Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Thailand insole ODM service provider

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Breathable insole ODM development Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Custom graphene foam processing Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Breathable insole ODM development Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan high-end foam product OEM/ODM factory

Cryo EM structure of the CENP-A nucleosome complex with KNL2. Credit: Jiang et al., EMBO J., 2023 Researchers led by Osaka University have used cryogenic electron microscopy analysis to reveal the structural change of the centromere at an atomic level during cell division. The genetic material inside cells is organized into structures called chromosomes. The centromere is essential for the correct division of the chromosomes via interaction with spindle microtubules when cells divide and grow. Now, a study by researchers at Osaka University has clarified the structure of the centromeric region in chicken cells using a technique known as cryogenic electron microscopy (cryo-EM). Cryo-EM freezes samples quickly to preserve and stabilize them, and then images them using collisions with electrons to reveal their structure. A complex of proteins called the “kinetochore” forms at the centromeric region, and this is essential for cells to divide correctly. The researchers were able to clarify a structural change to the kinetochore at the atomic level using cryo-EM analysis. KNL2 binds to the CENP-A nucleosome during interphase and it contributes to new CENP-A deposition into centromeres via HJURP and the Mis18 complex. Credit: Original content by Tatsuo Fukagawa CENP-A and KNL2 in Centromere Maintenance When DNA is condensed into chromosomes, it is coiled around a core made of proteins called histones to form a structure known as a nucleosome. The nucleosomes in the centromeric region contain a variant histone protein called CENP-A, which specifies the location of the centromere. However, the mechanisms by which CENP-A is deposited at the centromeres to correctly define their location were unknown until now. The research team showed that during mitosis (the process of cell division), a protein called CENP-C binds CENP-A and acts as a scaffold for other kinetochore proteins. However, during interphase (the time when the cell is not dividing), a different protein called KNL2 binds to centromeres instead. “KNL2 contains a CENP-C-like motif and is a component of the Mis18 complex, a licensing factor for new CENP-A deposition,” explains lead authors of the study Honghui Jiang and Mariko Ariyoshi. CENP-C excludes KNL2 from the CENP-A-KNL2 complex during mitosis. Credit: Original content by Tatsuo Fukagawa The team further revealed that this interaction between KNL2 and the centromere is required for new deposition of CENP-A during interphase, which in turn helps maintain the correct location of the centromere. “We also showed that CENP-C is phosphorylated during mitosis, and phosphorylated CENP-C excludes KNL2 from the KNL2–CENP-A complex,” explains senior author Tatsuo Fukagawa. This suggests that KNL2 binds to CENP-A through interphase, maintaining the location of the centromere until a phosphate molecule becomes bound to CENP-C as the cells reach mitosis. Then, CENP-C preferentially binds to CENP-A, allowing the formation of the kinetochore for cell division. These new insights into the structure of the centromeric region will prove invaluable in advancing knowledge of cell division and growth. Proteins involved in cell division and the kinetochore are targets for anti-cancer drugs; therefore, this work will also contribute to the design of novel drugs for diseases such as cancer. Reference: “The cryo-EM structure of the CENP-A nucleosome in complex with ggKNL2” by Honghui Jiang, Mariko Ariyoshi, Tetsuya Hori, Reito Watanabe, Fumiaki Makino, Keiichi Namba and Tatsuo Fukagawa, 6 February 2023, EMBO Journal. DOI: 10.15252/embj.2022111965 Funding: Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology, Japan Science and Technology Agency

While the concept of virgin birth has been historically linked to religious narratives like the birth of Jesus Christ to the Virgin Mary, researchers have now discovered a genetic trigger for virgin births in fruit flies. Once activated, this ability can be passed down to subsequent female generations. When devoid of males, these flies opt for virgin birth, a survival tactic ensuring the species’ continuation. For the first time, scientists have identified a genetic cause of virgin birth, and once activated, this ability is inherited by subsequent generations of females. Scientists have managed to induce virgin birth in an animal that usually reproduces sexually: the fruit fly Drosophila melanogaster. Once induced in this fruit fly, this ability is passed on through the generations: the offspring can reproduce either sexually if there are males around, or by virgin birth if there aren’t. For most animals, reproduction is sexual – it involves a female’s egg being fertilized by a male’s sperm. Virgin birth, or ‘parthenogenesis’, is the process by which an egg develops into an embryo without fertilization by sperm – a male is not needed. The offspring of a virgin birth are not exact clones of their mother but are genetically very similar, and are always female. Researchers have identified the genes that are switched on, or switched off, when these flies reproduce without fathers. Credit: Jose Casal and Peter Lawrence “We’re the first to show that you can engineer virgin births to happen in an animal – it was very exciting to see a virgin fly produce an embryo able to develop to adulthood, and then repeat the process,” said Dr Alexis Sperling, a researcher at the University of Cambridge and first author of the paper. She added: “In our genetically manipulated flies, the females waited to find a male for half their lives – about 40 days – but then gave up and proceeded to have a virgin birth.” In the experiments, only 1-2% of the second generation of female flies with the ability for virgin birth produced offspring, and this occurred only when there were no male flies around. When males were available, the females mated and reproduced in the normal way. A Survival Strategy for Species Continuation Switching to a virgin birth can be a survival strategy: a one-off generation of virgin births can help to keep the species going. Dr. Sperling (at left) in the lab with a student. Credit: University of Cambridge The study was recently published in the journal Current Biology. To achieve their results, researchers first sequenced the genomes of two strains of another species of fruit fly, called Drosophila mercatorum. One strain needs males to reproduce, the other reproduces only through virgin birth. They identified the genes that were switched on, or switched off, when the flies were reproducing without fathers. With the candidate genes for virgin birth ability identified in Drosophila mercatorum, the researchers altered what they thought were the corresponding genes in the model fruit fly, Drosophila melanogaster. It worked: Drosophila melanogaster suddenly acquired the ability for virgin birth. The research involved over 220,000 virgin fruit flies and took six years to complete. One strain of this fly reproduces only through virgin birth. Credit: Jose Casal and Peter Lawrence Key to the discovery was the fact that this work was done in Drosophila melanogaster – the researchers say it would have been incredibly difficult in any other animal. This fly has been the ‘model organism’ for research in genetics for over 100 years and its genes are very well understood. Potential Agricultural Impact Sperling, who carried out this work in the Department of Genetics, has recently moved to Cambridge Crop Science Centre to work on crop pests and hopes to eventually investigate why virgin birth in insects may be becoming more common, particularly in pest species. “If there’s continued selection pressure for virgin births in insect pests, which there seems to be, it will eventually lead to them reproducing only in this way. It could become a real problem for agriculture because females produce only females, so their ability to spread doubles,” said Sperling. The females of some egg-laying animals – including birds, lizards, and snakes, can switch naturally to give birth without males. But virgin birth in animals that normally sexually reproduce is rare, often only observed in zoo animals, and usually happens when the female has been isolated for a long time and has little hope of finding a mate. Reference: “A genetic basis for facultative parthenogenesis in Drosophila” by Alexis L. Sperling, Daniel K. Fabian, Erik Garrison and David M. Glover, 28 July 2023, Current Biology. DOI: 10.1016/j.cub.2023.07.006 The study was funded by the Leverhulme Trust.

An illustration by study coauthor Stephanie Gamez depicts flightless females and sterile male mosquitoes, features of the new precision-guided sterile insect technique, or pgSIT, which is designed to control disease-spreading Aedes aegypti mosquitoes. Credit: Stephanie Gamez, UC San Diego CRISPR-based system developed to safely restrain mosquito vectors via sterilization. Leveraging advancements in CRISPR-based genetic engineering, researchers at the University of California San Diego have created a new system that restrains populations of mosquitoes that infect millions each year with debilitating diseases. The new precision-guided sterile insect technique, or pgSIT, alters genes linked to male fertility — creating sterile offspring — and female flight in Aedes aegypti, the mosquito species responsible for spreading wide-ranging diseases including dengue fever, chikungunya, and Zika. “pgSIT is a new scalable genetic control system that uses a CRISPR-based approach to engineer deployable mosquitoes that can suppress populations,” said UC San Diego Biological Sciences Professor Omar Akbari. “Males don’t transmit diseases so the idea is that as you release more and more sterile males, you can suppress the population without relying on harmful chemicals and insecticides.” UC San Diego Postdoctoral Scholar Ming Li, first author of a Nature Communications paper describing a CRISPR-based precision-guided sterile insect technique in Aedes aegypti mosquitoes, shown sorting pgSIT mosquito larvae. Credit: Akbari Lab, UC San Diego Details of the new pgSIT are described September 10, 2021, in the journal Nature Communications. pgSIT differs from “gene drive” systems that could suppress disease vectors by passing desired genetic alterations indefinitely from one generation to the next. Instead, pgSIT uses CRISPR to sterilize male mosquitoes and render female mosquitoes, which spread disease, as flightless. The system is self-limiting and is not predicted to persist or spread in the environment, two important safety features that should enable acceptance for this technology.  Akbari says the envisioned pgSIT system could be implemented by deploying eggs of sterile males and flightless females at target locations where mosquito-borne disease spread is occurring. “Supported by mathematical models,  we empirically demonstrate that released pgSIT males can compete, and suppress and even eliminate mosquito populations,” the researchers note in the Nature Communications paper. “This platform technology could be used in the field, and adapted to many vectors, for controlling wild populations to curtail disease in a safe, confinable and reversible manner.” Although molecular genetic engineering tools are new, farmers have been sterilizing male insects to protect their crops since at least the 1930s. United States growers in the 1950s began using radiation to sterilize pest species such as the New World Screwworm fly, which is known to destroy livestock. Similar radiation-based methods continue today, along with the use of insecticides. pgSIT is designed as a much more precise and scalable technology since it uses CRISPR—not radiation or chemicals—to alter key mosquito genes. The system is based on a method that was announced by UC San Diego in 2019 by Akbari and his colleagues in the fruit fly Drosophila. As envisioned, Akbari says pgSIT eggs can be shipped to a location threatened by mosquito-borne disease or developed at an on-site facility that could produce the eggs for nearby deployment. Once the pgSIT eggs are released in the wild, typically at a peak rate of 100-200 pgSIT eggs per Aedes aegypti adult, sterile pgSIT males will emerge and eventually mate with females, driving down the wild population as needed. Beyond Aedes aegypti, the researchers believe the pgSIT technology could be directed to other species that spread disease. “… This study suggests pgSIT may be an efficient technology for mosquito population control and the first example of one suited for real-world release,” the researchers say. “Going forward, pgSIT may provide an efficient, safe, scalable, and environmentally friendly alternative next-generation technology for wild population control of mosquitoes resulting in wide-scale prevention of human disease transmission.” Reference: “Suppressing mosquito populations with precision guided sterile males” by Ming Li, Ting Yang, Michelle Bui, Stephanie Gamez, Tyler Wise, Nikolay P. Kandul, Junru Liu, Lenissa Alcantara, Haena Lee, Jyotheeswara R. Edula, Robyn Raban, Yinpeng Zhan, Yijin Wang, Nick DeBeaubien, Jieyan Chen, Héctor M. Sánchez C., Jared B. Bennett, Igor Antoshechkin, Craig Montell, John M. Marshall and Omar S. Akbari, 10 September 2021, Nature Communications. DOI: 10.1038/s41467-021-25421-w The complete list of paper co-authors: Ming Li, Ting Yang, Michelle Bui, Stephanie Gamez, Tyler Wise, Nikolay Kandul, Junru Liu, Lenissa Alcantara, Haena Lee, Jyotheeswara Edula, Robyn Raban, Yinpeng Zhan, Yijin Wang, Nick DeBeaubien, Jieyan Chen, Hector Sanchez C., Jared Bennett, Igor Antoshechkin, Craig Montell, John Marshall and Omar Akbari. Funding for the research was provided by a DARPA Safe Genes Program Grant (HR0011-17-2-0047); the National Institutes of Health (R01AI151004 and R56-AI153334); the U.S. Army Research Office (cooperative agreement W911NF-19-2-0026 for the Institute for Collaborative Biotechnologies); and the Innovative Genomics Institute. Note: Akbari is a co-founder with equity interest, and former consultant, scientific advisory board member and income recipient of Agragene Inc.

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