Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Insole ODM factory in China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan foot care insole ODM development factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China OEM insole and pillow supplier

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.PU insole OEM production in Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Breathable insole ODM development Taiwan

Fossils of the key groups used to unveil the Eocene-Oligocene extinction in Africa with primates on the left, the carnivorous hyaenodont, on the upper right, rodent, on the lower right. These fossils are from the Fayum Depression in Egypt and are stored at the Duke Lemur Center’s Division of Fossil Primates. Credit: Matt Borths, Duke University Lemur Center Fossils from Duke collection uncover a previously unknown mass extinction event in Africa. Sixty-three percent. That’s the proportion of mammal species that vanished from Africa and the Arabian Peninsula around 30 million years ago, after Earth’s climate shifted from swampy to icy. But we are only finding out about it now. Compiling decades of work, a new study published this week in the journal Communications Biology reports on a previously undocumented extinction event that followed the transition between the geological periods called the Eocene and Oligocene. That time period was marked by dramatic climate change. In a reverse image of what is happening today, the Earth grew cooler, ice sheets expanded, sea levels dropped, forests started changing to grasslands, and carbon dioxide became scarce. Nearly two-thirds of the species known in Europe and Asia at that time went extinct. African mammals were thought to have possibly escaped unscathed. Africa’s mild climate and proximity to the Equator could have been a buffer from the worst of that period’s cooling trend. Dental CT scans show that mammal teeth became less diverse during the early Oligocene extinction events. Here is an example of the three-dimensional tooth shape of a lower molar of a fossil anomaluroid rodent. Credit: Dorien de Vries, University of Salford Now, thanks in great part to a large collection of fossils housed at the Duke Lemur Center Division of Fossil Primates (DLCDFP), researchers have shown that, despite their relatively balmy environment, African mammals were just as affected as those from Europe and Asia. The collection was the life’s work of the late Elwyn Simons of Duke, who scoured Egyptian deserts for fossils for decades.  The team, comprising researchers from the United States, England, and Egypt, looked at fossils of five mammal groups: a group of extinct carnivores called hyaenodonts, two rodent groups, the anomalures (scaly-tail squirrels) and the hystricognaths (a group that includes porcupines and naked mole rats), and two primate groups, the strepsirrhines (lemurs and lorises), and our very own ancestors, the anthropoids (apes and monkeys). By gathering data on hundreds of fossils from multiple sites in Africa, the team was able to build evolutionary trees for these groups, pinpointing when new lineages branched out and time-stamping each species’ first and last known appearances. Their results show that all five mammal groups suffered huge losses around the Eocene-Oligocene boundary. “It was a real reset button,” said Dorien de Vries, a postdoctoral researcher at the University of Salford and lead author of the paper. After a few million years, these groups start popping up again in the fossil record, but with a new look. The fossil species that re-appear later in the Oligocene, after the big extinction event, are not the same as those that were found before. “It’s very clear that there was a huge extinction event, and then a recovery period,” said Steven Heritage, Researcher and Digital Preparator at Duke University’s DLCDFP and coauthor of the paper. The evidence is in these animals’ teeth. Molar teeth can tell a lot about what a mammal eats, which in turn tells a lot about their environment. The rodents and primates that reappeared after a few million years had different teeth. These were new species, that ate different things, and had different habitats. “We see a huge loss in tooth diversity, and then a recovery period with new dental shapes and new adaptations,” said de Vries. “Extinction is interesting in that way,” said Matt Borths, curator of Duke University’s DLCDFP and coauthor of the paper. “It kills things, but it also opens up new ecological opportunities for the lineages that survive into this new world.” This decline in diversity followed by a recovery confirms that the Eocene-Oligocene boundary acted as an evolutionary bottleneck: most lineages went extinct, but a few survived. Over the next several millions of years, these surviving lines diversified. “In our anthropoid ancestors, diversity bottoms out to almost nothing around 30 million years ago, leaving them with a single tooth type,” said Erik R. Seiffert, Professor and Chair of the Department of Integrative Anatomical Sciences at the Keck School of Medicine of the University of Southern California, a former graduate student of Simons, and senior coauthor of the paper. “That ancestral tooth shape determined what was possible in terms of later dietary diversification.” “There’s an interesting story about the role of that bottleneck in our own early evolutionary history,” said Seiffert. “We came pretty close to never existing, if our monkey-like ancestors had gone extinct 30 million years ago. Luckily they didn’t.” A rapidly changing climate wasn’t the only challenge facing these few surviving types of mammals. As temperatures dropped, East Africa was pummeled by a series of major geological events, such as volcanic super eruptions and flood basalts – enormous eruptions that covered vast expanses with molten rock. It was also at that time that the Arabian Peninsula separated from East Africa, opening the Red Sea and the Gulf of Aden. “We lost a lot of diversity at the Eocene-Oligocene boundary,” said Borths. “But the species that survived apparently had enough of a toolkit to persist through this fluctuating climate.” “Climate changes through geological time have shaped the evolutionary tree of life,” said Hesham Sallam, founder of the Mansoura University Vertebrate Paleontology Center in Egypt and coauthor of the paper. “Collecting evidence from the past is the easiest way to learn about how climate change will affect ecological systems.” Reference: “Widespread loss of mammalian lineage and dietary diversity in the early Oligocene of Afro-Arabia” by Dorien de Vries, Steven Heritage, Matthew R. Borths, Hesham M. Sallam and Erik R. Seiffert, 7 October 2021, Communications Biology. DOI: 10.1038/s42003-021-02707-9 Funding for this study came from The Leakey Foundation, the U.S. National Science Foundation (BSC-1824745 to DD. and DBI-1612062 to MRB), and the Natural Environment Research Council (NERC NE/T000341/1). Field work in the Fayum Depression, Egypt, and digital curation of Fayum fossils were supported by the U.S. National Science Foundation (BCS-0416164, BCS-0819186, and BCS-1231288) as well as Gordon and Ann Getty and The Leakey Foundation. Micro-CT scanning was partially supported by NSF grant DBI-1458192, DBI-2023087, and IMLS grant MA-245704-OMS-20.

Researchers discovered the first millipede with more than 1,000 legs 60 meters underground in a drill hole created for mineral exploration in the mining area of the Eastern Goldfields Province of Australia. Credit: P. Marek et al., 2021, Scientific Reports The discovery of the first millipede with more than 1,000 legs is reported in Scientific Reports this week. Prior to this, no millipede had been found with more than 750 legs. Paul Marek and colleagues discovered the millipede 60 meters underground in a drill hole created for mineral exploration in the mining area of the Eastern Goldfields Province of Australia. It has 1,306 legs — more than any other animal — and belongs to a new species that has been named Eumillipes persephone. The millipede’s name derives from the Greek word eu- (true), the Latin words mille (thousand) and pes (foot), and references the Greek goddess of the underworld, Persephone. The authors measured four members of the new species and found that they have long, thread-like bodies consisting of up to 330 segments and are up to 0.95mm wide and 95.7mm long. They are eyeless, have short legs, and cone-shaped heads with antennae and a beak. Named Eumillipes persephone, this millipede has 1,306 legs — more than any other animal. Credit: P. Marek et al., 2021, Scientific Reports Analysis of the relationships between species suggests that E. persephone is distantly related to the previous record holder for the greatest number of legs — the Californian millipede species, Illacme plenipes. The authors suggest that the large number of segments and legs that have evolved in both species may allow them to generate pushing forces that enable them to move through narrow openings in the soil habitats they live in. Credit: P. Marek et al., 2021, Scientific Reports Credit: P. Marek et al., 2021, Scientific Reports Credit: P. Marek et al., 2021, Scientific Reports The findings highlight the biodiversity found within the Eastern Goldfields Province. To minimize the impact of mining in this region on E. persephone, the authors advise that efforts should be made to conserve its underground habitat. Reference: “The first true millipede—1306 legs long” by Paul E. Marek, Bruno A. Buzatto, William A. Shear, Jackson C. Means, Dennis G. Black, Mark S. Harvey and Juanita Rodriguez, 16 December 2021, Scientific Reports. DOI: 10.1038/s41598-021-02447-0

New research challenges traditional views on ATP production and mitochondrial membrane potential, revealing that oxidative phosphorylation occurs in mitochondrial cristae and that sodium plays a significant role in charge gradients, with implications for mitochondrial diseases like LHON. A study conducted by researchers from the University of São Paulo sheds light on new discoveries about the mechanisms of oxidative phosphorylation in ATP production. Recent findings highlight the involvement of sodium in mitochondrial respiration. In an article published in Trends in Biochemical Sciences, Alicia Kowaltowski, a full professor at the University of São Paulo’s Institute of Chemistry (IQ-USP) in Brazil, calls for a “rewriting” of textbooks regarding the location of the electron transport chain in mitochondria and the role of sodium in mitochondrial respiration. Kowaltowski is also a member of the Research Center for Redox Processes in Biomedicine (Redoxoma), a Research, Innovation, and Dissemination Center (RIDC) funded by FAPESP and based at IQ-USP. The article, co-authored with Fernando Abdulkader, a professor at the University of São Paulo’s Biomedical Sciences Institute (ICB-USP), highlights a number of new discoveries about oxidative phosphorylation mechanisms, including an innovative study published in the journal Cell by José Antonio Enríquez and colleagues at the Spanish National Center for Cardiovascular Research, revealing the unexpected role of sodium in maintaining mitochondrial membrane potential. Textbook Misconceptions About ATP Production “Knowledge evolves, and what we present to students should also evolve,” Kowaltowski said. “Until a few years ago, we were sure that mitochondria produced ATP via oxidative phosphorylation in the intermembrane space, where the inner and outer membranes interact. This has changed. We’ve discovered that the process occurs in the mitochondrial cristae. The textbooks are wrong and it’s time to make the correction. The research done by Enríquez and his group has shown that mitochondrial membrane potential is also a property that may be somewhat different, and this too is a topic that isn’t addressed in the textbooks.” Often called the “energy currency” of cells, adenosine triphosphate (ATP) is produced in mitochondria by oxidative phosphorylation, a process of energy transfer driven by electron and proton gradients across the inner mitochondrial membrane. This mechanism links the gradual oxidation of electron donors in the electron transport chain to the pumping of protons through the membrane, generating the electrochemical gradient required for ATP synthesis. Sodium and membrane potential Scientists have known for some time that the proton gradient in mitochondria is narrow, owing to cellular buffering mechanisms that assure pH stabilization. The charge gradient is therefore considered the key factor in proton pumping. Until recently, this gradient was attributed to potassium, the most abundant cation in cells, but the study by Enríquez et al. showed that between 30% and 50% of the charge gradient can be attributed to sodium transported in exchange for protons in complex I of the electron transport chain. Complex I transfers electrons (initially derived from food) from the coenzyme NADH (nicotinamide adenine dinucleotide) to the other complexes in the chain. Part of the complex also functions as an exchanger of sodium ions for protons. “This study made two important contributions. It identified a second fundamental function of complex I, and it demonstrated the role of sodium in maintaining mitochondrial membrane potential,” Enríquez said. According to Kowaltowski and Abdulkader, the discovery was unexpected because cells do not contain a large amount of sodium, but the article by Enríquez et al. presents convincing evidence. The researchers deployed a large number of experimental models, including mutants of respiratory chain components, as well as several methodological approaches using different ionophores and sodium-depleted media. The experiments involved painstaking bioenergetic measurements, including calibrated quantifications of membrane potential, which are rarely found in the scientific literature. The study also showed that a point mutation in complex I associated with Leber hereditary optic neuropathy (LHON) specifically impairs proton-sodium exchange without affecting electron transport or proton pumping via the complex. LHON is a rare neurodegenerative mitochondrial disorder affecting the optic nerve and potentially causing vision loss in young adults. “The researchers not only describe a novel mechanism that’s central to the energy metabolism, but also relate it directly to a disease,” Kowaltowski said. Reference: “Textbook oxidative phosphorylation needs to be rewritten” by Alicia J. Kowaltowski and Fernando Abdulkader, 21 November 2024, Trends in Biochemical Sciences. DOI: 10.1016/j.tibs.2024.11.002 The study was funded by the ão Paulo Research Foundation.

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