPR enzymes, causing the rotor arm to spin like helicopter blades. With this system, they were able to measure the different responses to matches and mismatches within the DNA sequence. “We are able to directly measure the energy landscape of CRISPR/Cascade when it interacts with DNA for the first time,” said Madariaga Marcos. This technique will help scientists better understand CRISPR enzymes, and how they ultimately land on their match. That way, they can figure out how to optimize CRISPR so it makes fewer off-target matches. In the future, Madariaga Marcos is interested in “developing more tools and methods for studying these gene editing processes in new ways and at a more detailed level.”

To construct the body patterns it utilizes to disguise itself on the sea floor, European cuttlefish may use two independent brain systems that interpret particular visual elements from its immediate surroundings and visual signals from its general background environment. Research suggests that European cuttlefish use a more complex strategy than previously thought to camouflage themselves within underwater surroundings. According to a new study, European cuttlefish (sepia officinalis) may combine two distinct neural systems that process specific visual features from its local environment, and visual cues relating to its overall background environment, in order to generate the body patterns it uses to camouflage itself on the sea floor. The research was conducted by the City, University of London, and others and has been published in the journal Current Biology. This finding contradicts previous research suggesting that the cognitive (brain) processes involved are much simpler, in that the cuttlefish adopts one of only three major types of body patterns to visually merge with its background. However, that does not explain why the animal possesses around 30 different body pattern components it could use to achieve this. This new study explored whether the cuttlefish uses a cognitive process that is triggered by specific, visual features in its environment and which warrants the number of body pattern components it possesses. Cuttlefish are experts at blending in with their environments, thanks to the way their brains are able to control how pigments in special cells called chromatophores on their skin are displayed across their bodies. Mastering Camouflage: How Cuttlefish Blend In Cuttlefish are masters at blending in with their environments, like their cephalopod relatives the octopus and the squid, which is largely attributable to the way their brains are able to govern how pigments in special cells called chromatophores on their skin are displayed across their bodies. In the study, 15 European cuttlefish were independently acclimated to a small water tank in which they were randomly exposed to either a uniform, grey background, or one of seven backgrounds with detailed, patterned features (such as small black squares, small white squares, or white stripes).  The researchers photographed the animals’ camouflage responses to these visual cues with a camera, which were then analyzed to see which of the 30 body pattern components appeared activated across the sample of test subjects. Unveiling the Neural Complexity The analysis included a statistical technique called ‘principal component analysis’ (PCA) which searches for clusters of responses in the observed data and attempts to largely explain it with a reduced set of key characteristics of the data. The results of the PCA found that a few key characteristics did not explain most of the variability in the experimental data, but which would have been expected if the cuttlefish were employing a cognitive system that was expressing only three body patterns. Instead, the findings were more in line with a system whereby the whole range of the animals’ body pattern components could be activated, but selectively and in limited numbers, in response to the patterned feature they had been visually exposed to in the water tank. Whilst the study findings are preliminary, they are in line with a model in which European cuttlefish do employ a cognitive system that processes specific visual features of the environment,  and which is used in combination with a system that responds to the visual background overall. Furthermore, a model in which the visual feature system is implemented in a hierarchical fashion (i.e., when needed, to fine-tune a basic response to the overall background), in order for the animal to create the myriad camouflage responses used on the sea floor. Christopher Tyler, Professor of Visual Science at City, University of London and who co-authored the study said: “The cuttlefish provides a fascinating window into perceptual processing of such an alien species by expressing its perception of the surroundings on the dynamic canvas of its skin surface. The findings also lay the groundwork for further study to investigate which specific aspects of the patterned features used here are responsible for activating distinct groups of body components in cuttlefish, and indeed, whether these artificial visual cues are reflective of what is encountered in the animal’s natural environment.” Reference: “Multi-level control of adaptive camouflage by European cuttlefish” by Daniel Osorio, François Ménager, Christopher W. Tyler and Anne-Sophie Darmaillacq, 3 May 2022, Current Biology. DOI: 10.1016/j.cub.2022.04.030

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