Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia ergonomic pillow OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Custom foam pillow OEM in Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand athletic insole OEM supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan OEM insole and pillow supplier

Four squid embryos in their egg sac. These are the squid species Doryteuthis pealeii. Credit: Kristen Koenig Cephalopods Were Found To Have Similar Brain Development to Vertebrates in a New Study Cephalopods, which include octopuses, squid, and cuttlefish, exhibit impressive behaviors such as the ability to quickly adapt their appearance to blend into their surroundings, communicate with one another, demonstrate spatial learning, and use tools to solve problems. Their high level of intelligence even allows them to experience boredom. It’s no secret what makes it possible: Cephalopods, including octopuses, squid, and cuttlefish, have the most complex brains of any invertebrates. However, the process of how they develop these large brains has remained a mystery. A Harvard University lab studying the visual system of these creatures, which is where the majority of their central processing tissue is focused, believes they have made significant progress in understanding the process. The process, they say, looks surprisingly familiar. Researchers from the FAS Center for Systems Biology describe how they used a new live-imaging technique to watch neurons being created in the embryo in almost real time. They were then able to track those cells through the development of the nervous system in the retina. What they saw surprised them. This is an example of the live imaging data generated in this paper. The membranes of the cells in the eye are labeled with a fluorescent dye allowing us to visualize individual cell behavior during development. Credit: Kristen Koenig Surprising Similarities to Vertebrate Brain Formation The neural stem cells they tracked behaved eerily similar to the way these cells behave in vertebrates during the development of their nervous system. It suggests that vertebrates and cephalopods, despite diverging from each other 500 million years ago, not only are using similar mechanisms to make their big brains but that this process and the way the cells act, divide, and are shaped may essentially layout the blueprint required to develop this kind of nervous system. “Our conclusions were surprising because a lot of what we know about nervous system development in vertebrates has long been thought to be special to that lineage,” said Kristen Koenig, a John Harvard Distinguished Fellow and senior author of the study. “By observing the fact that the process is very similar, what it suggested to us is that these two independently evolved very large nervous systems are using the same mechanisms to build them. What that suggests is that those mechanisms — those tools — the animals use during development may be important for building big nervous systems.” The scientists from the Koenig Lab focused on the retina of a squid called Doryteuthis pealeii, more simply known as a type of longfin squid. The squid grow to be about a foot long and are abundant in the northwest Atlantic Ocean. As embryos, they look quite adorable with big heads and big eyes. The researchers used similar techniques to those made popular to study model organisms, like fruit flies and zebrafish. They created special tools and used cutting-edge microscopes that could take high-resolution images every ten minutes for hours on end to see how individual cells behave. The researchers used fluorescent dyes to mark the cells so they could map and track them. Pseudostratified Epithelium This live-imaging technique allowed the team to observe stem cells called neural progenitor cells and how they are organized. The cells form a special kind of structure called a pseudostratified epithelium. Its main feature is the cells are elongated so they can be densely packed. The researchers also saw the nucleus of these structures move up and down before and after dividing. This movement is important for keeping the tissue organized and growth continuing, they said. This type of structure is universal in how vertebrate species develop their brain and eyes. Historically, it was considered one of the reasons the vertebrate nervous system could grow so large and complex. Scientists have observed examples of this type of neural epithelium in other animals, but the squid tissue they looked at in this instance was unusually similar to vertebrate tissues in its size, organization, and the way the nucleus moved. The research was led by Francesca R. Napoli and Christina M. Daly, research assistants in the Koenig Lab. Next, the lab plans to look at how different cell types in cephalopod brains emerge. Koenig wants to determine whether they’re expressed at different times, how they decide to become one type of neuron versus another, and whether this action is similar across species. Koenig is excited about the potential discoveries that lie ahead. “One of the big takeaways from this type of work is just how valuable it is to study the diversity of life,” Koenig said. “By studying this diversity, you can actually really come back to fundamental ideas about even our own development and our own biomedically relevant questions. You can really speak to those questions.” Reference: “Cephalopod retinal development shows vertebrate-like mechanisms of neurogenesis” by Francesca R. Napoli, Christina M. Daly, Stephanie Neal, Kyle J. McCulloch, Alexandra R. Zaloga, Alicia Liu and Kristen M. Koenig, 9 November 2022, Current Biology. DOI: 10.1016/j.cub.2022.10.027

New research reveals a hybrid cell type in the human brain that exhibits both neuronal and glial properties, capable of generating electrical signals. This finding, important for glioma and normal brain function, suggests potential prognostic value in cancer treatment. Credit: SciTechDaily.com Scientists from Baylor College have identified a new cell type in the human brain that shares properties of neurons and glia. These cells, also found in glioma tumors, are capable of firing electrical impulses, challenging the conventional belief that only neurons can do so. Discovery of New Cell Type in Human Brain Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital have uncovered a new cell type in the human brain. The study published today (September 5) in the journal Cancer Cell reveals that a third of the cells in glioma, a type of brain tumor, fire electrical impulses. Interestingly, the impulses, also called action potentials, originate from tumor cells that are part neuron and part glia, supporting the groundbreaking idea that neurons are not the only cells that can generate electric signals in the brain. The scientists also discovered that cells with hybrid neuron-glia characteristics are present in the non-tumor human brain. The findings highlight the importance of further studying the role of these newly identified cells in both glioma and normal brain function. Impact on Glioma Research and Patient Survival “Gliomas are the most common tumors of the central nervous system with an estimated 12,000 cases diagnosed each year. These tumors are universally lethal and have devastating effects on neurological and cognitive functions. Previous studies have shown that patient survival outcomes are associated with tumor proliferation and invasiveness, which are influenced by tumor intrinsic and extrinsic factors, including communication between tumor cells and neurons that reside in the brain,” said Dr. Benjamin Deneen professor and Dr. Russell J. and Marian K. Blattner Chair in the Department of Neurosurgery, director of the Center for Cancer Neuroscience, a member of the Dan L Duncan Comprehensive Cancer Center at Baylor and a principal investigator at the Jan and Dan Duncan Neurological Research Institute. Researchers have previously described that glioma and surrounding healthy neurons connect with each other and that neurons communicate with tumors in ways that drive tumor growth and invasiveness. Unveiling Electrical Activity in Cancer Cells “We have known for some time now that tumor cells and neurons interact directly,” said first author Dr. Rachel N. Curry, postdoctoral fellow in pediatrics – neuro oncology at Baylor, who was responsible for conceptualizing the project. “But one question that always lingered in my mind was, ‘Are cancer cells electrically active?’ To answer this question correctly, we required human samples directly from the operating room. This ensured the biology of the cells as they would exist in the brain was preserved as much as possible.” To study the ability of glioma cells to spike electrical signals and identify the cells that produce the signals, the team used Patch-sequencing, a combination of techniques that integrates whole-cell electrophysiological recordings to measure spiking signals with single-cell RNA-sequencing and analysis of the cellular structure to identify the type of cells. Innovative Methods and Unexpected Findings The electrophysiology experiments were conducted by research associate and co-first author Dr. Qianqian Ma in the lab of co-corresponding author associate professor of neuroscience Dr. Xiaolong Jiang. This innovative approach has not been used before to study human brain tumor cells. “We were truly surprised to find these tumor cells had a unique combination of morphological and electrophysiological properties,” Ma said. “We had never seen anything like this in the mammalian brain before.” “We conducted all these analyses on single cells. We analyzed their individual electrophysiological activity. We extracted each cell’s content and sequenced the RNA to identify the genes that were active in the cell, which tells us what type of cell it is,” Deneen said. “We also stained each cell with dyes that would visualize its structural features.” Analysis and Computational Advances in Neuroscience Integrating this vast amount of individual data required the researchers to develop a novel way to analyze it. “To define the spiking cells and determine their identity, we developed a computational tool – Single Cell Rule Association Mining (SCRAM) – to annotate each cell individually,” said co-corresponding author, Dr. Akdes Serin Harmanci, assistant professor of neurosurgery at Baylor. Broader Implications for Neuroscience and Clinical Practice “Finding that so many glioma cells are electrically active was a surprise because it goes against a strongly held concept in neuroscience that states that, of all the different types of cells in the brain, neurons are the only ones that fire electric impulses,” Curry said. “Others have proposed that some glia cells known as oligodendrocyte precursor cells (OPCs) may fire electrical impulses in the rodent brain, but confirming this in humans had proven a difficult task. Our findings show that human cells other than neurons can fire electrical impulses. Since there is an estimated 100 million of these OPCs in the adult brain, the electrical contributions of these cells should be further studied.” “Moreover, the comprehensive data analyses revealed that the spiking hybrid cells in glioma tumors had properties of both neurons and OPC cells,” Harmanci said. “Interestingly, we found non-tumor cells that are neuron-glia hybrids, suggesting that this hybrid population not only plays a role in glioma growth but also contributes to healthy brain function.” “The findings also suggest that the proportion of spiking hybrid cells in glioma may have a prognostic value,” said co-corresponding author Dr. Ganesh Rao, Marc J. Shapiro Professor and chair of neurosurgery at Baylor. “The data shows that the more of these spiking hybrid glioma cells a patient has, the better the survival outcome. This information is of great value to patients and their doctors.” Collaboration and Conclusions in Cancer and Brain Research “This work is the result of extensive equal collaboration across multiple disciplines – neurosurgery, bioinformatics, neuroscience, and cancer modeling – disciplines strongly supported by state-of-the-art groups at Baylor,” Deneen said. “The results offer an enhanced understanding of glioma tumors and normal brain function, a sophisticated bioinformatics pipeline to analyze complex cellular populations and potential prognostic implications for patients with this devastating disease.” Reference: “Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma” by Rachel N. Curry, Qianqian Ma, Malcolm F. McDonald, Yeunjung Ko, Snigdha Srivastava, Pey-Shyuan Chin, Peihao He, Brittney Lozzi, Prazwal Athukuri, Junzhan Jing, Su Wang, Arif O. Harmanci, Benjamin Arenkiel, Xiaolong Jiang, Benjamin Deneen, Ganesh Rao and Akdes Serin Harmanci, 5 September 2024, Cancer Cell. DOI: 10.1016/j.ccell.2024.08.009 Other contributors to this work include Malcolm F. McDonald, Yeunjung Ko, Snigdha Srivastava, Pey-Shyuan Chin, Peihao He, Brittney Lozzi, Prazwal Athukuri, Junzhan Jing, Su Wang, Arif O. Harmanci and Benjamin Arenkiel. The authors are affiliated with one or more of the following institutions: Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and University of Texas Health Science Center, Houston. This work was supported by grants from the NIH (R35-NS132230, R01NS124093, R01CA223388, U01CA281902, R01NS094615, 5T32HL92332-15, F31CA265156, and F99CA274700). Further support was provided by NIH Shared Instrument Grants (S10OD023469, S10OD025240, P30EY002520) and CPRIT grant RP200504.

Brown Trout Human pollution is often evident from oil slicks and plastic drifting on shore, but many of the drugs that we consume also end up washing out into our water and current effluent treatment isn’t equipped to deal with them. Drugs such as fluoxetine — also known as Prozac — creeping into our waterways can embolden fish and alter their behavior, but pharmaceutical pollution doesn’t end with prescribed medication. Illegal drugs, such as methamphetamine, can also accumulate in our waterways. “Whether illicit drugs alter fish behavior at levels increasingly observed in surface water bodies was unclear,” says Pavel Horký from the Czech University of Life Sciences Prague, Czech Republic. He and his colleagues, from the same university and the University of Southern Bohemia in České Budějovice, Czech Republic, decided to investigate whether brown trout (Salmo trutta) are at risk of addiction from illegal methamphetamine in their waterways and discovered that they are. The team publish this alarming discovery in Journal of Experimental Biology. After isolating brown trout in a tank of water laced with 1 μg l-1 methamphetamine (a level that has been found in freshwater rivers) for 8 weeks, Horký and colleagues transferred the fish to a freshwater tank and checked whether the animals were experiencing withdrawal — offering them a choice between freshwater or water containing methamphetamine — every alternate day for 10 days. If the fish had become addicted to the low levels of methamphetamine in their water, they would be feeling the effects of withdrawal and would seek the drug when it was available. Tracking the fish’s choices, it was clear to the team that the trout that had spent 2 months in methamphetamine-contaminated water had become addicted, selecting water containing the drug as they suffered withdrawal during the first 4 days after moving to freshwater. In addition, the addicted fish were less active than trout that had never experienced the drug, and the researchers found evidence of the drug in the fish’s brains up to 10 days after the methamphetamine was withdrawn. It seems that, even low levels of illicit drugs in our waterways can affect the animals that reside there. Horký is also concerned that drug addiction could drive fish to congregate near unhealthy water treatment discharges in search of a fix, as well as disturbing their natural tempo of life. “The elicitation of drug addiction in wild fish could represent another example of unexpected pressure on species living in urban environments,” he suggests. Reference: “Methamphetamine pollution elicits addiction in wild fish” by Pavel Horký, Roman Grabic, Kateřina Grabicová, Bryan W. Brooks, Karel Douda, Ondřej Slavík, Pavla Hubená, Eugenia M. Sancho Santos and Tomáš Randák, 6 July 2021, Journal of Experimental Biology. DOI: 10.1242/jeb.242145

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