Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Indonesia ODM expert for comfort products

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Eco-friendly pillow OEM manufacturer Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Innovative insole ODM solutions in Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand OEM factory for footwear and bedding

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China graphene product OEM service

The Zoonomia Project has documented the genetic diversity in 240 mammalian species, covering over 80% of mammalian families. By sequencing and aligning the genomes, the team has identified conserved genomic regions across species, highlighting areas that may be biologically significant, but do not code for proteins. Their research suggests that at least 10% of the human genome is functional, a tenfold increase on the portion that codes for proteins. The data has illuminated genetic variants potentially connected to various human diseases, including cancer. Additionally, the genome analyses have shed light on distinct mammalian traits such as hibernation, exceptional brain size, and enhanced olfactory senses. The international Zoonomia Project has analyzed the genomes of 240 mammalian species, revealing conserved regions that could be biologically essential and may influence diseases. It suggests 10% of the human genome is functional, extending beyond protein-coding areas. The research has uncovered genetic traits related to human diseases and unique mammalian features, and has provided insights into evolutionary events and species diversity. From the two-gram bumblebee bat to whales weighing many tons, the more than 6,000 species of mammal on the planet – including humans – are highly divergent. Over the past 100 million years, they have adapted to nearly every environment on Earth. Now, an international collaboration of scientists with the Zoonomia Project – the largest comparative mammalian genomics resource in the world – has cataloged the diversity in the genomes of 240 mammalian species, representing over 80% of mammalian families. Their findings across 11 papers in this issue of Science pinpoint parts of the human genome that have remained unchanged after millions of years of evolution, providing information that may shed light on human health and disease. The authors’ work also reveals how certain uncommon mammalian traits – like the ability to hibernate – came to be. They say these analyses — and the breadth of questions they answer — only show a fraction of what is possible with this data for understanding both genome evolution and human disease. The Zoonomia Project is an international effort in which researchers sequenced a range of mammal genomes and then aligned them – a massive computational task. Using the alignment, the researchers identified regions of the genomes, sometimes just single letters of DNA, that are most conserved, or unchanged, across mammalian species and millions of years of evolution — regions that they hypothesized were biologically important. These regions – while they don’t give rise to proteins – may contain instructions that direct where, when, and how much protein is produced. Mutations in these regions could play an important role in the origin of diseases or in the distinctive features of mammal species, the authors hypothesized. Through their analyses, the researchers tested this hypothesis and were also able to ascertain that at least 10% of the human genome is functional, ten times as much as the approximately one percent that codes for proteins. The findings further revealed genetic variants likely to play causal roles in rare and common human diseases, including cancer. In one paper in the package, researchers studying patients with medulloblastoma identified mutations in evolutionarily conserved positions of the human genome they believe could be causing brain tumors to grow faster or to resist treatment. The results show how using this data and approach in disease studies could make it easier to find genetic changes that increase disease risk. In other papers in the package, the researchers pinpointed parts of the genome linked to a few exceptional traits in the mammalian world, such as extraordinary brain size, superior sense of smell, and the ability to hibernate during the winter. The authors use the genomes to confirm that estimate of effective population size and diversity can help predict risk in species that are hard to monitor and sample. Another study in the package shows that mammals had begun to change and diverge even before the Earth was hit by the asteroid that killed the dinosaurs, approximately 65 million years ago. A different study examined more than 10,000 genetic deletions specific to humans using both Zoonomia data and experimental analysis and linked some of them to the function of neurons. Other Zoonomia papers in the package uncovered a genetic explanation for why a famous sled dog from the 1920s named Balto was able to survive the harsh landscape of Alaska; discovered human-specific changes to genome organization; used machine learning to identify regions of the genome associated with brain size; described the evolution of regulatory sequences in the human genome; focused on sequences of DNA that move around the genome; discovered that species with smaller populations historically are at higher risk of extinction today; and compared genes between nearly 500 species of mammals. The special issue is accompanied by two Perspectives that provide further insights into the Zoonomia Project’s approach, findings, and future impacts. Zoonomia Special Issue Science – DOI: 10.1126/science.adi1599 Introduction “Zoonomia” by Sacha Vignieri (MS# adi1599) Perspective “Genomics expands the mammalverse” by Nathan S. Upham & Michael J. Landis (MS# add2209) “Seeing humans through an evolutionary lens” by Irene Gallego Romero (MS# adh0745) Research Article “Mammalian evolution of human cis-regulatory elements and transcription factor binding sites” by Gregory Andrews et al. (MS# abn7930) “Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs” by Katherine L. Moon et al. (MS# abn5887) “Relating enhancer genetic variation across mammals to complex phenotypes using machine learning” by Irene M. Kaplow et al. (MS# abm7993) “A genomic time scale for placental mammal evolution” by Nicole M. Foley et al. (MS# abl8189) “Evolutionary constraint and innovation across hundreds of placental mammals” by Matthew J. Christmas et al. (MS# abn3943) “Leveraging base-pair mammalian constraint to understand genetic variation and human disease” by Patrick F. Sullivan et al. (MS# abn2937) “Integrating gene annotation with orthology inference at scale” by Bogdan M. Kirilenko et al. (MS# abn3107) “The functional and evolutionary impacts of human-specific deletions in conserved elements” by James R. Xue et al. (MS# abn2253) “Three-dimensional genome rewiring in loci with human accelerated regions” by Kathleen C. Keough et al. (MS# abm1696) “Insights into mammalian TE diversity through the curation of 248 mammalian genome assemblies” by Austin B. Osmanski et al. (MS# abn1430) “The contribution of historical processes to contemporary extinction risk in placental mammals” by Aryn P. Wilder et al. (MS# abn5856)

In a new paper, researchers present a method to more efficiently produce biofuels from woody plant materials such as corn residues and some grasses. Credit: Markus Distelrath/Pixabay The new system streamlines the process of fermenting plant sugar to fuel by helping yeast survive industrial toxins. More corn is grown in the United States than any other crop, but we only use a small part of the plant for food and fuel production; once people have harvested the kernels, the inedible leaves, stalks and cobs are left over. If this plant matter, called corn stover, could be efficiently fermented into ethanol the way corn kernels are, stover could be a large-scale, renewable source of fuel. “Stover is produced in huge amounts, on the scale of petroleum,” said Whitehead Institute Member and Massachusetts Institute of Technology (MIT) biology professor Gerald Fink. “But there are enormous technical challenges to using them cheaply to create biofuels and other important chemicals.” And so, year after year, most of the woody corn material is left in the fields to rot. Now, a new study from Fink and MIT chemical engineering professor Gregory Stephanopolous led by MIT postdoctoral researcher Felix Lam offers a way to more efficiently harness this underutilized fuel source. By changing the growth medium conditions surrounding the common yeast model, baker’s yeast Saccharomyces cerevisiae, and adding a gene for a toxin-busting enzyme, they were able to use the yeast to create ethanol and plastics from the woody corn material at near the same efficiency as typical ethanol sources such as corn kernels. Sugarcoating the issue For years, the biofuels industry has relied on microorganisms such as yeast to convert the sugars glucose, fructose, and sucrose in corn kernels to ethanol, which is then mixed in with traditional gasoline to fuel our cars. Corn stover and other similar materials are full of sugars as well, in the form of a molecule called cellulose. While these sugars can be converted to biofuels too, it’s more difficult since the plants hold onto them tightly, binding the cellulose molecules together in chains and wrapping them in fibrous molecules called lignins. Breaking down these tough casings and disassembling the sugar chains results in a chemical mixture that is challenging for traditional fermentation microorganisms to digest. Whitehead Institute Member Gerald Fink standing in front of a field of the grass Miscanthus giganteus, which is another potential source of cellulose that could be converted to ethanol. Credit: Photo courtesy of Felix Lam To help the organisms along, workers in ethanol production plants pretreat high-cellulose material with an acidic solution to break down these complex molecules so yeast can ferment them. A side effect of this treatment, however, is the production of molecules called aldehydes, which are toxic to yeast. Researchers have explored different ways to reduce the toxicity of the aldehydes in the past, but solutions were limited considering that the whole process needs to cost close to nothing. “This is to make ethanol, which is literally something that we burn,” Lam said. “It has to be dirt cheap.” Faced with this economic and scientific problem, industries have cut back on creating ethanol from cellulose-rich materials. “These toxins are one of the biggest limitations to producing biofuels at a low cost.” said Gregory Stephanopoulos, who is the Willard Henry Dow Professor of Chemical Engineering at MIT. Lending yeast a helping hand To tackle the toxin problem, the researchers decided to focus on the aldehydes produced when acid is added to break down tough molecules. “We don’t know the exact mechanism by which aldehydes attack microbes, so then the question was, if we don’t really know what it attacks, how do we solve the problem?” Lam said. “So we decided to chemically convert these aldehydes into alcohol forms.” The team began looking for genes that specialized in converting aldehydes to alcohols, and landed on a gene called GRE2. They optimized the gene to make it more efficient through a process called directed evolution, and then introduced it into the yeast typically used for ethanol fermentation, Saccharomyces cerevisiae. When the yeast cells with the evolved GRE2 gene encountered aldehydes, they were able to convert them into alcohols by tacking on extra hydrogen atoms. The resultant high levels of ethanol and other alcohols produced from the cellulose might have posed a problem in the past, but at this point Lam’s past research came into play. In a 2015 paper from Lam, Stephanopoulos and Fink, the researchers developed a system to make yeast more tolerant to a wide range of alcohols, in order to produce greater volumes of the fuel from less yeast. That system involved measuring and adjusting the pH and potassium levels in the yeast’s growth media, which chemically stabilized the cell membrane. By combining this method with their newly modified yeast, “we essentially channeled the aldehyde problem into the alcohol problem, which we had worked on before,” Lam said. “We changed and detoxified the aldehydes into a form that we knew how to handle.” When they tested the system, the researchers were able to efficiently make ethanol and even plastic precursors from corn stover, miscanthus and other types of plant matter. “We were able to produce a high volume of ethanol per unit of material using our system,” Fink said. “That shows that there’s great potential for this to be a cost-effective solution to the chemical and economic issues that arise when creating fuel from cellulose-rich plant materials.” Scaling up Alternative fuel sources often face challenges when it comes to implementing them on a nationwide scale; electric cars, for example, require a nationwide charging infrastructure in order to be a feasible alternative to gas vehicles. An essential feature of the researchers’ new system is the fact that the infrastructure is already in place; ethanol and other liquid biofuels are compatible with existing gasoline vehicles so require little to no change in the automotive fleet or consumer fueling habits. “Right now [the US produces around] 15 billion gallons of ethanol per year, so it’s on a massive scale,” he said. “That means there are billions of dollars and many decades worth of infrastructure. If you can plug into that, you can get to market much faster.” And corn stover is just one of many sources of high-cellulose material. Other plants, such as wheat straw and miscanthus, also known as silvergrass, can be grown extremely cheaply. “Right now the main source of cellulose in this country is corn stover,” Lam said. “But if there’s demand for cellulose because you can now make all these petroleum-based chemicals in a sustainable fashion, then hopefully farmers will start planting miscanthus, and all these super dense straws.” In the future, the researchers hope to investigate the potential of modifying yeasts with these anti-toxin genes to create diverse types of biofuels such as diesel that can be used in typical fuel-combusting engines. “If we can [use this system for other fuel types], I think that would go a huge way toward addressing sectors such as ships and heavy machinery that continue to pollute because they have no other electric or non-emitting solution,” Lam said. Reference: “Engineered yeast tolerance enables efficient production from toxified lignocellulosic feedstocks” by Felix H. Lam, Burcu Turanli-Yildiz, Dany Liu, Michael G. Resch, Gerald R. Fink and Gregory Stephanopoulos, 25 June 2021, Science Advances. DOI: 10.1126/sciadv.abf7613

Oil and gas exploration in Ecuador. Credit: Julie Larson Maher/WCS Intact Forest Landscapes are critical for conserving biodiversity and fighting climate change. A new study from WCS and WWF reveals that nearly 20 percent of tropical Intact Forest Landscapes (IFLs) overlap with concessions for extractive industries such as mining, oil and gas. The total area of overlap is 376,449 square miles (975,000 square kilometers), about the size of Egypt. Mining concessions overlap most with tropical IFLs, at 11.33 percent of the total area, while oil and gas concessions overlap with 7.85 percent of the total area. IFLs are globally important for conserving biodiversity and fighting climate change. These landscapes represent some of the last places on Earth that still contain species assemblages at near-natural levels of abundance. According to 2013 estimates, 549 million acres of intact tropical forests remain. Only 20 percent of tropical forests can be considered “intact,” but those areas store some 40 percent of the above-ground carbon found in all tropical forests. At least 35 percent of intact forests are home to, and protected by, politically and economically marginalized Indigenous Peoples. Despite intact forests’ extraordinary value for biodiversity and humanity, they are declining at an alarming rate, with over 7 percent of their total area lost between 2000 and 2013. While the growth of extractive industries is recognized as a threat to IFLs, the extent of this threat has not been well understood prior to this study. The authors calculated the spatial overlap of extractive concessions – specifically, mining, and oil and gas – with IFL datasets in three tropical regions: South America, Asia-Pacific, and Central Africa. Of these regions, Central Africa’s IFLs had the highest overlap with extractive concessions (26 percent). In addition, they identified the specific stages of extractive projects overlapping with IFLs, and found that most leases are in the exploration stage. Said Dr. Hedley Grantham, lead author of the study. “Many of these extractive projects are still in the early stages. While this could imply a significant future threat to IFLs, it also means there is an opportunity to mitigate potential impacts before they occur.” The authors recommend that companies incorporate avoidance planning in the design phase of extractive projects, taking into account the most important intact forest areas. Ideally, coordination with governments will allow for landscape-scale planning. The authors encourage governments not to allocate extractives concessions within IFLs where possible. With the appropriate planning, future impacts to these crucial ecosystems can be avoided. The study is published in Frontiers in Forests and Global Change. Reference: “The Emerging Threat of Extractives Sector to Intact Forest Landscapes” by Hedley S. Grantham, Paolo Tibaldeschi, Pablo Izquierdo, Karen Mo, David J. Patterson, Hugo Rainey, J. E. M. Watson and Kendall R. Jones, 16 July 2021, Frontiers in Forests and Global Change. DOI: 10.3389/ffgc.2021.692338 WCS is a member of Forests for Life (FFL), a partnership with Re:wild, United Nations Development Programme, World Resources Institute and Rainforest Foundation Norway. Working with national governments, Indigenous Peoples, local communities and others, FFL has two aims – to place ecological integrity at the heart of managing and conserving the world’s forests and to halt and reverse declines in integrity across 1 billion hectares of the most intact forests worldwide. WCS is a proud partner of Trillion Trees, a joint venture between BirdLife International, WCS, and WWF to urgently speed up and scale up the positive power of forests, helping the world protect and restore one trillion trees by 2050.

DVDV1551RTWW78V