Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Smart pillow ODM manufacturer Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.High-performance graphene insole OEM Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia anti-odor insole OEM service

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene cushion OEM factory in Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene sheet OEM supplier China

Researchers have discovered that 5-formylcytosine (5fC) activates genes in early embryonic development, revealing a new type of epigenetic DNA modification in vertebrates. This breakthrough uncovers 5fC’s role during crucial developmental stages and opens the door for further research on its function in diseases like cancer. Credit: SciTechDaily.com In the embryonic development of vertebrates, 5-formylcytosine activates genes. Professor Christof Niehrs and his team at the Institute of Molecular Biology (IMB) in Mainz, Germany, have identified a DNA modification known as 5-formylcytosine (5fC) as an epigenetic switch that activates genes during the early stages of embryonic development. This finding proves for the first time that vertebrates have more than one type of epigenetic DNA mark and sheds new light on how genes are regulated in the earliest stages of development. Their findings were published in the journal Cell. 5fC is only the second proven epigenetic DNA modification besides methylcytosine Our bodies are composed of trillions of cells, all working together to form a functional organism. Yet each of us started off as just a single fertilized egg cell. To become a whole human being, this single cell must multiply rapidly, forming all the correct organs in the right places. This process of development depends on thousands of genes being activated at exactly the right time and place. The activation/deactivation of genes is controlled by so-called epigenetic modifications, i.e., chemical groups attached to DNA and its associated proteins that act like traffic lights to switch genes on or off. 5fC activates genes in the early embryo. Credit: IMB For decades, scientists thought that vertebrates had only one type of epigenetic modification on DNA called cytosine methylation, which is associated with gene silencing. Ten years ago, three more chemical modifications were discovered in vertebrate DNA, but as they were only present in very small amounts scientists were uncertain if they were functional epigenetic marks. Now, Professor Christof Niehrs and his team have shown for the first time that one of these modifications, 5-formylcytosine, is involved in activating genes in early development. The discovery is significant because it proves that vertebrates have more than one type of epigenetic DNA mark and uncovers a new, previously unknown mechanism of epigenetic gene regulation. “These findings are a real breakthrough in epigenetics because 5fC is only the second proven epigenetic DNA modification besides methylcytosine,” said Niehrs, Founding and Scientific Director of the IMB, which was opened on the campus of Johannes Gutenberg University Mainz (JGU) in 2011. Investigating 5fC in Frog and Mouse Embryos In their study, the scientists looked at 5fC in frog embryos. Using microscopy and chromatography, they discovered that 5fC increases dramatically at the very start of development during a key step called zygotic activation when many genes become switched on. As Eleftheria Parasyraki, the first author of the study, explained: “The observation of 5fC in microscopically visible tiny dots, or chromocenters, was exciting. Based on them, we suspected that 5fC must do something important in early embryonic development.” To prove that 5fC is an activating epigenetic mark, the scientists genetically manipulated enzymes in the embryo to increase or decrease the amount of 5fC on the DNA. Increasing 5fC resulted in increased gene expression while decreasing 5fC reduced gene expression, indicating that it was indeed the presence of 5fC on the DNA that activates genes. Finally, the scientists also observed 5fC chromocenters in mouse embryos during zygotic gene activation. This suggested that 5fC likely acts as an activating epigenetic mark in both mammals and frogs. The revelation that 5fC is an activating epigenetic regulator on DNA raises many questions as to how exactly it acts and what its role is beyond early zygotic genome activation. In particular, cancer cells can have very high amounts of 5fC. Additional studies on 5fC will be needed to answer these questions, which may ultimately help us to better understand how we develop and how gene regulation is disrupted in disease. Reference: “5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming” by Eleftheria Parasyraki, Medhavi Mallick, Victoria Hatch, Viviana Vastolo, Michael U. Musheev, Emil Karaulanov, Alexandr Gopanenko, Simon Moxon, Maria Méndez-Lago, Dandan Han, Lars Schomacher, Debasish Mukherjee and Christof Niehrs, 29 August 2024, Cell. DOI: 10.1016/j.cell.2024.08.011

New findings on the Great Barrier Reef show varied heat tolerance in corals, suggesting potential for genetic conservation. This research could help develop more resilient coral populations through targeted breeding and restoration initiatives. Southern Cross University’s research revealed significant variations in heat tolerance among corals on the Great Barrier Reef, a discovery that could improve restoration and adaptation efforts. By studying over 500 coral colonies, scientists identified genetic and environmental factors influencing these variations, with implications for future coral resilience and conservation strategies. Previously undocumented variation in coral heat tolerance on Australia’s Great Barrier Reef has been discovered by researchers from Southern Cross University. Their findings give hope that corals’ own genetic resources may hold the key for us to help in their recovery and adaptation. In a study to be published today (September 23, 2024) in the journal Communications Earth and Environment, researchers measured the bleaching thresholds of more than 500 colonies of the table coral, Acropora hyacinthus, using a portable experimental system that was used at sea at 17 reefs spanning the Great Barrier Reef. The study was led by Southern Cross University PhD candidate Melissa Naugle, with a team from Southern Cross University, the Australian Institute of Marine Science (AIMS), the University of Queensland, and the Research Institute for Development in New Caledonia as part of the Reef Restoration and Adaptation Program (RRAP). Various degrees of bleaching in corals next to each other at Lizard Island on Great Barrier Reef. Credit Melissa Naugle Genetic Resources for Coral Protection “We found heat-tolerant corals at almost all the reefs that we studied, highlighting how corals across the entire Great Barrier Reef may hold genetic resources that are important for protection and restoration,” said Melissa. “This is important news for corals, which are experiencing the 4th global mass bleaching event and unprecedented summer sea temperatures on the Great Barrier Reef. Naturally occurring heat tolerance variation is crucial for corals to adapt to climate warming and for the success of restoration initiatives.” These findings were substantiated in another recent study by co-author and fellow Southern Cross University PhD candidate Hugo Denis, who also found widespread variation in heat tolerance in a different coral species. Experimental system used to test bleaching thresholds of over 500 coral colonies while at sea. Credit AIMS Joanna Hurford Implications for Coral Reef Futures The results of this work have important implications for coral reef futures. “Differences between individual corals is the fuel for natural selection to produce future generations of more tolerant corals,” said Dr. Line Bay, co-author and Senior Principal Research Scientist and Research Program Director at AIMS. “Developing a solid understanding of this variation is crucial to understanding how corals will adapt to climate warming.” Targeted Conservation Efforts Dr. Cedric Robillot, Executive Director of the Reef Restoration and Adaptation Program, said: “This work highlights the availability of naturally heat-tolerant corals that can be targeted by RRAP, as a large-scale reef restoration and conservation effort, to protect this critical ecosystem from warming ocean temperatures that are already locked in from climate change.” Dr. Emily Howells, co-author and Senior Research Fellow at Southern Cross University and Project Lead in the Reef Restoration and Adaptation Program, said: “Heat tolerance variation can be useful for restoration programs such as selective breeding, which may accelerate adaptation to produce offspring better suited to warmer waters. Though, this outcome depends on how much of the heat tolerance variation we observe is tied to heritable gene variants.” Selective Breeding and Restoration Programs The most heat-tolerant corals identified in this study are currently being used for a selective breeding trial through the Reef Restoration and Adaptation Program. The study reported not only the extent of the variation in coral heat tolerance, but also investigated the sources underlying that variation. “In this paper, we explored many of the environmental influences that shape heat tolerance, like thermal history, nutrient concentrations, and the symbiotic algae that live inside coral tissue,” said Melissa. Future Research and Implications While the study found that environmental factors like sea temperatures were important in influencing heat tolerance, there was substantial heat tolerance variation that could not be explained by the environment and is likely due to genetic differences among individual corals. “Next, we’ll analyze DNA-sequencing data from these individuals to identify gene variants associated with heat tolerance. This can help us understand the adaptation potential of natural coral populations and inform selective breeding work,” Melissa said. “While restoration initiatives like selective breeding may strengthen coral populations, reducing greenhouse gas emissions is most crucial to give coral reefs the best future possible.” Reference: “Heat tolerance varies considerably within a reef-building coral species on the Great Barrier Reef” by Melissa S. Naugle, Hugo Denis, Véronique J. L. Mocellin, Patrick W. Laffy, Iva Popovic, Line K. Bay and Emily J. Howells, 23 September 2024, Communications Earth & Environment. DOI: 10.1038/s43247-024-01649-4

New research from the University of Chicago reveals that memory-related brain activity continues to evolve even after something is learned, challenging traditional views of synaptic plasticity. A newer rule called Behavioral Timescale Synaptic Plasticity (BTSP), rather than the classic Hebbian model, better explains the dynamic shifts in place cell activity in the hippocampus during learning and familiar experiences. Credit: SciTechDaily.com New research from the University of Chicago challenges long-held beliefs about how synaptic plasticity contributes to memory and learning. As animals encounter new experiences, the connections between their neurons, known as synapses, adjust in strength depending on the brain activity those experiences trigger. This process, called synaptic plasticity, is widely believed by neuroscientists to play a key role in how memories are stored. Despite its importance, the precise mechanisms that determine when and how much synapses change remain unclear. The traditional view holds that when two neurons frequently activate together, their connection strengthens, while firing separately weakens the link. However, new research from the University of Chicago challenges this simple model. Focusing on the hippocampus, a region critical for memory, the study finds that other, less understood rules of synaptic plasticity may have a greater influence, offering a more accurate explanation of how brain activity shapes memory over time. Patterns of activity and their neuronal representations change a lot as an animal becomes more familiar with a new environment or experience. Surprisingly, those patterns keep evolving even once something is learned, albeit more slowly. “When you go into a room, it’s new at first but it quickly becomes familiar to you every time you come back,” said Mark Sheffield, PhD, Associate Professor of Neurobiology and the Neuroscience Institute at UChicago and senior author of the new study published in Nature Neuroscience. “So, you might expect that neuronal activity representing that room would settle and become stable, but it continues to change. “These changes in representation, during learning and after, must be driven by synaptic plasticity, but what kind of plasticity exactly? It’s hard to know, because we don’t have the technology to measure that directly in behaving animals,” he said. Shifting place cells The 2014 Nobel Prize in Medicine was awarded for the discovery of “place cells”: neurons in the hippocampus that activate only when an animal is at a certain spot in a room, called the “place field.” Different neurons have their place fields at different locations in the room, covering the entire environment and forming what’s known as a cognitive map. In the new study, Antoine Madar, PhD, a postdoctoral researcher in Sheffield’s lab, studied place cell activity recorded in the brains of mice as they scampered through different environments. The mice first ran through a familiar environment, then switched to an unfamiliar one. The researchers expected to see the same patterns of activity when the mice were in a place they knew, and different patterns as they learned a new environment. Instead, they saw that the activity was slightly different every time, and reasoned that these changes reflected synaptic plasticity. To understand what drives these constant changes in neuronal representations, Madar built a computational model of hippocampal neurons, and then applied different plasticity rules to see if they would make place cells behave in the same patterns seen in the mouse data. Instead of the traditional “neurons that fire together wire together” rule, known as Hebbian Spike Timing-Dependent Plasticity (STDP), a different, non-Hebbian rule called Behavioral Timescale Synaptic Plasticity (BTSP) best explained the shifting place field dynamics. Some changes in place cell activity were subtle; the cell fired in a slightly different location than the previous time. Others were more drastic, jumping to a completely different location. STDP could only explain the small gradual shifts, Madar said, but BTSP could explain the whole range of shifting trajectories, including the big nonlinear shifts. “We know a lot about the physiology that supports synaptic plasticity, but we usually don’t know how important those things are for learning,” Madar said. “Our study provides evidence that BTSP is more impactful than STDP in shaping hippocampal activity during familiarization.” BTSP is a fairly recent discovery, so Madar said that comparing their data and models allowed them to learn a lot about this new plasticity rule. For instance, they knew that BSTP is triggered by large jumps in the amount of calcium inside cells, but they didn’t know how frequently these jumps happen. The new research shows that while these jumps are rare, they occur more frequently when an animal is learning and forming new memories. The researchers also found that once a place field forms, the probability of these BTSP-triggering events follows a simple decaying pattern, with only slight variations across brain regions or familiarity levels. “This is enough to explain the awesome diversity in individual place field dynamics that we observed,” Madar said. Encoding the entire experience Although the research shows that hippocampal activity is much more dynamic during memory formation than previously thought, it’s still not clear what purpose these shifting representations could serve. “Continually evolving neuronal representations could help the brain distinguish between similar memories that happened in the same place but at different times, a very important process to avoid pathological memory confusion, a hallmark of multiple neurological and cognitive disorders,” Madar said. Sheffield starts to sound Proustian when considering this question. “Every time you come back into the room that you’re sitting in, you’re somehow able to track that you’re in the same room. But it’s a different day and a different time, right? You can never completely replicate an experience, and somehow the brain tracks all that,” he said. “So, one idea is that these dynamics in memory representations are encoding just that. They’re encoding slight changes in the experience, like maybe you have a coffee one time and later you have lunch in the same room. These subtle differences in setting, odors, time — all these slight changes in experience could be encoded into the memory through the changes in these place fields. They’re not just encoding the environment; they’re encoding the entire experience that occurs there.” Reference: “Synaptic plasticity rules driving representational shifting in the hippocampus” by Antoine D. Madar, Anqi Jiang, Can Dong and Mark E. J. Sheffield, 20 March 2025, Nature Neuroscience. DOI: 10.1038/s41593-025-01894-6 The study was funded by the National Institutes of Health (DP2NS111657, F32MH126643), the Whitehall Foundation, the Searle Scholars Program and the Sloan Foundation. Anqi Jiang and Can Dong, current and former PhD students at UChicago, were additional authors.

DVDV1551RTWW78V